Department of Pathology, Microbiology, and Immunology



  W. Gray Jerome, Ph.D. (Jay)



Associate Professor
Director, Graduate Program in Cellular and Molecular Pathology

Dept of Pathology, Microbiology and Immunology


  Contact Information

  Office Location:

U-2206 MCN

Phone: 615-322-5530

E-mail: jay.jerome@vanderbilt.edu 

Lab Url: http://www.mc.vanderbilt.edu/jeromelab/index.html

   Campus Email address:
  Pathology, Microbiology, Immunology-3rd Fl
  C-3321 MCN (2561) 

US Mailing address:

Vanderbilt University School of Medicine

Dept of Pathology, Microbiology and Immunology-3rd Fl

C-3321 MCN

Nashville, TN 37232-2561 








Ph.D., Univ of Virginia
M.S., Northeastern University
B.A., St. Andrews College



Research Keywords



Atherosclerosis, Thrombosis, Lipid metabolism, Biochemistry, Heart, Pathology, Vascular Biology, Pathology, Apoptosis, Cancer, Cell Biology, Intracellular Traffic, Cholesterol



Research Description



Research in the laboratory is focused on vascular biology and how changes in the vasculature can affect heart disease, stroke, and cancer. The studies correlate microscopy and biochemistry evidence to determine what changes occur and how these changes affect the disease process. Currently, three interrelated studies are ongoing.

In the first, we are trying to learn why in atherosclerosis the lysosomes of macrophages and smooth muscle cells in the artery wall become bloated with cholesterol. To do this, we use cultured macrophages and look at the uptake and processing of cholesterol. The cholesterol is delivered to the cells within modified lipoproteins. This is similar to what occurs in vivo. We compare quantitative microscopic observations on the uptake and fate of the lipoproteins with measures of key biochemical pathways in cholesterol metabolism. In this way we are beginning to dissect why lysosomes cannot clear their cholesterol load. To relate these tissue culture experiments to the disease process, we also compare the appearance of these tissue culture cells to that exhibited by cells during various stages of atherosclerosis. This is also allowing us to investigate the effect this bloating has on progression of the disease. Among our findings, we have shown that lysosomal cholesterol accumulation occurs in two stages. In the initial stage, cholesteryl esters delivered by lipoproteins are broken down in th lysosome but the resulting unesterified cholesterol cannot escape the lysosome. In later stages, and perhaps related to the free cholesterol accumulation, hydrolysis of the cholesteryl esters is inhibited. This produces lysosomes rich in both free and esterified cholesterol.

In the second set of studies, we are exploring how triglycerides can alter intracellular cholesterol metabolism. We have found that triglycerides significantly increase the rate of cholesterol metabolism and cellular clearance of cholesterol. We are now trying to define the mechanisms by which this occurs.

In a new line of investigation in the laboratory, we are investigating how inhibition of cholesterol use can effect cell proliferation. Under conditions where cholesterol is scarce, cell proliferation, such as that seen in tumors, is slowed. The cell can acquire cholesterol exogenously or synthesize it internally. Each pool of cholesterol appears to have a slight different trafficking mechanism within the cells. It is still not clear whether an inhibition of use of one pool can be compensated by use of cholesterol from the other pool. Cholesterol restriction is a potential means of slowing some tumor growth. However, to fully understand the potential, much more knowledge of cholesterol trafficking and utilization within different cell types is required. . . .






Kojima, T, Van Deusen, M, Jerome, WG, Garrett, CG, Sivasankar, MP, Novaleski, CK, Rousseau, B. Quantification of acute vocal fold epithelial surface damage with increasing time and magnitude doses of vibration exposure. PLoS One, 9(3), e91615, 2014

Baudoin, JP, Jerome, WG, K??bel, C, de Jonge, N. Whole-cell analysis of low-density lipoprotein uptake by macrophages using STEM tomography. PLoS One, 8(1), e55022, 2013

