Collier, SP, Collins, PL, Williams, CL, Boothby, MR, Aune, TM. Cutting edge: influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells. J Immunol, 189(5), 2084-8, 2012
Yang, J, Kantrow, S, Sai, J, Hawkins, OE, Boothby, M, Ayers, GD, Young, ED, Demicco, EG, Lazar, AJ, Lev, D, Richmond, A. Ikk4a/Arf inactivation with activation of the NF-??B/IL-6 pathway is sufficient to drive the development and growth of angiosarcoma. Cancer Res, 72(18), 4682-95, 2012
Volanakis, EJ, Boothby, MR, Sherr, CJ. Epigenetic regulation of the Ink4a-Arf (Cdkn2a) tumor suppressor locus in the initiation and progression of Notch1 driven T-ALL. Exp Hematol, 2012
Boothby, M, Williams, CL. The goldilocks effect. Sci Transl Med, 4(163), 163fs42, 2012
Lee, K, Nam, KT, Cho, SH, Gudapati, P, Hwang, Y, Park, DS, Potter, R, Chen, J, Volanakis, E, Boothby, M. Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia. J Exp Med, 209(4), 713-28, 2012
Zhuang, G, Song, W, Amato, K, Hwang, Y, Lee, K, Boothby, M, Ye, F, Guo, Y, Shyr, Y, Lin, L, Carbone, DP, Brantley-Sieders, DM, Chen, J. Effects of cancer-associated EPHA3 mutations on lung cancer. J Natl Cancer Inst, 104(15), 1182-97, 2012
Cho, SH, Ahn, AK, Bhargava, P, Lee, CH, Eischen, CM, McGuinness, O, Boothby, M. Glycolytic rate and lymphomagenesis depend on PARP14, an ADP ribosyltransferase of the B aggressive lymphoma (BAL) family. Proc Natl Acad Sci U S A, 108(38), 15972-7, 2011
Gordy, LE, Bezbradica, JS, Flyak, AI, Spencer, CT, Dunkle, A, Sun, J, Stanic, AK, Boothby, MR, He, YW, Zhao, Z, Van Kaer, L, Joyce, S. IL-15 Regulates Homeostasis and Terminal Maturation of NKT Cells. J Immunol, 187(12), 6335-45, 2011
Dunaway, CM, Hwang, Y, Lindsley, CW, Cook, RS, Wu, JY, Boothby, M, Chen, J, Brantley-Sieders, DM. Cooperative signaling between Slit2 and Ephrin-A1 regulates a balance between angiogenesis and angiostasis. Mol Cell Biol, 31(3), 404-16, 2011
Boothby, M. CRACking the code without Rosetta: molecular regulation of calcium-stimulated gene transcription after T cell activation. J Immunol, 185(9), 4969-71, 2010
Lee, K, Gudapati, P, Dragovic, S, Spencer, C, Joyce, S, Killeen, N, Magnuson, MA, Boothby, M. Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity, 32(6), 743-53, 2010
Boothby, M. The calculus of integrating differentiation: timing control of T-bet. Immunity, 30(5), 666-8, 2009
Cho, SH, Goenka, S, Henttinen, T, Gudapati, P, Reinikainen, A, Eischen, CM, Lahesmaa, R, Boothby, M. PARP-14, a member of the B aggressive lymphoma (BAL) family, transduces survival signals in primary B cells. Blood, 2009
Adeeku, E, Gudapati, P, Mendez-Fernandez, Y, Van Kaer, L, Boothby, M. Flexibility accompanies commitment of memory CD4 lymphocytes derived from IL-4 locus-activated precursors. Proc Natl Acad Sci U S A, 105(27), 9307-12, 2008
Goenka, S, Cho, SH, Boothby, M. Collaborator of Stat6 (CoaSt6)-associated poly(ADP-ribose) polymerase activity modulates Stat6-dependent gene transcription. J Biol Chem, 282(26), 18732-9, 2007
Talati, M, Meyrick, B, Peebles, RS, Davies, SS, Dworski, R, Mernaugh, R, Mitchell, D, Boothby, M, Roberts, LJ, Sheller, JR. Oxidant stress modulates murine allergic airway responses. Free Radic Biol Med, 40(7), 1210-9, 2006
