Department of Pathology, Microbiology, and Immunology



   Pelayo Correa, M.D. 




Dept of Medicine

Anne Potter Wilson Professor of Cancer Research

Dept of Pathology, Microbiology and Immunology  



  Contact Information


  Office Location and US Mailing address:

Division of Gastroenterology

Vanderbilt University School of Medicine

1030 MRB IV

2215 Garland Ave.

Nashville, TN 37232-0252


Phone: 615-343 3958

Fax: 615-343 6229

E-mail: pelayo.correa@vanderbilt.edu


Campus Mail address:

Dept of Medicine

Division of Gastroenterology

1030C MRB IV (0252)






B.S., Universidad de Antioquia in Columbia
M.D., Universidad de Antioquia in Columbia



Research Keywords





Research Description








Wroblewski, LE, Piazuelo, MB, Chaturvedi, R, Schumacher, M, Aihara, E, Feng, R, Noto, JM, Delgado, A, Israel, DA, Zavros, Y, Montrose, MH, Shroyer, N, Correa, P, Wilson, KT, Peek, RM. Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells. Gut, 64(5), 720-30, 2015

Correa, P. [A pioneer cancer registry in Latin America]. Salud Publica Mex, 56(5), 417, 2015

Suarez, G, Romero-Gallo, J, Piazuelo, MB, Wang, G, Maier, RJ, Forsberg, LS, Azadi, P, Gomez, MA, Correa, P, Peek, RM. Modification of Helicobacter pylori Peptidoglycan Enhances NOD1 Activation and Promotes Cancer of the Stomach. Cancer Res, 75(8), 1749-59, 2015

Krakowiak, MS, Noto, JM, Piazuelo, MB, Hardbower, DM, Romero-Gallo, J, Delgado, A, Chaturvedi, R, Correa, P, Wilson, KT, Peek, RM. Matrix metalloproteinase 7 restrains Helicobacter pylori-induced gastric inflammation and premalignant lesions in the stomach by altering macrophage polarization. Oncogene, 34(14), 1865-71, 2015

Haley, KP, Delgado, AG, Piazuelo, MB, Mortensen, BL, Correa, P, Damo, SM, Chazin, WJ, Skaar, EP, Gaddy, JA. The human antimicrobial protein calgranulin C (S100A12) participates in control of Helicobacter pylori growth and regulation of virulence. Infect Immun, 2015

Soutto, M, Peng, D, Katsha, A, Chen, Z, Piazuelo, MB, Washington, MK, Belkhiri, A, Correa, P, El-Rifai, W. Activation of ??-catenin signalling by TFF1 loss promotes cell proliferation and gastric tumorigenesis. Gut, 2014

Gobert, AP, Verriere, T, Asim, M, Barry, DP, Piazuelo, MB, de Sablet, T, Delgado, AG, Bravo, LE, Correa, P, Peek, RM, Chaturvedi, R, Wilson, KT. Heme oxygenase-1 dysregulates macrophage polarization and the immune response to Helicobacter pylori. J Immunol, 193(6), 3013-22, 2014

Wei, J, Noto, JM, Zaika, E, Romero-Gallo, J, Piazuelo, MB, Schneider, B, El-Rifai, W, Correa, P, Peek, RM, Zaika, AI. Bacterial CagA protein induces degradation of p53 protein in a p14ARF-dependent manner. Gut, 2014

Epplein, M, Zheng, W, Li, H, Peek, RM, Correa, P, Gao, J, Michel, A, Pawlita, M, Cai, Q, Xiang, YB, Shu, XO. Diet, Helicobacter pylori strain-specific infection, and gastric cancer risk among Chinese men. Nutr Cancer, 66(4), 550-7, 2014

Whary, MT, Muthupalani, S, Ge, Z, Feng, Y, Lofgren, J, Shi, HN, Taylor, NS, Correa, P, Versalovic, J, Wang, TC, Fox, JG. Helminth co-infection in Helicobacter pylori infected INS-GAS mice attenuates gastric premalignant lesions of epithelial dysplasia and glandular atrophy and preserves colonization resistance of the stomach to lower bowel microbiota. Microbes Infect, 16(4), 345-55, 2014

