.

Department of Pathology, Microbiology, and Immunology

   

  Mary Ann Thompson Arildsen, M.D., Ph.D.

 

 

Associate Professor

Dept. of Pathology, Microbiology and Immunology
Director of Hematology


 

  Contact Information

 

 

Office Location:

TVC 4502

Phone: 615-322-3220

Fax: 615-343-7961

E-mail:  mary.ann.thompson@vanderbilt.edu

 

Campus Mail address:

Pathology Labs/Blood Bank

TVC 4601 (5310)

 

US Mailing address:

Pathology Labs/Blood Bank

Vanderbilt University School of Medicine

TVC 4601

Nashville, TN 37232-5310   

     

 

 

Education

 

 

Ph.D., Kuopio Univ (Finland)
M.D., Tampere Univ (Finland)



 

 

Publications

 

 

Pincus, T, Sokka, T. Evidence-based practice and practice-based evidence. Nat Clin Pract Rheumatol, 2(3), 114-5, 2006

Chung, CP, Sokka, T, Arbogast, P, Pincus, T. Work disability in rheumatoid arthritis: differences in patients with early disease in finland and the United States. Ann Rheum Dis, 2006

Pincus, T, Sokka, T. Should aggressive therapy for rheumatoid arthritis require early use of weekly low-dose methotrexate, as the first disease-modifying anti-rheumatic drug in most patients. Rheumatology (Oxford), 45(5), 497-9, 2006

Sokka, T, M??kinen, H. Improving outcomes in rheumatoid arthritis: what determines decisions to change ineffective therapy. J Rheumatol, 33(7), 1213-5, 2006

Pincus, T, Sokka, T, Chung, CP, Cawkwell, G. Declines in number of tender and swollen joints in patients with rheumatoid arthritis seen in standard care in 1985 versus 2001: possible considerations for revision of inclusion criteria for clinical trials. Ann Rheum Dis, 65(7), 878-83, 2006

H??kkinen, A, Kautiainen, H, Hannonen, P, Ylinen, J, M??kinen, H, Sokka, T. Muscle strength, pain and disease activity explain individual subdimensions of the Health Assessment Questionnaire disability index especially in females with rheumatoid arthritis. Ann Rheum Dis, 2005

Kauppi, M, Sokka, T, Hannonen, P. Survey nonresponse is associated with increased mortality in patients with rheumatoid arthritis and in a community population. J Rheumatol, 32(5), 807-10, 2005

Chung, CP, Oeser, A, Raggi, P, Gebretsadik, T, Shintani, AK, Sokka, T, Pincus, T, Avalos, I, Stein, CM. Increased coronary-artery atherosclerosis in rheumatoid arthritis: relationship to disease duration and cardiovascular risk factors. Arthritis Rheum, 52(10), 3045-53, 2005

H??kkinen, A, Neva, MH, Kauppi, M, Hannonen, P, Ylinen, J, M??kinen, H, J??ppinen, I, Sokka, T. Decreased muscle strength and mobility of the neck in patients with rheumatoid arthritis and atlantoaxial disorders. Arch Phys Med Rehabil, 86(8), 1603-8, 2005

Pincus, T, Sokka, T, Kautiainen, H. Further development of a physical function scale on a Multidimensional Health Assessment Questionnaire for standard care of patients with rheumatic diseases. J Rheumatol, 32(8), 1432-9, 2005

Vuorela, J, Kauppinen, T, Sokka, T. Distribution of radiation in synovectomy of the knee with 166Ho-FHMA using image fusion. Cancer Biother Radiopharm, 20(3), 333-7, 2005

M??kinen, H, Kautiainen, H, Hannonen, P, Sokka, T. Is DAS28 an appropriate tool to assess remission in rheumatoid arthritis. Ann Rheum Dis, 64(10), 1410-3, 2005

M??kinen, H, Kautiainen, H, Hannonen, P, Sokka, T. Frequency of remissions in early rheumatoid arthritis defined by 3 sets of criteria. a 5-year followup study. J Rheumatol, 32(5), 796-800, 2005

Pincus, T, Sokka, T, Kautiainen, H. Patients seen for standard rheumatoid arthritis care have significantly better articular, radiographic, laboratory, and functional status in 2000 than in 1985. Arthritis Rheum, 52(4), 1009-19, 2005