Yamamoto, S, Yancey, PG, Ikizler, TA, Jerome, WG, Kaseda, R, Cox, B, Bian, A, Shintani, A, Fogo, AB, Linton, MF, Fazio, S, Kon, V. Dysfunctional high-density lipoprotein in patients on chronic hemodialysis. J Am Coll Cardiol, 60(23), 2372-9, 2012

Kirkbride, KC, Hong, NH, French, CL, Clark, ES, Jerome, WG, Weaver, AM. Regulation of late endosomal/lysosomal maturation and trafficking by cortactin affects Golgi morphology. Cytoskeleton (Hoboken), 69(9), 625-43, 2012

Ooms, LS, Jerome, WG, Dermody, TS, Chappell, JD. Reovirus replication protein ??2 influences cell tropism by promoting particle assembly within viral inclusions. J Virol, 86(20), 10979-87, 2012

Cai, Q, Brissova, M, Reinert, RB, Pan, FC, Brahmachary, P, Jeansson, M, Shostak, A, Radhika, A, Poffenberger, G, Quaggin, SE, Jerome, WG, Dumont, DJ, Powers, AC. Enhanced expression of VEGF-A in ?? cells increases endothelial cell number but impairs islet morphogenesis and ?? cell proliferation. Dev Biol, 367(1), 40-54, 2012

Sorci-Thomas, MG, Owen, JS, Fulp, B, Bhat, S, Zhu, X, Parks, JS, Shah, D, Jerome, WG, Gerelus, M, Zabalawi, M, Thomas, MJ. Nascent high density lipoproteins formed by ABCA1 resemble lipid rafts and are structurally organized by three apoA-I monomers. J Lipid Res, 53(9), 1890-909, 2012

Yu, SS, Lau, CM, Thomas, SN, Jerome, WG, Maron, DJ, Dickerson, JH, Hubbell, JA, Giorgio, TD. Size- and charge-dependent non-specific uptake of PEGylated nanoparticles by macrophages. Int J Nanomedicine, 7, 799-813, 2012

Deng, X, Morris, J, Dressmen, J, Tubb, MR, Tso, P, Jerome, WG, Davidson, WS, Thompson, TB. The Structure of Dimeric Apolipoprotein A-IV and Its Mechanism of Self-Association. Structure, 20(5), 767-79, 2012

Weibel, GL, Joshi, MR, Jerome, WG, Bates, SR, Yu, KJ, Phillips, MC, Rothblat, GH. Cytoskeleton disruption in J774 macrophages: Consequences for lipid droplet formation and cholesterol flux. Biochim Biophys Acta, 2011

Huang, R, Silva, RA, Jerome, WG, Kontush, A, Chapman, MJ, Curtiss, LK, Hodges, TJ, Davidson, WS. Apolipoprotein A-I structural organization in high-density lipoproteins isolated from human plasma. Nat Struct Mol Biol, 18(4), 416-22, 2011

, 2011

Jerome, WG. Lysosomes, cholesterol and atherosclerosis. Clin Lipidol, 5(6), 853-865, 2010

Gauthamadasa, K, Rosales, C, Pownall, HJ, Macha, S, Jerome, WG, Huang, R, Silva, RA. Speciated human high-density lipoprotein protein proximity profiles. Biochemistry, 49(50), 10656-65, 2010

Vaezi, MF, Slaughter, JC, Smith, BS, Washington, MK, Jerome, WG, Garrett, CG, Hagaman, D, Goutte, M. Dilated intercellular space in chronic laryngitis and gastro-oesophageal reflux disease: at baseline and post-lansoprazole therapy. Aliment Pharmacol Ther, 32(7), 916-24, 2010

Jiang, M, Fernandez, S, Jerome, WG, He, Y, Yu, X, Cai, H, Boone, B, Yi, Y, Magnuson, MA, Roy-Burman, P, Matusik, RJ, Shappell, SB, Hayward, SW. Disruption of PPARgamma signaling results in mouse prostatic intraepithelial neoplasia involving active autophagy. Cell Death Differ, 17(3), 469-81, 2010

