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Vanderbilt Pathology Laboratory Services

Test Directory



HIGH RISK HPV DNA DETECTION (HPP)

Department: Molecular Infectious Disease
Test Synonym(s): HPP, HPV DNA, Human Papillomavirus
CPT Codes: 87624
Methodology: Roche 4800
Reference Range: HPV Type 16: Not detected; HPV Type 18: Not detected; Other High Risk HPV: Not Detected
Tube Type: Thin prep pap
Specimen: Endocervical brush
Alternate Specimen: Need Medical Director approval
Pediatric Requirements: Assay not approved for pediatric use (contact lab)
Volume: 10 mL
Minimum Volume: 4.2 mL
Temperature: Room temperature
Stability: Room temperature: 6 months
Reasons for Rejection: Alternative specimen sent without Medical Director approval
Days Performed: Monday, Wednesday and Friday
Times Performed: Once per day on Monday, Wednesday and Friday (batched)
TAT: 1 - 3 days
Significance: HPV can infect the cervix, vagina, vulva, urethra, or peri-anal area. HPV types are generally classified as high-risk or low-risk depending on their association with cancer and its precursor lesion, high-grade cervical intraepithelial neoplasia (CIN 2-3). To date, HPV cannot be cultured using standard methods, and immunological tests are inadequate to determine the presence of HPV cervical infection. Together, HPV types 16 and 18 account for approximately 70% of HPV+ cervical cancers worldwide. Additional high-risk HPV types, including 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68, have been identified as the principal HPVs detectable in the remaining cancers. This assay detects 14 high-risk HPV types and differentiates types 16 and 18 from the others. HPV testing of cervical specimens is intended to enhance detection of cervical disease and provides important diagnostic and prognostic information in conjunction with clinical findings, information derived from other diagnostic and screening tests, and medical history.
Special Instructions:
Click here to print the Molecular Diagnostics requisition.

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