Department of Pathology, Microbiology, and Immunology


David Aronoff, M.D.Aronoff



Associate Professor

Director, Division of Infectious Diseases

Dept. of Medicine

Associate Professor

Dept. of Pathology, Microbiology & Immunology



Contact Information



Office Location:
MCN B-3321A

Phone: 615-322-9668

Campus Mail address:

US Mailing address:

Vanderbilt University School of Medicine
Dept of Medicine, Division of Infectious Diseases
MCN D-3100

1161 21st Ave South

Nashville, TN 37232-2358








M.D., Tufts Univ
B.S., Indiana Univ



Research Keywords



Innate immunity, reproductive health, bacterial pathogenesis, anaerobic infections, Clostridium, Streptococcus, Macrophages, Eicosanoids, Lipids



Research Description



The overarching goal of the Aronoff lab is to improve human health through discovery, with a primary interest on maternal-child wellness. The Aronoff lab primarily studies bacterial infections that complicate pregnancy. These infections include perinatal streptococcal infections and postpartum clostridial infections. Our major interest is revealing root molecular mechanisms whereby bacterial pathogens evade innate immunity within the female reproductive tract. In this context we have a special interest in the role that host-derived lipid mediators (eicosanoids) play in modulating immune responses to microbial invaders. Our work with toxigenic clostridia has extended to non-reproductive tract infections, such as colitis caused by Clostridium diffficile. Members of our lab engage in a range of research approaches, from purely bench science to translational science to purely clinical research. We value interdisciplinary team science.



Clinical Research Description



The Aronoff lab studies infections that complicate pregnancy such as chorioamnionitis and postpartum sepsis. We have translational studies of these clinical diseases that focus on understanding how pregnant and postpartum women develop severe infections.
Our lab also participates in clinical studies of Clostridium difficile infection, work that sprang out of our lab research on toxigenic clostridial infections.






Abdelsattar, ZM, Krapohl, G, Alrahmani, L, Banerjee, M, Krell, RW, Wong, SL, Campbell, DA, Aronoff, DM, Hendren, S. Postoperative Burden of Hospital-Acquired Clostridium difficile Infection. Infect Control Hosp Epidemiol, 36(1), 40-6, 2015

Carlson, PE, Kaiser, AM, McColm, SA, Bauer, JM, Young, VB, Aronoff, DM, Hanna, PC. Variation in germination of Clostridium difficile clinical isolates correlates to disease severity. Anaerobe, 33C, 64-70, 2015

Kopliku, FA, Schubert, AM, Mogle, J, Schloss, PD, Young, VB, Aronoff, DM. Low prevalence of Clostridium septicum fecal carriage in an adult population. Anaerobe, 32C, 34-36, 2014

Rao, K, Erb-Downward, JR, Walk, ST, Micic, D, Falkowski, N, Santhosh, K, Mogle, JA, Ring, C, Young, VB, Huffnagle, GB, Aronoff, DM. The systemic inflammatory response to Clostridium difficile infection. PLoS One, 9(3), e92578, 2014

Mancuso, P, O Brien, E, Prano, J, Goel, D, Aronoff, DM. No Impairment in host defense against Streptococcus pneumoniae in obese CPEfat/fat mice. PLoS One, 9(9), e106420, 2014

Canavaci, AM, Sorgi, CA, Martins, VP, Morais, FR, de Sousa, ??V, Trindade, BC, Cunha, FQ, Rossi, MA, Aronoff, DM, Faccioli, LH, Nomizo, A. The acute phase of Trypanosoma cruzi infection is attenuated in 5-lipoxygenase-deficient mice. Mediators Inflamm, 2014, 893634, 2014

Bauer, ME, Bauer, ST, Rajala, B, MacEachern, MP, Polley, LS, Childers, D, Aronoff, DM. Maternal physiologic parameters in relationship to systemic inflammatory response syndrome criteria: a systematic review and meta-analysis. Obstet Gynecol, 124(3), 535-41, 2014

