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Research

Ongoing research emphasizes endovascular grafting for aortic aneurysms and peripheral vascular disease. Endovascular grafting was initiated in 1993 and has been rapidly expanding since that time. Additional endovascular grafting projects are underway in this exciting new area in the specialty of Vascular Surgery.

Vanderbilt Vascular Laboratory
Established in 1985, the Vanderbilt Vascular Laboratory was the first ever to provide a cohesive vascular diagnostic center at Vanderbilt University Medical Center. Hence, the dominant source for inpatient and outpatient vascular testing with ultrasound is accomplished at the Vanderbilt Vascular Laboratory. Accreditation by the Intersocietal Commission for the Accreditation of Vascular Laboratories (ICAVL) is established for cerebrovascular testing as well as venous testing.

Current Research
Clinical Research

  1. EnACT-T, a clinical study of the EndoVascular Grafting System (EGS®) as compared to the standard surgical procedure in the treatment of abdominal aortic aneurysms (AAA).
  2. EnACT-B, a Phase II clinical study of the bifurcated EGS® system as compared to the standard surgical procedure in the treatment of abdominal aortic aneurysms (AAA).
  3. EnACT-T, a Phase II clinical study of the aortoiliac EGS® System as compared to the standard surgical procedure in the treatment of abdominal aortic aneurysms (AAA).
  4. A Phase II dose-randing trial of intraarterial recombinant prourokinase (ABT-187) versus Urokinase (ABT-790) in the treatment of peripheral arterial thromboembolic occlusions.
  5. Epidural cooling as a means of inducing regional hypothermia of the spinal cord during thoracoabdominal aneurysm repair.
  6. A Phase III, controlled, multi-center, randomized, parallel-group, single-blind study to compare the safety and hemostatic efficacy of fibrin sealant with standard care of thrombin-soaked gelfoam® in the treatment of bleeding anastomosis sites in surgical patients receiving PTFE bypass grafts to the common femoral artery.
  7. A randomized, multicenter study comparing use of the Endovascular Prosthesis to percutaneous transluminal angioplasty (PTA) in the treatment of superficial femoral artery obstructive disease.
  8. Laparoscopic AFB

Basic Science Research:

  • Matrix metalloproteinase gene expression during injury and flow-induced arterial remodeling.




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