Department of Pathology, Microbiology, and Immunology



  Agnes B. Fogo, M.D.fogo



John L. Shapiro Chair of Pathology

Dept. of Pathology, Microbiology and Immunology

Dept. of Medicine and Pediatrics

  Director of Renal/EM Division of Pathology

  Director, Renal Pathology Fellowship Program


  Contact Information

  Office Location:

C-3310 MCN

Phone: 615-322-3114 

E-mail: agnes.fogo@vanderbilt.edu 


Campus Mail address: 

Pathology, Microbiology and Immunology-3rd Fl

C-3321, MCN (2561)


US Mailing address:

Dept. of Pathology, Microbiology and Immunology-3rd Fl

Vanderbilt University School of Medicine 

C-3321 MCN

Nashville, TN 37232-2561







M.D., Vanderbilt University School of Medicine, Nashville, TN
B.A., University of Tennessee at Chattanooga



Research Keywords



progression of kidney disease angiotensin PAI-1 regression of sclerosis



Research Description



Research efforts primarily concern renal pathology and involve: 1) basic research in mechanisms and pathophysiology of progression of chronic renal disease; including regression/remodeling of sclerosis; 2) basic research in mechanisms and pathophysiology of the renin angiotensin system; and 3) applied renal pathology with emphasis on prognostic features in minimal change disease/focal glomerulosclerosis.

Chronic rat animal models and knock-out mice are used to investigate the interactions of fibrotic and thrombotic mechanisms. Our work focuses on contributions of the renin angiotensin system to structural damage, and its interactions with other growth factors, and with mechanisms of thrombosis (i.e. plasmin/plasminogen activator system). Approaches include classical pathology, molecular biology and functional assessments. .



Clinical Research Description



Human kidney biopsies are studied using immunohistochemistry, in situ hybridization and morphologic and clinical correlations to gain insights into mechanisms of disease.






Wallace, E, Fogo, AB, Schulman, G. Imatinib Therapy for Non-Infection-Related Type II Cryoglobulinemia With Membranoproliferative Glomerulonephritis. Am J Kidney Dis, 59(1), 122-5, 2012

Fogo, AB. The targeted podocyte. J Clin Invest, 121(6), 2142-5, 2011

Zuo, Y, Yang, HC, Potthoff, SA, Najafian, B, Kon, V, Ma, LJ, Fogo, AB. Protective effects of PPAR{gamma} agonist in acute nephrotic syndrome. Nephrol Dial Transplant, 2011

Yamamoto, S, Yancey, PG, Zuo, Y, Ma, LJ, Kaseda, R, Fogo, AB, Ichikawa, I, Linton, MF, Fazio, S, Kon, V. Macrophage Polarization by Angiotensin II-Type 1 Receptor Aggravates Renal Injury-Acceleration of Atherosclerosis. Arterioscler Thromb Vasc Biol, 31(12), 2856-64, 2011

Ma, J, Matsusaka, T, Yang, HC, Zhong, J, Takagi, N, Fogo, AB, Kon, V, Ichikawa, I. Induction of podocyte-derived VEGF ameliorates podocyte injury and subsequent abnormal glomerular development caused by puromycin aminonucleoside. Pediatr Res, 70(1), 83-9, 2011

Scruggs, BS, Zuo, Y, Donnert, E, Ma, L, Bertram, JF, Fogo, AB. Increased capillary branching contributes to angiotensin type 1 receptor blocker (ARB)-induced regression of sclerosis. Am J Pathol, 178(4), 1891-8, 2011

Ma, LJ, Corsa, BA, Zhou, J, Yang, H, Li, H, Tang, YW, Babaev, VR, Major, AS, Linton, MF, Fazio, S, Hunley, TE, Kon, V, Fogo, AB. Angiotensin type 1 receptor modulates macrophage polarization and renal injury in obesity. Am J Physiol Renal Physiol, 300(5), F1203-13, 2011

Yamamoto, S, Zuo, Y, Ma, J, Yancey, PG, Hunley, TE, Motojima, M, Fogo, AB, Linton, MF, Fazio, S, Ichikawa, I, Kon, V. Oral activated charcoal adsorbent (AST-120) ameliorates extent and instability of atherosclerosis accelerated by kidney disease in apolipoprotein E-deficient mice. Nephrol Dial Transplant, 26(8), 2491-7, 2011

Basford, AW, Lewis, J, Dwyer, JP, Fogo, AB. Membranous nephropathy with crescents. J Am Soc Nephrol, 22(10), 1804-8, 2011

Fogo, AB. PPARI? and chronic kidney disease. Pediatr Nephrol, 26(3), 347-51, 2011

