Department of Pathology, Microbiology, and Immunology


Oliver G. McDonald , M.D., Ph.D.



Assistant Professor

Dept. of Pathology, Microbiology and Immunology



Contact Information



Office Location:

MCN CC-2201A

Phone: 615-

Campus Mail address:


Pathology, Microbiology and Immunology-3rd Fl

MCN C-3321 (2561)

US Mailing address:

Vanderbilt University School of Medicine
Dept of Pathology, Microbiology and Immunology-3rd Fl
MCN C-3321

Nashville, TN 37232-2561




Research Keywords



Epigenetics, cancer, chromatin



Research Description



Epigenetic reprogramming of chromatin structure during neoplastic transformation and malignant progression



Clinical Research Description



Diagnostic pathology of gastrointestinal, pancreatic, and hepatobiliary disease






Prusevich, P, Kalin, JH, Ming, SA, Basso, M, Givens, J, Li, X, Hu, J, Taylor, MS, Cieniewicz, AM, Hsiao, PY, Huang, R, Roberson, H, Adejola, N, Avery, LB, Casero, RA, Taverna, SD, Qian, J, Tackett, AJ, Ratan, RR, McDonald, OG, Feinberg, AP, Cole, PA. A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1. ACS Chem Biol, 2014

McDonald, OG, Maitra, A, Hruban, RH. Human correlates of provocative questions in pancreatic pathology. Adv Anat Pathol, 19(6), 351-62, 2012

Hansen, KD, Timp, W, Bravo, HC, Sabunciyan, S, Langmead, B, McDonald, OG, Wen, B, Wu, H, Liu, Y, Diep, D, Briem, E, Zhang, K, Irizarry, RA, Feinberg, AP. Increased methylation variation in epigenetic domains across cancer types. Nat Genet, 43(8), 768-75, 2011

McDonald, OG, Wu, H, Timp, W, Doi, A, Feinberg, AP. Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nat Struct Mol Biol, 18(8), 867-74, 2011

Gan, Q, Yoshida, T, McDonald, OG, Owens, GK. Concise review: epigenetic mechanisms contribute to pluripotency and cell lineage determination of embryonic stem cells. Stem Cells, 25(1), 2-9, 2007

Hastings, NE, Simmers, MB, McDonald, OG, Wamhoff, BR, Blackman, BR. Atherosclerosis-prone hemodynamics differentially regulates endothelial and smooth muscle cell phenotypes and promotes pro-inflammatory priming. Am J Physiol Cell Physiol, 293(6), C1824-33, 2007

McDonald, OG, Owens, GK. Programming smooth muscle plasticity with chromatin dynamics. Circ Res, 100(10), 1428-41, 2007

Davis, CA, Haberland, M, Arnold, MA, Sutherland, LB, McDonald, OG, Richardson, JA, Childs, G, Harris, S, Owens, GK, Olson, EN. PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells. Mol Cell Biol, 26(7), 2626-36, 2006

McDonald, OG, Wamhoff, BR, Hoofnagle, MH, Owens, GK. Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo. J Clin Invest, 116(1), 36-48, 2006

Hendrix, JA, Wamhoff, BR, McDonald, OG, Sinha, S, Yoshida, T, Owens, GK. 5'' CArG degeneracy in smooth muscle alpha-actin is required for injury-induced gene suppression in vivo. J Clin Invest, 115(2), 418-27, 2005

Liu, Y, Sinha, S, McDonald, OG, Shang, Y, Hoofnagle, MH, Owens, GK. Kruppel-like factor 4 abrogates myocardin-induced activation of smooth muscle gene expression. J Biol Chem, 280(10), 9719-27, 2005

Wamhoff, BR, Bowles, DK, McDonald, OG, Sinha, S, Somlyo, AP, Somlyo, AV, Owens, GK. L-type voltage-gated Ca2+ channels modulate expression of smooth muscle differentiation marker genes via a rho kinase/myocardin/SRF-dependent mechanism. Circ Res, 95(4), 406-14, 2004

Wamhoff, BR, Hoofnagle, MH, Burns, A, Sinha, S, McDonald, OG, Owens, GK. A G/C element mediates repression of the SM22alpha promoter within phenotypically modulated smooth muscle cells in experimental atherosclerosis. Circ Res, 95(10), 981-8, 2004

McDonald, OG, Krynetski, EY, Evans, WE. Molecular haplotyping of genomic DNA for multiple single-nucleotide polymorphisms located kilobases apart using long-range polymerase chain reaction and intramolecular ligation. Pharmacogenetics, 12(2), 93-9, 2002