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Vanderbilt Pathology Laboratory Services

Test Directory



BK VIRUS QUANTITATIVE (BKV)

Department: Molecular Infectious Disease
Test Synonym(s): BKV, BKV DNA Quant, Human Polyomavirus
CPT Codes: 87799
Methodology: PCR (Polymerase Chain Reaction)
Reference Range: Blood: 500 - 5,000,000 copies/mL; Urine: 50 - 500,000 copies/mL
Tube Type: Blood: Lavender top tube (EDTA) - 4.0 mL; Urine: Sterile container - 4.0 mL
Specimen: Whole blood and/or urine
Alternate Specimen: NEED MEDICAL DIRECTOR APPROVAL
Pediatric Requirements: Blood: 1.0 mL; Urine: 1.0 mL
Volume: Blood: 4.0 mL; Urine: 4.0 mL
Minimum Volume: Blood: 1.0 mL; Urine: 1.0 mL
Temperature: Room Temperature: same day; Refrigerated: overnight; Frozen: Longer than overnight
Stability: Room Temperature: same day; Refrigerated: overnight; Frozen: Longer than overnight
Reasons for Rejection: Alternate specimen sent without Medical Director Approval.
Days Performed: Urine - Tuesday; Blood - Friday
Times Performed: Batched
TAT: Performed once per week, 24 hours after performed
Significance: BKV is commonly first encountered in childhood where infection severity can be none (asymptomatic) to mild (fever and URI). BKV is a significant cause of morbidity and mortality in immunocompromised patients, such as solid organ or bone marrow transplant (BMT) recipients. BKV can manifest as non-hemorrhagic or hemorrhagic cystitis (HC) and ureteric stenosis. Renal transplant recipients can develop polyomavirus-associated nephropathy (PVAN). PVAN symptoms are mild and non-specific with slow loss of kidney function as infection progresses. Allograft rejection occurs in one-third to one-half of PVAN cases. Depending on the quantity of BKV present, reduction of immunosuppression or initiation anti-viral therapy can improve patient outcomes.


Special Instructions: Other sources or samples may be acceptable for this test. Please contact the Molecular Infectious Disease Lab at 615-936-6435.Click here to print the Molecular Diagnostics requisition.

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