Department of Pathology, Microbiology, and Immunology



   Mary Kay Washington, M.D., Ph.D.



Dept of Pathology, Microbiology and Immunology


  Contact Information



Office Location:

C-3316 MCN

Phone:  615-343-5655

Fax:      615-343-7023

E-mail:  kay.washington@vanderbilt.edu


Campus Mail address:

Pathology, Microbiology and Immunology-3rd Fl

C-3321 MCN (2561)


US Mailing address:

Pathology, Microbiology and Immunology-3rd Fl

Vanderbilt University School of Medicine

C-3321 MCN

Nashville, TN 37232-2561







M.D., University of North Carolina at Chapel Hill
Ph.D., University of North Carolina at Chapel Hill
B.S., Mississippi State



Research Keywords



Cancer, Knockout, Malignancy, Mouse, Translation



Research Description



My research focuses on morphology of gastrointestinal and hepatic diseases. I provide expertise in interpretation of histopathologic changes in a variety of animal models of gastrointestinal diseases to basic scientists at Vanderbilt. I also serve as Director for several research biorepositories and shared resources, including the Vanderbilt Digestive Diseases Research Center and the Western Division of the Cooperative Human Tissue Network.



Clinical Research Description



My research focuses on diagnostic aspects of gastrointestinal and hepatic pathology; specific areas of interest include Barrett's esophagus, colorectal neoplasia, inflammatory bowel disease, and gastrointestinal pathology of primary immunodeficiency. I also have an interest in morphology of mouse models of intestinal neoplasia and inflammatory bowel disease.






Barrett, CW, Fingleton, B, Williams, A, Ning, W, Fischer, MA, Washington, MK, Chaturvedi, R, Wilson, KT, Hiebert, SW, Williams, CS. MTGR1 Is Required for Tumorigenesis in the Murine AOM/DSS Colitis-Associated Carcinoma Model. Cancer Res, 17(4), 1302-12, 2011 PMC3150168

Moreira RK, Chopp W, Washington. . The concept of hepatic artery-bile duct parallelism in the diagnosis of ductopenia in liver biopsy samples.. Am J Surg Pathol, 35(3), 392-403, 2011

Nagaraj, NS, Washington, MK, Merchant, NB. Combined Blockade of Src Kinase and Epidermal Growth Factor Receptor with Gemcitabine Overcomes STAT3-Mediated Resistance of Inhibition of Pancreatic Tumor Growth. Clin Cancer Res, 17(3), 483-93, 2011

Freeman, TJ, Smith, JJ, Chen, X, Washington, MK, Roland, JT, Means, AL, Eschrich, SA, Yeatman, TJ, Deane, NG, Beauchamp, RD. Smad4-Mediated Signaling Inhibits Intestinal Neoplasia by Inhibiting Expression of I?-Catenin. Gastroenterology, November, e-pub ahead of print, 2011

Zhang, Y, Dub??, PE, Washington, MK, Yan, F, Polk, DB. ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival. Lab Invest, 2011

Ueda, Y, Hajri, T, Peng, D, Marks-Shulman, PA, Tamboli, RA, Shukrallah, B, Saliba, J, Jabbour, K, El-Rifai, W, Abumrad, NA, Abumrad, NN. Reduction of 8-iso-prostaglandin F2I? in the first week after Roux-en-Y gastric bypass surgery. Obesity (Silver Spring), 19(8), 1663-8, 2011

Smalley-Freed, WG, Efimov, A, Short, SP, Jia, P, Zhao, Z, Washington, MK, Robine, S, Coffey, RJ, Reynolds, AB. Adenoma formation following limited ablation of p120-catenin in the mouse intestine. PLoS One, 6(5), e19880, 2011

Peng, D, Hu, TL, Jiang, A, Washington, MK, Moskaluk, CA, Schneider-Stock, R, El-Rifai, W. Location-specific epigenetic regulation of the metallothionein 3 gene in esophageal adenocarcinomas. PLoS One, 6(7), e22009, 2011

Singh, AB, Sharma, A, Smith, JJ, Krishnan, M, Chen, X, Eschrich, S, Washington, MK, Yeatman, TJ, Beauchamp, RD, Dhawan, P. Claudin-1 Up-regulates the Repressor ZEB-1 to Inhibit E-Cadherin Expression in Colon Cancer Cells. Gastroenterology, 141(6), 2140-53, 2011

Williams, CS, Zhang, B, Smith, JJ, Jayagopal, A, Barrett, CW, Pino, C, Russ, P, Presley, SH, Peng, D, Rosenblatt, DO, Haselton, FR, Yang, JL, Washington, MK, Chen, X, Eschrich, S, Yeatman, TJ, El-Rifai, W, Beauchamp, RD, Chang, MS. BVES regulates EMT in human corneal and colon cancer cells and is silenced via promoter methylation in human colorectal carcinoma. J Clin Invest, 121(10), 4056-69, 2011

Anjani JA, Barthel JS, Bentrem DJ, DAmico TA, Das P, Denlinger CS, Fuchs CS, Gerdes H, Glasgow RE, Hayman, JA, Hofstetter WL, Ilson DH, Keswani RN, Kleinberg LR, Korn WM, Lockhart AC, Mulcahy MF, Orringer MB, Osarogiagbon RU, Posey JA, Sasson AR, Scott WJ, Shibata S, Strong VE, Varghese TK Jr., Warren G, Washington, MK, Willett C, Wright CD. Esophageal and esophagogastric junction cancers. J Natl Compr Canc Netw, 9(8), 830-87, 2011

Peng, D, Belkhiri, A, Hu, T, Chaturvedi, R, Asim, M, Wilson, KT, Zaika, A, El-Rifai, W. Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells. Gut, December 9 , Epub ahead of print, 2011

Singh, K, Chaturvedi, R, Barry, DP, Coburn, LA, Asim, M, Lewis, ND, Piazuelo, MB, Washington, MK, Vitek, MP, Wilson, KT. The apolipoprotein E-mimetic peptide COG112 inhibits NF-kappaB signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis. J Biol Chem, 286(5), 3839-50, 2011

Ray, KC, Bell, KM, Yan, J, Gu, G, Chung, CH, Washington, MK, Means, AL. Epithelial tissues have varying degrees of susceptibility to Kras(G12D)-initiated tumorigenesis in a mouse model. PLoS One, 6(2), e16786, 2011

Dhawan, P, Ahmad, R, Chaturvedi, R, Smith, JJ, Midha, R, Mittal, MK, Krishnan, M, Chen, X, Eschrich, S, Yeatman, TJ, Harris, RC, Washington, MK, Wilson, KT, Beauchamp, RD, Singh, AB. Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation. Oncogene, 30(29), 3234-47, 2011

Soutto, M, Belkhiri, A, Piazuelo, MB, Schneider, BG, Peng, D, Jiang, A, Washington, MK, Kokoye, Y, Crowe, SE, Zaika, A, Correa, P, Peek, RM, El-Rifai, W. Loss of TFF1 is associated with activation of NF-I?B-mediated inflammation and gastric neoplasia in mice and humans. J Clin Invest, 121(5), 1753-67, 2011

Yan, F, Cao, H, Cover, TL, Washington, MK, Shi, Y, Liu, L, Chaturvedi, R, Peek, RM, Wilson, KT, Polk, DB. Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. J Clin Invest, 121(6), 2242-53, 2011