Yang, HC, Rossini, M, Ma, LJ, Zuo, Y, Ma, J, Fogo, AB. Cells derived from young bone marrow alleviate renal aging. J Am Soc Nephrol, 22(11), 2028-36, 2011

Yang, HC, Zuo, Y, Fogo, AB. Models of chronic kidney disease. Drug Discov Today Dis Models, 7(1-2), 13-19, 2010

Yang, H, Fogo, AB. Cell senescence in the aging kidney. J Am Soc Nephrol, 21(9), 1436-9, 2010

Naito, T, Ma, LJ, Yang, H, Zuo, Y, Tang, Y, Han, JY, Kon, V, Fogo, AB. Angiotensin type 2 receptor actions contribute to angiotensin type 1 receptor blocker effects on kidney fibrosis. Am J Physiol Renal Physiol, 298(3), F683-91, 2010

Rossini, M, Naito, T, Yang, H, Freeman, M, Donnert, E, Ma, LJ, Dunn, SR, Sharma, K, Fogo, AB. Sulodexide ameliorates early but not late kidney disease in models of radiation nephropathy and diabetic nephropathy. Nephrol Dial Transplant, 25(6), 1803-10, 2010

Matsusaka, T, Asano, T, Niimura, F, Kinomura, M, Shimizu, A, Shintani, A, Pastan, I, Fogo, AB, Ichikawa, I. Angiotensin receptor blocker protection against podocyte-induced sclerosis is podocyte angiotensin II type 1 receptor-independent. Hypertension, 55(4), 967-73, 2010

Pedchenko, V, Bondar, O, Fogo, AB, Vanacore, R, Voziyan, P, Kitching, AR, Wieslander, J, Kashtan, C, Borza, DB, Neilson, EG, Wilson, CB, Hudson, BG. Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis. N Engl J Med, 363(4), 343-54, 2010

Fogo, AB, Kon, V. The glomerulus--a view from the inside--the endothelial cell. Int J Biochem Cell Biol, 42(9), 1388-97, 2010

He, W, Wang, Y, Zhang, MZ, You, L, Davis, LS, Fan, H, Yang, HC, Fogo, AB, Zent, R, Harris, RC, Breyer, MD, Hao, CM. Sirt1 activation protects the mouse renal medulla from oxidative injury. J Clin Invest, 120(4), 1056-68, 2010

Fogo, AB, Bostad, L, Svarstad, E, Cook, WJ, Moll, S, Barbey, F, Geldenhuys, L, West, M, Ferluga, D, Vujkovac, B, Howie, AJ, Burns, A, Reeve, R, Waldek, S, No?

Breyer, MD, Tchekneva, E, Qi, Z, Takahashi, T, Fogo, AB, Zhao, HJ, Harris, RC. Genetics of diabetic nephropathy: lessons from mice. Semin Nephrol, 27(2), 237-47, 2007

Kanjanabuch, T, Ma, LJ, Chen, J, Pozzi, A, Guan, Y, Mundel, P, Fogo, AB. PPAR-gamma agonist protects podocytes from injury. Kidney Int, 2007

Dwyer, JP, Yates, KM, Sumner, EL, Stone, WJ, Wang, Y, Koury, MJ, Fogo, AB, Zent, R. Chronic myeloid leukemia-associated membranoproliferative glomerulonephritis that responded to imatinib mesylate therapy. Clin Nephrol, 67(3), 176-81, 2007

Tchekneva, EE, Rinchik, EM, Polosukhina, D, Davis, LS, Kadkina, V, Mohamed, Y, Dunn, SR, Sharma, K, Qi, Z, Fogo, AB, Breyer, MD. A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy. J Am Soc Nephrol, 18(1), 103-12, 2007

Suganuma, E, Zuo, Y, Ayabe, N, Ma, J, Babaev, VR, Linton, MF, Fazio, S, Ichikawa, I, Fogo, AB, Kon, V. Antiatherogenic effects of angiotensin receptor antagonism in mild renal dysfunction. J Am Soc Nephrol, 17(2), 433-41, 2006

Liang, X, Kanjanabuch, T, Mao, SL, Hao, CM, Tang, YW, Declerck, PJ, Hasty, AH, Wasserman, DH, Fogo, AB, Ma, LJ. Plasminogen activator inhibitor-1 modulates adipocyte differentiation. Am J Physiol Endocrinol Metab, 290(1), E103-E113, 2006