Zhang, F, Boothby, M. T helper type 1-specific Brg1 recruitment and remodeling of nucleosomes positioned
at the IFN-gamma promoter are Stat4 dependent. J Exp Med, 203(6), 1493-505, 2006
Goenka, S, Boothby, M. Selective potentiation of Stat-dependent gene expression by collaborator of
Stat6 (CoaSt6), a transcriptional cofactor. Proc Natl Acad Sci U S A, 103(11), 4210-5, 2006
Corn, RA, Hunter, C, Liou, HC, Siebenlist, U, Boothby, MR. Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells,
GATA-3, and Th effector differentiation. J Immunol, 175(4), 2102-10, 2005
Corn RA, Hunter C, Liou HC, Siebenlist U, Boothby M
. Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells, GATA-3, and Th effector differentiation. J Immunol., 175(Aug 15 (4)), 2102-2110, 2005
Tong, Y, Aune, T, Boothby, M. T-bet antagonizes mSin3a recruitment and transactivates a fully methylated
IFN-gamma promoter via a conserved T-box half-site. Proc Natl Acad Sci U S A, 102(6), 2034-9, 2005
Stephenson, LM, Park, DS, Mora, AL, Goenka, S, Boothby, M. Sequence motifs in IL-4R alpha mediating cell-cycle progression of primary
lymphocytes. J Immunol, 175(8), 5178-85, 2005
Jones, RG, Saibil, SD, Pun, JM, Elford, AR, Bonnard, M, Pellegrini, M, Arya, S, Parsons, ME, Krawczyk, CM, Gerondakis, S, Yeh, WC, Woodgett, JR, Boothby, MR, Ohashi, PS. NF-kappaB couples protein kinase B/Akt signaling to distinct survival pathways
and the regulation of lymphocyte homeostasis in vivo. J Immunol, 175(6), 3790-9, 2005
Aronica, MA, Swaidani, S, Zhang, YH, Mitchell, D, Mora, AL, McCarthy, S, O''Neal, J, Topham, D, Sheller, JR, Boothby, M. Susceptibility to allergic lung disease regulated by recall responses of dual-receptor
memory T cells. J Allergy Clin Immunol, 114(6), 1441-8, 2004
Stanic, AK, Bezbradica, JS, Park, JJ, Van Kaer, L, Boothby, MR, Joyce, S. Cutting edge: the ontogeny and function of Va14Ja18 natural T lymphocytes require
signal processing by protein kinase C theta and NF-kappa B. J Immunol, 172(8), 4667-71, 2004
Stephenson, L, Johns, MH, Woodward, E, Mora, AL, Boothby, M. An IL-4R alpha allelic variant, I50, acts as a gain-of-function variant relative
to V50 for Stat6, but not Th2 differentiation. J Immunol, 173(7), 4523-8, 2004
Aronica MA, Swaidani, S, Zhang YH, Mitchell D, Mora AL, McCarthy S, Topham D, Sheller JR, and Boothby M. Susceptibility to allergic lung disease regulated by recall responses of dual-specificity memory T cells. J Allergy and Clin Immunol, in press, 2004
Stanic, Aleksandar K, Bezbradica, Jelena S, Park, Jang-June, Matsuki, Naoto, Mora, Ana L, Van Kaer, Luc, Boothby, Mark R, Joyce, Sebastian. NF-kappaB controls cell fate specification, survival, and molecular differentiation of immunoregulatory natural T lymphocytes. J Immunol, 172(4), 2265-73, 2004
Heller, NM, Matsukura, S, Georas, SN, Boothby, MR, Rothman, PB, Stellato, C, Schleimer, RP. Interferon-gamma inhibits STAT6 signal transduction and gene expression in
human airway epithelial cells. Am J Respir Cell Mol Biol, 31(5), 573-82, 2004
Heller, NM, Matsukura, S, Georas, SN, Boothby, MR, Stellato, C, Schleimer, RP. Assessment of signal transducer and activator of transcription 6 as a target