Le Bras, GF, Allison, GL, Richards, NF, Ansari, SS, Washington, MK, Andl, CD. CD44 upregulation in E-cadherin-negative esophageal cancers results in cell invasion. PLoS One, 6(11), e27063, 2011

Rosen, MJ, Frey, MR, Washington, MK, Chaturvedi, R, Kuhnhein, LA, Matta, P, Revetta, FL, Wilson, KT, Polk, DB. STAT6 activation in ulcerative colitis: A new target for prevention of IL-13-induced colon epithelial cell dysfunction. Inflamm Bowel Dis, 2011

Goettel, JA, Scott Algood, HM, Olivares-Villag??mez, D, Washington, MK, Chaturvedi, R, Wilson, KT, Van Kaer, L, Polk, DB. KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-I? production. Gastroenterology, 140(1), 265-74, 2011

Mukherjee, K, Peng, D, Brifkani, Z, Belkhiri, A, Pera, M, Koyama, T, Koehler, EA, Revetta, FL, Washington, MK, El-Rifai, W. Dopamine and cAMP regulated phosphoprotein MW 32 kDa is overexpressed in early stages of gastric tumorigenesis. Surgery, 148(2), 354-63, 2010

Bhaskara, S, Knutson, SK, Jiang, G, Chandrasekharan, MB, Wilson, AJ, Zheng, S, Yenamandra, A, Locke, K, Yuan, JL, Bonine-Summers, AR, Wells, CE, Kaiser, JF, Washington, MK, Zhao, Z, Wagner, FF, Sun, ZW, Xia, F, Holson, EB, Khabele, D, Hiebert, SW. Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell, 18(5), 436-47, 2010

Vangamudi, B, Peng, DF, Cai, Q, El-Rifai, W, Zheng, W, Belkhiri, A. t-DARPP regulates phosphatidylinositol-3-kinase-dependent cell growth in breast cancer. Mol Cancer, 9, 240, 2010

Soutto, M, Peng, D, Razvi, M, Ruemmele, P, Hartmann, A, Roessner, A, Schneider-Stock, R, El-Rifai, W. Epigenetic and genetic silencing of CHFR in esophageal adenocarcinomas. Cancer, 116(17), 4033-42, 2010

Blaine, SA, Ray, KC, Anunobi, R, Gannon, MA, Washington, MK, Means, AL. Adult pancreatic acinar cells give rise to ducts but not endocrine cells in response to growth factor signaling. Development, 137(14), 2289-96, 2010

Smalley-Freed, WG, Efimov, A, Burnett, PE, Short, SP, Davis, MA, Gumucio, DL, Washington, MK, Coffey, RJ, Reynolds, AB. p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice. J Clin Invest, 120(6), 1824-35, 2010

Nagaraj, NS, Smith, JJ, Revetta, F, Washington, MK, Merchant, NB. Targeted Inhibition of Src Kinase Signaling Attenuates Pancreatic Tumorigenesis. Mol Cancer Ther, 9(8), 2322-32, 2010

Washington, MK, Tang, LH, Berlin, J, Branton, PA, Burgart, LJ, Carter, DK, Compton, CC, Fitzgibbons, PL, Frankel, WL, Jessup, JM, Kakar, S, Minsky, B, Nakhleh, RE, , . Protocol for the examination of specimens from patients with neuroendocrine tumors (carcinoid tumors) of the appendix. Arch Pathol Lab Med, 134(2), 171-5, 2010

Washington, MK, Tang, LH, Berlin, J, Branton, PA, Burgart, LJ, Carter, DK, Compton, CC, Fitzgibbons, PL, Frankel, WL, Jessup, JM, Kakar, S, Minsky, B, Nakhleh, RE, , . Protocol for the examination of specimens from patients with neuroendocrine tumors (carcinoid tumors) of the colon and rectum. Arch Pathol Lab Med, 134(2), 176-80, 2010

Washington, MK, Tang, LH, Berlin, J, Branton, PA, Burgart, LJ, Carter, DK, Compton, CC, Fitzgibbons, PL, Frankel, WL, Jessup, JM, Kakar, S, Minsky, B, Nakhleh, RE, , . Protocol for the examination of specimens from patients with neuroendocrine tumors (carcinoid tumors) of the small intestine and ampulla. Arch Pathol Lab Med, 134(2), 181-6, 2010

Schneider, BG, Peng, DF, Camargo, MC, Piazuelo, MB, Sicinschi, LA, Mera, R, Romero-Gallo, J, Delgado, AG, Bravo, LE, Wilson, KT, Peek, RM, Correa, P, El-Rifai, W. Promoter DNA hypermethylation in gastric biopsies from subjects at high and low risk for gastric cancer. Int J Cancer, 127(11), 2588-97, 2010

Washington, MK, Tang, LH, Berlin, J, Branton, PA, Burgart, LJ, Carter, DK, Compton, CC, Fitzgibbons, PL, Frankel, WL, Jessup, JM, Kakar, S, Minsky, B, Nakhleh, RE, , . Protocol for the examination of specimens from patients with neuroendocrine tumors (carcinoid tumors) of the stomach. Arch Pathol Lab Med, 134(2), 187-91, 2010

Vilgelm, AE, Washington, MK, Wei, J, Chen, H, Prassolov, VS, Zaika, AI. Interactions of the p53 protein family in cellular stress response in gastrointestinal tumors. Mol Cancer Ther, 9(3), 693-705, 2010

Washington, MK, Berlin, J, Branton, PA, Burgart, LJ, Carter, DK, Compton, CC, Frankel, WL, Jessup, JM, Kakar, S, Minsky, B, Nakhleh, RE, Vauthey, JN, , . Protocol for the examination of specimens from patients with carcinoma of the intrahepatic bile ducts. Arch Pathol Lab Med, 134(4), e14-8, 2010

Washington, MK, Berlin, J, Branton, PA, Burgart, LJ, Carter, DK, Compton, CC, Fitzgibbons, PL, Frankel, WL, Jessup, JM, Kakar, S, Minsky, B, Nakhleh, RE, Vauthey, JN, , . Protocol for the examination of specimens from patients with carcinoma of the perihilar bile ducts. Arch Pathol Lab Med, 134(4), e19-24, 2010

Washington, MK, Berlin, J, Branton, PA, Burgart, LJ, Carter, DK, Compton, CC, Fitzgibbons, PL, Frankel, WL, Jessup, JM, Kakar, S, Minsky, B, Nakhleh, RE, Vauthey, JN, , . Protocol for the examination of specimens from patients with carcinoma of the distal extrahepatic bile ducts. Arch Pathol Lab Med, 134(4), e8-13, 2010

Miles, S, Piazuelo, MB, Semino-Mora, C, Washington, MK, Dubois, A, Peek, RM, Correa, P, Merrell, DS. Detailed in vivo Analysis of the Role of Helicobacter pylori Fur in Colonization and Disease. Infect Immun, 78(7), 3073-82, 2010

Smith, JJ, Deane, NG, Wu, F, Merchant, NB, Zhang, B, Jiang, A, Lu, P, Johnson, JC, Schmidt, C, Edwards, CM, Eschrich, S, Kis, C, Levy, S, Washington, MK, Heslin, MJ, Coffey, RJ, Yeatman, TJ, Shyr, Y, Beauchamp, RD. Experimentally Derived Metastasis Gene Expression Profile Predicts Recurrence and Death in Patients With Colon Cancer. Gastroenterology, 138 (3), 958-68, 2010

