Department of Pathology, Microbiology, and Immunology


  Leslie Crofford, M.D.  a




Dept. of Medicine, Division of Rheumatology

Dept. of Pathology, Microbiology & Immunology



   Contact Information



Office Location:

MCN T-3113

Phone: 615-322-4746

Fax:  615-322-6248

E-mail:  leslie.j.crofford@vanderbilt.edu


Campus Mail Address:

Department of Medicine, Rheumatology Division

MCN T-3113  (2681)


Mailing Address:

Vanderbilt University School of Medicine

Department of Medicine, Rheumatology Division

1161 21st Ave South

MCN T-3113

Nashville, TN 37232 - 2681






MD, University of Tennessee Health Sciences Center, Memphis, TN
BS, Vanderbilt University, Nashville, TN



Research Keywords





Research Description



Inflammatory arthritis, including rheumatoid arthritis, is a systemic disease causing pain, fatigue, disability, and early mortality. Clinical expression of systemic autoimmune inflammatory arthritis is associated with activation of innate and acquired immune systems. In addition to the local effects of synovitis, systemic effects include skeletal muscle dysfunction likely mediated by pro-inflammatory cytokines.

Our research focuses on the role of prostaglandins and other lipid mediators in mediating innate immune functions and the transition from innate to acquired immunity.

We also are involved with the intersection of inflammation and pain in patients with rheumatic diseases.

Finally, we have focused on the systemic effects of inflammatory arthritis on skeletal muscle function.



Clinical Research Description








Noehren, B, Dailey, DL, Rakel, BA, Vance, CG, Zimmerman, MB, Crofford, LJ, Sluka, KA. Effect of transcutaneous electrical nerve stimulation on pain, function, and quality of life in fibromyalgia: a double-blind randomized clinical trial. Phys Ther, 95(1), 129-40, 2015

Salt, E, Rayens, MK, Kerr, AM, Alikhan, M, Crofford, LJ. Examining rheumatoid arthritis patients'' trust in their provider over time: the effects of demographic factors and accessing sources of information. Orthop Nurs, 34(3), 159-65, 2015

Cleary, LC, Crofford, LJ, Long, D, Charnigo, R, Clasey, J, Beaman, F, Jenkins, KA, Fraser, N, Srinivas, A, Dhaon, N, Hanaoka, BY. Does computed tomography-based muscle density predict muscle function and health-related quality of life in patients with idiopathic inflammatory myopathies. Arthritis Care Res (Hoboken), 67(7), 1031-40, 2015

Crofford, LJ. Psychological aspects of chronic musculoskeletal pain. Best Pract Res Clin Rheumatol, 29(1), 147-55, 2015

Maseda, D, Bonami, RH, Crofford, LJ. Regulation of B lymphocytes and plasma cells by innate immune mechanisms and stromal cells in rheumatoid arthritis. Expert Rev Clin Immunol, 10(6), 747-62, 2014

Brogden, NK, Ghosh, P, Hardi, L, Crofford, LJ, Stinchcomb, AL. Development of in vivo impedance spectroscopy techniques for measurement of micropore formation following microneedle insertion. J Pharm Sci, 102(6), 1948-56, 2013

Pagorek, S, Kuperstein, J, Guo, J, Ballert, KN, Crofford, LJ. The Association of Chronic Back Pain and Stress Urinary Incontinence: A Cross-Sectional Study. J Womens Health Phys Therap, 37(1), 11-18, 2013

Brogden, NK, Banks, SL, Crofford, LJ, Stinchcomb, AL. Diclofenac enables unprecedented week-long microneedle-enhanced delivery of a skin impermeable medication in humans. Pharm Res, 30(8), 1947-55, 2013

Srikuea, R, Symons, TB, Long, DE, Lee, JD, Shang, Y, Chomentowski, PJ, Yu, G, Crofford, LJ, Peterson, CA. Association of fibromyalgia with altered skeletal muscle characteristics which may contribute to postexertional fatigue in postmenopausal women. Arthritis Rheum, 65(2), 519-28, 2013

Hung, EW, Mayes, MD, Sharif, R, Assassi, S, Machicao, VI, Hosing, C, St Clair, EW, Furst, DE, Khanna, D, Forman, S, Mineishi, S, Phillips, K, Seibold, JR, Bredeson, C, Csuka, ME, Nash, RA, Wener, MH, Simms, R, Ballen, K, Leclercq, S, Storek, J, Goldmuntz, E, Welch, B, Keyes-Elstein, L, Castina, S, Crofford, LJ, Mcsweeney, P, Sullivan, KM. Gastric antral vascular ectasia and its clinical correlates in patients with early diffuse systemic sclerosis in the SCOT trial. J Rheumatol, 40(4), 455-60, 2013