Ayabe, N, Babaev, VR, Tang, Y, Tanizawa, T, Fogo, AB, Linton, MF, Ichikawa, I, Fazio, S, Kon, V. Transiently heightened angiotensin II has distinct effects on atherosclerosis and aneurysm formation in hyperlipidemic mice. Atherosclerosis, 184(2), 312-21, 2006

Zhao, HJ, Wang, S, Cheng, H, Zhang, MZ, Takahashi, T, Fogo, AB, Breyer, MD, Harris, RC. Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice. J Am Soc Nephrol, 17(10), 2664-9, 2006

Fogo, AB. Can glomerulosclerosis be reversed. Nat Clin Pract Nephrol, 2(6), 290-1, 2006

Fogo, AB. The clot thickens. Kidney Int, 70(4), 620-1, 2006

Schaefer, HM, Helderman, JH, Fogo, AB. Slow decline in allograft function in a renal transplant patient. Am J Kidney Dis, 48(2), 335-8, 2006

Liang, XB, Ma, LJ, Naito, T, Wang, Y, Madaio, M, Zent, R, Pozzi, A, Fogo, AB. Angiotensin type 1 receptor blocker restores podocyte potential to promote glomerular endothelial cell growth. J Am Soc Nephrol, 17(7), 1886-95, 2006

Yang, HC, Ma, LJ, Ma, J, Fogo, AB. Peroxisome proliferator-activated receptor-gamma agonist is protective in podocyte injury-associated sclerosis. Kidney Int, 69(10), 1756-64, 2006

Ma, J, Weisberg, A, Griffin, JP, Vaughan, DE, Fogo, AB, Brown, NJ. Plasminogen activator inhibitor-1 deficiency protects against aldosterone-induced glomerular injury. Kidney Int, 69(6), 1064-72, 2006

Zuo, Y, Matsusaka, T, Zhong, J, Ma, J, Ma, LJ, Hanna, Z, Jolicoeur, P, Fogo, AB, Ichikawa, I. HIV-1 genes vpr and nef synergistically damage podocytes, leading to glomerulosclerosis. J Am Soc Nephrol, 17(10), 2832-43, 2006

Wang, XP, Fogo, AB, Colon, S, Giannico, G, Abul-Ezz, SR, Miner, JH, Borza, DB. Distinct epitopes for anti-glomerular basement membrane alport alloantibodies and goodpasture autoantibodies within the noncollagenous domain of alpha3(IV) collagen: a janus-faced antigen. J Am Soc Nephrol, 16(12), 3563-71, 2005

Revelo, MP, Federspiel, C, Helderman, H, Fogo, AB. Chronic allograft nephropathy: expression and localization of PAI-1 and PPAR-gamma. Nephrol Dial Transplant, 20(12), 2812-9, 2005

Aldigier, JC, Kanjanbuch, T, Ma, LJ, Brown, NJ, Fogo, AB. Regression of existing glomerulosclerosis by inhibition of aldosterone. J Am Soc Nephrol, 16(11), 3306-14, 2005

G??kden, N, Rossini, M, Kumar, J, Fogo, AB. Membranoproliferative injury pattern in a renal allograft. Am J Kidney Dis, 46(3), 573-6, 2005

Zhong, J, Zuo, Y, Ma, J, Fogo, AB, Jolicoeur, P, Ichikawa, I, Matsusaka, T. Expression of HIV-1 genes in podocytes alone can lead to the full spectrum of HIV-1-associated nephropathy. Kidney Int, 68(3), 1048-60, 2005

Qi, Z, Fujita, H, Jin, J, Davis, LS, Wang, Y, Fogo, AB, Breyer, MD. Characterization of susceptibility of inbred mouse strains to diabetic nephropathy. Diabetes, 54(9), 2628-37, 2005

Xu, BJ, Shyr, Y, Liang, X, Ma, LJ, Donnert, EM, Roberts, JD, Zhang, X, Kon, V, Brown, NJ, Caprioli, RM, Fogo, AB. Proteomic patterns and prediction of glomerulosclerosis and its mechanisms. J Am Soc Nephrol, 16(10), 2967-75, 2005

Fogo, AB. New capillary growth: a contributor to regression of sclerosis. Curr Opin Nephrol Hypertens, 14(3), 201-3, 2005

Matsusaka, T, Xin, J, Niwa, S, Kobayashi, K, Akatsuka, A, Hashizume, H, Wang, QC, Pastan, I, Fogo, AB, Ichikawa, I. Genetic engineering of glomerular sclerosis in the mouse via control of onset and severity of podocyte-specific injury. J Am Soc Nephrol, 16(4), 1013-23, 2005

Basi, S, Schulman, G, Fogo, AB. Multiple complications in multiple myeloma. Am J Kidney Dis, 45(3), 619-23, 2005

