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Vanderbilt Pathology Laboratory Services

Test Directory



ELECTROPHORESIS AND IMMUNOFIXATION FOR MONOCLONAL IMMUNOGLOBULIN (BLOOD) (SPEP)

Department: Immunology
Test Synonym(s): SPEP, Protein Electrophoresis, SI, SPE
Test Components: Includes both electrophoresis densitometric scan and immunofixation of Kappa and Lambda.
CPT Codes: 84165
Reference Range: No monoclonal
Tube Type: Red top (no anti-coagulant)
Specimen: Blood
Alternate Specimen: None
Volume: 5 mL whole blood
Minimum Volume: 1 mL whole blood
Temperature: Refrigerate, spin and separate
Reasons for Rejection: Drawn in any anticoagulant
Days Performed: Monday - Friday
Times Performed: Morning
TAT: Usually 48 hours
Significance: Principle clinical indications for ordering include suspected multiple myeloma, Waldenstrom's macroglobulinemia, amyloidosis, peripheral neuropathy, unexplained renal insufficiency, Nephrotic syndrome, hypogammaglobulinemia in adults and autonomic insufficiency.
Special Instructions: Must order total protein (blood). If none ordered, total protein will be ordered and charged. Screening test for identification of monoclonal gammopathies in serum. If monoclonal protein is detected, follow-up identification will be performed and charged additionally.

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