Vilgelm, AE, Hong, SM, Washington, MK, Wei, J, Chen, H, El-Rifai, W, Zaika, A. Characterization of DeltaNp73 expression and regulation in gastric and esophageal tumors. Oncogene, Advance(online), August, 2010

Ogden, SR, Noto, JM, Allen, SS, Patel, DA, Romero-Gallo, J, Washington, MK, Fingleton, B, Israel, DA, Lewis, ND, Wilson, KT, Chaturvedi, R, Zhao, Z, Shyr, Y, Peek, RM. Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice. Cancer Res, 70(1), 30-5, 2010

Vaezi, MF, Slaughter, JC, Smith, BS, Washington, MK, Jerome, WG, Garrett, CG, Hagaman, D, Goutte, M. Dilated intercellular space in chronic laryngitis and gastro-oesophageal reflux disease: at baseline and post-lansoprazole therapy. Aliment Pharmacol Ther, 32(7), 916-24, 2010

Nagaraj, NS, Manning, HC, Revetta, F, Washington, MK, Smith, JJ, Merchant, NB. Oncogenic SRC as a therapeutic target in pancreas cancer. J Surg Res, 158(2), 195-6, 2010

Rich, A, Toro, TZ, Tanksley, J, Fiske, WH, Lind, CD, Ayers, GD, Piessevaux, H, Washington, MK, Coffey, RJ. Distinguishing M??n??trier''s disease from its mimics. Gut, 59(12), 1617-24, 2010

Wei, J, Nagy, TA, Vilgelm, A, Zaika, E, Ogden, SR, Romero-Gallo, J, Piazuelo, MB, Correa, P, Washington, MK, El-Rifai, W, Peek, RM, Zaika, A. Regulation of p53 Tumor Suppressor by Helicobacter pylori in Gastric Epithelial Cells. Gastroenterology, ahead of print(Pub ), Jun 12, 2010

Franco, AT, Friedman, DB, Nagy, TA, Romero-Gallo, J, Krishna, U, Kendall, A, Israel, DA, Tegtmeyer, N, Washington, MK, Peek, RM. Delineation of a carcinogenic Helicobacter pylori proteome. Mol Cell Proteomics, 8(8), 1947-58, 2009

Zhang, H, Ables, ET, Pope, CF, Washington, MK, Hipkens, S, Means, AL, Path, G, Seufert, J, Costa, RH, Leiter, AB, Magnuson, MA, Gannon, M. Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mech Dev, 126(11-12), 958-73, 2009

VanSaun, MN, Lee, IK, Washington, MK, Matrisian, L, Gorden, DL. High fat diet induced hepatic steatosis establishes a permissive microenvironment for colorectal metastases and promotes primary dysplasia in a murine model. Am J Pathol, 175(1), 355-64, 2009

Johnson, EM, Doyle, JD, Wetzel, JD, McClung, RP, Katunuma, N, Chappell, JD, Washington, MK, Dermody, TS. Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis. J Virol, 83(19), 9630-40, 2009

Ray, KC, Blaine, SA, Washington, MK, Braun, AH, Singh, AB, Harris, RC, Harding, PA, Coffey, RJ, Means, AL. Transmembrane and soluble isoforms of heparin-binding epidermal growth factor-like growth factor regulate distinct processes in the pancreas. Gastroenterology, 137(5), 1785-94, 2009

Xu, BJ, Li, J, Beauchamp, RD, Shyr, Y, Li, M, Washington, MK, Yeatman, TJ, Whitehead, RH, Coffey, RJ, Caprioli, RM. Identification of early intestinal neoplasia protein biomarkers using laser capture microdissection and MALDI MS. Mol Cell Proteomics, Epub 2009 Jan 21. 8(5), 936-45, 2009

Fiske, WH, Tanksley, J, Nam, KT, Goldenring, JR, Slebos, RJ, Liebler, DC, Abtahi, AM, La Fleur, B, Ayers, GD, Lind, CD, Washington, MK, Coffey, RJ. Efficacy of cetuximab in the treatment of Menetrier''s disease. Sci Transl Med, 1(8), 8ra18, 2009

Sprung, RW, Brock, JW, Tanksley, JP, Li, M, Washington, MK, Slebos, RJ, Liebler, DC. Equivalence of protein inventories obtained from formalin-fixed paraffin-embedded and frozen tissue in multidimensional liquid chromatography-tandem mass spectrometry shotgun proteomic analysis. Mol Cell Proteomics, 8(8), 1988-98, 2009

Peng, DF, Razvi, M, Chen, H, Washington, K, Roessner, A, Schneider-Stock, R, El-Rifai, W. DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett''s adenocarcinoma. Gut, 58(1), 5-15, 2009

Trobridge, P, Knoblaugh, S, Washington, MK, Munoz, NM, Tsuchiya, KD, Rojas, A, Song, X, Ulrich, CM, Sasazuki, T, Shirasawa, S, Grady, WM. TGF-beta Receptor Inactivation and Mutant Kras Induce Intestinal Neoplasms in Mice via a beta-Catenin-Independent Pathway. Gastroenterology, Epub 2009 Feb 4. 136(5), 1680-8, 2009

Yan, F, Cao, H, Chaturvedi, R, Krishna, U, Hobbs, SS, Dempsey, PJ, Peek, RM, Cover, TL, Washington, MK, Wilson, KT, Polk, DB. Epidermal Growth Factor Receptor Activation Protects Gastric Epithelial Cells From Helicobacter pylori-Induced Apoptosis. Gastroenterology, 136(4), 1297-1307, 2009

Sparks, EE, Huppert, KA, Brown, MA, Washington, MK, Huppert, SS. Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice. Hepatology, 51(4), 1391-400, 2009

Algood, HM, Allen, SS, Washington, MK, Peek, RM, Miller, GG, Cover, TL. Regulation of gastric B cell recruitment is dependent on IL-17 receptor A signaling in a model of chronic bacterial infection. J Immunol, 183(9), 5837-46, 2009

Washington, MK, Berlin, J, Branton, P, Burgart, LJ, Carter, DK, Fitzgibbons, PL, Halling, K, Frankel, W, Jessup, J, Kakar, S, Minsky, B, Nakhleh, R, Compton, CC, , . Protocol for the examination of specimens from patients with primary carcinoma of the colon and rectum. Arch Pathol Lab Med, 133(10), 1539-51, 2009

Boomershine, CS, Chamberlain, A, Kendall, P, Afshar-Sharif, AR, Huang, H, Washington, MK, Lawson, WE, Thomas, JW, Blackwell, TS, Bhowmick, NA. Autoimmune pancreatitis results from loss of TGFbeta signalling in S100A4-positive dendritic cells. Gut, 58(9), 1267-74, 2009

Lee, W, Belkhiri, A, Lockhart, AC, Merchant, N, Glaeser, H, Harris, EI, Washington, MK, Brunt, EM, Zaika, A, Kim, RB, El-Rifai, W. Overexpression of OATP1B3 confers apoptotic resistance in colon cancer. Cancer Res, 68(24), 10315-23, 2008

Manning, HC, Merchant, NB, Foutch, AC, Virostko, JM, Wyatt, SK, Shah, C, McKinley, ET, Xie, J, Mutic, NJ, Washington, MK, LaFleur, B, Tantawy, MN, Peterson, TE, Ansari, MS, Baldwin, RM, Rothenberg, ML, Bornhop, DJ, Gore, JC, Coffey, RJ. Molecular imaging of therapeutic response to epidermal growth factor receptor blockade in colorectal cancer. Clin Cancer Res, 14(22), 7413-22, 2008

