: CRH, High Sensitivity CRP, Cardiac CRP, C Reactive Protein
: Particle Enhanced Turbidimetric
: HS-Cardiac 18 yrs to 150 yrs: 0-2.9 mg/L; HS-Inflammatory: 0 to14 days: 0.3-6.1 mg/L; 15 days to <15 yrs: 0.1-1 mg/L, 15 yrs to <19 yrs: 0.1-137 mg/L, Adults 19 yrs to 150 yrs: 0-5 mg/L
: Light green PST (Lithium Heparin with gel) tube - 4.5 mL
: Red top tube - 5 mL
: 1 mL plasma
: 0.5 mL plasma
: Separate within one hour and store at 2-8șC until delivery
: < 3 days at 2 - 8șC; 6 months at -20șC
Reasons for Rejection
: Hemolysis; improper collection
: CRP is a non-specific inflammatory marker. Elevations of HS-CRP have been correlated with increased future cardiovascular events, primarily myocardial infarction and stroke. The concentration of HS-CRP can be used to categorize patients for their risk of future cardiovascular disease as follows:
Low risk: <1.0 mg/L
Average risk: 1.0 - 3.0 mg/L
High risk: >3.0 mg/L
Very high risk/Acute Inflammation: >1.0 mg/L
The use of HS-CRP to assess for the risk of cardiovascular disease in asymptomatic low risk (5% 10-year predicted risk) patients is not recommended. HS-CRP may be helpful in stratification of adult patients at intermediate risk (10% - 20% 10-year predicted risk) into a higher or lower risk category. If the concentration of HS-CRP is >3.0 mg/L, repeating test at least 2 weeks later in a metabolically stable state, free of infection or acute illness is recommended. The lower of the two results should be used to assess the patient's risk.
1. Myers GL, et.al. National Academy of Clinical Biochemistry Laboratory Medicine Practice guidelines: emerging biomarkers for primary prevention of cardiovascular disease. Clin Chem. 2009 Feb;55(2):378-84.
2. U.S. Preventive Services Task Force. Using nontraditional risk factors in coronary heart disease risk assessment: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2009 Oct 6;151(7):474-82.
3. Greenland P, et. al., American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2010 Dec 21;122(25):e584-636.
4. Lim LS, et. al., ACPM Prevention Practice Committee; American College of Preventive Medicine. Atherosclerotic cardiovascular disease screening in adults: American College Of Preventive Medicine position statement on preventive practice. Am J Prev Med. 2011 Mar;40(3):381.e1-10.
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