Implantable mouse BP transmitters (TA11PA-C20, Data Sciences International, St. Paul, MN) will be used to directly measure arterial pressure in individual, conscious and freely moving mice (20, 21). Details of the methods used are included on the protocol page for this segment.
All mice are allowed 10 days of recovery from transmitter implantation surgery before any measurements are made. This time interval is necessary for the mice to regain their circadian blood pressure and heart rate rhythm. Thereafter, BP and HR were telemetrically recorded and stored with the Dataquest ART data acquisition system (Data Sciences International). The baseline measures will be averaged for a period of 1-7 days before subjecting the animal to the desired physiologic maneuver (e.g. high salt diet, L-NAME treatment). Blood pressure and heart rate data will be collected over a period of days to weeks.
Publications for BP telemetry (1)
Kramer K, Kinter L, Brockway BP, Voss HP, Remie R, Van Zutphen BL. The use of radiotelemetry in small laboratory animals: recent advances. Contemp Top Lab Anim Sci (2001) 40:8-16
View abstract View in PubMed
Radiotelemetry provides an alternative means of obtaining physiological measurements from awake and freely moving laboratory animals, without introducing stress artifacts. For researchers, especially those in the fields of pharmacology and toxicology, the technique may provide a valuable tool for predicting the effectiveness and safety of new compounds in humans. In light of studies described in the literature, it is concluded that there is ample evidence that the use of radiotelemetry for measuring blood pressure, cardiac activity, heart rate, body temperature, and locomotor activity in rodents has been validated sufficiently. Today, this technology is an important tool for the stress-free collection of these physiologic data in small rodents, including mice.
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Last updated on 2013-11-06 Moderated by Jimmy Hao