Gu, F, Jones, MK, Chen, J, Patterson, JC, Catte, A, Jerome, WG, Li, L, Segrest, JP. Structures of discoidal high density lipoproteins: a combined computational-experimental approach. J Biol Chem, 285(7), 4652-65, 2010

Jiang, M, Jerome, WG, Hayward, SW. Autophagy in nuclear receptor PPARgamma-deficient mouse prostatic carcinogenesis. Autophagy, 6(1), 175-6, 2010

Ullery-Ricewick, JC, Cox, BE, Griffin, EE, Jerome, WG. Triglyceride alters lysosomal cholesterol metabolism in cholesteryl ester-laden macrophage foam cells. J Lipid Res, 2009

Sun, Y, Ishibashi, M, Seimon, T, Lee, M, Sharma, SM, Fitzgerald, KA, Samokhin, AO, Wang, Y, Sayers, S, Aikawa, M, Jerome, WG, Ostrowski, MC, Bromme, D, Libby, P, Tabas, IA, Welch, CL, Tall, AR. Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K. Circ Res, 104(4), 455-65, 2009

Chen, B, Ren, X, Neville, T, Jerome, WG, Hoyt, DW, Sparks, D, Ren, G, Wang, J. Apolipoprotein AI tertiary structures determine stability and phospholipid-binding activity of discoidal high-density lipoprotein particles of different sizes. Protein Sci, 18(5), 921-35, 2009

Cao, Z, Li, C, Higginbotham, JN, Franklin, JL, Tabb, DL, Graves-Deal, R, Hill, S, Cheek, K, Jerome, WG, Lapierre, LA, Goldenring, JR, Ham, AJ, Coffey, RJ. Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis. Mol Cell Proteomics, 7(9), 1651-67, 2008

Jerome, WG, Cox, BE, Griffin, EE, Ullery, JC. Lysosomal cholesterol accumulation inhibits subsequent hydrolysis of lipoprotein cholesteryl ester. Microsc Microanal, 14(2), 138-49, 2008

Silva, RA, Huang, R, Morris, J, Fang, J, Gracheva, EO, Ren, G, Kontush, A, Jerome, WG, Rye, KA, Davidson, WS. Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes. Proc Natl Acad Sci U S A, 105(34), 12176-81, 2008

Zhang, Y, Vasudevan, S, Sojitrawala, R, Zhao, W, Cui, C, Xu, C, Fan, D, Newhouse, Y, Balestra, R, Jerome, WG, Weisgraber, K, Li, Q, Wang, J. A monomeric, biologically active, full-length human apolipoprotein E. Biochemistry, 46(37), 10722-32, 2007

Yancey, PG, Jerome, WG, Yu, H, Griffin, EE, Cox, BE, Babaev, VR, Fazio, S, Linton, MF. Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI. J Lipid Res, 48(5), 1140-9, 2007

Cox, BE, Griffin, EE, Ullery, JC, Jerome, WG. Effects of cellular cholesterol loading on macrophage foam cell lysosome acidification. J Lipid Res, 48(5), 1012-21, 2007

Fan, D, Qiu, S, Overton, CD, Yancey, PG, Swift, LL, Jerome, WG, Linton, MF, Fazio, S. Impaired secretion of apolipoprotein E2 from macrophages. J Biol Chem, 282(18), 13746-53, 2007

Jerome, WG. Advanced atherosclerotic foam cell formation has features of an acquired lysosomal storage disorder. Rejuvenation Res, 9(2), 245-55, 2006

Catte, A, Patterson, JC, Jones, MK, Jerome, WG, Bashtovyy, D, Su, Z, Gu, F, Chen, J, Aliste, MP, Harvey, SC, Li, L, Weinstein, G, Segrest, JP. Novel changes in discoidal high density lipoprotein morphology: a molecular dynamics study. Biophys J, 90(12), 4345-60, 2006

Brissova, M, Shostak, A, Shiota, M, Wiebe, PO, Poffenberger, G, Kantz, J, Chen, Z, Carr, C, Jerome, WG, Chen, J, Baldwin, HS, Nicholson, W, Bader, DM, Jetton, T, Gannon, M, Powers, AC. Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function. Diabetes, 55(11), 2974-85, 2006