Ma, LJ, Nakamura, S, Aldigier, JC, Rossini, M, Yang, H, Liang, X, Nakamura, I, Marcantoni, C, Fogo, AB. Regression of glomerulosclerosis with high-dose angiotensin inhibition is linked to decreased plasminogen activator inhibitor-1. J Am Soc Nephrol, 16(4), 966-76, 2005

Weisberg, AD, Albornoz, F, Griffin, JP, Crandall, DL, Elokdah, H, Fogo, AB, Vaughan, DE, Brown, NJ. Pharmacological inhibition and genetic deficiency of plasminogen activator inhibitor-1 attenuates angiotensin II/salt-induced aortic remodeling. Arterioscler Thromb Vasc Biol, 25(2), 365-71, 2005

Rossini, M, Cheunsuchon, B, Donnert, E, Ma, LJ, Thomas, JW, Neilson, EG, Fogo, AB. Immunolocalization of fibroblast growth factor-1 (FGF-1), its receptor (FGFR-1), and fibroblast-specific protein-1 (FSP-1) in inflammatory renal disease. Kidney Int, 68(6), 2621-8, 2005

Rossini, M, Coventry, S, Duff, DR, Fogo, AB. Chronic renal failure and abnormal tubular cells in 2 siblings. Am J Kidney Dis, 46(5), 982-7, 2005

Hunley, TE, Corzo, D, Dudek, M, Kishnani, P, Amalfitano, A, Chen, YT, Richards, SM, Phillips, JA, Fogo, AB, Tiller, GE. Nephrotic syndrome complicating alpha-glucosidase replacement therapy for Pompe disease. Pediatrics, 114(4), e532-5, 2004

Wang, Y, Fogo, AB. Quiz page. Anti-GBM antibody-mediated glomerulonephritis with superimposed ANCA-associated vasculitis. Am J Kidney Dis, 44(3), A45, e31-2, 2004

Chen, X, Moeckel, G, Morrow, JD, Cosgrove, D, Harris, RC, Fogo, AB, Zent, R, Pozzi, A. Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury. Am J Pathol, 165(2), 617-30, 2004

Fogo, AB, Rossini, M, Lazin, A. Quiz page. Light chain cast nephropathy. Am J Kidney Dis, 44(1), A45, e1-2, 2004

Ma, Li-Jun, Mao, Su-Li, Taylor, Kevin L, Kanjanabuch, Talerngsak, Guan, YouFei, Zhang, YaHua, Brown, Nancy J, Swift, Larry L, McGuinness, Owen P, Wasserman, David H, Vaughan, Douglas E, Fogo, Agnes B. Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1. Diabetes, 53(2), 336-46, 2004

Milstone, A, Vilchez, RA, Geiger, X, Fogo, AB, Butel, JS, Dummer, S. Polyomavirus simian virus 40 infection associated with nephropathy in a lung-transplant recipient. Transplantation, 77(7), 1019-24, 2004

Wang, Y, Rossini, M, Fogo, AB. Quiz page. HIV-associated nephropathy is the overwhelmingly most likely diagnosis. Am J Kidney Dis, 43(4), A47, e1, 2004

Ma, Li-Jun, Jha, Sharda, Ling, Hong, Pozzi, Ambra, Ledbetter, Steve, Fogo, Agnes B. Divergent effects of low versus high dose anti-TGF-beta antibody in puromycin aminonucleoside nephropathy in rats. Kidney Int, 65(1), 106-15, 2004

Qi, Zhonghua, Whitt, Irene, Mehta, Amit, Jin, Jianping, Zhao, Min, Harris, Raymond C, Fogo, Agnes B, Breyer, Matthew D. Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance. Am J Physiol Renal Physiol, 286(3), F590-6, 2004

Good, KS, O''Brien, K, Schulman, G, Kerjaschki, D, Fogo, AB. Unexplained nephrotic-range proteinuria in a 38-year-old man: a case of "no change disease". Am J Kidney Dis, 43(5), 933-8, 2004

Fogo, Agnes B, . Renal fibrosis: not just PAI-1 in the sky.. J Clin Invest, 112, 326-8, 2003

Fogo, Agnes B, . Editorial Review: The potential for regression of renal scarring.. Curr Opin Nephrol Hypertens, 12, 223-5, 2003

Chang, Ingrid J, Cheunsuchon, Boonyarit, Miller, Frank J, Fogo, Agnes B. A 66-year-old woman with progressive renal insufficiency, nephrotic syndrome, and monoclonal protein. Am J Kidney Dis, 41(2), 508-17, 2003