Krishnan, E, H??kkinen, A, Sokka, T, Hannonen, P. Impact of age and comorbidities on the criteria for remission and response in rheumatoid arthritis. Ann Rheum Dis, 64(9), 1350-2, 2005

Pincus, T, Wang, X, Chung, C, Sokka, T, Koch, GG. Patient preference in a crossover clinical trial of patients with osteoarthritis of the knee or hip: face validity of self-report questionnaire ratings. J Rheumatol, 32(3), 533-9, 2005

Pincus, T, Sokka, T. How aggressive should initial therapy for rheumatoid arthritis be. Rheumatology (Oxford), 44(1), 133-4; author reply 135-6, 2005

Yazici, Y, Sokka, T, Kautiainen, H, Swearingen, C, Kulman, I, Pincus, T. Long term safety of methotrexate in routine clinical care: discontinuation is unusual and rarely the result of laboratory abnormalities. Ann Rheum Dis, 64(2), 207-11, 2005

H??kkinen, A, Kautiainen, H, Hannonen, P, Ylinen, J, Arkela-Kautiainen, M, Sokka, T. Pain and joint mobility explain individual subdimensions of the health assessment questionnaire (HAQ) disability index in patients with rheumatoid arthritis. Ann Rheum Dis, 64(1), 59-63, 2005

Sokka, T, Pincus, T. An Early Rheumatoid Arthritis Treatment Evaluation Registry (ERATER) in the United States. Clin Exp Rheumatol, 23(5 Suppl 39), S178-81, 2005

Sokka, T, Hannonen, P, M??tt??nen, T. Conventional Disease-Modifying Antirheumatic Drugs in Early Arthritis. Rheum Dis Clin North Am, 31(4), 729-744, 2005

Sokka, T. Rheumatoid arthritis databases in Finland. Clin Exp Rheumatol, 23(5 Suppl 39), S201-4, 2005

Sokka, T. Assessment of pain in rheumatic diseases. Clin Exp Rheumatol, 23(5 Suppl 39), S77-84, 2005

Sokka, T, Pincus, T. Quantitative joint assessment in rheumatoid arthritis. Clin Exp Rheumatol, 23(5 Suppl 39), S58-62, 2005

Pincus, T, Sokka, T. Complexities in the quantitative assessment of patients with rheumatic diseases in clinical trials and clinical care. Clin Exp Rheumatol, 23(5 Suppl 39), S1-9, 2005

Neva, MH, Hakkinen, A, M??kinen, H, Hannonen, P, Kauppi, M, Sokka, T. High Prevalence of Asymptomatic Cervical Spine Subluxations in Patients with Rheumatoid Arthritis Waiting for Orthopaedic Surgery. Ann Rheum Dis, 2005

Pincus, T, Keysor, J, Sokka, T, Krishnan, E, Callahan, LF. Patient questionnaires and formal education level as prospective predictors of mortality over 10 years in 97% of 1416 patients with rheumatoid arthritis from 15 United States private practices. J Rheumatol, 31(2), 229-34, 2004

H??kkinen, A, Sokka, T, Hannonen, P. A home-based two-year strength training period in early rheumatoid arthritis led to good long-term compliance: a five-year followup. Arthritis Rheum, 51(1), 56-62, 2004

Sokka, T, Pincus, T. A historical perspective concerning population-based and clinical studies of early arthritis and early rheumatoid arthritis. Clin Exp Rheumatol, 21(5 Suppl 31), S5-14, 2004

Sokka, T. Work disability in early rheumatoid arthritis. Clin Exp Rheumatol, 21(5 Suppl 31), S71-4, 2004

Pincus, T, Sokka, T. Uniform databases in early arthritis: specific measures to complement classification criteria and indices of clinical change. Clin Exp Rheumatol, 21(5 Suppl 31), S79-88, 2004

Sokka, T. Early rheumatoid arthritis in Finland. Clin Exp Rheumatol, 21(5 Suppl 31), S133-7, 2004

Sokka, T, Willoughby, J, Yazici, Y, Pincus, T. Databases of patients with early rheumatoid arthritis in the USA. Clin Exp Rheumatol, 21(5 Suppl 31), S146-53, 2004