Korir, ML, Knupp, D, LeMerise, K, Boldenow, E, Loch-Caruso, R, Aronoff, DM, Manning, SD. Association and virulence gene expression vary among serotype III group B streptococcus isolates following exposure to decidual and lung epithelial cells. Infect Immun, 82(11), 4587-95, 2014

Rogers, MA, Micic, D, Blumberg, N, Young, VB, Aronoff, DM. Storage duration of red blood cell transfusion and Clostridium difficile infection: a within person comparison. PLoS One, 9(2), e89332, 2014

Aronoff, DM. Editorial commentary: Host-pathogen interactions in Clostridium difficile infection: it takes two to tango. Clin Infect Dis, 58(10), 1401-3, 2014

Trindade, BC, Theriot, CM, Leslie, JL, Carlson, PE, Bergin, IL, Peters-Golden, M, Young, VB, Aronoff, DM. Clostridium difficile-induced colitis in mice is independent of leukotrienes. Anaerobe, 30, 90-8, 2014

Carlson, PE, Walk, ST, Bourgis, AE, Liu, MW, Kopliku, F, Lo, E, Young, VB, Aronoff, DM, Hanna, PC. The relationship between phenotype, ribotype, and clinical disease in human Clostridium difficile isolates. Anaerobe, 2013

Boldenow, E, Jones, S, Lieberman, RW, Chames, MC, Aronoff, DM, Xi, C, Loch-Caruso, R. Antimicrobial peptide response to group B Streptococcus in human extraplacental membranes in culture. Placenta, 34(6), 480-5, 2013

Waslawski, S, Lo, ES, Ewing, SA, Young, VB, Aronoff, DM, Sharp, SE, Novak-Weekley, SM, Crist, AE, Dunne, WM, Hoppe-Bauer, J, Johnson, M, Brecher, SM, Newton, DW, Walk, ST. Clostridium difficile ribotype diversity at six health care institutions in the United States. J Clin Microbiol, 51(6), 1938-41, 2013

Rao, K, Walk, ST, Micic, D, Chenoweth, E, Deng, L, Galecki, AT, Jain, R, Trivedi, I, Yu, M, Santhosh, K, Ring, C, Young, VB, Huffnagle, GB, Aronoff, DM. Procalcitonin levels associate with severity of Clostridium difficile infection. PLoS One, 8(3), e58265, 2013

Walk, ST, Micic, D, Galecki, AT, Rogers, MA, Washer, L, Newton, DW, Malani, PN, Young, VB, Aronoff, DM. Reply to Walker et al. Clin Infect Dis, 56(12), 1846-7, 2013

Krapohl, GL, Morris, AM, Cai, S, Englesbe, MJ, Aronoff, DM, Campbell, DA, Hendren, S. Preoperative risk factors for postoperative Clostridium difficile infection in colectomy patients. Am J Surg, 205(3), 343-7; discussion 347-8, 2013

Soares, EM, Mason, KL, Rogers, LM, Serezani, CH, Faccioli, LH, Aronoff, DM. Leukotriene B4 enhances innate immune defense against the puerperal sepsis agent Streptococcus pyogenes. J Immunol, 190(4), 1614-22, 2013

Walk, ST, Micic, D, Galecki, AT, Rogers, MA, Washer, L, Newton, DW, Malani, PN, Young, VB, Aronoff, DM. Reply to McDonald. Clin Infect Dis, 56(6), 907-8, 2013

Rogers, MA, Greene, MT, Young, VB, Saint, S, Langa, KM, Kao, JY, Aronoff, DM. Depression, antidepressant medications, and risk of Clostridium difficile infection. BMC Med, 11, 121, 2013

Walk, ST, Micic, D, Galecki, AT, Young, VB, Aronoff, DM. Understanding increased mortality in Clostridium difficile-infected older adults. Clin Infect Dis, 57(4), 625-6, 2013

Natarajan, M, Walk, ST, Young, VB, Aronoff, DM. A clinical and epidemiological review of non-toxigenic Clostridium difficile. Anaerobe, 22, 1-5, 2013