Fogo, Agnes B, Rossini, Michele. Monoclonal immunoglobin deposition disease, heavy chain deposition type. Am J Kidney Dis, 42(6), A48, E1-2, 2003

Moeckel, Gilbert W, Zhang, Li, Fogo, Agnes B, Hao, Chuan-Ming, Pozzi, Ambra, Breyer, Matthew D. COX2 activity promotes organic osmolyte accumulation and adaptation of renal medullary interstitial cells to hypertonic stress. J Biol Chem, 278(21), 19352-7, 2003

Fogo, Agnes B. Quiz page. Proliferative glomerulonephritis. Am J Kidney Dis, 41(3), xlvii, 2003

Fogo, Agnes B. Quiz page. Acute interstitial nephritis and minimal change disease lesion, caused by NSAID injury. Am J Kidney Dis, 42(2), A41, E1, 2003

Fogo, Agnes B, . Hypertensive risk factors in kidney disease in African Americans.. Kidney Int Suppl, S17-21, 2003

Ma, Li-Jun, Fogo, Agnes B, . Model of robust induction of glomerulosclerosis in mice: importance of genetic background.. Kidney Int, 64, 350-5, 2003

Fogo, Agnes B. Quiz page. Diabetic nephropathy with superimposed acute interstitial nephritis. Am J Kidney Dis, 41(6), A47, E1-3, 2003

Fogo, Agnes B, . Animal models of FSGS: Lessons for pathogenesis and treatment.. Semin Nephrol, 23, 161-71, 2003

Paueksakon, Paisit, Revelo, Monica P, Horn, Robert G, Shappell, Scott, Fogo, Agnes B, . Monoclonal gammopathy: Significance and possible causality in renal disease.. Am J Kidney Dis, 42, 87-95, 2003

Fogo, Agnes B. Approach to renal biopsy. Am J Kidney Dis, 42(4), 826-36, 2003

Ma, Li-Jun, Yang, Haichun, Gaspert, Ariana, Carlesso, Gianluca, Barty, Melissa M, Davidson, Jeffrey M, Sheppard, Dean, Fogo, Agnes B. Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice. Am J Pathol, 163(4), 1261-73, 2003

Nishida M, Fujinaka H, Matsusaka T, Price J, Kon V, Fogo AB, Davidson JM, Linton MF, Fazio S, Homma T, Yoshida H, Ichikawa I. . IAbsence of angiotensin II type 1 receptor in bone marrow-derived cells is detrimental in the evolution of renal fibrosis. . J Clin Invest , 110, 1859-1868, 2002

Kaikita, Koichi, Schoenhard, John A, Painter, Corrie A, Ripley, Robert T, Brown, Nancy J, Fogo, Agnes B, Vaughan, Douglas E. Potential roles of plasminogen activator system in coronary vascular remodeling induced by long-term nitric oxide synthase inhibition. J Mol Cell Cardiol, 34(6), 617-27, 2002

Moeckel, Gilbert W, Jabs, Kathy, Fogo, Agnes B. An 11-year-old African-American girl with systemic lupus erythematosus and ANCA-negative renal vasculitis. Am J Kidney Dis, 39(2), 433-8, 2002

Fogo, A B. Mechanisms in nephrosclerosis and hypertension-beyond hemodynamics. J Nephrol, 14 Suppl 4, S63-9, 2002

Nishida, Masashi, Fujinaka, Hidehiko, Matsusaka, Taiji, Price, James, Kon, Valentina, Fogo, Agnes B, Davidson, Jeffrey M, Linton, MacRae F, Fazio, Sergio, Homma, Toshio, Yoshida, Hiroaki, Ichikawa, Iekuni. Absence of angiotensin II type 1 receptor in bone marrow-derived cells is detrimental in the evolution of renal fibrosis. J Clin Invest, 110(12), 1859-68, 2002

Fogo, Agnes B. Quiz page. Mesangial lupus nephritis, WHO IIb, and severe acute tubular necrosis, secondary to gentamycin toxicity. Am J Kidney Dis, 40(5), xlix, 2002

Brown, Nancy J, Vaughan, Douglas E, Fogo, Agnes B. The renin-angiotensin-aldosterone system and fibrinolysis in progressive renal disease. Semin Nephrol, 22(5), 399-406, 2002

Fogo, Agnes B. Quiz page. Transplant glomerulopathy. Am J Kidney Dis, 40(3), xli, 2002

Fogo, Agnes B. Quiz page. Diabetic nephropathy and extensive, superimposed, intratubular, calcium oxalate crystals, due to enteric hyperoxaluria. Am J Kidney Dis, 40(2), xl, 2002

