Department of Pathology, Microbiology, and Immunology



   Michael Laposata, M.D., Ph.D.



Edward and Nancy Fody Professor

Executive Vice Chair of Pathology, Microbiology and Immunology

Pathologist-in-Chief, Vanderbilt University Hospital
Director, Division of Laboratory Medicine 
           and Clinical Laboratories


  Contact Information


  Office Location:

4605A TVC

Phone:  615-322-7862

Fax: 615-343-8976

E-mail: michael.laposata@vanderbilt.edu


Campus Mail address:

Pathology Labs/Blood Bank

4605 TVC (5310)


US Mailing address:

Pathology Labs/Blood Bank

Vanderbilt University School of Medicine

4605 TVC

Nashville, TN 37232-5310



  Research Specialty


Fatty acid metabolism/Consultative Laboratory Medicine/Clinical coagulation diagnosis & treatment.  Basic Research:  Our work focuses on understanding the biochemical basis for the fatty acid abnormalities in cystic fibrosis and the impact  of fatty acid supplementation in reversal of the abnormalities.



  Clinical Research Description


Developing laboratory directors into the role of a clinical consultant to assist physicians in test selection and the provision of patient-specific, expert driven narrative interpretations of complex clinical laboratory evaluations.

The development of improved diagnostic testing strategies to assess patients for bleeding and thrombotic disorders





 Freedman, S.D., M.H. Katz, E.M. Parker, M. Laposata, M.Y. Urman, and J.G. Alvarez.  1999.  A membrane lipid imbalance plays a role in the phenotypic expression of cystic fibrosis in cftr-/-mice.  Proc. Natl. Acad. Sci. U.S.A.  96:13995-14000.  

Brenner, B.R., U. Nowak-Gottl, A. Kosch, M. Manco-Johnson, and M. Laposata.  2002.  Diagnostic studies for thrombophilia in women on hormonal therapy and during pregnancy, and in children.  Arch. Pathol. Lab. Med.  126:1296-1303.


Freedman, S.D., P.G. Blanco, M.M. Zaman, J.C. Shea, M. Ollero, I.K. Hopper, D.A. Weed, A. Gelrud, M.M. Regan, M. Laposata, J.G. Alvarez, and B.P. O’Sullivan.  2004. Association of cystic fibrosis with abnormalities in fatty acid metabolism.  N. Engl. J. Med.  350:560-569. 


Laposata, M.E., M. Laposata (corresponding author), E.M. Van Cott, D.S. Buchner, M.S. Kashalo, and A.S. Dighe.  2004.  Physician survey of a laboratory medicine interpretative service and evaluation of the influence of interpretations on laboratory test ordering.  Arch. Pathol. Lab. Med.  128:1424-1427.


Batel, I., M.-B. Ericsoussi,  J.E. Cluette-Brown, B.P. O’Sullivan, S.D. Freedman, J.E. Savaille, M . Laposata.  2007.  Potential utility of plasma fatty acid analysis in the diagnosis of cystic fibrosis.  Clin. Chem. 53:78-84.


Laposata, M. and A.S. Dighe.  2007. “Pre-pre” and “post-post” analytical error: High incidence patient safety hazards involving the clinical laboratory.  Clin. Chem. Lab. Med.  45:712-719.


Peershke, E.I., Y. Agrawal, C-B. Alexander, E. Bovill, and M. Laposata. 2007.  Proposed research training guidelines for residents in laboratory medicine.  Clin. Lab Med. 27:241-253.


Al-Turkmani, M.R., C. Anderson, R. Alturkmani, W. Katrangi, J.E. Cluette-Brown, S.D. Freedman and M. Laposata. 2008.  A mechanism accounting for the low cellular level of linoleic acid in cystic fibrosis and its reversal by DHA.  J. Lipid Res. 49: 1946-1954.  








M.D., PhD, Johns Hopkins
BS, Bucknell