October 11-14, 2001

Westin Mission Hills Resort
Palm Springs, California  

Preliminary Program    click here to download in Word Format

Thursday, October 11, 2001

4:00-5:30 PM


5:30-8:00 PM

Satellite Symposium Syncope:  An Integrated Approach


Friday, October 12, 2001

7:00-7:40 AM

Breakfast & Registration

7:40-7:45 AM

Welcome - Felicia Axelrod

Orthostatic Intolerance

Chairs:  Drs. Phillip Low & Blair Grubb

7:45-8:30 AM

Plenary Lecture Blood pressure reductions after exercise:  Causes and concerns

John R. Halliwill, Ph.D.

Rochester, MN

8:30-8:45 AM

Cerebral autoregulation is intact in patients with head-up tilt (HUT) induced neurally-mediated syncope (NMS)

R Schondorf, R Stein, J Benoit

Montreal, Canada

8:45-9:00 AM

Sympathoadrenal imbalance and skeletal muscle vasodilation before tilt-evoked neurocardiogenic syncope

DS Goldstein, C Holmes, M Naqibuddin, R Dendi, S Brentzel, SM Frank

Bethesda, MD

9:00-9:15 AM

Assessment of venous compliance in patients with orthostatic intolerance

R Freeman, MR Risk, VA Lirofonis, WB Farquhar

Boston, MA

9:15-9:30 AM

Orthostasis fails to produce active limb venoconstriction in adolescents

JM Stewart

Valhalla, NY

9:30-9:45 AM

Leg crossing combined with leg and abdominal muscles tensing can abort vasovagal fainting

CTP Krediet, N van Dijk, I de Bruin, JJ van Lieshout, W Wieling

Amsterdam, The Netherlands

9:45-10:00 AM

Acetylcholinesterase inhibition as new approach in the treatment of patients with orthostatic intolerance

W Singer, TL Opfer-Gehrking, SM Hines, BR McPhee, H Tani, PA Low

Rochester, MN

10:00-10:15 AM

Safely training senior citizens with orthostatic hypotension

AS Zion, RE De Meersman, DM Bloomfield

New York, NY

10:15-10:30 AM

Quality of life in patients with postural tachycardia syndrome

LM Benrud-Larson, PA Low, M Dewar, P Sandroni, T Rummans

Rochester, MN

10:30-10:45 AM

Coffee Break

Spectral Analysis and Modeling

Chairs:  Drs. Roy Freeman & Irwin Schatz

10:45-11:00 AM

Parasympathetic cardiac modulation increases during exercise in chronic obstructive lung disease (COPD)

MN Bartels, S Jelic, P Ngai, RC Basner, RE De Meersman

New York, NY

11:00-11:15 AM

The effects of respiration on RR interval spectra during exercise

R De Meersman, M Bartels, D Newandee, S Reisman

New York, NY

11:15-11:30 AM

The neural mechanism for sudden cardiac death

DL Jardine, CJ Charles, MD Forrester, M Whitehead, H Ikram

Christchurch, New Zealand

11:30-11:45 AM

Sympathetically-mediated sodium retention does not contribute to the hypertension of autonomic failure

T Tellioglu, B Black, V Watkins, G Farley, RM Robertson, I Biaggioni

Nashville, TN

11:45-12:00 PM

The sympathetic nervous system in essential hypertension.  Lessons from autonomic failure

A Diedrich, J Jordan, J Tank, JR Shannon, RM Robertson, F Luft, D Robertson, I Biaggioni

Nashville, TN

12:00-1:30 PM

Lunch & Poster Session I

1:30-5:00 PM

Free Time

5:00-7:30 PM

Satellite Symposium Genetic Autonomic Disorders:  Models to Understand Development and Maintenance of the Autonomic Nervous System


Saturday, October 13, 2001

7:00-7:45 AM


Molecular Biology/Genetics

Chairs:  Drs. Felicia Axelrod & David Robertson

7:45-8:30 AM

Plenary Lecture Mechanisms of reflex sympathetic dystrophy

Wilfrid Janig, M.D.

