.

Vanderbilt Pathology Laboratory Services

Test Directory



PARVOVIRUS B 19 DNA (PVB)

Department: Molecular Infectious Disease
Test Synonym(s): PVB, Fifth Disease, Parvovirus PCR
CPT Codes: 87798
Methodology: Detection of Viral DNA Using Real-Time PCR
Reference Range: Not detected
Tube Type: Red top SST (Clot activator with gel)
Specimen: Serum, separated within 6 hours
Alternate Specimen: Need Medical Director approval
Pediatric Requirements: 0.1 mL serum
Volume: 0.4 mL serum
Minimum Volume: 0.1 mL serum
Temperature: Refrigerated
Stability: Room temperature: 1 day; Refrigerated: 5 days; Frozen (preferably -80C): longer than 5 days
Reasons for Rejection: Alternative specimen sent without Medical Director Approval
Days Performed: Monday, Wednesday and Friday
Times Performed: Once per day on Monday, Wednesday and Friday (Batched)
TAT: 1 - 3 days
Significance: Parvovirus B19 is most commonly recognized for its etiologic role in erythema infectiosum (EI), also known as fifth disease, in children. However, B19 also associates with a variety of other disease conditions, including arthritis, aplastic crisis in chronic hemolytic anemia, chronic anemia in immunodeficiency syndromes, and hydrops fetalis. Extremely contagious, B19 transmission usually occurs person-to-person through infectious respiratory droplets. Infection occurs worldwide in people of all ages, either in epidemics or as sporadic cases. However, infection most frequently comes to attention during outbreaks of EI in schools. Seropositivity rates increase with age, with over 50% of adults seropositive and immune. Practical cell-culture systems for isolation of B19 are not available. Serologic assays in conjunction with classical clinical presentation form the mainstay of B19 diagnosis in immunocompetent hosts. However, PCR for B19 DNA in blood may be required to document infection in immunocompromised hosts who fail to mount detectable antibody responses.
Special Instructions: Click here to print the Molecular Diagnostics requisition.

Search Tests

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Enter Keyword:

Search Help


Search Options for the Test Directory:

1. Enter the test name in the Keyword search field.
Hint: You can also enter any part of the test name to expand the search.
(Example: you can type "west" or "sed" or "rate" to find Westergren Sedimentation Rate)

2. Enter the Vanderbilt Test Code, if known.

3. Choose one of the letter boxes to display a list of all test names and keywords starting with that letter.

If you are unable to find a test in our directory, please contact VPLS at
1-800-551-5227 or e-mail emily.k.thompson@vanderbilt.edu.