Edgerton, ME, Morrison, C, Livolsi, VA, Moskaluk, CA, Qualman, SJ, Washington, MK, Grizzle, WE. A Standards based Ontological Approach to Information Handling for use by Organizations Providing Human Tissue for Research. Cancer Inform, 6, 127-37, 2008

Ajani, JA, Barthel, JS, Bekaii-Saab, T, Bentrem, DJ, D'Amico, TA, Fuchs, CS, Gerdes, H, Hayman, JA, Hazard, L, Ilson, DH, Kleinberg, LR, McAleer, MF, Meropol, NJ, Mulcahy, MF, Orringer, MB, Osarogiagbon, RU, Posey, JA, Sasson, AR, Scott, WJ, Shibata, S, Strong, VE, Swisher, SG, Washington, MK, Willett, C, Wood, DE, Wright, CD, Yang, G . Esophageal cancer. J Natl Compr Canc Netw, 6(9), 818-49, 2008

Dar, AA, Zaika, A, Piazuelo, MB, Correa, P, Koyama, T, Belkhiri, A, Washington, K, Castells, A, Pera, M, El-Rifai, W. Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions. Cancer, 112(8), 1688-98, 2008

Marcellin, P, Heathcote, EJ, Buti, M, Gane, E, de Man, RA, Krastev, Z, Germanidis, G, Lee, SS, Flisiak, R, Kaita, K, Manns, M, Kotzev, I, Tchernev, K, Buggisch, P, Weilert, F, Kurdas, OO, Shiffman, ML, Trinh, H, Washington, MK, Sorbel, J, Anderson, J, Snow-Lampart, A, Mondou, E, Quinn, J, Rousseau, F. Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B. N Engl J Med, 359(23), 2442-55, 2008

Peng, D, Sheta, EA, Powell, SM, Moskaluk, CA, Washington, K, Goldknopf, IL, El-Rifai, W. Alterations in Barrett''s-related adenocarcinomas: a proteomic approach. Int J Cancer, 122(6), 1303-10, 2008

Edelblum, KL, Washington, MK, Koyama, T, Robine, S, Baccarini, M, Polk, DB. Raf protects against colitis by promoting mouse colon epithelial cell survival through NF-kappaB. Gastroenterology, 135(2), 539-51, 2008

Vilgelm, A, Wei, JX, Piazuelo, MB, Washington, MK, Prassolov, V, El-Rifai, W, Zaika, A. DeltaNp73alpha regulates MDR1 expression by inhibiting p53 function. Oncogene, 27(15), 2170-6, 2008

Romero-Gallo, J, Harris, EJ, Krishna, U, Washington, MK, Perez-Perez, GI, Peek, RM. Effect of Helicobacter pylori eradication on gastric carcinogenesis. Lab Invest, 88(3), 328-36, 2008

Merchant, NB, Voskresensky, I, Rogers, CM, Lafleur, B, Dempsey, PJ, Graves-Deal, R, Revetta, F, Foutch, AC, Rothenberg, ML, Washington, MK, Coffey, RJ. TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer. Clin Cancer Res, 14(4), 1182-91, 2008

Wei, J, O''Brien, D, Vilgelm, A, Piazuelo, MB, Correa, P, Washington, MK, El-Rifai, W, Peek, RM, Zaika, A. Interaction of Helicobacter pylori with gastric epithelial cells is mediated by the p53 protein family. Gastroenterology, 134(5), 1412-23, 2008

Thompson, BJ, Washington, MK, Kurre, U, Singh, M, Rula, EY, Emeson, RB. Protective roles of alpha-calcitonin and beta-calcitonin gene-related peptide in spontaneous and experimentally induced colitis. Dig Dis Sci, 53(1), 229-41, 2008

Cates, JM, Byrd, RH, Fohn, LE, Tatsas, AD, Washington, MK, Black, CC. Epithelial-Mesenchymal Transition Markers in Pancreatic Ductal Adenocarcinoma. Pancreas, 38(1), e1-6, 2008

Harris, EI, Lewin, DN, Wang, HL, Lauwers, GY, Srivastava, A, Shyr, Y, Shakhtour, B, Revetta, F, Washington, MK. Lymphovascular Invasion in Colorectal Cancer: An Interobserver Variability Study. Am J Surg Pathol, 32(12), 1816-21, 2008

Washington, MK. Colorectal carcinoma: selected issues in pathologic examination and staging and determination of prognostic factors. Arch Pathol Lab Med, 132(10), 1600-7, 2008

Grady, WM, Parkin, RK, Mitchell, PS, Lee, JH, Kim, YH, Tsuchiya, KD, Washington, MK, Paraskeva, C, Willson, JK, Kaz, AM, Kroh, EM, Allen, A, Fritz, BR, Markowitz, SD, Tewari, M. Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer. Oncogene, 27(27), 3880-8, 2008

Belkhiri, A, Dar, AA, Peng, DF, Razvi, MH, Rinehart, C, Arteaga, CL, El-Rifai, W. Expression of t-DARPP mediates trastuzumab resistance in breast cancer cells. Clin Cancer Res, 14(14), 4564-71, 2008

Washington, MK, Berlin, J, Branton, PA, Burgart, LJ, Carter, DK, Fitzgibbons, PL, Frankel, WL, Jessup, JM, Kakar, S, Minsky, B, Nakhleh, RE, Compton, CC . Protocol for the examination of specimens from patients with primary carcinomas of the colon and rectum. Arch Pathol Lab Med, 132(7), 1182-93, 2008

Farmer, TE, Williams, CS, Washington, MK, Hiebert, SW. Inactivation of the p19(ARF) tumor suppressor affects intestinal epithelial cell proliferation and integrity. J Cell Biochem, 104(6), 2228-40, 2008

Rojas, A, Meherem, S, Kim, YH, Washington, MK, Willis, JE, Markowitz, SD, Grady, WM. The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer. Int J Cancer, 123(1), 14-21, 2008

M''Koma, AE, Wise, PE, Muldoon, RL, Schwartz, DA, Washington, MK, Herline, AJ. Evolution of the restorative proctocolectomy and its effects on gastrointestinal hormones. Int J Colorectal Dis, 22(10), 1143-63, 2007

Yan, F, Cao, H, Cover, TL, Whitehead, R, Washington, MK, Polk, DB. Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth. Gastroenterology, 132(2), 562-75, 2007

Finegold, MJ, Lopez-Terrada, DH, Bowen, J, Washington, MK, Qualman, SJ. Protocol for the examination of specimens from pediatric patients with hepatoblastoma. Arch Pathol Lab Med, 131(4), 520-9, 2007

Bamborough, P, Angell, RM, Bhamra, I, Brown, D, Bull, J, Christopher, JA, Cooper, AW, Fazal, LH, Giordano, I, Hind, L, Patel, VK, Ranshaw, LE, Sims, MJ, Skone, PA, Smith, KJ, Vickerstaff, E, Washington, M. N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics. Bioorg Med Chem Lett, 17(15), 4363-8, 2007

Felts, AS, Ji, C, Stafford, JB, Crews, BC, Kingsley, PJ, Rouzer, CA, Washington, MK, Subbaramaiah, K, Siegel, BS, Young, SM, Dannenberg, AJ, Marnett, LJ. Desmethyl derivatives of indomethacin and sulindac as probes for cyclooxygenase-dependent biology. ACS Chem Biol, 2(7), 479-83, 2007

