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Vanderbilt Pathology Laboratory Services

Test Directory



HSV DETECTION BY AMPLIFIED PROBE (HSD)

Department: Molecular Infectious Disease
Test Synonym(s): Herpes Simplex Virus DNA, HSD, HSV DNA, Herpes Simplex Virus CSF, HSV CSF
CPT Codes: 87529
Methodology: PCR - Polymerase Chain Reaction
Reference Range: Not detected
Tube Type: CSF container - 1.0 mL
Specimen: CSF
Alternate Specimen: : Whole blood, lesions/ulcers, and eye/vitreous fluid will be accepted as nonpreferred specimen types, and results will be reported with a disclaimer. Blood should be collected in a lavender top (EDTA) tube. Lesions/ulcer swabs should be submitted in Universal (viral) Transport Medium. Eye/vitreous fluid should be submitted in a sterile container (preferably) or Universal Transport Medium. Other specimen types require Medical Director approval; contact the lab prior to specimen collection for approval and collection instructions.
Pediatric Requirements: CSF container - 1 mL
Volume: 1 mL
Minimum Volume: 0.2 mL
Temperature: Room Temperature - same day, refrigerated - overnight, frozen - longer than overnight
Stability: Room temperature: same day, refrigerated: overnight, frozen: longer than overnight
Reasons for Rejection: Alternative specimen sent without Medical Director approval
Days Performed: Monday, Wednesday, Friday and Saturday
Times Performed: Once per day on Monday, Wednesday, Friday and Saturday (batched)
TAT: 24 hours (Monday - Saturday)
Significance: HSV-1 and HSV-2 are important pathogens causing encephalitis and meningitis. Prompt recognition of the presence of HSV is critical to the initiation of Acyclovoir therapy which may greatly improve patient outcome. Cell cultures have not been reliable for recovering this virus from cerebrospinal fluid (CSF). Detection of HSV DNA in CSF is now the gold standard for the laboratory diagnosis of central nervous system diseases caused by this virus.
Special Instructions: Other sources or samples may be acceptable for this test; please check with the lab, 615-936-6435.
Click here to print the Molecular Diagnostics requisition.

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