Fogo, Agnes B. Quiz page. Light chain cast nephropathy with light chain deposition disease. Am J Kidney Dis, 39(6), xlii, 2002

Fogo, Agnes B. Quiz page. Fibrillary glomerulonephritis. Am J Kidney Dis, 39(5), liii, 2002

Paueksakon, Paisit, Revelo, Monica P, Ma, Li-Jun, Marcantoni, Carmelita, Fogo, Agnes B. Microangiopathic injury and augmented PAI-1 in human diabetic nephropathy. Kidney Int, 61(6), 2142-8, 2002

Fogo, Agnes B. Quiz page. AA amyloidosis. Am J Kidney Dis, 39(3), 444, 2002

Fogo, Agnes B. Quiz page. IgA nephropathy. Am J Kidney Dis, 39(2), xlviii, 2002

Brown, Nancy J, Vaughan, Douglas E, Fogo, Agnes B. Aldosterone and PAI-1: implications for renal injury. J Nephrol, 15(3), 230-5, 2002

Paueksakon P, Revelo MP, Ma L-j, Marcantoni C, Fogo AB.. Microangiopathic injury and augmented PAI-1 in human diabetic nephropathy. . Kidney Int , 61, 2142-2148, 2002

Fogo A. Progression and potential regression of glomerulosclerosis. Nephrology Forum. Kidney Int, 59, 804-819, 2001

Fogo, A B. Renal fibrosis and the renin-angiotensin system. Adv Nephrol Necker Hosp, 31, 69-87, 2001

Fogo, A B. Minimal change disease and focal segmental glomerulosclerosis. Nephrol Dial Transplant, 16 Suppl 6, 74-6, 2001

Ma, L, Fogo, A B. Role of angiotensin II in glomerular injury. Semin Nephrol, 21(6), 544-53, 2001

Fogo, A B. Progression and potential regression of glomerulosclerosis. Kidney Int, 59(2), 804-19, 2001

Ma, L J, Fogo, A B. Angiotensin as inducer of plasminogen activator inhibitor-1 and fibrosis. Contrib Nephrol(135), 161-70, 2001

Kaikita, K, Fogo, A B, Ma, L, Schoenhard, J A, Brown, N J, Vaughan, D E. Plasminogen activator inhibitor-1 deficiency prevents hypertension and vascular fibrosis in response to long-term nitric oxide synthase inhibition. Circulation, 104(7), 839-44, 2001

Ma, L J, Marcantoni, C, Linton, M F, Fazio, S, Fogo, A B. Peroxisome proliferator-activated receptor-gamma agonist troglitazone protects against nondiabetic glomerulosclerosis in rats. Kidney Int, 59(5), 1899-910, 2001

Revelo, M P, Staffeld, C, Copley, J B, Fogo, A B. A 26-year-old man with kidney allograft failure and foot pain. Am J Kidney Dis, 37(4), 871-5, 2001

Langone, A J, Revelo, M P, Schulman, G, Fogo, A B. A young man with 20 years of nephrotic range proteinuria without loss of renal function. Am J Kidney Dis, 38(6), 1329-33, 2001

Brown NJ, Nakamura S, Ma L-J, Nakamura I, Donnert E, Freeman M, Vaughan DE, Fogo AB. Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo. Kidney Int , 58, 1219-1227, 2000

Fogo, A B. The role of angiotensin II and plasminogen activator inhibitor-1 in progressive glomerulosclerosis. Am J Kidney Dis, 35(2), 179-88, 2000

Fogo AB. The role of angiotensin II and plasminogen activator inhibitor- 1 in progressive glomerulosclerosis. Am J Kidney Dis , 35, 179-188, 2000

Miyazaki Y, Oshima K, Fogo A, Hogan BL, Ichikawa I. Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse urete. J Clin Invest, 105, 863-873, 2000

Matsusaka T, Kon V, Takaya J, Katori H, Chen Xm, Miyazaki Ji, Homma T, Fogo A, Ichikawa I. : Dual renin gene targeting by Cre-mediated interchromosomal recombination. Genomics, 64, 127-131, 2000

Nakamura S, Nakamura I, Ma LJ, Vaughan DE, Fogo AB. Plasminogen activator inhibitor-1 expression is regulated by the angiotensin type 1 receptor in vivo. Kidney Int, 58, 251-259, 2000

Hoyer JR, Fogo AB, Terrell CH, Delaney MM. Immunomorphometric studies of proteinuria in individual deep and superficial nephrons of rats. Lab Invest, 80, 1691-1700, 2000

