A study that is appropriate for any patient that is thought to have autonomic impairment. The aim of this study is to establish the baseline health of the autonomic nervous system and to help establish or confirm a preliminary diagnosis. It includes autonomic reflex testing, blood pressure measurements lying, seated and standing along with blood sampling for plasma catecholamines. There may be a tilt test, cardiac output measurements taken. There are also some questionnaires.
This is a longitudinal observational study of participants between the ages of 18 and 80 who have neurogenic orthostatic hypotension with a drop in blood pressure (systolic – top number) of ≥30 mmHg within 5 minutes of standing. This study includes all the procedures in the Phenotype and Natural History of Primary Autonomic Disorders study, plus a medication trial (take the medication one time) to determine response to taking a drug called atomoxetine / Straterra. It involves follow-up communication every 6 months for 3 years. At year 3, participants may be invited back for a follow-up examination.