Gould Lab

Gould Lab

Research

Regulation of the eukaryotic cell cycle

Research in the Gould laboratory is focused on understanding cell cycle progression in eukaryotes, especially the mechanics and regulation of mitotic exit and cytokinesis. Each round of the cell cyclce is highly coordinated and consists of DNA replication (S phase) and separation of the duplicated chromosomes and cellular constituents in mitosis (M phase). These two phases are temporally separated by two gap phases: G1, prior to S phase, and G2, prior to M phase. Initiation and completion of DNA replication and mitosis are strictly regulated to ensure that genetic information and other critical cellular components are duplicated and then divided evenly between daughter cells during each cell cycle. Failure to properly coordinate these events can lead to cell death or genomic instability. To better understand the mechanisms regulating cell division, the Gould Lab uses a combination of proteomics, biochemistry, molecular biology, yeast genetics, cell biology and microscopy.