PARVOVIRUS B 19 DNA (PVB)
: Molecular Infectious Disease
: PVB, Fifth Disease, Parvovirus PCR
: Detection of Viral DNA Using Real-Time PCR
: Not detected
: Red top SST (Clot activator with gel)
: Serum, separated within 6 hours
: Need Medical Director approval
: 0.1 mL serum
: 0.4 mL serum
: 0.1 mL serum
: Room temperature: 1 day; Refrigerated: 5 days; Frozen (preferably -80C): longer than 5 days
Reasons for Rejection
: Alternative specimen sent without Medical Director Approval
: Monday, Wednesday and Friday
: Once per day on Monday, Wednesday and Friday (Batched)
: 1 - 3 days
: Parvovirus B19 is most commonly recognized for its etiologic role in erythema infectiosum (EI), also known as fifth disease, in children. However, B19 also associates with a variety of other disease conditions, including arthritis, aplastic crisis in chronic hemolytic anemia, chronic anemia in immunodeficiency syndromes, and hydrops fetalis. Extremely contagious, B19 transmission usually occurs person-to-person through infectious respiratory droplets. Infection occurs worldwide in people of all ages, either in epidemics or as sporadic cases. However, infection most frequently comes to attention during outbreaks of EI in schools. Seropositivity rates increase with age, with over 50% of adults seropositive and immune. Practical cell-culture systems for isolation of B19 are not available. Serologic assays in conjunction with classical clinical presentation form the mainstay of B19 diagnosis in immunocompetent hosts. However, PCR for B19 DNA in blood may be required to document infection in immunocompromised hosts who fail to mount detectable antibody responses.
: Click here to print the Molecular Diagnostics requisition.
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