of glucocorticoid action in human airway epithelial cells. Clin Exp Allergy, 34(11), 1690-700, 2004
Kelly-Welch, Ann E, Hanson, Erica M, Boothby, Mark R, Keegan, Achsah D . Interleukin-4 and interleukin-13 signaling connections maps. Science, 300, 1527-8, 2003
Zhou, Ping, Hwang, Kwang Woo, Palucki, David A, Guo, Zhong, Boothby, Mark, Newell, Kenneth A, Alegre, Maria-Luisa. Impaired NF-kappaB activation in T cells permits tolerance to primary heart allografts and to secondary donor skin grafts. Am J Transplant, 3, 139-47, 2003
Tato, Cristina M, Villarino, Alejandro, Caamano JH, Jorge H, Boothby, Mark, Hunter, Christopher A, . Inhibition of NF-kappa B activity in T and NK cells results in defective effector cell expansion and production of IFN-gamma required for resistance to Toxoplasma gondii.. J Immunol, 170, 3139-46, 2003
Goenka, Shreevrat, Marlar, Clinton, Schindler, Ulrike, Boothby, Mark. Differential roles of C-terminal activation motifs in the establishment of Stat6 transcriptional specificity. J Biol Chem, 2003
Aronica, Mark A, McCarthy, Susan, Swaidani, Shadi, Mitchell, Daphne, Goral, Mehmet, Sheller, James R, Boothby, Mark. Recall Th2 response: Th1-resistant allergic susceptibility without biasing uncommitted CD4 T cells. Am J Respir Crit Care Med, 2003
Mora, Ana L, Stephenson, Linda M, Enerson, Ben, Youn, Jeehee, Keegan, Achsah D, Boothby, Mark, . New programming of IL-4 receptor signal transduction in activated T cells: Stat6 induction and Th2 differentiation mediated by IL-4Ralpha lacking cytoplasmic tyrosines.. J Immunol, 171:, 1891-1900, 2003
Corn, Radiah A, Aronica, Mark A, Zhang, Fuping, Tong, Yingkai, Stanley, Sarah A, Kim, Se Ryoung Agnes, Stephenson, Linda, Enerson, Ben, McCarthy, Susan, Mora, Ana, Boothby, Mark . T cell-intrinsic requirement for NF-kappaB induction in postdifferentiation IFN-gamma production and clonal expansion in a Th1 response. J Immunol, 171, 1816-1824, 2003
Boothby, Mark. Signaling advances from immunogenetics to immunogenomics. Genome Biol, 4(12), 239, 2003
Yang, Li, Yamagata, Noboru, Yadav, Rajwardhan, Brandon, Suzanne, Courtney, Regina L, Morrow, Jason D, Shyr, Yu, Boothby, Mark, Joyce, Sebastian, Carbone, David P, Breyer, Richard M. Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor. J Clin Invest, 111(5), 727-35, 2003
Mora, A L, Corn, R A, Stanic, A K, Goenka, S, Aronica, M, Stanley, S, Ballard, D W, Joyce, S, Boothby, M. Antiapoptotic function of NF-kappaB in T lymphocytes is influenced by their differentiation status: roles of Fas, c-FLIP, and Bcl-xL. Cell Death Differ, 10(9), 1032-44, 2003
Harlin, Helena, Podack, Eckhard, Boothby, Mark, Alegre, Maria-Luisa. TCR-independent CD30 signaling selectively induces IL-13 production via a TNF receptor-associated factor/p38 mitogen-activated protein kinase-dependent mechanism. J Immunol, 169(5), 2451-9, 2002
Harlin, Helena, Hwang, Kwang Woo, Palucki, David A, Kim, Oliver, Thompson, Craig B, Boothby, Mark, Alegre, Maria-Luisa. CTLA-4 engagement regulates NF-kappaB activation in vivo. Eur J Immunol, 32(8), 2095-104, 2002
Haley, Kathleen J, Ciota, Alex, Contreras, Johanna P, Boothby, Mark R, Perkins, David L, Finn, Patricia W. Alterations in lung collectins in an adaptive allergic immune response. Am J Physiol Lung Cell Mol Physiol, 282(3), L573-84, 2002
