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Vanderbilt Pathology Laboratory Services

Test Directory



ALDOSTERONE / RENIN RATIO (ART)

Department: Estoeric Chemistry
Test Synonym(s): ART, ARR
Test Components: Aldosterone, Plasma Renin Activity, Aldosterone/Plasma Renin Activity Ratio
CPT Codes: 82088, 84244
Methodology: Radioimmunoassay
Reference Range: Aldosterone: Supine (<16.1 ng/dL), Upright (4 - 31 ng/dL); Plasma Renin Activity: Normal Salt Intake - Upright (0.7 - 3.3 ng/mL/hr), Supine (0.3 - 1.7 ng/mL/hr), Aldosterone/Plasma Renin Activity Ratio - less than or equal to 30
Tube Type: ALD: Light green PST (Lithium Heparin with gel) tube - 4.5 mL; RN: Lavender top (EDTA)
Specimen: Plasma


Click here to view Aldosterone/Renin Recommendations.
Alternate Specimen: ALD: Serum (Red top tube)
Pediatric Requirements: 2 microtainers - ALD: 1.0 mL serum; RN: 1.0 mL Plasma (EDTA)
Volume: ALD: 4 mL; RN: 4 mL
Minimum Volume: Ald: 2.0 mL Adults, 1.0 mL Children; RN: 2.0 mL Adults, 1.0 mL Children
Temperature: Room Temperature
Stability: ALD: Refridgerated 1 week, Frozen 2 months; RN: Room Temperature 6 hours; Frozen 1 month (Do not refridgerate or store on ice)
Reasons for Rejection: ALD: QNS, delay in processing; RN: Collection and/or Transport to lab on ice or refrigerated; Specimen not frozen within 6 hours; QNS
Days Performed: Tuesday and Thursday
Times Performed: 8:00 a.m.
TAT: 5 days
Significance: The Endocrine Society suggests that an Aldosterone/Plasma Renin Activity Ratio >30 may be associated with hyperaldosteronism. Due to assay and biological variability, interpret this ratio in the context of the aldosterone result and interfering medications. Please see recommendations and appended table for more information on assay interferences and retesting. Funder, JW, et al. JCEM. 2008; 93: 3266-3281



Click here to view Aldosterone/Renin Interference Table.


Click here to view Aldosterone/Renin Recommendations.
Special Instructions: Specimens should be collected midmorning after the patient has been up for at least 2 hours and seated for 5 - 15 minutes. Collect specimens at room temperature (not on ice) and delivery immediately to the laboratory. Avoid stasis, hemolysis, and fist clenching during collection.

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