The Ohi Lab

Laboratory of Cell Division

 
 

How cells divide is the biological process that captivates us. Properly executed cell divisions are fundamentally important to the growth and development of all organisms - and, they’re fun to watch! During cell division, the replicated genome, parceled into units called chromosomes, is packaged and divided equally between two daughter cells. The micromachine that powers chromosome movement is the mitotic spindle, an elegant construct that can assemble and divide chromosomes with astonishing speed and precision.


Our research group is focused on understanding how cells build and properly control the function of the mitotic spindle. A key feature of the spindle is that it is assembled from microtubules, unstable polymeric filaments that perform work. Both the organization and polymerization dynamics of microtubules are subject to regulation in both space and time  throughout mitosis. Our efforts strive to identify and shed light on these mechanisms, with the goal of better understanding how chromosomes are accurately segregated during mitosis and meiosis.


Please use the menu to the left to navigate through our site, and learn more about our research.

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Department of Cell and Developmental Biology

Vanderbilt University Medical Center

Nashville, TN

Copyright 2008, Vanderbilt University Medical Center

Last modified: May 8, 2010

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