Publications

  • 2015-present (Vanderbilt)
    Simmons, AJ, Lau, KS. 2016. Deciphering tumor heterogeneity from FFPE tissues: its promise and challenges. Molecular & Cellular Oncology (in press)
    Simmons, AJ, Scurrah, CR, McKinley, ET, Herring CA, Irish, JM, Washington, MK, Coffey, RJ, Lau, KS. 2016. Impaired coordination between signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocks. Science Signaling 9(449):rs11.
    Gierut, JJ, Wood, LB, Lau, KS , Lin, YJ, Genetti, C, Samatar, AA, Lauffenburger, DA, Haigis, KM. 2015. Network-level effects of kinase inhibitors modulate TNF-α-induced apoptosis in the intestinal epithelium. Science Signaling 8(407):ra129.
    Simmons, AJ, Banerjee, A, McKinley, ET, Scurrah, CR, Herring CA, Gewin LS, Masuzaki R, Karp SJ, Franklin, JL, Gerdes, MJ, Irish, JM, Coffey, RJ, Lau, KS. 2015. Cytometry-based single cell analysis of intact epithelial signaling reveals MAPK activation divergent from TNF-α-induced apoptosis in vivo. Molecular Systems Biology 11(10):835.
    Lyons, J, Herring, CA, Banerjee, A, Simmons, AJ, Lau, KS. 2015. Multiscale analysis of the murine intestine for modeling human diseases. Integrative Biology 7(7):740-57.
  • 2009-2013 (MIT/Harvard)
    Lau, KS, Schrier, SB, Gierut, J, Lyons, J, Lauffenburger, DA, Haigis, KM. 2013. Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α. Integrative Biology 5(11):1355-1365.
    Miraldi, ER, Sharfi, H, Friedline, RH, Johnson, H, Zhang, T, Lau, KS, Ko, HJ, Curran, TG, Haigis, KM, Yaffe, MB, Bonneau, R, Lauffenburger, DA, Kahn, BB, Kim, JK, Neel, BG, Saghatelian, A, White, FM. 2013. Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. Integrative Biology 5(7): 940-963.
    Lau, KS, Cortez-Retamozo, V, Philips, SR, Pittet, MJ, Lauffenburger, DA, Haigis, KM. 2012. Multi-scale in vivo systems analysis reveals the influence of immune cells on TNF-α-induced apoptosis in the intestinal epithelium. PLoS Biology 10(9):e1001393.
    Lau, KS, Zhang, T, Kendall, KR, Lauffenburger, D, Gray, NS, Haigis, KM. 2012. BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner. PLoS One 7(7):e41343.
    Lau, KS, Juchheim, AM, Cavaliere, KR, Philips, SR, Lauffenburger, DA, Haigis, KM. 2011. In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-α-induced apoptosis and proliferation by MAPKs. Science Signaling 4(165):ra16.
    Lau, KS, Haigis, KM. 2009. Non-redundancy within the RAS oncogene family: insights into mutational disparities in cancer. Molecule and Cells 28(4):315-320.
  • 2008-2011 (Lunenfeld Institute - Part 1)
    Mkhikian, H, Grigorian, A, Li, CF, Chen, HL, Newton, B, Zhou, RW, Beeton, C, Torossian, S, Tatarian, GG, Lee, SU, Lau, K, Walker, E, Siminovitch, KA, Chandy, KG, Yu, Z, Dennis, JW, Demetriou, M. 2011. Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis. Nature Communications 2: 334.
    Dennis, JW, Lau, KS, Demetriou, M, Nabi, IR. 2009. Adaptive regulation at the cell surface by N-glycosylation. Traffic 10(11):1569-1578.
    Beheshti Zavareh, R, Lau, KS, Hurren, R, Datti, A, Ashline, DJ, Gronda, M, Cheung, P, Simpson, CD, Liu, W, Wasylishen, AR, Boutros, PC, Shi, H, Vengopal, A, Jurisica, I, Penn, LZ, Reinhold, VN, Ezzat, S, Wrana, J, Rose, DR, Schachter, H, Dennis, JW, Schimmer, AD. 2008. Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function. Cancer Research 68(16): 6688-6697.
    Lau, KS , Nabi, IR, Demetriou, M, and Dennis, JW. 2008. Golgi N-glycan processing and galectin functions. Animal Lectins: A Functional View ed. Gerado R. Vasta and Hafiz Ahmed, CRC Press (Taylor and Francis): 285-302.
    Lau, KS, Dennis, JW. 2008. N-Glycans in cancer progression. Glycobiology 18(10): 750-760.
  • 2007-2008 (Lunenfeld Institute - Part 2)
    Katz, D, Ito, E, Lau, KS, Mocanu, JD, Bastianutto, C, Schimmer, AD, Liu, FF. 2008. Increased efficiency for performing colony formation assays in 96-well plates: novel applications to combination therapies and high-throughput screening. Biotechniques 44(2):ix-xiv.
    Lau, KS, Khan, S, Dennis, JW. 2008. Genome-scale identification of UDP-GlcNAc-dependent pathways. Proteomics 8(16):3294-3302.
    Lau, KS, Partridge, EA, Grigorian, A, Silvescu, CI, Reinhold, VN, Demetriou, M, Dennis, JW. 2007. Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation. Cell 129(1): 123-134.
    Mendelsohn, R, Cheung, P, Berger, L, Partridge, E, Lau, K, Datti, A, Pawling, J, Dennis, JW. 2007. Complex N-glycan and metabolic control in tumor cells. Cancer Research 67(20): 9771-9780.
  • 2002-2003 (University of Toronto Undergrad)
    Cheung, J, Estivill, X, Khaja, R, MacDonald, JR, Lau, K, Tsui, LC, Scherer, SW. 2003. Genome-wide detection of segmental duplications and potential assembly errors in the human genome sequence. Genome Biology 4(4): R25.
    Lau, KS, Mantas, M, Chass, GA, Ferretti, FH, Estrada M, Zamarbide G, Csizmadia, IG. 2002. Ab initio and DFT conformational analysis of selected flavones: 5,7-dihydroxyflavone (chrysin) and 7,8-dihydroxyflavone. Canadian Journal of Chemistry 80(7): 845-855.