Fujinaka H, Miyazaki Y, Matsusaka T, Yoshida H, Fogo AB, Inagami T, Ichikawa I. Salutary role for angiotensin in partial urinary tract obstruction. Kidney Int, 58, 2018-2027, 2000

Brown, N J, Nakamura, S, Ma, L, Nakamura, I, Donnert, E, Freeman, M, Vaughan, D E, Fogo, A B. Aldosterone modulates plasminogen activator inhibitor-1 and glomerulosclerosis in vivo. Kidney Int, 58(3), 1219-27, 2000

Paueksakon, P, Revelo, M, Lee, S M, Horn, R G, Fogo, A B. Acute renal failure in a 64-year-old white man. Am J Kidney Dis, 36(3), 669-74, 2000

Ma, L J, Nakamura, S, Whitsitt, J S, Marcantoni, C, Davidson, J M, Fogo, A B. Regression of sclerosis in aging by an angiotensin inhibition-induced decrease in PAI-1. Kidney Int, 58(6), 2425-36, 2000

Nakamura, S, Nakamura, I, Ma, L, Vaughan, D E, Fogo, A B. Plasminogen activator inhibitor-1 expression is regulated by the angiotensin type 1 receptor in vivo. Kidney Int, 58(1), 251-9, 2000

Fogo, A B. Pathology of progressive nephropathies. Curr Opin Nephrol Hypertens, 9(3), 241-6, 2000

Revelo, M P, Pauesakon, P, Weidner, M, Helderman, J H, Horn, R G, Fogo, A B. A 37-year-old woman with systemic lupus erythematosus and acute allograft failure. Am J Kidney Dis, 35(6), 1242-7, 2000

Fogo, A B. Glomerular hypertension, abnormal glomerular growth, and progression of renal diseases. Kidney Int Suppl, 75, S15-21, 2000

Fujinaka, H, Miyazaki, Y, Matsusaka, T, Yoshida, H, Fogo, A B, Inagami, T, Ichikawa, I. Salutary role for angiotensin in partial urinary tract obstruction. Kidney Int, 58(5), 2018-27, 2000

Revelo, M P, Paueksakon, P, Goral, S, Helderman, H, Fogo, A B. A 14-year-old boy with kidney allograft failure in the first month after transplantation. Am J Kidney Dis, 36(4), 871-4, 2000

Fogo, A B. New insights into the renin-angiotensin system and hypertensive renal disease. Curr Hypertens Rep, 1(2), 187-94, 2000

Ma LJ, Nakamura S, Whitsitt JS, Marcantoni C, Davidson JM, Fogo AB. Regression of sclerosis in aging by an angiotensin inhibition- induced decrease in PAI-1. Kidney Int, 58, 2425-2436, 2000

Fogo, A B. Mesangial matrix modulation and glomerulosclerosis. Exp Nephrol, 7(2), 147-59, 1999

Tsuchida S, Miyazaki Y, Matsusaka T, Hunley TE, Inagami T, Fogo A, Ichikawa I. Potent antihypertrophic effect of the bradykinin B2 receptor system on the renal vasculature. Kidney Int , 56, 509-516, 1999

Fogo, A B. Current concepts in glomerulosclerosis. Am J Kidney Dis, 34(5), liv-lvi, 1999

Paueksakon, P, Hunley, T E, Lee, S M, Fogo, A B. A 12-year-old girl with pulmonary hemorrhage, skin lesions, and hematuria. Am J Kidney Dis, 33(2), 404-9, 1999

Miyazaki Y, Tsuchida S, Fogo A, Ichikawa I. The renal lesions that develop in neonatal mice during angiotensin inhibition mimic obstructive nephropathy. Kidney Int, 55, 1683-1695, 1999

Matsusaka T, Katori H, Inagami T, Fogo A, Ichikawa I. Communication between myocytes and fibroblasts in cardiac remodeling in angiotensin chimeric mice. J Clin Invest, 103, 1451-1458, 1999

Miyazaki Y, Tsuchida S, Nishimura H, Pope JC IV, Harris RC, McKanna JM, Inagami T, Hogan BLM, Fogo A, Ichikawa I. Angiotensin induces the urinary peristaltic machinery during the perinatal period. J Clin Invest, 102, 1489-1497, 1998

Ma J, Nishimura H, Fogo A, Kon V, Inagami T, Ichikawa I. Accelerated fibrosis and collagen deposition develop in the renal interstitium of angiotensin type 2 receptor null mutant mice during ureteral obstruction. Kidney Int, 53, 937-944, 1998