Shao, J, Washington, MK, Saxena, R, Sheng, H. Heterozygous disruption of the PTEN promotes intestinal neoplasia in APCmin/+ mouse: roles of osteopontin. Carcinogenesis, 28(12), 2476-83, 2007

Coffey, RJ, Washington, MK, Corless, CL, Heinrich, MC. Menetrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach. J Clin Invest, 117(1), 70-80, 2007

Deane, NG, Manning, HC, Foutch, AC, Washington, MK, Aronow, BJ, Aronow, BA, Bornhop, DJ, Coffey, RJ. Targeted imaging of colonic tumors in smad3-/- mice discriminates cancer and inflammation. Mol Cancer Res, 5(4), 341-9, 2007

Washington, MK. Autoimmune liver disease: overlap and outliers. Mod Pathol, 20 Suppl 1, S15-30, 2007

Barnes, SL, Lyshchik, A, Washington, MK, Gore, JC, Miga, MI. Development of a mechanical testing assay for fibrotic murine liver. Med Phys, 34(11), 4439-50, 2007

Razvi, MH, Peng, D, Dar, AA, Powell, SM, Frierson, HF, Moskaluk, CA, Washington, K, El-Rifai, W. Transcriptional oncogenomic hot spots in Barrett''s adenocarcinomas: serial analysis of gene expression. Genes Chromosomes Cancer, 46(10), 914-28, 2007

Li, JQ, Xu, BJ, Shakhtour, B, Deane, N, Merchant, N, Heslin, MJ, Washington, K, Coffey, RJ, Beauchamp, RD, Shyr, Y, Billheimer, D. Variability of in situ proteomic profiling and implications for study design in colorectal tumors. Int J Oncol, 31(1), 103-11, 2007

Shiou, SR, Singh, AB, Moorthy, K, Datta, PK, Washington, MK, Beauchamp, RD, Dhawan, P. Smad4 regulates claudin-1 expression in a transforming growth factor-beta-independent manner in colon cancer cells. Cancer Res, 67(4), 1571-9, 2007

Su, Y, Shrubsole, MJ, Ness, RM, Cai, Q, Kataoka, N, Washington, K, Zheng, W. Immunohistochemical expressions of Ki-67, cyclin D1, beta-catenin, cyclooxygenase-2, and epidermal growth factor receptor in human colorectal adenoma: a validation study of tissue microarrays. Cancer Epidemiol Biomarkers Prev, 15(9), 1719-26, 2006

Ye, C, Shrubsole, MJ, Cai, Q, Ness, R, Grady, WM, Smalley, W, Cai, H, Washington, K, Zheng, W. Promoter methylation status of the MGMT, hMLH1, and CDKN2A/p16 genes in non-neoplastic mucosa of patients with and without colorectal adenomas. Oncol Rep, 16(2), 429-35, 2006

Welch, DC, Wirth, PS, Goldenring, JR, Ness, E, Jagasia, M, Washington, K. Gastric graft-versus-host disease revisited: does proton pump inhibitor therapy affect endoscopic gastric biopsy interpretation. Am J Surg Pathol, 30(4), 444-9, 2006

Smith, LH, Dixon, JD, Stringham, JR, Eren, M, Elokdah, H, Crandall, DL, Washington, K, Vaughan, DE. Pivotal role of PAI-1 in a murine model of hepatic vein thrombosis. Blood, 107(1), 132-4, 2006

Washington K. Hepatic iron deposition: new observations in non-HFE hemochromatosis. Advances in Anatomic Pathology, 13(6), 341-2, 2006

Lee, OJ, Hong, SM, Razvi, MH, Peng, D, Powell, SM, Smoklin, M, Moskaluk, CA, El-Rifai, W. Expression of calcium-binding proteins S100A2 and S100A4 in Barrett''s adenocarcinomas. Neoplasia, 8(10), 843-50, 2006

Kim, YH, Petko, Z, Dzieciatkowski, S, Lin, L, Ghiassi, M, Stain, S, Chapman, WC, Washington, MK, Willis, J, Markowitz, SD, Grady, WM. CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer. Genes Chromosomes Cancer, 45(8), 781-9, 2006

Gray, KD, Ballard, BR, Washington, MK, Belue, R, Grady, WM, Chapman, WC, Stain, SC. Do adverse histopathologic findings in colorectal cancer patients explain disparate outcomes. J Natl Med Assoc, 98(3), 348-51, 2006

Lim, SG, Ng, TM, Kung, N, Krastev, Z, Volfova, M, Husa, P, Lee, SS, Chan, S, Shiffman, ML, Washington, MK, Rigney, A, Anderson, J, Mondou, E, Snow, A, Sorbel, J, Guan, R, Rousseau, F . A double-blind placebo-controlled study of emtricitabine in chronic hepatitis B. Arch Intern Med, 166(1), 49-56, 2006

Shulman, HM, Kleiner, D, Lee, SJ, Morton, T, Pavletic, SZ, Farmer, E, Moresi, JM, Greenson, J, Janin, A, Martin, PJ, McDonald, G, Flowers, ME, Turner, M, Atkinson, J, Lefkowitch, J, Washington, MK, Prieto, VG, Kim, SK, Argenyi, Z, Diwan, AH, Rashid, A, Hiatt, K, Couriel, D, Schultz, K, Hymes, S, Vogelsang, GB. Histopathologic diagnosis of chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. Pathology Working Group Report. Biol Blood Marrow Transplant, 12(1), 31-47, 2006

Martinez, JA, Williams, CS, Amann, JM, Ellis, TC, Moreno-Miralles, I, Washington, MK, Gregoli, P, Hiebert, SW. Deletion of Mtgr1 sensitizes the colonic epithelium to dextran sodium sulfate-induced colitis. Gastroenterology, 131(2), 579-88, 2006

Halder, SK, Anumanthan, G, Maddula, R, Mann, J, Chytil, A, Gonzalez, AL, Washington, MK, Moses, HL, Beauchamp, RD, Datta, PK. Oncogenic function of a novel WD-domain protein, STRAP, in human carcinogenesis. Cancer Res, 66(12), 6156-66, 2006

Johnson, JC, Schmidt, CR, Shrubsole, MJ, Billheimer, DD, Joshi, PR, Morrow, JD, Heslin, MJ, Washington, MK, Ness, RM, Zheng, W, Schwartz, DA, Coffey, RJ, Beauchamp, RD, Merchant, NB. Urine PGE-M: A metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia. Clin Gastroenterol Hepatol, 4(11), 1358-65, 2006

Leys, CM, Nomura, S, Rudzinski, E, Kaminishi, M, Montgomery, E, Washington, MK, Goldenring, JR. Expression of Pdx-1 in human gastric metaplasia and gastric adenocarcinoma. Hum Pathol, 37(9), 1162-8, 2006

Munoz, NM, Upton, M, Rojas, A, Washington, MK, Lin, L, Chytil, A, Sozmen, EG, Madison, BB, Pozzi, A, Moon, RT, Moses, HL, Grady, WM. Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. Cancer Res, 66(20), 9837-44, 2006

Settle, SH, Washington, K, Lind, C, Itzkowitz, S, Fiske, WH, Burdick, JS, Jerome, WG, Ray, M, Weinstein, W, Coffey, RJ. Chronic treatment of M??n??trier''s disease with Erbitux: clinical efficacy and insight into pathophysiology. Clin Gastroenterol Hepatol, 3(7), 654-9, 2005

Washington, K. Update on post-liver transplantation infections, malignancies, and surgical complications. Adv Anat Pathol, 12(4), 221-6, 2005

