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V-ATPase B1-Cre - Renal specific transgenic database

Common name V-ATPase B1-Cre
Mouse strain C57BL/6
Genebank listing: ATP6V1B1 (32767)
Source Raoul Nelson (email)
Renal cell types Connecting Tubule,Intercalated cells Type A (collecting duct),Intercalated cells Type B (collecting duct),Intercalated cells Type non-A/N (collecting duct)
Extent of expression/recombination in renal target cells >95% recombination in intercalated cells
Other cell types 15% of brain cells, 10% of large intestine cells, 28% of small intestine cells, 4% of uterus, extensively expressed in male reproductive tract
Applications Intercalated cell-specific gene recombination in kidney
Image (click to zoom) None provided
  • Raphael KL, Strait KA, Stricklett PK, Miller RL, Nelson RD, Piontek KB, Germino GG, Kohan DE. Inactivation of Pkd1 in principal cells causes a more severe cystic kidney disease than in intercalated cells. Kidney Int (2009) 75:626-33 View in PubMed

  • Miller RL, Lucero OM, Riemondy KA, Baumgartner BK, Brown D, Breton S, Nelson RD. The V-ATPase B1-subunit promoter drives expression of Cre recombinase in intercalated cells of the kidney. Kidney Int (2009) 75:435-9 View in PubMed

Availability Yes
Available states Breeding pairs
Available at (source) PI: Raoul Nelson
Added on/by 2010-01-19 / Donald Kohan
Modified on/by 2010-03-01 / Donald Kohan