Department of Pathology, Microbiology, and Immunology



  Justin M.M. Cates, M.D., Ph.D.



Assistant Director, Translational Pathology Shared Resource

Dept. of Pathology, Microbiology and Immunology


 Contact Information


Office Location:

MCN  C-2310C
   Phone: 615-936-6694

Fax: 615-322-0511

E-mail: justin.m.cates@vanderbilt.edu

Campus Mail address:

Pathology, Microbiology and Immunology-3rd Fl

MCN C-3321 (2561)

US Mailing address:

Vanderbilt University School of Medicine

Dept of Pathology, Microbiology and Immunology-3rd Fl

MCN  C-3321

Nashville, TN 37232-2561






MD, Tufts University School of Medicine, Boston, MA
PhD, Sackler School of Graduate Biomedical Sciences, Boston, MA
BS, Tufts University, Medford, MA



Research Keywords



Bone and soft tissue tumors; Sarcoma



Research Description





Clinical Research Description



Pathology and molecular diagnostics of bone and soft tissue tumors. Diagnostic and prognostic biomarkers.






DeGraff, DJ, Grabowska, MM, Case, TC, Yu, X, Herrick, MK, Hayward, WJ, Strand, DW, Cates, JM, Hayward, SW, Gao, N, Walter, MA, Buttyan, R, Yi, Y, Kaestner, KH, Matusik, RJ. FOXA1 deletion in luminal epithelium causes prostatic hyperplasia and alteration of differentiated phenotype. Lab Invest, 94(7), 726-39, 2014

Ohba, T, Cates, JM, Cole, HA, Slosky, DA, Haro, H, Ando, T, Schwartz, HS, Schoenecker, JG. Autocrine VEGF/VEGFR1 signaling in a subpopulation of cells associates with aggressive osteosarcoma. Mol Cancer Res, 12(8), 1100-11, 2014

Chamberlain, BK, McClain, CM, Gonzalez, RS, Coffin, CM, Cates, JM. Alveolar soft part sarcoma and granular cell tumor: an immunohistochemical comparison study. Hum Pathol, 45(5), 1039-44, 2014

Cole, HA, Ohba, T, Nyman, JS, Hirotaka, H, Cates, JM, Flick, MJ, Degen, JL, Schoenecker, JG. Fibrin accumulation secondary to loss of plasmin-mediated fibrinolysis drives inflammatory osteoporosis in mice. Arthritis Rheumatol, 66(8), 2222-33, 2014

Ohba, T, Cates, JM, Cole, HA, Slosky, DA, Haro, H, Ichikawa, J, Ando, T, Schwartz, HS, Schoenecker, JG. Pleiotropic effects of bisphosphonates on osteosarcoma. Bone, 63, 110-20, 2014

Ohba, T, Cole, HA, Cates, JM, Slosky, DA, Haro, H, Ando, T, Schwartz, HS, Schoenecker, JG. Bisphosphonates inhibit osteosarcoma-mediated osteolysis via attenuation of tumor expression of MCP-1 and RANKL. J Bone Miner Res, 29(6), 1431-45, 2014

Cole, HA, Ohba, T, Ichikawa, J, Nyman, JS, Cates, JM, Haro, H, Schwartz, HS, Schoenecker, JG. Micro-computed tomography derived anisotropy detects tumor provoked deviations in bone in an orthotopic osteosarcoma murine model. PLoS One, 9(6), e97381, 2014

Cates, JM, Troutman, KA. Quality Management of the Immunohistochemistry Laboratory: A Practical Guide. Appl Immunohistochem Mol Morphol, 2014

Cates, JM. Pregnancy does not increase the local recurrence rate after surgical resection of desmoid-type fibromatosis. Int J Clin Oncol, 2014

Yu, X, Cates, JM, Morrissey, C, You, C, Grabowska, MM, Zhang, J, DeGraff, DJ, Strand, DW, Franco, OE, Lin-Tsai, O, Hayward, SW, Matusik, RJ. SOX2 expression in the developing, adult, as well as, diseased prostate. Prostate Cancer Prostatic Dis, 2014

Cates, JM, Stricker, TP, Sturgeon, D, Coffin, CM. Desmoid-type fibromatosis-associated Gardner fibromas: prevalence and impact on local recurrence. Cancer Lett, 353(2), 176-81, 2014