Kiel, Germany

8:30-8:45 AM

A novel syndrome of familial noradrenergic failure

I Biaggioni

Nashville, TN

8:45-9:00 AM

The genetic basis of dopamine-beta-hydroxylase deficiency

CH Kim, CP Zabetian, JF Cubells, S Cho, I Biaggioni, B Cohen, D Robertson, KS Kim

Nashville, TN

9:00-9:15 AM

Cutaneous innervation in familial dysautonomia

MJ Hilz, WR Kennedy, B Stemper, G Wendelschafer-Crabb, FB Axelrod

Minneapolis, MN

9:15-9:30 AM

A human model of orthostatic intolerance:  Selective norepinephrine reuptake inhibition

C Schroeder, J Tank, AM Sharma, FC Luft, J Jordan

Berlin, Germany

9:30-9:45 AM

Comparative biomonitoring of autonomic functions in patients treated with various psychotropic drugs

M Mueck-Weymann, R Rauh, J Acker, P Joraschky

Dresden, Germany

9:45-10:00 AM

Cerebrovascular reactivity to CO2 at high altitude and sea level in Andean natives

R Roach, C Passino, L Bernardi, J Gamboa, A Gamboa, O Appenzeller

Albuquerque, NM

10:00-10:15 AM

Coffee Break

Central Autonomic Nervous System

Chairs:  Drs. Horacio Kaufmann & Eduardo Benarroch

10:15-10:30 AM

Acute cardiovascular responses upon tilt in spinal cord-injured and control individuals

MTE Hopman, JT Groothuis, S Houtman, H van Langen

Nijmegen, The Netherlands

10:30-10:45 AM

Autonomic and cardiovascular response to acute orthostatic challenge in subjects with paraplegia and controls

JM Wecht, JP Weir, AM Spungen, RE De Meersman, WA Bauman

Bronx, NY


Catechol-O-methyl-transferase inhibition in multiple system atrophy

J Jordan, J Tank, A Lipp, C Schroder, A Diedrich, G Arnold, AM Sharma, FC Luft

Berlin, Germany

11:00-11:15 AM

Effect of acute unilateral high frequency stimulation of the subthalamic nucleus on the heart rate and blood pressure in patients with Parkinson's disease

A Voustianouk, KF Bhattacharya, JM Gracies, M Mata, H Kaufmann

New York, NY

11:15-11:30 AM

The isolated spinal cord can generate sympathetic adrenergic but not sympathetic cholinergic activity

CJ Mathias, P Cariga, M Catley, G Savic, HL Frankel, PH Ellaway

London, United Kingdom

11:30-11:45 AM

Does the integrated microneurogram provide a complete assessment of muscle sympathetic neural activity?

A Diedrich, W Charoensuk, R Shiavi, RJ Brychta, A Ertl, S Paranjape, LD Lane, BD Levine, J Zuckerman, JF Cox, I Biaggioni

Nashville, TN

12:00-1:30 PM

Lunch & Poster Session II

1:30-7:00 PM

Free Time

7:00-10:00 PM

Presidential Dinner


Sunday, October 14, 2001

7:00-7:45 AM


Peripheral Autonomic Nervous System/Diabetes

Chairs:  Drs. Christopher Mathias & Janice Gilden

7:45-8:30 AM

Plenary Lecture Hypoglycemia-induced transient autonomic failure in diabetes

Stephen N. Davis, M.B.,B.S., Ph.D.