Soutto, Mohammed, Zhang, Feng, Enerson, Ben, Tong, Yingkai, Boothby, Mark, Aune, Thomas M, . A minimal IFN-gamma promoter confers Th1 selective expression.. J Immunol, 169, 4205-12, 2002
Boothby M and Aronica MA. Transcription regulation, allergic responses, and asthma . Immunol Allergy Clin N. Amer , 22, 871-889, 2002
Chen, Ying, Rosloniec, Ed, Price, Jim, Boothby, Mark, Chen, Jin. Constitutive expression of BCL-X(L) in the T lineage attenuates collagen-induced arthritis in Bcl-X(L) transgenic mice. Arthritis Rheum, 46(2), 514-21, 2002
Finn, Patricia W, He, Hongzhen, Ma, Chunyan, Mueller, Thomas, Stone, James R, Liou, Hsiou-Chi, Boothby, Mark R, Perkins, David L. Molecular profiling of the role of the NF-kappaB family of transcription factors during alloimmunity. J Leukoc Biol, 72(5), 1054-62, 2002
, 2001.
Boothby, M. Specificity of sn50 for NF-kappa B. Nat Immunol, 2(6), 471-2, 2001
Mora, A L, Stanley, S, Armistead, W, Chan, A C, Boothby, M. Inefficient ZAP-70 phosphorylation and decreased thymic selection in vivo result from inhibition of NF-kappaB/Rel. J Immunol, 167(10), 5628-35, 2001
Finn, P W, Stone, J R, Boothby, M R, Perkins, D L. Inhibition of NF-kappaB-dependent T cell activation abrogates acute allograft rejection. J Immunol, 167(10), 5994-6001, 2001
Mora A, Youn J, Keegan A, and Boothby, M . NF-kappa B/Rel participation in the lymphokine-dependent proliferation of T lymphoid cells. J Immunol, 166, 2218-2227, 2001
Chen, Y, Rosloniec, E, Goral, M I, Boothby, M, Chen, J. Redirection of T cell effector function in vivo and enhanced collagen-induced arthritis mediated by an IL-2R beta/IL-4R alpha chimeric cytokine receptor transgene. J Immunol, 166(6), 4163-9, 2001
Boothby, M, Mora, A L, Aronica, M A, Youn, J, Sheller, J R, Goenka, S, Stephenson, L, . IL-4 signaling, gene transcription regulation, and the control of effector T cells. Immunol Res, 23, 179-191, 2001
Boothby M, Mora AL, Stephenson, LM . Lymphokine-dependent proliferation of T-lymphoid cells: regulated responsiveness and role in vivo. Crit Rev Immunol, 21, 487-522, 2001
Zamorano, J, Mora, A L, Boothby, M, Keegan, A D. NF-kappa B activation plays an important role in the IL-4-induced protection from apoptosis. Int Immunol, 13(12), 1479-87, 2001
Aronica MA, Goenka S, and Boothby, M . IL-4-dependent induction of BCL-2 and BCL-x(L) in activated T lymphocytes through a STAT6- and PI 3-kinase-independent pathway. Cytokine, 12, 578-587, 2000
Aune, T M, Mora, A L, Kim, S, Boothby, M, Lichtman, A H. Costimulation reverses the defect in IL-2 but not effector cytokine production by T cells with impaired IkappaBalpha degradation. J Immunol, 162(10), 5805-12, 1999
Goenka, S, Youn, J, Dzurek, L M, Schindler, U, Yu-Lee, L Y, Boothby, M. Paired Stat6 C-terminal transcription activation domains required both for inhibition of an IFN-responsive promoter and trans-activation. J Immunol, 163(9), 4663-72, 1999
Aronica, M A, Mora, A L, Mitchell, D B, Finn, P W, Johnson, J E, Sheller, J R, Boothby, M R. Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo. J Immunol, 163(9), 5116-24, 1999
