December 10, 2013

Shureiqi to discuss molecularly targeted treatment of colon cancer today

Imad Shureiqi, M.D., will discuss “Molecular Targeting of Colon Cancer: The Tale of Two Proteins” at the next Department of Surgery Research Collaborative on Tuesday, Dec. 10, from 5-6 p.m. in Conference Room 7455 MRB IV.

A physician-scientist, Shureiqi’s research focuses on colon cancer risk, prevention and treatment. He is associate professor in the Department of Gastrointestinal Medical Oncology, at the University of Texas MD Anderson Cancer Center in Houston. Shureiqi’s research focuses on molecularly targeted treatment.

15-Lipoxygenase-1 (15-LOX-1) is a critical enzyme for the production of various inflammation-regulatory lipid signaling mediators, including 13-S-hydroxyoctadecadienoic acid from linoleic acid, lipoxins from arachidonic acid and resolvins and protectins from docosahexaenoic acid. Given the important regulatory function of 15-LOX-1 in terminal cell differentiation and inflammation, its expression is inducible and highly regulated in normal human cells. 15-LOX-1 is, however, down-regulated in various human cancers, esophageal, breast and pancreatic. 15-LOX-1 re-expression via pharmaceutical agents or adenoviral vectors induces growth inhibition and reestablishes terminal differentiation and apoptosis in cancer cells. His lab’s major research interests is to define the mechanisms of 15-LOX-1transcription silencing in cancer cells and develop interventions to molecularly target 15-LOX-1 transcriptional silencing to suppress colonic tumorigenesis.

Shureiqi holds a dual-adjunct appointment as associate professor in the Department of Clinical Cancer Prevention, Division of OVP, Cancer Prevention and Population Sciences at MD Anderson Cancer Center.

The Department of Surgery Research Collaborative was developed to provide synergy between the basic sciences and clinical research as a means of enhancing research opportunities within the Section of Surgical Sciences.

The collaborative hosts meetings the second Tuesday of every month in Conference Room 7455 MRB IV from 5-6 p.m., offering opportunities for informal discussion as well as presentations from both the basic sciences and translational research. Section faculty, residents, fellows and staff are invited and encouraged to attend.

This discussion will conclude the series for the fall and will return next year.