VUMC Main Calendar Events

  • 2/21/2018
    12:15 pm - 1:15 pm
    VICB Seminar: Sam Gellman, U. Wisconsin-Madison, 'Impact of Backbone Modifications on the

       The Vanderbilt Institute of Chemical Biology (VICB) presents Dr. Samuel Gellman, University of Wisconsin - Madison: "Impact of Backbone Modifications on the Informational Properties of Polypeptides"

    Key Lecture Points
    · Biological systems rely on two families of sequence-specific heteropolymers that adopt discrete conformations, proteins and RNA, to perform many complex functions. The fact that two very different biopolymers have these properties inspires chemists to explore the structures and functions unnatural sequence-specific heterooligomers.
    · Fundamental studies of "foldamers" led our laboratory to begin exploring the impact of site-specific backbone modifications on the biological properties of polypeptides.
    · We have identified peptides containing mixtures of alpha- and beta-amino acid residues that display useful biological activity profiles, such the ability to inhibit specific protein-protein interactions with low susceptibility to proteolytic degradation, or modulated signaling at specific cell-surface receptors.

    Contact: Michelle Armstrong

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