Directional cell migration is critical for multiple physiological and pathophysiological processes. Cell migration is driven by the actin cytoskeleton, which is, in turn, precisely regulated by microtubules. We have found that the Golgi-derived microtubule array is required for directionally persistent cell migration.

Now, we would like to know:

How are these three functions distributed between centrosomal and Golgi-derived microtubule arrays?

Microtubules facilitate three polarized processes that likely support directional cell movement: adhesion turnover, actin polymerization and vesicular trafficking.