Yuasa, M, Mignemi, NA, Barnett, JV, Cates, JM, Nyman, JS, Okawa, A, Yoshii, T, Schwartz, HS, Stutz, CM, Schoenecker, JG. The temporal and spatial development of vascularity in a healing displaced fracture. Bone, 67, 208-21, 2014

Ettinger, DS, Handorf, CR, Agulnik, M, Bowles, DW, Cates, JM, Cristea, M, Dotan, E, Eaton, KD, Fidias, PM, Gierada, D, Gilcrease, GW, Godby, K, Iyer, R, Lenzi, R, Phay, J, Rashid, A, Saltz, L, Schwab, RB, Shulman, LN, Smerage, JB, Stevenson, MM, Varadhachary, GR, Zager, JS, Zhen, WK, Bergman, MA, Freedman-Cass, DA. Occult primary, version 3.2014. J Natl Compr Canc Netw, 12(7), 969-74, 2014

Wang, XJ, Hartley, K, Holt, GE, Fadare, O, Cates, JM. Intracortical schwannoma of the femur. Skeletal Radiol, 43(5), 687-91, 2014

McClain, CM, Friedman, DB, Hajri, T, Coffin, CM, Cates, JM. Predicting dedifferentiation in liposarcoma: a proteomic approach. Virchows Arch, 463(1), 85-92, 2013

Strand, DW, DeGraff, DJ, Jiang, M, Sameni, M, Franco, OE, Love, HD, Hayward, WJ, Lin-Tsai, O, Wang, AY, Cates, JM, Sloane, BF, Matusik, RJ, Hayward, SW. Deficiency in metabolic regulators PPAR?? and PTEN cooperates to drive keratinizing squamous metaplasia in novel models of human tissue regeneration. Am J Pathol, 182(2), 449-59, 2013

Cole, HA, Yuasa, M, Hawley, G, Cates, JM, Nyman, JS, Schoenecker, JG. Differential development of the distal and proximal femoral epiphysis and physis in mice. Bone, 52(1), 337-46, 2013

Pruitt, FL, He, Y, Franco, OE, Jiang, M, Cates, JM, Hayward, SW. Cathepsin D acts as an essential mediator to promote malignancy of benign prostatic epithelium. Prostate, 73(5), 476-88, 2013

Weiss, VL, Antonescu, CR, Alaggio, R, Cates, JM, Gaskin, D, Stefanovici, C, Coffin, CM. Myxoinflammatory fibroblastic sarcoma in children and adolescents: clinicopathologic aspects of a rare neoplasm. Pediatr Dev Pathol, 16(6), 425-31, 2013

Xiang, Y, Qiu, Q, Jiang, M, Jin, R, Lehmann, BD, Strand, DW, Jovanovic, B, DeGraff, DJ, Zheng, Y, Yousif, DA, Simmons, CQ, Case, TC, Yi, J, Cates, JM, Virostko, J, He, X, Jin, X, Hayward, SW, Matusik, RJ, George, AL, Yi, Y. SPARCL1 suppresses metastasis in prostate cancer. Mol Oncol, 7(6), 1019-30, 2013

Cates, JM, Coffin, CM. Neurogenic tumors of soft tissue. Pediatr Dev Pathol, 15(1 Suppl), 62-107, 2012

DeGraff, DJ, Clark, PE, Cates, JM, Yamashita, H, Robinson, VL, Yu, X, Smolkin, ME, Chang, SS, Cookson, MS, Herrick, MK, Shariat, SF, Steinberg, GD, Frierson, HF, Wu, XR, Theodorescu, D, Matusik, RJ. Loss of the urothelial differentiation marker FOXA1 is associated with high grade, late stage bladder cancer and increased tumor proliferation. PLoS One, 7(5), e36669, 2012

Cates, JM, Coffin, CM. Extraskeletal cartilaginous, osseous, and chordoid tumors in children and adolescents. Pediatr Dev Pathol, 15(1 Suppl), 255-66, 2012

Gehrie, EA, Cates, JM, Nian, H, Olson, SJ, Young, PP. Blood Group A antigen expression on cardiac endothelium is highly individualized: possible implications for transplantation. Cardiovasc Pathol, 22(4), 251-6, 2012

