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Vanderbilt Pathology Laboratory Services

Test Directory



HIV - 1 GENOTYPING (HVG)

Department: Molecular Infectious Disease
Test Synonym(s): HVG, HIV resistance testing
CPT Codes: 87901
Methodology: PCR (Polymerase Chain Reaction)
Reference Range: No HIV RNA Detected
Tube Type: Lavender top (EDTA) - 4.0 mL
Specimen: Plasma
Alternate Specimen: Need Medical Director approval
Pediatric Requirements: 1.0 mL EDTA plasma
Volume: 2.0 mL EDTA plasma
Minimum Volume: 1.0 mL EDTA plasma
Temperature: Room Temperature: 1 day; Refrigerated: 5 days; -80C: longer than 5 days
Stability: Room temperature: 1 day, Refrigerated: 5 days, Frozen: longer than 5 days
Reasons for Rejection: Alternative specimen sent without Medical Director approval
Days Performed: Tuesday and Thursday
Times Performed: Batched (2x per week)
TAT: 3-10 days
Significance: Certain mutations in HIV-1 genes (especially protease and RT regions) targeted by antiretroviral drugs can confer drug resistance. Whereas phenotypic testing directly measures HIV-1 susceptibility to various drugs, genotypic testing detects mutations that confer phenotypic resistance. Genotypic resistance testing is recommended for (1) patients entering HIV care, (2) patients initiating ART therapy, (3) patients with virologic failure or suboptimal viral load reductions on ART, and (4) HIV-positive pregnant women. Expert interpretation is recommended given the complexity of results. The ViroSeq HIV-1 Genotyping system detects changes in the RT and protease regions of the pol gene and renders interpretations of antiretroviral drug resistance based on mutational patterns.
Special Instructions:
Click here to print the Molecular Diagnostics requisition.

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