Nashville, TN

8:30-8:45 AM

Sympathetic dysfunction in early diabetes is associated with increased nitric oxide

RD Hoeldtke, KD Bryner, JE Riggs, GR Hobbs, C Baylis

Morgantown, WV

8:45-9:00 AM

Local cutaneous vasodilation during acute systemic hyperglycemia in humans

N Charkoudian, AS Reed, A Vella, P Shah, RA Rizza, MJ Joyner

Rochester, MN

9:00-9:15 AM

Neuropathological diagnosis of enteric diabetic autonomic neuropathy

M Selim, G Wendelschafer-Crabb, WR Kennedy

Minneapolis, MN

9:15-9:30 AM

Comparison of SSR and QSART in early diabetic neuropathy - The value of length-dependent pattern in QSART

H Shimada, M Kihara, S Kosaka, H Ikeda, K Kawabata, T Tsutada, T Miki

Osaka, Japan

9:30-10:00 AM

Business Meeting

10:00-10:15 AM



Chairs:  Drs. Italo Biaggioni & Michael Joyner

10:15-10:30 AM

Impaired baroreflex and enhanced chemoreflex sensitivity in normotensive atherosclerotic mice

W Sun, X Ma, FM Abboud, MW Chapleau

Iowa City, IA

10:30-10:45 AM

Are all autonomic responses to hypoxia regulated through the peripheral chemoreflex arc?

BE Hunt, P Kaushal, W Weiss, JA Taylor

Boston, MA

10:45-11:00 AM

Hypoxic chemoreceptor stimulation induces paradoxic cardiovascular responses in familial dysautonomia

B Stemper, MJ Hilz, L Bernardi, G Welsch, C Passino, FB Axelrod

Erlangen, Germany

11:00-11:15 AM

Improved oxygenation relieves baroreflex dysfunction in Andean altitude natives

L Bernardi, C Passino, J Gamboa, M Bonfichi, A Gamboa, M Vargas, L Malcovati, R Roach, O Appenzeller

Pavia, Italy

11:15-11:30 AM

Arterial baroreflex function after carotid endarterectomy

HJLM Timmers, JM Karemaker, W Wieling, F Buskens, JWM Lenders

Nijmegen, The Netherlands

11:30-11:45 AM

Baroreflex control of sinus node during sleep

JM Legramante, F Placidi, MG Marciani, A Romiti, M Tombini, A Galante, S Aquilani, G Raimondi, M Massaro, F Iellamo

Roma, Italy

11:45-12:00 PM

Menstrual cycle affects b-adrenoreceptor and baroreflex sensitivity

G Jacob, N Hirshorn, I Zoran, Y Itzkovitz

Haifa, Israel

12:00-12:15 PM

Change of spontaneous baroreflex sensitivity by long-term use of an angiotensin II blocker Losartan in mild to moderate essential hypertension

SJ Yeh, EY Tu, CC Chiu

Taichung, Taiwan

12:15-12:30 PM

Homogeneous response of postganglionic neural sympathetic activity (MSNA) following mono- and bi-lateral carotid baroreceptor stimulation

R Furlan, A Diedrich, A Rimoldi, L Palazzolo, C Porta, L Vasquez, D Robertson, L Bernardi

Milan, Italy



Friday, October 12, 2001

12:00-1:30 PM

Poster #1

Analysis of raw microneurographic recordings based on wavelet denoising technique and classification algorithm

A Diedrich, W Charoensuk, R Shiavi, RJ Brychta, A Ertl, I Biaggioni

Nashville, TN

Poster #2

Exercise and manipulated breathing affect peripheral blood flow, blood pressure and heart rate in synchronized manner

DM Cataldo, R Cataldo, JK Prentice, RA Robergs

Albuquerque, NM

Poster #3

Manipulated breathing enhances parasympathetic tone during exercise by heart rate and blood pressure variability

DM Cataldo, R Cataldo, RA Robergs

Albuquerque, NM

Poster #4

Is pediatric autonomic testing valuable?