Okubo S, Niimura F, Matsusaka T, Fogo A, Hogan BLM, Ichikawa I. Angiotensinogen gene null-mutant mice lack homeostatic regulation of glomerular filtration and tubular reabsorption. Kidney Int, 53, 617-625, 1998

Mrukowicz, J Z, Wetzel, J D, Goral, M I, Fogo, A B, Wright, P F, Dermody, T S. Viruses and cells with mutations affecting viral entry are selected during persistent rotavirus infections of MA104 cells. J Virol, 72(4), 3088-97, 1998

Tsuchida S, Matsusaka T, Chen X, Okubo S, Niimura F, Nishimura H, Fogo A, Utsunomiya H, Inagami T, Ichikawa I. Murine double nullizygotes of the angiotensin type 1A and type 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. J Clin Invest, 101, 755-760, 1998

Wetzel, J D, Chappell, J D, Fogo, A B, Dermody, T S. Efficiency of viral entry determines the capacity of murine erythroleukemia cells to support persistent infections by mammalian reoviruses. J Virol, 71(1), 299-306, 1997

Fogo A, Breyer JA, Smith MC, Cleveland WH, Agodoa L, Kirk KA, Glassock R. Accuracy of the diagnosis of hypertensive nephrosclerosis in African Americans- a report from the AASK trial. Kidney Int, 51, 244-252, 1997

Dunn, N R, Winnier, G E, Hargett, L K, Schrick, J J, Fogo, A B, Hogan, B L. Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. Dev Biol, 188(2), 235-47, 1997

Niimura F, Okubo S, Fogo A, Ichikawa I. Temporal and spatial expression pattern of the angiotensinogen gene in mice and rats. Am J Physiol, R142-R147, 272, 1997

Chen X, Li W, Yoshida H, Tsuchida S, Nishimura H, Takemoto F, Okubo S, Fogo A, Matsusaka T, Ichikawa I. Targeting deletion of angiotensin type 1B receptor gene in the mouse. Am J Physiol, 272, F299-F304, 1997

Okubo S, Niimura F, Nishimura H, Takemoto F, Fogo A, Matsusaka T, Ichikawa I. Angiotensin-independent mechanism for aldosterone synthesis during chronic extracellular fluid volume depletion. J Clin Invest , 855-860, 99, 1997

Oikawa T, Freeman M, Lo W, Vaughan DE, Fogo A. Modulation of plasminogen activator inhibitor-1 (PAI-1) in vivo: A new mechanism for the anti-fibrotic effect of renin-angiotensin inhibition. Kidney Int, 51, 164-172, 1997

Nishimura H, Matsusaka T, Fogo A, Kon V, Ichikawa I. A novel in vivo mechanism for angiotensin type 1 receptor regulation. Kidney Int, 52, 345-355, 1997

Hunley TE, Julian BA, Phillips JA, Summar ML, Yoshida H, Horn RG, Brown NJ, Fogo A, Ichikawa I, Kon V. Angiotensin converting enzyme gene polymorphism: Potential silencer motif and impact on progression in IgA nephropathy. Kidney Int, 571-577, 49, 1996

Suzuki, N, Labosky, P A, Furuta, Y, Hargett, L, Dunn, R, Fogo, A B, Takahara, K, Peters, D M, Greenspan, D S, Hogan, B L. Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid. Development, 122(11), 3587-95, 1996

Matsusaka T, Nishimura H, Utsunomiya H, Kakuchi J, Niimura F, Inagami T, Fogo A, Ichikawa I. Chimeric mice carrying "regional" targeted deletion of the angiotensin type 1a receptor gene: Evidence against the role for local angiotensin in the in vivo feedback regulation of renin synthesis in juxtaglomerular cells. J Clin Invest, 98, 1867-1877, 1996

Ichiki, T., Labosky, P. A., Shiota, C., Okuyama, S., Imagawa, Y., Fogo, A., Miimura, F., Ichikawa, I., Hogan, B. L. M., Inagami, T. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature, 377, 748-750, 1995

Motojima, M, Nishijima, F, Ikoma, M, Kawamura, T, Yoshioka, T, Fogo, A B, Sakai, T, Ichikawa, I. Role for 'uremic toxin' in the progressive loss of intact nephrons in chronic renal failure. Kidney Int, 40(3), 461-9, 1991

Teague, M W, Glick, A D, Fogo, A B. Adenovirus infection of the kidney: mass formation in a patient with Hodgkin's disease. Am J Kidney Dis, 18(4), 499-502, 1991

Butler, M G, Fogo, A B, Fuchs, D A, Collins, F S, Dev, V G, Phillips, J A. Two patients with ring chromosome 15 syndrome. Am J Med Genet, 29(1), 149-54, 1988