Painter, JT, Crofford, LJ. Chronic opioid use in fibromyalgia syndrome: a clinical review. J Clin Rheumatol, 19(2), 72-7, 2013

Painter, JT, Crofford, LJ, Talbert, J. Geographic variation of chronic opioid use in fibromyalgia. Clin Ther, 35(3), 303-11, 2013

Oddis, CV, Reed, AM, Aggarwal, R, Rider, LG, Ascherman, DP, Levesque, MC, Barohn, RJ, Feldman, BM, Harris-Love, MO, Koontz, DC, Fertig, N, Kelley, SS, Pryber, SL, Miller, FW, Rockette, HE, , . Rituximab in the treatment of refractory adult and juvenile dermatomyositis and adult polymyositis: a randomized, placebo-phase trial. Arthritis Rheum, 65(2), 314-24, 2013

Salt, E, Crofford, LJ, Studts, JL, Lightfoot, R, Hall, LA. Development of a quality of patient-health care provider communication scale from the perspective of patients with rheumatoid arthritis. Chronic Illn, 9(2), 103-15, 2013

Hanaoka, BY, Peterson, CA, Horbinski, C, Crofford, LJ. Implications of glucocorticoid therapy in idiopathic inflammatory myopathies. Nat Rev Rheumatol, 8(8), 448-57, 2012

Hanaoka, BY, Peterson, CA, Crofford, LJ. Glucocorticoid effects on skeletal muscle: benefit and risk in patients with autoimmune inflammatory rheumatoid diseases. Expert Rev Clin Immunol, 8(8), 695-7, 2012

Aschbacher, K, Adam, EK, Crofford, LJ, Kemeny, ME, Demitrack, MA, Ben-Zvi, A. Linking disease symptoms and subtypes with personalized systems-based phenotypes: a proof of concept study. Brain Behav Immun, 26(7), 1047-56, 2012

Arnold, LM, Stanford, SB, Welge, JA, Crofford, LJ. Development and testing of the fibromyalgia diagnostic screen for primary care. J Womens Health (Larchmt), 21(2), 231-9, 2012

Schiopu, E, Phillips, K, MacDonald, PM, Crofford, LJ, Somers, EC. Predictors of survival in a cohort of patients with polymyositis and dermatomyositis: effect of corticosteroids, methotrexate and azathioprine. Arthritis Res Ther, 14(1), R22, 2012

Brogden, NK, Milewski, M, Ghosh, P, Hardi, L, Crofford, LJ, Stinchcomb, AL. Diclofenac delays micropore closure following microneedle treatment in human subjects. J Control Release, 163(2), 220-9, 2012

Salt, E, Crofford, L. Rheumatoid arthritis: new treatments, better outcomes. Nurse Pract, 37(11), 16-22; quiz 23, 2012

Shang, Y, Gurley, K, Symons, B, Long, D, Srikuea, R, Crofford, LJ, Peterson, CA, Yu, G. Noninvasive optical characterization of muscle blood flow, oxygenation, and metabolism in women with fibromyalgia. Arthritis Res Ther, 14(6), R236, 2012

Lommel, K, Bandyopadhyay, A, Martin, C, Kapoor, S, Crofford, L. A pilot study of a combined intervention for management of juvenile primary fibromyalgia symptoms in adolescents in an inpatient psychiatric unit. Int J Adolesc Med Health, 23(3), 193-7, 2011

Kojima, F, Matnani, RG, Kawai, S, Ushikubi, F, Crofford, LJ. Potential roles of microsomal prostaglandin E synthase-1 in rheumatoid arthritis. Inflamm Regen, 31(2), 157-166, 2011

Sarnes, E, Crofford, L, Watson, M, Dennis, G, Kan, H, Bass, D. Incidence and US costs of corticosteroid-associated adverse events: a systematic literature review. Clin Ther, 33(10), 1413-32, 2011

Boomershine, CS, Crofford, LJ. A symptom-based approach to pharmacologic management of fibromyalgia. Nat Rev Rheumatol, 5(4), 191-9, 2009

Dubois, RN, Abramson, SB, Crofford, L, Gupta, RA, Simon, LS, Van De Putte, LB, Lipsky, PE. Cyclooxygenase in biology and disease. FASEB J, 12(12), 1063-73, 1998