Rothenberg, ML, LaFleur, B, Levy, DE, Washington, MK, Morgan-Meadows, SL, Ramanathan, RK, Berlin, JD, Benson, AB, Coffey, RJ. Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma. J Clin Oncol, 23(36), 9265-74, 2005

Hansel, DE, Dhara, S, Huang, RC, Ashfaq, R, Deasel, M, Shimada, Y, Bernstein, HS, Harmon, J, Brock, M, Forastiere, A, Washington, MK, Maitra, A, Montgomery, E. CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug target. Am J Surg Pathol, 29(3), 390-9, 2005

Huang, W, Zhang, J, Washington, M, Liu, J, Parant, JM, Lozano, G, Moore, DD. Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor. Mol Endocrinol, 19(6), 1646-53, 2005

Thliveris, AT, Halberg, RB, Clipson, L, Dove, WF, Sullivan, R, Washington, MK, Stanhope, S, Newton, MA. Polyclonality of familial murine adenomas: analyses of mouse chimeras with low tumor multiplicity suggest short-range interactions. Proc Natl Acad Sci U S A, 102(19), 6960-5, 2005

Robert, ME, Washington, MK, Lee, JR, Goldenring, JR, Bronner, MP, Goldblum, JR, Greenson, JK, Haber, MM, Hart, JA, Lamps, LW, Lauwers, GY, Lewin, D, Lazenby, AJ, Montgomery, E, Crawford, JM. Rab11a immunohistochemical analysis does not distinguish indefinite, low-, and high-grade dysplasia in Barrett esophagus. Am J Clin Pathol, 124(4), 519-27, 2005

Bao, P, Welch, DC, Washington, MK, Herline, AJ. Resection of mesenteric inflammatory veno-occlusive disease causing ischemic colitis. J Gastrointest Surg, 9(6), 812-7, 2005

Franco, AT, Israel, DA, Washington, MK, Krishna, U, Fox, JG, Rogers, AB, Neish, AS, Collier-Hyams, L, Perez-Perez, GI, Hatakeyama, M, Whitehead, R, Gaus, K, O''Brien, DP, Romero-Gallo, J, Peek, RM. Activation of beta-catenin by carcinogenic Helicobacter pylori. Proc Natl Acad Sci U S A, 102(30), 10646-51, 2005

Park, YK, Franklin, JL, Settle, SH, Levy, SE, Chung, E, Jeyakumar, LH, Shyr, Y, Washington, MK, Whitehead, RH, Aronow, BJ, Coffey, RJ. Gene expression profile analysis of mouse colon embryonic development. Genesis, 41(1), 1-12, 2005

Petko, Z, Ghiassi, M, Shuber, A, Gorham, J, Smalley, W, Washington, MK, Schultenover, S, Gautam, S, Markowitz, SD, Grady, WM. Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps. Clin Cancer Res, 11(3), 1203-9, 2005

Amann, JM, Chyla, BJ, Ellis, TC, Martinez, A, Moore, AC, Franklin, JL, McGhee, L, Meyers, S, Ohm, JE, Luce, KS, Ouelette, AJ, Washington, MK, Thompson, MA, King, D, Gautam, S, Coffey, RJ, Whitehead, RH, Hiebert, SW. Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine. Mol Cell Biol, 25(21), 9576-85, 2005

Dhawan, P, Singh, AB, Deane, NG, No, Y, Shiou, SR, Schmidt, C, Neff, J, Washington, MK, Beauchamp, RD. Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer. J Clin Invest, 115(7), 1765-76, 2005

Thomas, KT, Welch, D, Trueblood, A, Sulur, P, Wise, P, Gorden, DL, Chari, RS, Wright, JK, Washington, K, Pinson, CW. Effective treatment of biliary cystadenoma. Ann Surg, 241(5), 769-73; discussion 773-5, 2005

Buttemere, CR, Chari, RS, Anderson, CD, Washington, MK, Mahadevan-Jansen, A, Lin, WC. In vivo assessment of thermal damage in the liver using optical spectroscopy. J Biomed Opt, 9(5), 1018-27, 2004

Scoggins, C, Moore, D, Washington, K, Wright, J, Chari, R. Supra-elevated CA 19-9 in a benign hepatic cyst adenoma. HPB (Oxford), 6(1), 43-4, 2004

Anderson, CD, Lin, WC, Buttemere, CR, Washington, MK, Mahadevan-Jansen, A, Pierce, J, Nicoud, IB, Pinson, CW, Chari, RS. Real-time spectroscopic assessment of thermal damage: implications for radiofrequency ablation. J Gastrointest Surg, 8(6), 660-9, 2004

Biswas, S, Chytil, A, Washington, K, Romero-Gallo, J, Gorska, AE, Wirth, PS, Gautam, S, Moses, HL, Grady, WM. Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer. Cancer Res, 64(14), 4687-92, 2004

Stack, E, Washington, K, Avant, GR, Eisen, GM. Cytomegalovirus enteritis in common variable immunodeficiency. South Med J, 97(1), 96-101, 2004

Deane, NG, Lee, H, Hamaamen, J, Ruley, A, Washington, MK, LaFleur, B, Thorgeirsson, SS, Price, R, Beauchamp, RD. Enhanced tumor formation in cyclin D1 x transforming growth factor beta1 double transgenic mice with characterization by magnetic resonance imaging. Cancer Res, 64(4), 1315-22, 2004

Bhowmick, NA, Chytil, A, Plieth, D, Gorska, AE, Dumont, N, Shappell, S, Washington, MK, Neilson, EG, Moses, HL. TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science, 303(5659), 848-51, 2004

Qualman, SJ, France, M, Grizzle, WE, LiVolsi, VA, Moskaluk, CA, Ramirez, NC, Washington, MK. Establishing a tumour bank: banking, informatics and ethics. Br J Cancer, 90(6), 1115-9, 2004

Yan, F, John, SK, Wilson, G, Jones, DS, Washington, MK, Polk, DB. Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation. J Clin Invest, 114(9), 1272-80, 2004

Barton, ES, Youree, BE, Ebert, DH, Forrest, JC, Connolly, JL, Valyi-Nagy, T, Washington, K, Wetzel, JD, Dermody, TS. Utilization of sialic acid as a coreceptor is required for reovirus-induced biliary disease. J Clin Invest, 111(12), 1823-33, 2003

Gray, KD, Simovic, MO, Chapman, WC, Blackwell, TS, Christman, JW, Washington, MK, Yull, FE, Jaffal, N, Jansen, ED, Gautman, S, Stain, SC. Systemic nf-kappaB activation in a transgenic mouse model of acute pancreatitis. J Surg Res, 110(1), 310-4, 2003

Wudel, LJ, Delbeke, D, Morris, D, Rice, M, Washington, MK, Shyr, Y, Pinson, CW, Chapman, WC. The role of [18F]fluorodeoxyglucose positron emission tomography imaging in the evaluation of hepatocellular carcinoma. Am Surg, 69(2), 117-24; discussion 124-6, 2003

Rice, PL, Washington, M, Schleman, S, Beard, KS, Driggers, LJ, Ahnen, DJ. Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells. Cancer Res, 63(3), 616-20, 2003

Limitations of histopathology in distinguishing high grade dysplasia and early adenocarcinoma in Barretts esophagus: an interobserver agreement study. Washington K. Evidence Based Gastroenterology , 4, 37-38, 2003