Cates, JM, Black, JO, Itani, DM, Fasig, JH, Keedy, VL, Hande, KR, Whited, BW, Homlar, KC, Halpern, JL, Holt, GE, Schwartz, HS, Coffin, CM. Signal transduction pathway analysis in fibromatosis: receptor and nonreceptor tyrosine kinases. Hum Pathol, 43(10), 1711-8, 2012

Cates, JM, Black, J, Wolfe, CC, Shinohara, ET, Holt, GE, Keedy, VL, Hande, KR, Homlar, KC, Halpern, JL, Schwartz, HS, Troutman, A, Coffin, CM. Morphologic and immunophenotypic analysis of desmoid-type fibromatosis after radiation therapy. Hum Pathol, 43(9), 1418-24, 2012

Rosado, FG, Itani, DM, Coffin, CM, Cates, JM. Utility of immunohistochemical staining with FLI1, D2-40, CD31, and CD34 in the diagnosis of acquired immunodeficiency syndrome-related and non-acquired immunodeficiency syndrome-related Kaposi sarcoma. Arch Pathol Lab Med, 136(3), 301-4, 2012

Kallen, ME, Sanders, ME, Gonzalez, AL, Black, JO, Keedy, VL, Hande, KR, Homlar, KC, Halpern, JL, Holt, GE, Schwartz, HS, Coffin, CM, Cates, JM. Nuclear p63 expression in osteoblastic tumors. Tumour Biol, 33(5), 1639-44, 2012

Mignemi, NA, Itani, DM, Fasig, JH, Keedy, VL, Hande, KR, Whited, BW, Homlar, KC, Correa, H, Coffin, CM, Black, JO, Yi, Y, Halpern, JL, Holt, GE, Schwartz, HS, Schoenecker, JG, Cates, JM. Signal transduction pathway analysis in desmoid-type fibromatosis: transforming growth factor-??, COX2 and sex steroid receptors. Cancer Sci, 103(12), 2173-80, 2012

Kallen, ME, Nunes Rosado, FG, Gonzalez, AL, Sanders, ME, Cates, JM. Occasional staining for p63 in malignant vascular tumors: a potential diagnostic pitfall. Pathol Oncol Res, 18(1), 97-100, 2012

Ichikawa, J, Cole, HA, Magnussen, RA, Mignemi, NA, Butler, M, Holt, GE, O''Rear, L, Yuasa, M, Pabla, B, Haro, H, Cates, JM, Hamm, HE, Schwartz, HS, Schoenecker, JG. Thrombin induces osteosarcoma growth, a function inhibited by low molecular weight heparin in vitro and in vivo: procoagulant nature of osteosarcoma. Cancer, 118(9), 2494-506, 2012

Polosukhin, VV, Cates, JM, Lawson, WE, Milstone, AP, Matafonov, AG, Massion, PP, Lee, JW, Randell, SH, Blackwell, TS. Hypoxia-inducible factor-1 signalling promotes goblet cell hyperplasia in airway epithelium. J Pathol, 224(2), 203-11, 2011

Polosukhin, VV, Cates, JM, Lawson, WE, Zaynagetdinov, R, Milstone, AP, Massion, PP, Ocak, S, Ware, LB, Lee, JW, Bowler, RP, Kononov, AV, Randell, SH, Blackwell, TS. Bronchial secretory immunoglobulin a deficiency correlates with airway inflammation and progression of chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 184(3), 317-27, 2011

Degraff, DJ, Cates, JM, Mauney, JR, Clark, PE, Matusik, RJ, Adam, RM. When urothelial differentiation pathways go wrong: Implications for bladder cancer development and progression. Urol Oncol, 2011

Cates, JM, Friedman, DB, Seeley, EH, Dupont, WD, Schwartz, HS, Holt, GE, Caprioli, RM, Young, PP. Proteomic analysis of osteogenic sarcoma: association of tumour necrosis factor with poor prognosis. Int J Exp Pathol, 2010

Tatsas, AD, Keedy, VL, Florell, SR, Simpson, JF, Coffin, CM, Kelley, MC, Cates, JM. Foamy cell angiosarcoma: a rare and deceptively bland variant of cutaneous angiosarcoma. J Cutan Pathol, 2010