Rogers, LM, Thelen, T, Fordyce, K, Bourdonnay, E, Lewis, C, Yu, H, Zhang, J, Xie, J, Serezani, CH, Peters-Golden, M, Aronoff, DM. EP4 and EP2 Receptor Activation of Protein Kinase A by Prostaglandin E2 Impairs Macrophage Phagocytosis of Clostridium sordellii. Am J Reprod Immunol, 2013

Mason, KL, Rogers, LM, Soares, EM, Bani-Hashemi, T, Erb Downward, J, Agnew, D, Peters-Golden, M, Weinberg, JB, Crofford, LJ, Aronoff, DM. Intrauterine group A streptococcal infections are exacerbated by prostaglandin E2. J Immunol, 191(5), 2457-65, 2013

Behroozian, AA, Chludzinski, JP, Lo, ES, Ewing, SA, Waslawski, S, Newton, DW, Young, VB, Aronoff, DM, Walk, ST. Detection of mixed populations of Clostridium difficile from symptomatic patients using capillary-based polymerase chain reaction ribotyping. Infect Control Hosp Epidemiol, 34(9), 961-6, 2013

Aronoff, DM, Marrazzo, JM, Sears, CL. Introduction to the special issue highlighting Anaerobe 2012. Anaerobe, 2013

Aronoff, DM. Clostridium novyi, sordellii, and tetani: Mechanisms of disease. Anaerobe, 2013

Depestel, DD, Aronoff, DM. Epidemiology of Clostridium difficile Infection. J Pharm Pract, 26(5), 464-75, 2013

Zas??ona, Z, Okunishi, K, Bourdonnay, E, Domingo-Gonzalez, R, Moore, BB, Lukacs, NW, Aronoff, DM, Peters-Golden, M. Prostaglandin E2 suppresses allergic sensitization and lung inflammation by targeting the E prostanoid 2 receptor on T??cells. J Allergy Clin Immunol, 2013

Rao, K, Micic, D, Chenoweth, E, Deng, L, Galecki, AT, Ring, C, Young, VB, Aronoff, DM, Malani, PN. Poor Functional Status as a Risk Factor for Severe Clostridium difficile Infection in Hospitalized Older Adults. J Am Geriatr Soc, 61(10), 1738-42, 2013

Rogers, MA, Aronoff, DM. Depression and clostridium difficile infection. J Psychosoc Nurs Ment Health Serv, 51(10), 5, 2013

Aronoff, DM, Boutaud, O, Marnett, LJ, Oates, JA. Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes. J Pharmacol Exp Ther, 304(2), 589-95, 2003

Aronoff, DM. Using live pathogens to treat infectious diseases: a historical perspective on the relationship between GB virus C and HIV. Antivir Ther, 7(2), 73-80, 2002

Boutaud, O, Aronoff, DM, Richardson, JH, Marnett, LJ, Oates, JA. Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases. Proc Natl Acad Sci U S A, 99(10), 7130-5, 2002

Aronoff, DM. Comments to the editor concerning the paper entitled "Orexin-A regulates body temperature in coordination with arousal status" by Yoshimichi et al. Exp Biol Med (Maywood), 227(1), 1-2; discussion 3, 2002

Aronoff, DM, Neilson, EG. Antipyretics: mechanisms of action and clinical use in fever suppression. Am J Med, 111(4), 304-15, 2001

Slifer, A, Aronoff, DM. Bilateral adrenal cortical hyperplasia. Tenn Med, 93(5), 172-3, 2000

Williams, SJ, Aronoff, DM. Vanderbilt Morning Report. A young woman with gastrointestinal bleeding. Tenn Med, 93(3), 103, 105, 2000

Aronoff, DM, Morgan, HJ. A patient with an acute viral syndrome. Tenn Med, 93(2), 64-5, 2000

Shedd, OL, Hamilton, K, Aronoff, DM. A 30-year-old woman with disseminated histoplasmosis. Tenn Med, 92(11), 420-1, 1999

Aronoff, DM, Roshon, M. Severe hemorrhage complicating the Klippel-Tr??naunay-Weber syndrome. South Med J, 91(11), 1073-5, 1998