Powell, W C, Fingleton, B, Wilson, C L, Boothby, M, Matrisian, L M. The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis. Curr Biol, 9(24), 1441-7, 1999
Mora, A L, Chen, D, Boothby, M, Rubin, D H. Lineage-specific differences among CD8+ T cells in their dependence of NF-kappa B/Rel signaling. Eur J Immunol, 29(9), 2968-80, 1999
Seetharaman, R, Mora, A L, Nabozny, G, Boothby, M, Chen, J. Essential role of T cell NF-kappa B activation in collagen-induced arthritis. J Immunol, 163(3), 1577-83, 1999
Lee, S Y, Kaufman, D R, Mora, A L, Santana, A, Boothby, M, Choi, Y. Stimulus-dependent synergism of the antiapoptotic tumor necrosis factor receptor-associated factor 2 (TRAF2) and nuclear factor kappaB pathways. J Exp Med, 188(7), 1381-4, 1998
Youn, J, Chen, J, Goenka, S, Aronica, M A, Mora, A L, Correa, V, Sheller, J R, Boothby, M. In vivo function of an interleukin 2 receptor beta chain (IL-2Rbeta)/IL-4Ralpha cytokine receptor chimera potentiates allergic airway disease. J Exp Med, 188(10), 1803-16, 1998
Zhang, F, Wang, D Z, Boothby, M, Penix, L, Flavell, R A, Aune, T M. Regulation of the activity of IFN-gamma promoter elements during Th cell differentiation. J Immunol, 161(11), 6105-12, 1998
Wang, D, Zamorano, J, Keegan, A D, Boothby, M. HMG-I(Y) phosphorylation status as a nuclear target regulated through insulin receptor substrate-1 and the I4R motif of the interleukin-4 receptor. J Biol Chem, 272(40), 25083-90, 1997
Boothby, M R, Mora, A L, Scherer, D C, Brockman, J A, Ballard, D W. Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB. J Exp Med, 185(11), 1897-907, 1997
Wang, D Z, Cherrington, A, Famakin-Mosuro, B, Boothby, M. Independent pathways for de-repression of the mouse Ig heavy chain germ-line epsilon promoter: an IL-4 NAF/NF-IL-4 site as a context-dependent negative element. Int Immunol, 8(7), 977-89, 1996
Kovalik, J P, Ansari, B, Boothby, M. Rapid commitment to negative selection of a thymocyte line independent of CD4 co-engagement. J Immunol, 157(12), 5290-9, 1996
Kim, J, Reeves, R, Rothman, P, Boothby, M. The non-histone chromosomal protein HMG-I(Y) contributes to repression of the immunoglobulin heavy chain germ-line epsilon RNA promoter. Eur J Immunol, 25(3), 798-808, 1995
Wang, D Z, Ray, P, Boothby, M. Interleukin 4-inducible phosphorylation of HMG-I(Y) is inhibited by rapamycin. J Biol Chem, 270(39), 22924-32, 1995
Whitley, M Z, Cheng, H L, Tomasi, T B, Boothby, M. Distinct IL-4 response mechanisms of the MHC gene A alpha in different mouse B cell lines. Mol Immunol, 30(9), 821-32, 1993
Casey, L S, Lichtman, A H, Boothby, M. IL-4 induces IL-2 receptor p75 beta-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes. J Immunol, 148(11), 3418-26, 1992
Li, S C, Rothman, P, Boothby, M, Ferrier, P, Glimcher, L, Alt, F W. Control of immunoglobulin heavy chain constant region gene expression. Adv Exp Med Biol, 292, 245-51, 1991
Whitley, M Z, Sisk, R, Ivashkiv, L B, Finn, P W, Glimcher, L H, Boothby, M R. Non-consensus DNA sequences function in a cell-type-specific enhancer of the mouse class II MHC gene A alpha. Int Immunol, 3(9), 877-88, 1991
Gravallese, E M, Darling, J M, Glimcher, L H, Boothby, M. Role of lipopolysaccharide and IL-4 in control of transcription of the class II A alpha gene. J Immunol, 147(7), 2377-83, 1991