Sommer, J, Itani, DM, Homlar, KC, Keedy, VL, Halpern, JL, Holt, GE, Schwartz, HS, Coffin, CM, Kelley, MJ, Cates, JM. Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma. J Pathol, 220(5), 608-17, 2010

Herceg, ME, Tsiatis, AC, Halpern, JL, Holt, GE, Schwartz, HS, Keedy, VL, Cates, JM. Cyclooxygenase 2 expression in soft tissue leiomyosarcoma. Anticancer Res, 29(8), 2913-7, 2009

Tsiatis, AC, Herceg, ME, Keedy, VL, Halpern, JL, Holt, GE, Schwartz, HS, Cates, JM. Prognostic significance of c-Myc expression in soft tissue leiomyosarcoma. Mod Pathol, 22(11), 1432-8, 2009

Adelani, MA, Schultenover, SJ, Holt, GE, Cates, JM. Primary leiomyosarcoma of extragnathic bone: clinicopathologic features and reevaluation of prognosis. Arch Pathol Lab Med, 133(9), 1448-56, 2009

Cates, JM, Byrd, RH, Fohn, LE, Tatsas, AD, Washington, MK, Black, CC. Epithelial-mesenchymal transition markers in pancreatic ductal adenocarcinoma. Pancreas, 38(1), e1-6, 2009

Li, B, Vincent, A, Cates, J, Brantley-Sieders, DM, Polk, DB, Young, PP. Low levels of tumor necrosis factor alpha increase tumor growth by inducing an endothelial phenotype of monocytes recruited to the tumor site. Cancer Res, 69(1), 338-48, 2009

Fasig, JH, Dupont, WD, LaFleur, BJ, Olson, SJ, Cates, JM. Immunohistochemical analysis of receptor tyrosine kinase signal transduction activity in chordoma. Neuropathol Appl Neurobiol, 34(1), 95-104, 2008

Cates, JM, Dupont, WD, Barnes, JW, Edmunds, HS, Fasig, JH, Olson, SJ, Black, CC. Markers of epithelial-mesenchymal transition and epithelial differentiation in sarcomatoid carcinoma: utility in the differential diagnosis with sarcoma. Appl Immunohistochem Mol Morphol, 16(3), 251-62, 2008

Noordzij, JP, Cates, JM, Cohen, SM, Bennett, ML, Ries, WM, Russell, PT, Haynes, D, Garrett, CG, Ossoff, RH. Preparation techniques for the injection of human autologous cartilage: an ex vivo feasibility study. Laryngoscope, 118(1), 185-8, 2008

Alfaro, MP, Pagni, M, Vincent, A, Atkinson, J, Hill, MF, Cates, J, Davidson, JM, Rottman, J, Lee, E, Young, PP. The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair. Proc Natl Acad Sci U S A, 105(47), 18366-71, 2008

Brantley-Sieders, DM, Zhuang, G, Hicks, D, Fang, WB, Hwang, Y, Cates, JM, Coffman, K, Jackson, D, Bruckheimer, E, Muraoka-Cook, RS, Chen, J. The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling. J Clin Invest, 118(1), 64-78, 2008

Hoene, KA, Kaufman, MR, Cates, JM, Chang, SS. Inflammatory myofibroblastic tumor of the urinary bladder in a 27-year-old woman with systemic lupus erythematosus. Int J Urol, 15(2), 182-4, 2008

Tsiatis, AC, Atkinson, JB, Wright, JK, Cates, JM. Primary hepatic myxoid leiomyosarcoma: a case report and review of the literature. Ultrastruct Pathol, 32(1), 25-8, 2008

Fasig, JH, Dupont, WD, Olson, SJ, Lafleur, BJ, Cates, JM. Steroid hormone receptor and COX-2 expression in chordoma. Am J Clin Pathol, 128(3), 375-81, 2007

Cates, JM, Coffing, BN, Harris, BT, Black, CC. Calretinin expression in tumors of adipose tissue. Hum Pathol, 37(3), 312-21, 2006

Pitchford, CW, Schwartz, HS, Atkinson, JB, Cates, JM. Soft tissue perineurioma in a patient with neurofibromatosis type 2: a tumor not previously associated with the NF2 syndrome. Am J Surg Pathol, 30(12), 1624-9, 2006