G Chelimsky, T Chelimsky

Cleveland, OH

Poster #5

Heart rate variability and autonomic nervous system.  An experimental approach

JM Legramante, G Raimondi, F Iellamo, A Galante, S Sacco, M Massaro, C Michelassi, S Chillemi, R Balocchi

Roma, Italy

Poster #6

A case of chorea-acanthocytosis with dysautonomia - Quantitative autonomic deficits using CASS

M Kihara, H Nakashima, M Taki, M Takahashi, Y Kawamura

Osaka, Japan

Poster #7

A new system for autonomic tests:  Feasibility to perform multicenter clinical studies

M Risk, C Broadbridge, A Cohen

Wakefield, MA

Poster #8

The role of the vagus in vasovagal syncope

DL Jardine, J Sutherland, MD Forrester, SI Bennett, H Ikram

Christchurch, New Zealand

Poster #9

Cardiovascular and cerebrovascular response to combined heat and orthostatic stress:  A model of postural tachycardia syndrome (POTS)?

F Huang, R Stein, J Benoit, R Schondorf

Montreal, Canada

Poster #10

Easy identification of subjects with poor orthostatic tolerance through cross-spectral analysis of cardiovascular parameters in supine

G Gulli, V Cooper, MJ Hilz, R Hainsworth

Erlangen, Germany

Poster #11

Unaltered peripheral capacitance vessel volume-pressure compliance relation in postural tachycardia of adolescents

JM Stewart

Valhalla, NY

Poster #12

Biphasic assessment of venous compliance before and after sympathetic stress

MR Risk, VA Lirofonis, WB Farquhar, R Freeman

Boston, MA

Poster #13

Comparison of the effects of water and carbohydrate ingestion on blood pressure responses to rising from the squatting position

MS Pitt, R Hainsworth

Leeds, United Kingdom

Poster #14

Risk-stratification in syncope

N Colman, J Reitsma, M Linzer, W Wieling

Amsterdam, The Netherlands

Poster #15

Prevalence and triggers of syncope in young adults:  A questionnaire

N Colman, K Ganzeboom, J Reitsma, W Shen, W Wieling

Amsterdam, The Netherlands

Poster #16

An unusual case of situational syncope

RK  Khurana

Baltimore, MD

Poster #17

The relationship between tilt-table testing and physiological plasma volume loss

T Ketch, H Snyder, A Diedrich, A Ertl, D Robertson

Nashville, TN

Poster #18

Acute human pharmacological model of norepinephrine transporter (NET) deficiency

T Tellioglu, B Black, V Watkins, S Lonce, D Robertson

Nashville, TN

Poster #19

Postural sway behaviour in control subjects with good and poor orthostatic tolerance

VE Bush, R Soames, R Hainsworth

Leeds, United Kingdom

Poster #20

Are the clinical features of patients with orthostatic intolerance influenced by the severity of postural tachycardia or a history of antecedent viral illness?

W Singer, G Paul, TL Opfer-Gehrking, M Camilleri, PA Low

Rochester, MN

Poster #21

Vascular resistance of the upper extremity in orthostatic hypotension and the postural tachycardia syndrome

W Singer, SM Hines, TL Opfer-Gehrking, PA Low

Rochester, MN

Poster #22

Dyautonomia in the hypermobility syndrome

Y Gazit, AM Nahir, G Jacob

Haifa, Israel

Poster #23

Distinguishing clinical and laboratory features in patients with pure autonomic failure (PAF) or idiopathic autonomic neuropathy (IAN)

CM Klein, P Sandroni, L Benrud-Larson, S Vernino, PA Low

Rochester, MN

Poster #24

Orthostatic hypotension and mortality:  A meta-analysis

JL Izzo, QQ Fu

Buffalo, NY

Poster #25

Evidence for denervation hypersensitivity to norepinephrine in patients with familial dysautonomia - A microdialysis study

A Bickel, F Axelrod, H Marthol, B Stemper, B Neundoerfer, MJ Hilz

Erlangen, Germany

Poster #26

Hypersensitivity of sympathetic receptors and hypertrophy of left ventricle in patients with diabetes mellitus and autonomic neuropathy

