Fesik Lab




Research Professor of Biochemistry                                           


Office:      804-A RRB

Phone:     615-936-8705

Email:      edward.t.olejniczak@vanderbilt.edu


Structural Biology


Edward T. Olejniczak, Ph.D is a Research Professor of Biochemistry in the Vanderbilt University School of Medicine. His research focuses on how to use structural biology to help elucidate biological processes. Areas of interest include structural studies of proteins, structure based drug design, and biomarkers.

Prior to joining Vanderbilt he worked in the structural biology group of Abbott Labs. He has published over 100 papers and has three issued patents.


  1. Stewart, K.D., J.R. Huth, T.I. Ng, K. McDaniel , R.N. Hutchinson, V.S. Stoll, R.R. Mendoza, E.D. Matayoshi, R. Carrick, H. Mo, J. Severin, K. Walter, P.L. Richardson, L.W. Barrett, R. Meadows, S. Anderson, W. Kohlbrenner, C. Maring, D.J. Kempf, A. Molla, E.T.Olejniczak Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket Bioorg Med Chem Lett. 20,612 (2010).
  2. Olejniczak, E. T. , Q Ruan,R.N. Ziemann, L.G. Birkenmeyer, S. C. Saldana, S. Y.Tetin Rapid Determination of Antigenic Epitopes in Human NGAL using NMR. Biopolmers 93,657 (2010).
  3. Yu, L., R.  Edalji, J. E. Harlan, T. F. Holzman,  A. Pereda Lopez, B. Labkovsky,H. Hillen, S. Barghorn,U. Ebert, P. L. Richardson, L. Miesbauer, L. Solomon, D. Bartley,  K.Walter,  R. W. Johnson,  P. J. Hajduk and E. T.Olejniczak Structural Characterization of a Soluble Amyloid beta-Peptide Oligomer   Biochemistry 48,1870 (2009).
  4. Olejniczak, E. T., C. Van Sant, M. G. Anderson, G. Wang, S. K. Tahir, G. Sauter, R. Lesniewski, and D. Semizarov, Integrative Genomic Analysis of Small-Cell LungCarcinoma Reveals Correlates of Sensitivity to Bcl-2 Antagonists and Uncovers Novel Chromosomal Gains. Mol. Cancer Res. 5. 4 (2007).
  5. Olejniczak, E. T., P. J. Hajduk, P. A. Marcotte, D. G. Nettesheim, R. P. Meadows, R. Edalji, T. F. Holzman, and S. W. Fesik.  Stromelysin inhibitors designed from weakly bound fragments:  Effects of linking and cooperativity.  J. Am. Chem. Soc. 119, 5828-5832 (1997).
  6. Hajduk, P.J., E.T. Olejniczak,  and S.W. Fesik.  One dimensional relaxation- and diffusion-edited NMR methods for screening compounds that bind to macromolecules.  J. Am. Chem. Soc. 119, 12257-12261 (1997).
  7. Huth, J.R., E.T. Olejniczak, R. Menaldo, H. Liang, E.A.S. Harris, M.L. Lupher, A.E.Wilson, S.W.Fesik D.E. Staunton.  NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding. Proc. Natl. Acad. Sci. USA, 97,10,5231 (2000).
  8. Liu, G. Huth JR. Olejniczak ET. Mendoza R. DeVries P. Leitza S. Reilly EB. Okasinski GF. Fesik SW. von Geldern TW. Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties. Journal of Medicinal Chemistry. 44,1202 (2001).
  9. Huang, Q., A.M. Petros, S.W. Fesik, H. Virgin, E.T. Olejniczak. Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus.  Proc. Natl. Acad. Sci. USA. 99,3428 (2002).
  10. Huang, Q., A.M. Petros, S.W. Fesik, H. Virgin, E.T. Olejniczak. Solution structure of the BHRF1 Protein from Epstein Barr Virus, a Homolog of Human Bcl-2.  J. Molecular  Biology 332,1123 (2003).
  11. Zech, S. G., E. T. Olejniczak, P. Hajduk, J. Mack, and A. E. McDermott, Characterization of Protein-Ligand Interactions by Solid State NMR: J. Am. Chem. Soc., 126, 13948 (2004).
  12. Sun, C., D. Nettesheim, Z. Liu  and E. T. Olejniczak Solution Structure of Human Survivin and Its Binding interface with Smac/Diablo, Biochemistry 44,11 (2005).
  13. Park, Cheol-Min, C.Sun, E. T. Olejniczak, A.E. Wilson, R. P. Meadows, S.W. Elmore, and S. W. Fesik, Non-peptidic small molecule inhibitors of XIAP. Biorg. Med. Chem. Lett. 15,771 (2005).
  14. Yu, L., C. Sun, D. Song, J. Shen, N. Xu, A. Gunasekera, P. J. Hajduk, E. T. Olejniczak,  NMR Structural Studies of a Potassium Channel/Charybdotoxin  Complex.  Biochemistry; 44,15834 (2005).
  15. Huth, R. J., R. Mendoza, E. T. Olejniczak , R. W. Johnson, C.A. Colthron, Y. Liu, C. Lerner, J. Chen and P. Hajduk, Alarm NMR: A Rapid and Robust Method to Detect Reactive False Positives in Biochemical Screens.  J. Am. Chem Soc.  127,217 (2005).