Crawford, HC, Krishna, US, Israel, DA, Matrisian, LM, Washington, MK, Peek, RM. Helicobacter pylori strain-selective induction of matrix metalloproteinase-7 in vitro and within gastric mucosa. Gastroenterology, 125(4), 1125-36, 2003

Wudel, LJ, Allos, TM, Washington, MK, Sheller, JR, Chapman, WC. Multi-organ inflammation after hepatic cryoablation in BALB/c mice. J Surg Res, 112(2), 131-7, 2003

Schmidt, CR, Washington, MK, Gi, YJ, Coffey, RJ, Beauchamp, RD, Pearson, AS. Dysregulation of E-cadherin by oncogenic Ras in intestinal epithelial cells is blocked by inhibiting MAP kinase. Am J Surg, 186(5), 426-30, 2003

Sotomayor, RE, Washington, M, Nguyen, L, Nyang''anyi, R, Hinton, DM, Chou, M. Effects of intermittent exposure to aflatoxin B1 on DNA and RNA adduct formation in rat liver: dose-response and temporal patterns. Toxicol Sci, 73(2), 329-38, 2003

Parker, MA, Deane, NG, Thompson, EA, Whitehead, RH, Mithani, SK, Washington, MK, Datta, PK, Dixon, DA, Beauchamp, RD. Over-expression of cyclin D1 regulates Cdk4 protein synthesis. Cell Prolif, 36(6), 347-60, 2003

Means, AL, Ray, KC, Singh, AB, Washington, MK, Whitehead, RH, Harris, RC, Wright, CV, Coffey, RJ, Leach, SD. Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia. Gastroenterology, 124(4), 1020-36, 2003

Koay, MA, Gao, X, Washington, MK, Parman, KS, Sadikot, RT, Blackwell, TS, Christman, JW. Macrophages are necessary for maximal nuclear factor-kappa B activation in response to endotoxin. Am J Respir Cell Mol Biol, 26(5), 572-8, 2002

Wise, PE, Wudel, LJ, Belous, AE, Allos, TM, Kuhn, SJ, Feurer, ID, Washington, MK, Pinson, CW, Chapman, WC. Biliary reconstruction is enhanced with a collagen-polyethylene glycol sealant. Am Surg, 68(6), 553-61; discussion 561-2, 2002

Crawford, HC, Scoggins, CR, Washington, MK, Matrisian, LM, Leach, SD. Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas. J Clin Invest, 109(11), 1437-44, 2002

Roberts, RB, Min, L, Washington, MK, Olsen, SJ, Settle, SH, Coffey, RJ, Threadgill, DW. Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. Proc Natl Acad Sci U S A, 99(3), 1521-6, 2002

Washington, K, Greenson, JK, Montgomery, E, Shyr, Y, Crissinger, KD, Polk, DB, Barnard, J, Lauwers, GY. Histopathology of ulcerative colitis in initial rectal biopsy in children. Am J Surg Pathol, 26(11), 1441-9, 2002

Washington, K. Autoimmune cholangitis: not just AMA-negative primary biliary cirrhosis. Adv Anat Pathol, 9(4), 244-50, 2002

Washington K. Autoimmune cholangitis: not just AMA-negative primary biliary cirrhosis. Commentary on Autoimmune cholangitis within the spectrum of autoimmune liver disease. Czaja A.J., Carpenter H.A., Santrach P.J., Moore S.B., Hepatology, 2000, 31: 1231-1238. Advances in Anatomic Pathology, 9(6), 244-250, 2002

Washington K. Solid-pseudopapillary tumor of the pancreas: challenges presented by an unusual pancreatic neoplasm. Annals Surg Oncol, 9, 3-4, 2002

Wise, PE, Shi, YY, Washington, MK, Chapman, WC, Wright, JK, Sharp, KW, Pinson, CW. Radical resection improves survival for patients with pT2 gallbladder carcinoma. Am Surg, 67(11), 1041-7, 2001

, 2001

Washington, K, Debelak, JP, Gobbell, C, Sztipanovits, DR, Shyr, Y, Olson, S, Chapman, WC. Hepatic cryoablation-induced acute lung injury: histopathologic findings. J Surg Res, 95(1), 1-7, 2001

Deane, NG, Parker, MA, Aramandla, R, Diehl, L, Lee, WJ, Washington, MK, Nanney, LB, Shyr, Y, Beauchamp, RD. Hepatocellular carcinoma results from chronic cyclin D1 overexpression in transgenic mice. Cancer Res, 61(14), 5389-95, 2001

Williams, CS, Sheng, H, Brockman, JA, Armandla, R, Shao, J, Washington, MK, Elkahloun, AG, DuBois, RN. A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts. Neoplasia, 3(5), 428-36, 2001

Kong, FM, Anscher, MS, Sporn, TA, Washington, MK, Clough, R, Barcellos-Hoff, MH, Jirtle, RL. Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor (M6P/IGF2R) locus predisposes patients to radiation-induced lung injury. Int J Radiat Oncol Biol Phys, 49(1), 35-41, 2001

Wolfe, SG, Chey, WY, Washington, MK, Harding, J, Heath, AT, McSorley, DJ, Dukes, GE, Hunt, CM. Tolerability and safety of alosetron during long-term administration in female and male irritable bowel syndrome patients. Am J Gastroenterol, 96(3), 803-11, 2001

Sheng, H, Shao, J, Washington, MK, DuBois, RN. Prostaglandin E2 increases growth and motility of colorectal carcinoma cells. J Biol Chem, 276(21), 18075-81, 2001

Chapman, WC, Debelak, JP, Wright Pinson, C, Washington, MK, Atkinson, JB, Venkatakrishnan, A, Blackwell, TS, Christman, JW. Hepatic cryoablation, but not radiofrequency ablation, results in lung inflammation. Ann Surg, 231(5), 752-61, 2000

Shattuck-Brandt, RL, Varilek, GW, Radhika, A, Yang, F, Washington, MK, DuBois, RN. Cyclooxygenase 2 expression is increased in the stroma of colon carcinomas from IL-10(-/-) mice. Gastroenterology, 118(2), 337-45, 2000

Washington, K, Wright, K, Shyr, Y, Hunter, EB, Olson, S, Raiford, DS. Hepatic stellate cell activation in nonalcoholic steatohepatitis and fatty liver. Hum Pathol, 31(7), 822-8, 2000

Lamps, LW, Gray, GF, Dilday, BR, Washington, MK. The coexistence of low-grade mucinous neoplasms of the appendix and appendiceal diverticula: a possible role in the pathogenesis of pseudomyxoma peritonei. Mod Pathol, 13(5), 495-501, 2000

Kong, FM, Anscher, MS, Washington, MK, Killian, JK, Jirtle, RL. M6P/IGF2R is mutated in squamous cell carcinoma of the lung. Oncogene, 19(12), 1572-8, 2000

Song, SY, Gannon, M, Washington, MK, Scoggins, CR, Meszoely, IM, Goldenring, JR, Marino, CR, Sandgren, EP, Coffey, RJ, Wright, CV, Leach, SD. Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha. Gastroenterology, 117(6), 1416-26, 1999

Stutts, JT, Washington, K, Barnard, JA. Cholestatic jaundice with skin desquamation in a 12-year-old girl. J Pediatr, 134(5), 649-53, 1999

Shao, J, Sheng, H, Aramandla, R, Pereira, MA, Lubet, RA, Hawk, E, Grogan, L, Kirsch, IR, Washington, MK, Beauchamp, RD, DuBois, RN. Coordinate regulation of cyclooxygenase-2 and TGF-beta1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors. Carcinogenesis, 20(2), 185-91, 1999