Cates, JM, Williams, TL, Suriawinata, AA. Intraductal papillary mucinous adenoma that arises from pancreatic heterotopia within a meckel diverticulum. Arch Pathol Lab Med, 129(3), e67-9, 2005

Gutmann, EJ, Cates, JM. Initial diagnosis of breast cancer via cytological examination of a pleural effusion: a rare event facilitated by recognition of an unusual morphological pattern. Diagn Cytopathol, 32(3), 177-81, 2005

Pipas, JM, Barth, RJ, Zaki, B, Tsapakos, MJ, Suriawinata, AA, Bettmann, MA, Cates, JM, Ripple, GH, Sutton, JE, Gordon, SR, McDonnell, CE, Perez, RP, Redfield, N, Meyer, LP, Marshall, JF, Cole, BF, Colacchio, TA. Docetaxel/Gemcitabine followed by gemcitabine and external beam radiotherapy in patients with pancreatic adenocarcinoma. Ann Surg Oncol, 12(12), 995-1004, 2005

Lin, JT, Kitzmiller, TJ, Cates, JM, Gorham, JD. MHC-independent genetic regulation of liver damage in a mouse model of autoimmune hepatocellular injury. Lab Invest, 85(4), 550-61, 2005

Gardner, TB, Manning, HL, Beelen, AP, Cimis, RJ, Cates, JM, Lewis, LD. Ethylene glycol toxicity associated with ischemia, perforation, and colonic oxalate crystal deposition. J Clin Gastroenterol, 38(5), 435-9, 2004

Rudner, LA, Lin, JT, Park, IK, Cates, JM, Dyer, DA, Franz, DM, French, MA, Duncan, EM, White, HD, Gorham, JD. Necroinflammatory liver disease in BALB/c background, TGF-beta 1-deficient mice requires CD4+ T cells. J Immunol, 170(9), 4785-92, 2003

Tang, P, Hornicek, FJ, Gebhardt, MC, Cates, J, Mankin, HJ. Surgical treatment of hemangiomas of soft tissue. Clin Orthop Relat Res(399), 205-10, 2002

Sami, S, Liu, G, Hornicek, F, Cates, JM, Mankin, HJ. Membranous lipodystrophy. A case report. J Bone Joint Surg Am, 84-A(4), 630-3, 2002

Hau, MA, Fox, EJ, Cates, JM, Brigman, BE, Mankin, HJ. Jaffe-Campanacci syndrome. A case report and review of the literature. J Bone Joint Surg Am, 84-A(4), 634-8, 2002

Ramnath, RR, Rosenthal, DI, Cates, J, Gebhardt, M, Quinn, RH. Intracortical chondroma simulating osteoid osteoma treated by radiofrequency. Skeletal Radiol, 31(10), 597-602, 2002

Erickson, JK, Rosenthal, DI, Zaleske, DJ, Gebhardt, MC, Cates, JM. Primary treatment of chondroblastoma with percutaneous radio-frequency heat ablation: report of three cases. Radiology, 221(2), 463-8, 2001

Cates, JM, Rosenberg, AE, O''Connell, JX, Nielsen, GP. Chondroblastoma-like chondroma of soft tissue: an underrecognized variant and its differential diagnosis. Am J Surg Pathol, 25(5), 661-6, 2001

Cates, JM, Damassa, DA. Characterization and developmental expression patterns of testicular androgen-binding protein in the Djungarian hamster (Phodopus sungorus). J Reprod Fertil, 111(2), 291-8, 1997

Damassa, DA, Cates, JM. Sex hormone-binding globulin and male sexual development. Neurosci Biobehav Rev, 19(2), 165-75, 1995

Cates, JM, Damassa, DA, Gagin, GA, Dempsey, RV. Hepatic expression of sex hormone-binding globulin associated with the postnatal surge of serum androgen-binding activity in the Djungarian hamster. J Steroid Biochem Mol Biol, 55(2), 147-58, 1995

Yu, M, Cates, J, Leav, I, Ho, SM. Heterogeneity of [3H]estradiol binding sites in the rat prostate: properties and distribution of type I and type II sites. J Steroid Biochem, 33(3), 449-57, 1989