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Vanderbilt Pathology Laboratory Services

Test Directory



CMV QUANTIFICATION (CMQ)

Department: Molecular Infectious Disease
Test Synonym(s): Cytomegalovirus, CMQ, CMV DNA quant
CPT Codes: 87497
Methodology: PCR (Polymerase Chain Reaction)
Reference Range: 137 - 3,000,000 copies/mL
Tube Type: Lavender top (EDTA) - 4.0 mL
Specimen: Plasma spun, separated from RBCs and refrigerated within 6 hours of collection
Alternate Specimen: Need Medical Director approval
Pediatric Requirements: Lavender top (EDTA)- 1.0 mL
Volume: EDTA plasma 1.0 mL
Minimum Volume: EDTA plasma 0.5 mL
Temperature: Room Temperature: 6 hours, refrigerated: 7 days, frozen: 6 weeks
Stability: Room temperature: 6 hours, refrigerated: 7 days, frozen: 6 weeks
Reasons for Rejection: Alternative specimen sent without Medical Director approval
Days Performed: Monday - Friday
Times Performed: Batched
TAT: 24 hours (Monday - Friday)
Significance: Human cytomegalovirus (CMV or HCMV) is a viral pathogen belonging to the herpesvirus family. CMV can be transmitted through a variety of body fluids and secretions, including blood, oropharyngeal secretions, urine, cervical and vaginal excretions, spermatic fluid, breast milk, tears, and feces. CMV infection in immunocompetent individuals is usually asymptomatic; however, primary infection is associated with persistent latent infection in a wide range of organs and tissues, including leukocytes. Primary infection or secondary reactivation during pregnancy can lead to congenital CMV infection and significant morbidity. Immunocompromised individuals, including transplant patients and AIDS patients, are at risk for reactivation of latent CMV infection and development of severe disease. Clinical manifestations of CMV disease in immunocompromised hosts include fever, hematological abnormalities, retinitis, gastroenteritis, hepatitis, encephalitis, esophagitis, enterocolitis, pancreatitis, and pneumonia. Studies in transplant recipients have shown an association between CMV viral load in blood and risk of developing CMV disease. Similarly, increases in viral load over time have been associated with worse clinical outcomes. Quantitative polymerase chain reaction (PCR) assays allow for diagnosis of active CMV infection, monitoring progression of disease, and assessing the virologic response to antiviral treatment.
Special Instructions: Transportation of whole blood, room temperature or refrigerated. Transportation of plasma, refrigerated or frozen.
Click here to print the Molecular Diagnostics requisition.

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