VUMC Main Calendar Events

  • 2/28/2018
    12:15 pm - 1:15 pm
    VICB Seminar: Brad Pentelute, MIT: 'Cysteine Arylation to Engineer Peptides and Proteins'

       The Vanderbilt Institute of Chemical Biology (VICB) presents Dr. Brad Pentelute, MIT: "Cysteine Arylation to Engineer Peptides and Proteins"

    Key Lecture Points
    · We report a robust bioconjugation method using cysteine arylation.
    · This chemistry enables site-specific conjugation at cysteine residues within peptides, proteins, and antibodies.
    · Our two developed approaches use either perfluoroaryl-cysteine SNAr chemistry or organometallic palladium reagents.
    · This work led to the discovery of a self-labeling four-residue sequence that enables regioselective conjugation at only one cysteine residue within an intact antibody containing natural amino acids.
    · Recently, we discovered a new approach for the native conjugation of complex natural products such as vancomycin onto peptides and proteins without the introduction of linkers or chemical handles.

    Contact: Michelle Armstrong

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