Settle, SH, Washington, K, Lind, C, Itzkowitz, S, Fiske, WH, Burdick, JS, Jerome, WG, Ray, M, Weinstein, W, Coffey, RJ. Chronic treatment of M??n??trier''s disease with Erbitux: clinical efficacy and insight into pathophysiology. Clin Gastroenterol Hepatol, 3(7), 654-9, 2005

Swift, LL, Kakkad, B, Boone, C, Jovanovska, A, Jerome, WG, Mohler, PJ, Ong, DE. Microsomal triglyceride transfer protein expression in adipocytes: a new component in fat metabolism. FEBS Lett, 579(14), 3183-9, 2005

Griffin, EE, Ullery, JC, Cox, BE, Jerome, WG. Aggregated LDL and lipid dispersions induce lysosomal cholesteryl ester accumulation in macrophage foam cells. J Lipid Res, 2005

Dove, DE, Su, YR, Zhang, W, Jerome, WG, Swift, LL, Linton, MF, Fazio, S. ACAT1 deficiency disrupts cholesterol efflux and alters cellular morphology in macrophages. Arterioscler Thromb Vasc Biol, 25(1), 128-34, 2005

W. Gray Jerome, Stefan Handt, Roy R. Hantgan . Endothelial Cells Organize Fibrin Clots into Structures That Are More Resistant to Lysis . Microscopy and Microanalysis, 11(3), 268-277, 2005

de Grey, AD, Alvarez, PJ, Brady, RO, Cuervo, AM, Jerome, WG, McCarty, PL, Nixon, RA, Rittmann, BE, Sparrow, JR. Medical bioremediation: prospects for the application of microbial catabolic diversity to aging and several major age-related diseases. Ageing Res Rev, 4(3), 315-38, 2005

Jerome, WG, Handt, S, Hantgan, RR. Endothelial cells organize fibrin clots into structures that are more resistant to lysis. Microsc Microanal, 11(3), 268-77, 2005

Wilkinson, M, Cline, M, Jerome, WG. Cytopathic herpesvirus infection in a green iguana (Iguana iguana). J Zoo Wildl Med, 36(4), 724-6, 2005

Ren, X, Zhao, L, Sivashanmugam, A, Miao, Y, Korando, L, Yang, Z, Reardon, CA, Getz, GS, Brouillette, CG, Jerome, WG, Wang, J. Engineering mouse apolipoprotein A-I into a monomeric, active protein useful for structural determination. Biochemistry, 44(45), 14907-19, 2005

Fan, Daping, Li, Qianqian, Korando, Leslie, Jerome, W Gray, Wang, Jianjun. A monomeric human apolipoprotein E carboxyl-terminal domain. Biochemistry, 43(17), 5055-64, 2004

Li, Cunxi, Franklin, Jeffrey L, Graves-Deal, Ramona, Jerome, W Gray, Cao, Zheng, Coffey, Robert J. Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cells. Proc Natl Acad Sci U S A, 101(15), 5571-6, 2004

Prentice, Erik, Jerome, W Gray, Yoshimori, Tamotsu, Mizushima, Noboru, Denison, Mark R. Coronavirus replication complex formation utilizes components of cellular autophagy. J Biol Chem, 279(11), 10136-41, 2004

Jerome, W Gray, Yancey, Patricia G. The role of microscopy in understanding atherosclerotic lysosomal lipid metabolism. Microsc Microanal, 9(1), 54-67, 2003

Swift, Larry L, Zhu, Mei-Ying, Kakkad, Bharati, Jovanovska, Aneta, Neely, M Diana, Valyi-Nagy, Klara, Roberts, Richard L, Ong, David E, Jerome, W Gray. Subcellular localization of microsomal triglyceride transfer protein. J Lipid Res, 44(10), 1841-9, 2003