Pincus, T, Yazici, Y, Sokka, T, Aletaha, D, Smolen, JS. Methotrexate as the "anchor drug" for the treatment of early rheumatoid arthritis. Clin Exp Rheumatol, 21(5 Suppl 31), S179-85, 2004

Smolen, JS, Sokka, T, Pincus, T, Breedveld, FC. A proposed treatment algorithm for rheumatoid arthritis: aggressive therapy, methotrexate, and quantitative measures. Clin Exp Rheumatol, 21(5 Suppl 31), S209-10, 2004

Pincus, T, Sokka, T. Partial control of Core Data Set measures and Disease Activity Score (DAS) measures of inflammation does not prevent long-term joint damage: evidence from longitudinal observations over 5-20 years. Clin Exp Rheumatol, 20(5 Suppl 27), S42-7, 2004

Krishnan, E, Sokka, T, H??kkinen, A, Hubert, H, Hannonen, P. Normative values for the Health Assessment Questionnaire disability index: benchmarking disability in the general population. Arthritis Rheum, 50(3), 953-60, 2004

Pincus, T, Koch, G, Lei, H, Mangal, B, Sokka, T, Moskowitz, R, Wolfe, F, Gibofsky, A, Simon, L, Zlotnick, S, Fort, JG. Patient Preference for Placebo, Acetaminophen (paracetamol) or Celecoxib Efficacy Studies (PACES): two randomised, double blind, placebo controlled, crossover clinical trials in patients with knee or hip osteoarthritis. Ann Rheum Dis, 63(8), 931-9, 2004

Sokka, T, H??kkinen, A, Krishnan, E, Hannonen, P. Similar prediction of mortality by the health assessment questionnaire in patients with rheumatoid arthritis and the general population. Ann Rheum Dis, 63(5), 494-7, 2004

Sokka, T, Kautiainen, H, H??kkinen, A, Hannonen, P. Radiographic progression is getting milder in patients with early rheumatoid arthritis. Results of 3 cohorts over 5 years. J Rheumatol, 31(6), 1073-82, 2004

H??kkinen, A, Sokka, T, Kautiainen, H, Kotaniemi, A, Hannonen, P. Sustained maintenance of exercise induced muscle strength gains and normal bone mineral density in patients with early rheumatoid arthritis: a 5 year follow up. Ann Rheum Dis, 63(8), 910-6, 2004

Yazici, Y, Pincus, T, Kautiainen, H, Sokka, T. Morning stiffness in patients with early rheumatoid arthritis is associated more strongly with functional disability than with joint swelling and erythrocyte sedimentation rate. J Rheumatol, 31(9), 1723-6, 2004

Pincus, T, Sokka, T. Should contemporary rheumatoid arthritis clinical trials be more like standard patient care and vice versa. Ann Rheum Dis, 63 Suppl 2, ii32-ii39, 2004

Olsen, N, Sokka, T, Seehorn, CL, Kraft, B, Maas, K, Moore, J, Aune, TM. A gene expression signature for recent onset rheumatoid arthritis in peripheral blood mononuclear cells. Ann Rheum Dis, 63(11), 1387-92, 2004

Pincus, T, Sokka, T. Clinical trials in rheumatic diseases: designs and limitations. Rheum Dis Clin North Am, 30(4), 701-24, v-vi, 2004

Pincus, T, Sokka, T. Quantitative measures and indices to assess rheumatoid arthritis in clinical trials and clinical care. Rheum Dis Clin North Am, 30(4), 725-51, vi, 2004

Sokka, T. Rheumatoid arthritis databases. Rheum Dis Clin North Am, 30(4), 769-81, vi, 2004

Sokka, T. National databases and rheumatology research I: longitudinal databases in Scandinavia. Rheum Dis Clin North Am, 30(4), 851-67, viii, 2004

Sokka, T, Krishnan, E. National databases and rheumatology research II: the National Health and Nutrition Examination Surveys. Rheum Dis Clin North Am, 30(4), 869-78, viii, 2004

Pincus, T, Kavanaugh, A, Sokka, T. Benefit/risk of therapies for rheumatoid arthritis: underestimation of the "side effects" or risks of RA leads to underestimation of the benefit/risk of therapies. Clin Exp Rheumatol, 22(5 Suppl 35), S2-11, 2004

