Fesik Lab


Frank, A. O.; Vangamudi, B.; Feldkamp, M.; Souza-Fagundes, E.; Luzwick, J.; Cortez, D.; Olejniczak, E. T.; Waterson, A. G.; Rossanese, O. W.; Chazin, W.; Fesik, S. W. Discovery of a potent stapled helix peptide that binds to the 70N domain of Replication Protein A. J. Med. Chem. 2014 Feb 19. [Epub ahead of print] (2014).

Burns M.C., Sun Q., Daniels R.N., Camper D.V., Kennedy J. P., Phan, J., Olejniczak E. T., Lee T., Waterson A. G., Rossanese O. W., Fesik S.W. (2013), Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange. Proceed. Natl. Acad. Sci. USA. 111(9):3401-6 (2014).

Frank A. O., Feldkamp M.D., Kennedy J. P., Waterson A. G., Pelz N. F., Patrone J. D., Vangamudi B., Camper D.V., Rossanese O. W., Chazin W. J., Fesik S.W. Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions Using a Fragment Linking Approach. J. Med. Chem. 56(22):9242-50 (2013). PMCID: PMC3932990

Feldkamp M.D., Frank A.O., Kennedy J.P., Patrone J., Vangamudi B., Waterson A.G., Fesik S.W., Chazin W.J. Surface reengineering of RPA70N enables co-crystallization with an inhibitor of the Replication Protein A interaction motif of ATR Interacting Protein. Biochemistry. 52(37):6515-24 (2013). PMCID: PMC3804075

Harner M.J., Frank A.O., Fesik S.W. Fragment-Based Drug Discovery Using NMR Spectroscopy. J. Biomol. NMR. 56(2):65-75 (2013). PMCID: PMC3699969

Patrone J.D., Kennedy J.P., Frank A.O., Feldkamp M.D., Vangamudi B., Pelz N.F., Rossanese O.W., Waterson A.G., Chazin W.J., Fesik S.W. Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A. ACS Med. Chem. Lett. 4(7):601–605 (2013). PMCID: PMC3728914

Friberg A, Vigil D, Zhao B, Daniels RN, Burke JP, Garcia-Barrantes P, Camper D, Chauder B, Lee T, Olejniczak ET, Fesik SW. Discovery of potent myeloid cell leukemia-1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. J. Med. Chem. 56(1):15-30 (2013). PMCID: PMC3646517

Sun Q, Burke JP, Phan J, Burns MC, Olejniczak ET, Waterson AG, Lee T, Rossanese OW, Fesik SW. Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation. Angew. Chem. Int. Ed. Engl. 51(25):6140-3 (2012). PMCID: PMC3620661

Souza-Fagundes EM, Frank AO, Feldkamp MD, Dorset DC, Chazin WJ, Rossanese OW, Olejniczak ET, Fesik SW. A high-throughput fluorescence polarization anisotropy assay for the 70N domain of Replication Protein A. Anal. Biochem. 421(2):742–749 (2012). PMCID: PMC3274598