Lamps, LW, Carson, K, Bradley, AL, Pinson, CW, Johnson, JE, Coogan, AC, Hunter, EB, Clavien, PA, Washington, MK. Pulmonary vascular morphological changes in cirrhotic patients undergoing liver transplantation. Liver Transpl Surg, 5(1), 57-64, 1999

Blackwell, TS, Debelak, JP, Venkatakrishnan, A, Schot, DJ, Harley, DH, Pinson, CW, Williams, P, Washington, K, Christman, JW, Chapman, WC. Acute lung injury after hepatic cryoablation: correlation with NF-kappa B activation and cytokine production. Surgery, 126(3), 518-26, 1999

Taga, SA, Washington, MK, Terrault, N, Wright, TL, Somberg, KA, Ferrell, LD. Cholestatic hepatitis C in liver allografts. Liver Transpl Surg, 4(4), 304-10, 1998

Lamps, LW, Hunt, CM, Green, A, Gray, GF, Washington, K. Alterations in colonic mucosal vessels in patients with cirrhosis and noncirrhotic portal hypertension. Hum Pathol, 29(5), 527-35, 1998

Yan, HP, Carter, CE, Wang, EZ, Page, DL, Washington, K, Wamil, BD, Yakes, FM, Thurman, GB, Hellerqvist, CG. Functional studies on the anti-pathoangiogenic properties of CM101. Angiogenesis, 2(3), 219-33, 1998

Sheng, H, Shao, J, Williams, CS, Pereira, MA, Taketo, MM, Oshima, M, Reynolds, AB, Washington, MK, DuBois, RN, Beauchamp, RD. Nuclear translocation of beta-catenin in hereditary and carcinogen-induced intestinal adenomas. Carcinogenesis, 19(4), 543-9, 1998

Chapman, WC, Fisk, J, Schot, D, Debelak, JP, Washington, MK, Bluth, RF, Pierce, D, Williams, LF. Establishment and characterization of primary gallbladder epithelial cell cultures in the prairie dog. J Surg Res, 80(1), 35-43, 1998

Lamps, LW, Pinson, CW, Raiford, DS, Shyr, Y, Scott, MA, Washington, MK. The significance of microabscesses in liver transplant biopsies: a clinicopathological study. Hepatology, 28(6), 1532-7, 1998

Roselli, HT, Su, M, Washington, K, Kerins, DM, Vaughan, DE, Russell, WE. Liver regeneration is transiently impaired in urokinase-deficient mice. Am J Physiol, 275(6 Pt 1), G1472-9, 1998

Washington, K, Chiappori, A, Hamilton, K, Shyr, Y, Blanke, C, Johnson, D, Sawyers, J, Beauchamp, D. Expression of beta-catenin, alpha-catenin, and E-cadherin in Barrett''s esophagus and esophageal adenocarcinomas. Mod Pathol, 11(9), 805-13, 1998

Washington, K, Bentley, RC, Green, A, Olson, J, Treem, WR, Krigman, HR. Gastric graft-versus-host disease: a blinded histologic study. Am J Surg Pathol, 21(9), 1037-46, 1997

Carson, K, Washington, MK, Treem, WR, Clavien, PA, Hunt, CM. Recurrence of nonalcoholic steatohepatitis in a liver transplant recipient. Liver Transpl Surg, 3(2), 174-6, 1997

McCauley, J, Irish, W, Thompson, L, Stevenson, J, Lockett, R, Bussard, R, Washington, M. Factors determining the rate of referral, transplantation, and survival on dialysis in women with ESRD. Am J Kidney Dis, 30(6), 739-48, 1997

Gao, W, Washington, MK, Bentley, RC, Clavien, PA. Antiangiogenic agents protect liver sinusoidal lining cells from cold preservation injury in rat liver transplantation. Gastroenterology, 113(5), 1692-700, 1997

Washington, K, Clavien, PA, Killenberg, P. Peribiliary vascular plexus in primary sclerosing cholangitis and primary biliary cirrhosis. Hum Pathol, 28(7), 791-5, 1997

Mergener, K, Washington, MK, Pappas, TN, Sharara, AI. Benign gastric ulcer masquerading as a submucosal tumor. Endoscopy, 29(4), 331, 1997

Bodily, K, Perfect, JR, Procop, G, Washington, MK, Affronti, J. Small intestinal histoplasmosis: successful treatment with itraconazole in an immunocompetent host. Gastrointest Endosc, 43(5), 518-21, 1996

Clavien, PA, Camargo, CA, Gorczynski, R, Washington, MK, Levy, GA, Langer, B, Greig, PD. Acute reactant cytokines and neutrophil adhesion after warm ischemia in cirrhotic and noncirrhotic human livers. Hepatology, 23(6), 1456-63, 1996

Clavien, PA, Camargo, CA, Cameron, R, Washington, MK, Phillips, MJ, Greig, PD, Levy, GA. Kupffer cell erythrophagocytosis and graft-versus-host hemolysis in liver transplantation. Gastroenterology, 110(6), 1891-6, 1996

Mantyh, CR, Pappas, TN, Lapp, JA, Washington, MK, Neville, LM, Ghilardi, JR, Rogers, SD, Mantyh, PW, Vigna, SR. Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum. Gastroenterology, 111(5), 1272-80, 1996

Procop, GW, Harrell, LJ, Washington, MK, Owen, CH, Pappas, TN. Pericolic abscess due to Streptococcus pyogenes: report of a case that clinically mimicked acute cholecystitis. Clin Infect Dis, 23(1), 182-3, 1996

Kong, FM, Washington, MK, Jirtle, RL, Anscher, MS. Plasma transforming growth factor-beta 1 reflects disease status in patients with lung cancer after radiotherapy: a possible tumor marker. Lung Cancer, 16(1), 47-59, 1996

Camargo, CA, Washington, MK, Fitz, JG, Clavien, PA. Adult presentation of diffuse bile duct stenosis: therapy with liver transplantation. Liver Transpl Surg, 2(3), 235-7, 1996

Telen, MJ, Udani, M, Washington, MK, Levesque, MC, Lloyd, E, Rao, N. A blood group-related polymorphism of CD44 abolishes a hyaluronan-binding consensus sequence without preventing hyaluronan binding. J Biol Chem, 271(12), 7147-53, 1996

Caniza, MA, Granger, DL, Wilson, KH, Washington, MK, Kordick, DL, Frush, DP, Blitchington, RB. Bartonella henselae: etiology of pulmonary nodules in a patient with depressed cell-mediated immunity. Clin Infect Dis, 20(6), 1505-11, 1995

De Souza, AT, Hankins, GR, Washington, MK, Orton, TC, Jirtle, RL. M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity. Nat Genet, 11(4), 447-9, 1995

De Souza, AT, Hankins, GR, Washington, MK, Fine, RL, Orton, TC, Jirtle, RL. Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors. Oncogene, 10(9), 1725-9, 1995

Boockvar, KS, Granger, DL, Poston, RM, Maybodi, M, Washington, MK, Hibbs, JB, Kurlander, RL. Nitric oxide produced during murine listeriosis is protective. Infect Immun, 62(3), 1089-100, 1994

Eisen, GM, Schutz, SM, Washington, MK, Burton, CS, Sidhu-Malik, N, Wilson, JA. Atypical presentation of inflammatory bowel disease in the elderly. Am J Gastroenterol, 88(12), 2098-101, 1993

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