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Vanderbilt Pathology Laboratory Services

Test Directory



HIGH RISK HPV DNA DETECTION (HPP)

Department: Molecular Infectious Disease
Test Synonym(s): HPP, HPV DNA
CPT Codes: 87621
Methodology: Roche 4800
Reference Range: HPV Type 16: Not detected; HPV Type 18: Not detected; Other High Risk HPV: Not Detected
Tube Type: Thin prep pap
Specimen: Endocervical brush
Alternate Specimen: Need Medical Director approval
Pediatric Requirements: Endocervical brush
Volume: 10 mL
Minimum Volume: 4.2 mL
Temperature: Room temperature
Stability: One month
Reasons for Rejection: Alternative specimen sent without Medical Director approval
Days Performed: Monday, Wednesday and Friday
Times Performed: Once per day on Monday, Wednesday and Friday (batched)
TAT: 24 hours (Monday)
Significance: More than 70 types of HPV have been identified, and are generally classified as high-risk or low-risk depending on their known association or lack of association with cancer and its precursor lesion, high-grade cervical intraepithelial neoplasia (CIN 2-3). Prospective studies (age 16-60 years) have shown that 15-28% of HPV DNA positive women developed squamous intraepithelial lesions (SIL) suggestive of CIN 1-3 or cancer within 2 years compared to only 1-3% of HPV DNA negative women. Although current scientific literature suggests that persistent infection with high-risk HPV is the main risk factor for development of high-grade cervical neoplasia and cancer, apparent persistence may represent continuous infection with a single HPV type, with multiple HPV types, or reinfection. Nonetheless, women who are repeatedly Pap negative and HR HPV negative appear to be at low risk for having or developing cervical precancerous lesions.
Special Instructions: Other sources or samples may be acceptable for this test; please check with the lab, 615-936-6435.

Click here to print the Molecular Diagnostics requisition.

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