Pincus, T, Sokka, T, Kavanaugh, A. Quantitative documentation of benefit/risk of new therapies for rheumatoid arthritis: patient questionnaires as an optimal measure in standard care. Clin Exp Rheumatol, 22(5 Suppl 35), S26-33, 2004

Pincus, T, Sokka, T, Kavanaugh, A. Relative versus absolute goals of therapies for RA: ACR 20 or ACR 50 responses versus target values for "near remission" of DAS or single measures. Clin Exp Rheumatol, 22(5 Suppl 35), S50-6, 2004

Neva, MH, Isom??ki, P, Hannonen, P, Kauppi, M, Krishnan, E, Sokka, T. Early and extensive erosiveness in peripheral joints predicts atlantoaxial subluxations in patients with rheumatoid arthritis. Arthritis Rheum, 48(7), 1808-13, 2003

Vuorela, J, Sokka, T, Pukkala, E, Hannonen, P. Does yttrium radiosynovectomy increase the risk of cancer in patients with rheumatoid arthritis. Ann Rheum Dis, 62(3), 251-3, 2003

Sokka, T, Pincus, T. Most patients receiving routine care for rheumatoid arthritis in 2001 did not meet inclusion criteria for most recent clinical trials or american college of rheumatology criteria for remission. J Rheumatol, 30(6), 1138-46, 2003

Pincus, T, Sokka, T. Quantitative measures for assessing rheumatoid arthritis in clinical trials and clinical care. Best Pract Res Clin Rheumatol, 17(5), 753-81, 2003

Krishnan, E, Sokka, T, Hannonen, P. Smoking-gender interaction and risk for rheumatoid arthritis. Arthritis Res Ther, 5(3), R158-62, 2003

Sokka, T, Kautiainen, H, M??tt??nen, T, Hannonen, P. Erosions develop rarely in joints without clinically detectable inflammation in patients with early rheumatoid arthritis. J Rheumatol, 30(12), 2580-4, 2003

Sokka, T. Assessment of pain in patients with rheumatic diseases. Best Pract Res Clin Rheumatol, 17(3), 427-49, 2003

H??kkinen, A, Sokka, T, Lietsalmi, AM, Kautiainen, H, Hannonen, P. Effects of dynamic strength training on physical function, Valpar 9 work sample test, and working capacity in patients with recent-onset rheumatoid arthritis. Arthritis Rheum, 49(1), 71-7, 2003

Sokka, T, Pincus, T. Eligibility of patients in routine care for major clinical trials of anti-tumor necrosis factor alpha agents in rheumatoid arthritis. Arthritis Rheum, 48(2), 313-8, 2003

Sokka, T, Krishnan, E, H??kkinen, A, Hannonen, P. Functional disability in rheumatoid arthritis patients compared with a community population in Finland. Arthritis Rheum, 48(1), 59-63, 2003

Pincus, T, Sokka, T, Stein, CM. Are long-term very low doses of prednisone for patients with rheumatoid arthritis as helpful as high doses are harmful?. Ann Intern Med, 136(1), 76-8, 2002

Pincus, T, Ferraccioli, G, Sokka, T, Larsen, A, Rau, R, Kushner, I, Wolfe, F. Evidence from clinical trials and long-term observational studies that disease-modifying anti-rheumatic drugs slow radiographic progression in rheumatoid arthritis: updating a 1983 review. Rheumatology (Oxford), 41(12), 1346-56, 2002

Sokka, T, Pincus, T. Contemporary disease modifying antirheumatic drugs (DMARD) in patients with recent onset rheumatoid arthritis in a US private practice: methotrexate as the anchor drug in 90% and new DMARD in 30% of patients. J Rheumatol, 29(12), 2521-4, 2002

Pincus, T, Sokka, T, Wolfe, F. Premature mortality in patients with rheumatoid arthritis: evolving concepts. Arthritis Rheum, 44(6), 1234-6, 2001

Pincus, T, Koch, GG, Sokka, T, Lefkowith, J, Wolfe, F, Jordan, JM, Luta, G, Callahan, LF, Wang, X, Schwartz, T, Abramson, SB, Caldwell, JR, Harrell, RA, Kremer, JM, Lautzenheiser, RL, Markenson, JA, Schnitzer, TJ, Weaver, A, Cummins, P, Wilson, A, Morant, S, Fort, J. A randomized, double-blind, crossover clinical trial of diclofenac plus misoprostol versus acetaminophen in patients with osteoarthritis of the hip or knee. Arthritis Rheum, 44(7), 1587-98, 2001