Hantgan, Roy R, Stahle, Mary C, Jerome, W Gray, Nagaswami, Chandrasekaran, Weisel, John W. Tirofiban blocks platelet adhesion to fibrin with minimal perturbation of GpIIb/IIIa structure. Thromb Haemost, 87(5), 910-7, 2002

Grant, Kenneth, Jerome, W Gray. Laser capture microdissection as an aid to ultrastructural analysis. Microsc Microanal, 8(3), 170-5, 2002

Yancey, Patricia G, Miles, Stacia, Schwegel, Jennifer, Jerome, W Gray. Uptake and trafficking of mildly oxidized LDL and acetylated LDL in THP-1 cells does not explain the differences in lysosomal metabolism of these two lipoproteins. Microsc Microanal, 8(2), 81-93, 2002

Bonnefoy, A, Liu, Q, Jerome, W G, Legrand, C, Frojmovic, M M. Platelets in suspension require preactivation to adhere to immobilized fibrinogen. Ann N Y Acad Sci, 936, 459-63, 2001

Yancey PG, Jerome WG. Lysosomal cholesterol derived from mildly oxidized low density lipoprotein is resistant to efflux. J Lipid Res, 42, 317-327, 2001

Hantgan, R R, Stahle, M, Del Gaizo, V, Adams, M, Lasher, T, Jerome, W G, McKenzie, M, Lyles, D S. AlphaIIb's cytoplasmic domain is not required for ligand-induced clustering of integrin alphaIIbbeta3. Biochim Biophys Acta, 1540(1), 82-95, 2001

Yancey, P G, Jerome, W G. Lysosomal cholesterol derived from mildly oxidized low density lipoprotein is resistant to efflux. J Lipid Res, 42(3), 317-27, 2001

Stokes, A H, Lewis, D Y, Lash, L H, Jerome, W G, Grant, K W, Aschner, M, Vrana, K E. Dopamine toxicity in neuroblastoma cells: role of glutathione depletion by L-BSO and apoptosis. Brain Res, 858(1), 1-8, 2000

Cashell, A W, Jerome, W G, Flores, E. Signet ring stromal tumor of the ovary occurring in conjunction with brenner tumor. Gynecol Oncol, 77(2), 323-6, 2000

Kellner-Weibel G, Yancey PG, Jerome WG, Walser T, Mason RP, Phillips MC,Rothblat GH. Crystallization of free cholesterol in model macrophage foam cells. Arterioscler Thromb Vasc Biol, 19, 1891-8, 1999

Avart, S J, Bernard, D W, Jerome, W G, Glick, J M. Cholesteryl ester hydrolysis in J774 macrophages occurs in the cytoplasm and lysosomes. J Lipid Res, 40(3), 405-14, 1999

Kellner-Weibel, G, Yancey, P G, Jerome, W G, Walser, T, Mason, R P, Phillips, M C, Rothblat, G H. Crystallization of free cholesterol in model macrophage foam cells. Arterioscler Thromb Vasc Biol, 19(8), 1891-8, 1999

Hantgan RR, Jerome WG, Handt S. Platelets and endothelial cells act in concert to delay thrombolysis--evidence from an in vitro model of the human occlusive thrombus. Thromb Haemost, 79, 602-8, 1998

Yancey, P G, Jerome, W G. Lysosomal sequestration of free and esterified cholesterol from oxidized low density lipoprotein in macrophages of different species. J Lipid Res, 39(7), 1349-61, 1998

Hantgan, R R, Jerome, W G, Handt, S. Platelets and endothelial cells act in concert to delay thrombolysis--evidence from an in vitro model of the human occlusive thrombus. Thromb Haemost, 79(3), 602-8, 1998

Kellner-Weibel, G, Jerome, W G, Small, D M, Warner, G J, Stoltenborg, J K, Kearney, M A, Corjay, M H, Phillips, M C, Rothblat, G H. Effects of intracellular free cholesterol accumulation on macrophage viability: a model for foam cell death. Arterioscler Thromb Vasc Biol, 18(3), 423-31, 1998

