M.D./Ph.D. Student
Vanderbilt University Medical Center
Department of Cell & Developmental Biology
Email: christopher.s.cselenyi@vanderbilt.edu
Duck Key, FL
B.A. English and Biochemistry, Magna Cum Laude
University of Miami, Miami, FL 2002
Christopher S. Cselenyi and Ethan Lee. Context-Dependent Activation or Inhibition of Wnt-β-Catenin Signaling by Kremen. Sci. Signal. 26 February 2008: pe10.
Project 1: What is the molecular mechanism by which a Wnt signal is transduced from the plasma membrane to the cytoplasm? I use Xenopus cytoplasmic egg extracts, Xenopus embryos, and purified protein assays to answer this question.
Project 2: What is the role of degradation of Axin, the limiting scaffold protein that is required for beta-catenin degradation, in Wnt signaling?
Project 3: How is glycosylation regulated in early vertebrate development? How does perturbation of glycosylation affect development?