VUMC Main Calendar Events

  • 5/23/2017
    11:00 am - 12:00 pm
    Transkingdom Interactions in the Gut

    Ken Cadwell, PhD

    Associate Professor, Molecular Pathogenesis Program at the Skirball Institute, Department of Microbiology, New York University School of Medicine

    Tuesday, May 23, 2017

    11:00 a.m. – 12:00 p.m.

    512 Light Hall

    Infection, Inflammation & Immunity Frontiers Seminar Series

    Transkingdom Interactions in the Gut

    The trillions of bacteria that are part of the gut microbiome provide key benefits to the host, but are also implicated in various disorders such as inflammatory bowel disease (IBD). For this reason, a large-scale effort has been placed in elucidating the mechanisms that determine how intestinal bacteria evoke beneficial and adverse responses from the host. However, the mammalian gastrointestinal tract can also harbor other infectious agents including viruses, fungi, protozoa, and helminths. The extent to which these infectious entities interact with the bacterial microbiome and shape the development of the mucosal immune system is unclear. In the first part of the talk, we will provide an example of an enteric animal virus that behaves similarly to bacterial members of the microbiome by providing key benefits to the host, while also inducing disease in a host that is genetically susceptible to IBD. In the second part of the talk, we will address the mechanism behind a striking epidemiological observation. Inflammatory diseases display an inverse relationship with helminths (parasitic worms). We found that helminth infections can evoke anti-inflammatory responses through rearrangement of the microbiome. We will discuss how understanding these complex transkingdom interactions involving infectious agents in the gut can lead to new insight into the origin and epidemiology of IBD and other inflammatory disorders.

    Sponsored by: Vanderbilt Centers for Immunobiology, Microbial Pathogenesis, Vanderbilt Vaccine Center, Medicine Divisions of Rheumatology, Pediatric Infectious Diseases, and Infectious Diseases

    Contact: Eve Stephens

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