Jerome, W G, Cash, C, Webber, R, Horton, R, Yancey, P G. Lysosomal lipid accumulation from oxidized low density lipoprotein is correlated with hypertrophy of the Golgi apparatus and trans-Golgi network. J Lipid Res, 39(7), 1362-71, 1998

Hantgan, R R, Jerome, W G, Hursting, M J. No effect of clot age or thrombolysis on argatroban's inhibition of thrombin. Blood, 92(6), 2064-74, 1998

Tansey, J T, Thuren, T Y, Jerome, W G, Hantgan, R R, Grant, K, Waite, M. Hydrolysis of phosphatidylcholine by hepatic lipase in discoidal and spheroidal recombinant high-density lipoprotein. Biochemistry, 36(40), 12227-34, 1997

Carlson, C S, O'Sullivan, M G, Jayo, M J, Anderson, D K, Harber, E S, Jerome, W G, Bullock, B C, Heberling, R L. Fatal disseminated cercopithecine herpesvirus 1 (herpes B infection in cynomolgus monkeys (Macaca fascicularis). Vet Pathol, 34(5), 405-14, 1997

Jerome, W G, Lewis, J C. Cellular dynamics in early atherosclerotic lesion progression in white carneau pigeons. Spatial and temporal analysis of monocyte and smooth muscle invasion of the intima. Arterioscler Thromb Vasc Biol, 17(4), 654-64, 1997

Handt, S, Jerome, W G, Tietze, L, Hantgan, R R. Plasminogen activator inhibitor-1 secretion of endothelial cells increases fibrinolytic resistance of an in vitro fibrin clot: evidence for a key role of endothelial cells in thrombolytic resistance. Blood, 87(10), 4204-13, 1996

Lyles, D S, McKenzie, M O, Kaptur, P E, Grant, K W, Jerome, W G. Complementation of M gene mutants of vesicular stomatitis virus by plasmid-derived M protein converts spherical extracellular particles into native bullet shapes. Virology, 217(1), 76-87, 1996

Endenburg, S C, Hantgan, R R, Lindeboom-Blokzijl, L, Lankhof, H, Jerome, W G, Lewis, J C, Sixma, J J, de Groot, P G. On the role of von Willebrand factor in promoting platelet adhesion to fibrin in flowing blood. Blood, 86(11), 4158-65, 1995

Braaten, J V, Jerome, W G, Hantgan, R R. Uncoupling fibrin from integrin receptors hastens fibrinolysis at the platelet-fibrin interface. Blood, 83(4), 982-93, 1994

Tangirala, R K, Jerome, W G, Jones, N L, Small, D M, Johnson, W J, Glick, J M, Mahlberg, F H, Rothblat, G H. Formation of cholesterol monohydrate crystals in macrophage-derived foam cells. J Lipid Res, 35(1), 93-104, 1994

Lantz, P E, Jerome, W G, Jaworski, J A. Radiopaque deposits surrounding a contact small-caliber gunshot wound. Am J Forensic Med Pathol, 15(1), 10-3, 1994

Jerome, WL. The scientific method. Br Dent J, 177(11-12), 401, 1994

Braaten, J V, Handt, S, Jerome, W G, Kirkpatrick, J, Lewis, J C, Hantgan, R R. Regulation of fibrinolysis by platelet-released plasminogen activator inhibitor 1: light scattering and ultrastructural examination of lysis of a model platelet-fibrin thrombus. Blood, 81(5), 1290-9, 1993

Tangirala, R K, Mahlberg, F H, Glick, J M, Jerome, W G, Rothblat, G H. Lysosomal accumulation of unesterified cholesterol in model macrophage foam cells. J Biol Chem, 268(13), 9653-60, 1993

Thomas, M J, Hedrick, C C, Smith, S, Pang, J, Jerome, W G, Willard, A S, Shirley, P S. Superoxide generation by the human polymorphonuclear leukocyte in response to latex beads. J Leukoc Biol, 51(6), 591-6, 1992

