HIGH RISK HPV DNA DETECTION (HPP)
: Molecular Infectious Disease
: HPP, HPV DNA
: Roche 4800
: HPV Type 16: Not detected; HPV Type 18: Not detected; Other High Risk HPV: Not Detected
: Thin prep pap
: Endocervical brush
: Need Medical Director approval
: Endocervical brush
: 10 mL
: 4.2 mL
: Room temperature
: One month
Reasons for Rejection
: Alternative specimen sent without Medical Director approval
: Monday, Wednesday and Friday
: Once per day on Monday, Wednesday and Friday (batched)
: 24 hours (Monday)
: More than 70 types of HPV have been identified, and are generally classified as high-risk or low-risk depending on their known association or lack of association with cancer and its precursor lesion, high-grade cervical intraepithelial neoplasia (CIN 2-3). Prospective studies (age 16-60 years) have shown that 15-28% of HPV DNA positive women developed squamous intraepithelial lesions (SIL) suggestive of CIN 1-3 or cancer within 2 years compared to only 1-3% of HPV DNA negative women. Although current scientific literature suggests that persistent infection with high-risk HPV is the main risk factor for development of high-grade cervical neoplasia and cancer, apparent persistence may represent continuous infection with a single HPV type, with multiple HPV types, or reinfection. Nonetheless, women who are repeatedly Pap negative and HR HPV negative appear to be at low risk for having or developing cervical precancerous lesions.
: Other sources or samples may be acceptable for this test; please check with the lab, 615-936-6435. Click here to print the Molecular Diagnostics requisition.
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