Sokka, T, Pincus, T. Markers for work disability in rheumatoid arthritis. J Rheumatol, 28(7), 1718-22, 2001

Pincus, T, Sokka, T. Quantitative target values of predictors of mortality in rheumatoid arthritis as possible goals for therapeutic interventions: an alternative approach to remission or ACR20 responses. J Rheumatol, 28(7), 1723-34, 2001

Pincus, T, Sokka, T. How can the risk of long-term consequences of rheumatoid arthritis be reduced. Best Pract Res Clin Rheumatol, 15(1), 139-70, 2001

H??kkinen, A, Sokka, T, Kotaniemi, A, Hannonen, P. A randomized two-year study of the effects of dynamic strength training on muscle strength, disease activity, functional capacity, and bone mineral density in early rheumatoid arthritis. Arthritis Rheum, 44(3), 515-22, 2001

Sokka, T, Hannonen, P. Healing of erosions in rheumatoid arthritis. Ann Rheum Dis, 59(8), 647-9, 2000

Sokka, T, M??tt??nen, T, Hannonen, P. Disease-modifying anti-rheumatic drug use according to the ''sawtooth'' treatment strategy improves the functional outcome in rheumatoid arthritis: results of a long-term follow-up study with review of the literature. Rheumatology (Oxford), 39(1), 34-42, 2000

Sokka, T, Kankainen, A, Hannonen, P. Scores for functional disability in patients with rheumatoid arthritis are correlated at higher levels with pain scores than with radiographic scores. Arthritis Rheum, 43(2), 386-9, 2000

Sokka, T, Mottonen, T, Hannonen, P. Mortality in early "sawtooth" treated rheumatoid arthritis patients during the first 8-14 years. Scand J Rheumatol, 28(5), 282-7, 1999

H??kkinen, A, Sokka, T, Kotaniemi, A, Kautiainen, H, Jappinen, I, Laitinen, L, Hannonen, P. Dynamic strength training in patients with early rheumatoid arthritis increases muscle strength but not bone mineral density. J Rheumatol, 26(6), 1257-63, 1999

H??kkinen, A, Sokka, T, Kotaniemi, A, Paananen, ML, M??lki??, E, Kautiainen, H, Hannonen, P. Muscle strength characteristics and central bone mineral density in women with recent onset rheumatoid arthritis compared with healthy controls. Scand J Rheumatol, 28(3), 145-51, 1999

Sokka, T, Kautiainen, H, M??tt??nen, T, Hannonen, P. Work disability in rheumatoid arthritis 10 years after the diagnosis. J Rheumatol, 26(8), 1681-5, 1999

Sokka, TM, Kaarela, K, M??tt??nen, TT, Hannonen, PJ. Conventional monotherapy compared to a "sawtooth" treatment strategy in the radiographic progression of rheumatoid arthritis over the first eight years. Clin Exp Rheumatol, 17(5), 527-32, 1999

Sokka, T, Hannonen, P. Utility of disease modifying antirheumatic drugs in "sawtooth" strategy. A prospective study of early rheumatoid arthritis patients up to 15 years. Ann Rheum Dis, 58(10), 618-22, 1999

Voutilainen, M, Sokka, T, Juhola, M, Farkkil??, M, Hannonen, P. Nonsteroidal anti-inflammatory drug-associated upper gastrointestinal lesions in rheumatoid arthritis patients. Relationships to gastric histology, Helicobacter pylori infection, and other risk factors for peptic ulcer. Scand J Gastroenterol, 33(8), 811-6, 1998

Sokka, TM, Kautiainen, HJ, Hannonen, PJ. A retrospective study of treating RA patients with various combinations of slow-acting antirheumatic drugs in a county hospital. Scand J Rheumatol, 26(6), 440-3, 1997

Huhtaniemi, IT, Pakarinen, P, Sokka, T, Kolho, KL, Eskola, V, Warren, DW. Molecular aspects of the ontogeny of pituitary and gonadal function. Ann N Y Acad Sci, 626, 62-72, 1991