Moyer, C F, Jerome, W G, Taylor, R, Tulli, H, Reinisch, C L. Autoimmune vasculitis in MRL/Mp-lpr/lpr mice: orthochromatic basophils participate in the development of delayed-type hypersensitivity angiitis. Autoimmunity, 12(3), 159-65, 1992

Loeser, R, Carlson, C S, Tulli, H, Jerome, W G, Miller, L, Wallin, R. Articular-cartilage matrix gamma-carboxyglutamic acid-containing protein. Characterization and immunolocalization. Biochem J, 282 ( Pt 1), 1-6, 1992

Taylor, R G, Jerome, W G, Lewis, J C. Ultrastructural localization of peroxidase in atherosclerotic lesions of pigeons. Exp Mol Pathol, 57(3), 167-79, 1992

Jerome, WL. Mercury from dental amalgam. Br Dent J, 173(7), 227-8, 1992

Jones, N L, Jerome, W G, Lewis, J C. Pigeon monocyte/macrophage lysosomes during beta VLDL uptake. Induction of acid phosphatase activity. A model for complex arterial lysosomes. Am J Pathol, 139(2), 383-92, 1991

Minor, L K, Mahlberg, F H, Jerome, W G, Lewis, J C, Rothblat, G H, Glick, J M. Lysosomal hydrolysis of lipids in a cell culture model of smooth muscle foam cells. Exp Mol Pathol, 54(2), 159-71, 1991

Jerome, W G, Minor, L K, Glick, J M, Rothblat, G H, Lewis, J C. Lysosomal lipid accumulation in vascular smooth muscle cells. Exp Mol Pathol, 54(2), 144-58, 1991

Barr, D A, Jerome, W G, Lewis, J C. Morphologic characteristics of naturally occurring atherosclerosis in the brachiocephalic artery of the pigeon. Exp Mol Pathol, 54(2), 99-111, 1991

Mahlberg, F H, Glick, J M, Jerome, W G, Rothblat, G H. Metabolism of cholesteryl ester lipid droplets in a J774 macrophage foam cell model. Biochim Biophys Acta, 1045(3), 291-8, 1990

Jerome, W G, Lewis, J C. Early atherogenesis in White Carneau pigeons: effect of a short-term regression diet. Exp Mol Pathol, 53(3), 223-38, 1990

Taylor, R G, Jerome, W G, Lewis, J C. Ultrastructural events associated with endothelial cell changes during the initiation and early progression of atherosclerosis. Adv Exp Med Biol, 273, 89-93, 1990

Noseda, A, White, J G, Godwin, P L, Jerome, W G, Modest, E J. Membrane damage in leukemic cells induced by ether and ester lipids: an electron microscopic study. Exp Mol Pathol, 50(1), 69-83, 1989

Jerome, W G, Lewis, J C. Early atherogenesis in the White Carneau pigeon. III. Lipid accumulation in nascent foam cells. Am J Pathol, 128(2), 253-64, 1987

Jerome, W G, Lewis, J C. Early atherogenesis in White Carneau pigeons. II. Ultrastructural and cytochemical observations. Am J Pathol, 119(2), 210-22, 1985

Lewis, J C, Taylor, R G, Jerome, W G. Foam cell characteristics in coronary arteries and aortas of White Carneau pigeons with moderate hypercholesterolemia. Ann N Y Acad Sci, 454, 91-100, 1985

Jerome, W G, Lewis, J C. Early atherogenesis in White Carneau pigeons. I. Leukocyte margination and endothelial alterations at the celiac bifurcation. Am J Pathol, 116(1), 56-68, 1984

Jerome, W G, Lewis, J C, Taylor, R G, White, M S. Concurrent endothelial cell turnover and leukocyte margination in early atherosclerosis. Scan Electron Microsc(Pt 3), 1453-9, 1983

Jerome, W G, Cardell, R R. Observations on the role of smooth endoplasmic reticulumin glucocorticoid-induced hepatic glycogen deposition. Tissue Cell, 15(5), 711-27, 1983

Jerome, W G. Medical electron microscopy. Invest Urol, 19(3), 131-5, 1981