Rothman, P, Li, S C, Gorham, B, Glimcher, L, Alt, F, Boothby, M. Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line epsilon transcripts. Mol Cell Biol, 11(11), 5551-61, 1991
Finn, P W, Kara, C J, Van, T T, Douhan, J, Boothby, M R, Glimcher, L H. The presence of a DNA binding complex correlates with E beta class II MHC gene expression. EMBO J, 9(5), 1543-9, 1990
Liou, H C, Boothby, M R, Finn, P W, Davidon, R, Nabavi, N, Zeleznik-Le, N J, Ting, J P, Glimcher, L H. A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter. Science, 247(4950), 1581-4, 1990
Boothby, M, Liou, H C, Finn, P W, Gravallese, E, Glimcher, L H. Control of transcription at the murine A alpha locus. Immunol Res, 9(2), 77-92, 1990
Gravallese, E M, Boothby, M R, Smas, C M, Glimcher, L H. A lipopolysaccharide-induced DNA-binding protein for a class II gene in B cells is distinct from NF-kappa B. Mol Cell Biol, 9(8), 3184-92, 1989
Boothby, M, Liou, H C, Glimcher, L H. Differences in DNA sequence specificity among MHC class II X box binding proteins. J Immunol, 142(3), 1005-14, 1989
Boothby, M, Gravallese, E, Liou, H C, Glimcher, L H. A DNA binding protein regulated by IL-4 and by differentiation in B cells. Science, 242(4885), 1559-62, 1988
Liou, H C, Boothby, M R, Glimcher, L H. Distinct cloned class II MHC DNA binding proteins recognize the X box transcription element. Science, 242(4875), 69-71, 1988
Boime, I, Boothby, M, Darnell, R B, Policastro, P. Structure and expression of human placental hormone genes. Adv Exp Med Biol, 205, 267-80, 1986
Hoshina, M, Boothby, M, Hussa, R, Pattillo, R, Camel, H M, Boime, I. Linkage of human chorionic gonadotrophin and placental lactogen biosynthesis to trophoblast differentiation and tumorigenesis. Placenta, 6(2), 163-72, 1985
Hoshina, M, Boothby, M R, Hussa, R D, Pattillo, R A, Camel, H M, Boime, I. Segregation patterns of polymorphic restriction sites of the gene encoding the alpha subunit of human chorionic gonadotropin in trophoblastic disease. Proc Natl Acad Sci U S A, 81(8), 2504-7, 1984
Boothby, M, Kukowska, J, Boime, I. Imbalanced synthesis of human choriogonadotropin alpha and beta subunits reflects the steady state levels of the corresponding mRNAs. J Biol Chem, 258(15), 9250-3, 1983
Policastro, P, Ovitt, C E, Hoshina, M, Fukuoka, H, Boothby, M R, Boime, I. The beta subunit of human chorionic gonadotropin is encoded by multiple genes. J Biol Chem, 258(19), 11492-9, 1983
Hoshina, M, Boothby, M, Boime, I. Cytological localization of chorionic gonadotropin alpha and placental lactogen mRNAs during development of the human placenta. J Cell Biol, 93(1), 190-8, 1982
Boime, I, Boothby, M, Hoshina, M, Daniels-McQueen, S, Darnell, R. Expression and structures of human placental hormone genes as a function of placental development. Biol Reprod, 26(1), 73-91, 1982
Kohler, PO, Riser, M, Hardin, J, Boothby, M, Boime, I, Norris, J, Siciliano, MJ. Chorionic gonadotropin synthesis and gene assignment in human:mouse hybrid
cells. Adv Exp Med Biol, 138, 405-18, 1981
Boothby, M, Ruddon, R W, Anderson, C, McWilliams, D, Boime, I. A single gonadotropin alpha-subunit gene in normal tissue and tumor-derived cell lines. J Biol Chem, 256(10), 5121-7, 1981
