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Ethan Lee uses Xenopus, biochemistry, small molecule compounds, and cell culture to study Wnt signal transduction during development and disease.
Laura Lee studies the cell cycle in a developmental context using Drosophila melanogaster as a model organism.
News
Chris Cselenyi receives Ph.D.
Congratulations to Chris who successfully defended his thesis on July 16, 2008. He has since returned to his second year of medical school and will be missed if he ever stops coming by the lab.
8/15/08
Co-first author publication for Chris Cselenyi and Kristin Jernigan in PNAS
Chris and Kristin recently published the results of their work on the role of LRP6 in canonical Wnt signaling. Their article describes a mechanism by which LRP6 stabilizes β-catenin independently of Axin degradation by inhibiting GSK3's phosphorylation of β-catenin. This paper was cited by the faculty of 1000.
8/15/08
First publication for Chris Cselenyi
Congratulations to Chris for his first publication! Chris wrote a perspective for Science Signaling about the effects of Kremen on Wnt signaling. A summary can be accessed on the Science Signaling site.
2/26/08
Article from Emilios Tahinci (Ethan Lee lab) published in the November 15, 2007 issue of Development
A summary of Emilios's article, "Lrp6 is required for convergent extension during Xenopus gastrulation," can be found here. If you do not have personal or institutional access to download the article, we have a limited number of free downloads that you can access by clicking this link. This paper was cited by the faculty of 1000.
11/28/07
Article from Jamie Rickmyre (Laura Lee lab) published in the October 15, 2007 issue of the Journal of Cell Science
Our article entitled "The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo" has been published. You can find the article summary here.