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Renal specific transgenic database

This database is intended to assist all investigators interested in renal-specific transgene expression, focusing specifically of transgenic lines expressing Cre, reporter mice and "Tetmice" (expressing tetracycline-regulated transactivators). It will be updated as soon as new information becomes available, thereby providing the most timely information on gene targeting in the kidney. The database is also intended to contain valuable information that is not easily found otherwise, including all sites of transgene expression as well as the amount of transgene expression (degree of variegation) within the targeted cell type(s). This information, combined with existing databases on floxed alleles, including the Nagy Lab website and the Jackson Labs website, will allow renal investigators to easily understand what transgenic tools are available and how they might be utilized.



Renal Cell TypeCommon NameCategoryContributor
 Cited1 CreERT2Cre/ERTMark de Caestecker
 Aquaporin 2-CrecreDonald Kohan
 V-ATPase B1-CrecreRaoul Nelson
 11-hydroxysteroid dehydrogenase-2-CrecreAniko Naray-Fejes-Toth
 HoxB7-CrecreAndrew McMahon
 Nephrin-CrecreSusan Quaggin
 Podocin-rtTA (Kopp)tetJeffrey Kopp
 Podocin-CrecreLarry Holzman
 Odd-skipped related-2-CrecreYu Lan
 Sodium-glucose cotransporter-2-CrecreMichel Tauc
 Pax8-rtTAtetRobert Koesters
 Pax8-CrecreMeinrad Busslinger
 Ksp-cadherin-CrecrePeter Igarashi
 Tamm Horsfall Protein-CrecreDonald Kohan
 Gamma glutamyl transpeptidase (GGT)-CrecreEric Neilson
 Ksp-cadherin-CreERT2Cre/ERTDorien J. M. Peters
 Phosphoenolpyruvate carboxykinase (PEPCK)-CrecreVolker Haase
 Gamma glutamyl transpeptidase (GGT)-CreERT2Cre/ERTPetra Pennekamp
 Podocin-rtTA (Holthofer)tetHarry Holthofer
 Renin-CrecreJurgen Schnermann
 Podocin-CreERT2Cre/ERTFarhad Danesh
 none
 none
 Aquaporin 2-CrecreEdith Hummler
Cap mesenchyme
 Cited1 CreERT2Cre/ERTMark de Caestecker
Condensing metanephric mesenchyme (early after UB bud)
 Odd-skipped related-2-CrecreYu Lan
 Pax8-CrecreMeinrad Busslinger
 Ksp-cadherin-CrecrePeter Igarashi
Connecting Tubule
 V-ATPase B1-CrecreRaoul Nelson
 11-hydroxysteroid dehydrogenase-2-CrecreAniko Naray-Fejes-Toth
 Pax8-rtTAtetRobert Koesters
 Ksp-cadherin-CrecrePeter Igarashi
 Ksp-cadherin-CreERT2Cre/ERTDorien J. M. Peters
Distal convoluted tubule
 Pax8-rtTAtetRobert Koesters
 Ksp-cadherin-CrecrePeter Igarashi
 Ksp-cadherin-CreERT2Cre/ERTDorien J. M. Peters
Glomerular podocytes
 Nephrin-CrecreSusan Quaggin
 Podocin-rtTA (Kopp)tetJeffrey Kopp
 Podocin-CrecreLarry Holzman
 Podocin-rtTA (Holthofer)tetHarry Holthofer
 Podocin-CreERT2Cre/ERTFarhad Danesh
Intercalated cells Type A (collecting duct)
 V-ATPase B1-CrecreRaoul Nelson
 HoxB7-CrecreAndrew McMahon
 Pax8-rtTAtetRobert Koesters
 Ksp-cadherin-CrecrePeter Igarashi
Intercalated cells Type B (collecting duct)
 V-ATPase B1-CrecreRaoul Nelson
 HoxB7-CrecreAndrew McMahon
 Pax8-rtTAtetRobert Koesters
 Ksp-cadherin-CrecrePeter Igarashi
Intercalated cells Type non-A/N (collecting duct)
 V-ATPase B1-CrecreRaoul Nelson
 HoxB7-CrecreAndrew McMahon
 Pax8-rtTAtetRobert Koesters
 Ksp-cadherin-CrecrePeter Igarashi
Macula Densa (Thick Ascending Limb)
 Pax8-rtTAtetRobert Koesters
Principal cells (collecting duct)
 Aquaporin 2-CrecreDonald Kohan
 11-hydroxysteroid dehydrogenase-2-CrecreAniko Naray-Fejes-Toth
 HoxB7-CrecreAndrew McMahon
 Pax8-rtTAtetRobert Koesters
 Ksp-cadherin-CrecrePeter Igarashi
 Ksp-cadherin-CreERT2Cre/ERTDorien J. M. Peters
 Aquaporin 2-CrecreEdith Hummler
Proximal tubule
 Sodium-glucose cotransporter-2-CrecreMichel Tauc
 Pax8-rtTAtetRobert Koesters
 Gamma glutamyl transpeptidase (GGT)-CrecreEric Neilson
 Ksp-cadherin-CreERT2Cre/ERTDorien J. M. Peters
 Phosphoenolpyruvate carboxykinase (PEPCK)-CrecreVolker Haase
 Gamma glutamyl transpeptidase (GGT)-CreERT2Cre/ERTPetra Pennekamp
Proximal tubule S1 segment
 Sodium-glucose cotransporter-2-CrecreMichel Tauc
 Pax8-rtTAtetRobert Koesters
 Gamma glutamyl transpeptidase (GGT)-CrecreEric Neilson
 Ksp-cadherin-CreERT2Cre/ERTDorien J. M. Peters
 Phosphoenolpyruvate carboxykinase (PEPCK)-CrecreVolker Haase
Proximal tubule S2 segment
 Sodium-glucose cotransporter-2-CrecreMichel Tauc
 Pax8-rtTAtetRobert Koesters
 Gamma glutamyl transpeptidase (GGT)-CrecreEric Neilson
 Ksp-cadherin-CreERT2Cre/ERTDorien J. M. Peters
 Phosphoenolpyruvate carboxykinase (PEPCK)-CrecreVolker Haase
Proximal tubule S3 segment
 Sodium-glucose cotransporter-2-CrecreMichel Tauc
 Pax8-rtTAtetRobert Koesters
 Gamma glutamyl transpeptidase (GGT)-CrecreEric Neilson
 Ksp-cadherin-CreERT2Cre/ERTDorien J. M. Peters
 Phosphoenolpyruvate carboxykinase (PEPCK)-CrecreVolker Haase
 Gamma glutamyl transpeptidase (GGT)-CreERT2Cre/ERTPetra Pennekamp
Thick Limb (Loop of Henle)
 Pax8-rtTAtetRobert Koesters
 Ksp-cadherin-CrecrePeter Igarashi
 Tamm Horsfall Protein-CrecreDonald Kohan
 Ksp-cadherin-CreERT2Cre/ERTDorien J. M. Peters
Thin limb Ascending (Loop of Henle)
 Pax8-rtTAtetRobert Koesters
Thin limb Descending (Loop of Henle)
 Pax8-rtTAtetRobert Koesters
Ureteric bud
 HoxB7-CrecreAndrew McMahon
 Pax8-CrecreMeinrad Busslinger
 Ksp-cadherin-CrecrePeter Igarashi
Ureteric bud stalk
 HoxB7-CrecreAndrew McMahon
Ureteric bud tip
 HoxB7-CrecreAndrew McMahon