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Aquaporin 2-Cre - Renal specific transgenic database

Common name Aquaporin 2-Cre
Mouse strain C57BL/6
Genebank listing: AQP2 (11827)
Source Donald Kohan (email)
Renal cell types Principal cells (collecting duct)
Extent of expression/recombination in renal target cells 95% recombination in collecting duct principal cells
Other cell types sperm, vas deferens
Applications principal cell-specific gene targeting
Image (click to zoom)

 Co-localization of YFP expression and AQP2 immunofluorescence in mice doubly heterozygous for ROSA26-YFP and AQP2-Cre. Images are 600X.

References
  • Ge Y, Bagnall A, Stricklett PK, Webb D, Kotelevtsev Y, Kohan DE. Combined knockout of collecting duct endothelin A and B receptors causes hypertension and sodium retention. Am J Physiol Renal Physiol (2008) 295:F1635-40 View in PubMed

  • Ge Y, Bagnall A, Stricklett PK, Strait K, Webb DJ, Kotelevtsev Y, Kohan DE. Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention. Am J Physiol Renal Physiol (2006) 291:F1274-80 View in PubMed

  • Guan Y, Hao C, Cha DR, Rao R, Lu W, Kohan DE, Magnuson MA, Redha R, Zhang Y, Breyer MD. Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption. Nat Med (2005) 11:861-6 View in PubMed

  • Zhang H, Zhang A, Kohan DE, Nelson RD, Gonzalez FJ, Yang T. Collecting duct-specific deletion of peroxisome proliferator-activated receptor gamma blocks thiazolidinedione-induced fluid retention. Proc Natl Acad Sci U S A (2005) 102:9406-11 View in PubMed

  • Ge Y, Stricklett PK, Hughes AK, Yanagisawa M, Kohan DE. Collecting duct-specific knockout of the endothelin A receptor alters renal vasopressin responsiveness, but not sodium excretion or blood pressure. Am J Physiol Renal Physiol (2005) 289:F692-8 View in PubMed

  • Ge Y, Ahn D, Stricklett PK, Hughes AK, Yanagisawa M, Verbalis JG, Kohan DE. Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality. Am J Physiol Renal Physiol (2005) 288:F912-20 View in PubMed

  • Ahn D, Ge Y, Stricklett PK, Gill P, Taylor D, Hughes AK, Yanagisawa M, Miller L, Nelson RD, Kohan DE. Collecting duct-specific knockout of endothelin-1 causes hypertension and sodium retention. J Clin Invest (2004) 114:504-11 View in PubMed

Availability Yes
Available states Frozen embryos
Available at (source) Jackson Labs. Strain ID: Tg(Aqp2-cre)1Dek
Added on/by 2009-08-12 / Donald Kohan
Modified on/by 2009-08-12 / Donald Kohan