B Milovanovic, M Krotin, A Milovanovic, V Bisenic, S Simikic, S Markovic, L Vusovic

Belgrade, Yugoslavia

Poster #27

The significance of hand grip in diagnosis of sympathetic denervation and coronary insufficiency in patients with diabetes mellitus and autonomic neuropathy

B Milovanovic, M Krotin, V Bisenic, S Markovic, S Simikic, A Milovanovic, L Vusovic

Belgrade, Yugoslavia

Poster #28

Subacute diabetic autonomic neuropathy:  Recovery following treatment

JD Stewart, R Schondorf

Montreal, Canada

Poster #29

Different autonomic manifestations in acute and chronic inflammatory demyelinating polyneuropathy

M Asahina, A Suzuki, Y Kikkawa, S Kuwabara, T Hattori

Chiba, Japan

Poster #30

Sympathetic sudomotor and sensory small fiber function in familial dysautonomia

M Brys, MJ Hilz, B Stemper, A Bickel, H Marthol, F Axelrod

Erlangen, Germany

Poster #31

Headache in familial dysautonomia patients

M Duetsch, MJ Hilz, A Mauerer, D Berlin, B Neundoerfer, I Fish, O Appenzeller, FB Axelrod

Erlangen, Germany

Poster #32

Inspiratory induced vasoconstrictive episodes in healthy skin described by simultaneous measurement of blood flow and oxygen saturation

R Rauh, M Kessler, E Ochsmann, M Mueck-Weymann

Dresden, Germany


Poster Session II

Saturday, October 13, 2001

12:00-1:30 PM

Poster #33

Transnasal iontophoresis, a new non-invasive drug delivery system for the brain that circumvents the blood-brain barrier

E van Zanten, EN Lerner, GR Stewart

Amsterdam, The Netherlands

Poster #34

Is chronic fatigue syndrome a disorder of the autonomic nervous system?

E Lerner

Amsterdam, The Netherlands

Poster #35

The effect of diabetes on the central autonomic nervous system assessed by electroautonomography

EN Lerner, HF Dankmeijer, H Rollman, E van Zanten

Amsterdam, The Netherlands

Poster #36

Relationship between autonomic dysfunction and fatigue in multiple sclerosis patients:  An exploratory study

A Merico, F Piccione, G Levedianos, F Giorgi, P Tonin

Lido-Venice, Italy

Poster #37

Depletion of cholinergic neurons in the mesopontine tegmentum in multiple system atrophy

EE Benarroch, AM Schmeichel

Rochester, MN

Poster #38

Depression and hyperautonomic dysfunctioning

JJ Shen, YT Lin

Hsin-Tien, Taiwan

Poster #39

Controlled breathing in Parkinson's disease during cyclic exercise

S Reisman, I Dardik, S Hagberg, M Rymer, A Petrock, A Stuckey

Livingston, NJ

Poster #40

Blood pressure changes during hypoxic stimulation are altered in ALS patients

MJ Hecht, CM Brown, F Mittelhamm, B Neundoerfer, MJ Hilz

Erlangen, Germany

Poster #41

Carbamazepine attenuates parasympathetic heart rate modulation in chronic temporal lobe epilepsy

A Druschky, MJ Hilz, G Platsch, P Hopp, K Druschky, T Kuwert, H Stefan, B Neundoerfer

Erlangen, Germany

Poster #42

The dry ice test for the assessment of oral mucosal blood flow

JG Heckmann, SM Heckmann, T Hummel, M Popp, H Marthol, B Neundoerfer, MJ Hilz

Erlangen, Germany

Poster #43

Effects of bathing in carbonated water on skin blood flow, sympathetic skin responses and sympathetic nerve activity in the skin

H Tanaka, H Iida, H Watanabe, T Nagasaka, K Shindo, Z Shiozawa

Yamanashi, Japan

Poster #44

Autonomic cardiovascular reflexes in Wilson's disease

KF Bhattacharya, M Velickovic, A Wang, M Schilsky, H Kaufmann

New York, NY

Poster #45

Slow breathing, chemoreflex and oxygen saturation in Andean altitude natives

L Bernardi, M Bonfichi, A Gamboa, J Gamboa, C Passino, T Ramirez, L Malcovati, R Roach, O Appenzeller

Pavia, Italy

Poster #46

Effects of hot and warm water immersion in Japanese bathtub on autonomic functional parameters

M Suzuki, S Hori, I Nakamura, K Yamaguchi, N Aikawa

Tokyo, Japan

Poster #47

a,b-methylene ATP elicits the muscle chemoreflex in decerebrate cats

RL Hanna, SG  Hayes, MP Kaufman

Davis, CA

Poster #48

The mechanism of the physiological gustatory sweating

Y Inukai, T Sugenoya, N Matsumoto, N Nishimura, M Kato

Aichi, Japan

Poster #49

Cardiac vagal function is impaired in amyotrophic lateral sclerosis

CM Brown, MJ Hecht, F Mittelhamm, B Neundoerfer, MJ Hilz

Erlangen, Germany

Poster #50

Paroxysmal hypertension during a complex partial seizure

DL Jardine, IG Crozier, TJ Anderson, H Ikram

Christchurch, New Zealand

Poster #51

Plasma leptin levels and sympathetic outflow in non-obese subjects

J Tank, G Brabant, A Diedrich, C Schroeder, AM Sharma, FC Luft, J Jordan

Berlin, Germany

Poster #52

Carotid artery distensibility and baroreflex sensitivity are reduced in young normotensives with a parental history of hypertension

M Kollai, Z Kovats, P Studinger, Z Lenard

Budapest, Hungary

Poster #53

Baroreflex sensitivity in fibromyalgia

S Colombo, P Sarzi Puttini, G Randisi, A Malliani, R Furlan

Milan, Italy

Poster #54

Potent pressor effect of ambient light in baroreflex failure

T Ketch, T Oeltmann, BK Black, D Robertson

Nashville, TN

Poster #55

Effects of negative pressure breathing on the carotid baroreceptor - vascular resistance reflex

VL Cooper, C Bowker, P Kanthapallai, S Pearson, R Hainsworth

Leeds, United Kingdom

Poster #56

Circadian rhythm abnormalities of gastric myoelectrical activity in patients with multiple system atrophy

A Suzuki, M Asahina, C Ishikawa, T Fukutake, T Hattori

Chiba, Japan

Poster #57

Dysfunction in peripheral sympathetic mediated neurovascular transmission in complex regional pain syndrome type I (CRPS I) as shown by 123-I-metaiodobenzylguanidine uptake of the forearm

CA Haensch, H Lerch, J Jorg

Wuppertal, Germany

Poster #58

The assessment of autonomic dysfunction using RR interval spectral analysis in diabetic patients with increased urine albumin excretion rate

Y Zhang, LAH Critchley, JAJH Critchley, YH Tam, CK Chung, WB Chan, B Tomlinson, CS Cockram, JCN Chan

Hong Kong, China

Poster #59

Possible mechanisms of degeneration of preganglionic neurons in acetylcholinesterase antibody injected rats

H Tang, S Brimijoin

Rochester, MN

Poster #60


The prevalence of neurogenic orthostatic hypotension in patients with endocrinologic disorders

JL Gilden, D Ramirez, I Garcia, A Tartakover, P Um, H Ha, E Mensah

North Chicago, IL

Poster #61

Heterogeneity of hemodynamic responses in patients with neurogenic orthostatic hypotension

JL Gilden, D Ramirez, P Um, H Ha, A Tartakover, I Garcia, E Mensah

North Chicago, IL




Major financial support was provided by:

      Shire US Inc.


Financial support was also provided by:



This support is gratefully acknowledged.