Kodaman, N, Pazos, A, Schneider, BG, Piazuelo, MB, Mera, R, Sobota, RS, Sicinschi, LA, Shaffer, CL, Romero-Gallo, J, de Sablet, T, Harder, RH, Bravo, LE, Peek, RM, Wilson, KT, Cover, TL, Williams, SM, Correa, P. Human and Helicobacter pylori coevolution shapes the risk of gastric disease. Proc Natl Acad Sci U S A, 111(4), 1455-60, 2014

Chaturvedi, R, de Sablet, T, Asim, M, Piazuelo, MB, Barry, DP, Verriere, TG, Sierra, JC, Hardbower, DM, Delgado, AG, Schneider, BG, Israel, DA, Romero-Gallo, J, Nagy, TA, Morgan, DR, Murray-Stewart, T, Bravo, LE, Peek, RM, Fox, JG, Woster, PM, Casero, RA, Correa, P, Wilson, KT. Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. Oncogene, 2014

Chaturvedi, R, Asim, M, Piazuelo, MB, Yan, F, Barry, DP, Sierra, JC, Delgado, AG, Hill, S, Casero, RA, Bravo, LE, Dominguez, RL, Correa, P, Polk, DB, Washington, MK, Rose, KL, Schey, KL, Morgan, DR, Peek, RM, Wilson, KT. Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damage. Gastroenterology, 146(7), 1739-51.e14, 2014

Noto, JM, Gaddy, JA, Lee, JY, Piazuelo, MB, Friedman, DB, Colvin, DC, Romero-Gallo, J, Suarez, G, Loh, J, Slaughter, JC, Tan, S, Morgan, DR, Wilson, KT, Bravo, LE, Correa, P, Cover, TL, Amieva, MR, Peek, RM. Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans. J Clin Invest, 123(1), 479-92, 2013

Noto, JM, Khizanishvili, T, Chaturvedi, R, Piazuelo, MB, Romero-Gallo, J, Delgado, AG, Khurana, SS, Sierra, JC, Krishna, US, Suarez, G, Powell, AE, Goldenring, JR, Coffey, RJ, Yang, VW, Correa, P, Mills, JC, Wilson, KT, Peek, RM. Helicobacter pylori promotes the expression of Kr??ppel-like factor 5, a mediator of carcinogenesis, in vitro and in vivo. PLoS One, 8(1), e54344, 2013

Arboleda, RN, Schneider, BG, Bravo, LE, Romero-Gallo, J, Peek, RM, Mera, RM, Yepez, MC, Campo, C, Correa, P. Use of the noninvasive entero-test in the detection of Helicobacter pylori in children in an endemic area in Colombia. J Pediatr Gastroenterol Nutr, 57(2), 192-6, 2013

Correa, P. Gastric cancer: overview. Gastroenterol Clin North Am, 42(2), 211-7, 2013

Morgan, DR, Torres, J, Sexton, R, Herrero, R, Salazar-Mart??nez, E, Greenberg, ER, Bravo, LE, Dominguez, RL, Ferreccio, C, Lazcano-Ponce, EC, Meza-Montenegro, MM, Pe??a, EM, Pe??a, R, Correa, P, Mart??nez, ME, Chey, WD, Valdivieso, M, Anderson, GL, Goodman, GE, Crowley, JJ, Baker, LH. Risk of recurrent Helicobacter pylori infection 1 year after initial eradication therapy in 7 Latin American communities. JAMA, 309(6), 578-86, 2013

Epplein, M, Xiang, YB, Cai, Q, Peek, RM, Li, H, Correa, P, Gao, J, Wu, J, Michel, A, Pawlita, M, Zheng, W, Shu, XO. Circulating cytokines and gastric cancer risk. Cancer Causes Control, 24(12), 2245-50, 2013

Schneider, BG, Piazuelo, MB, Sicinschi, LA, Mera, R, Peng, DF, Roa, JC, Romero-Gallo, J, Delgado, AG, de Sablet, T, Bravo, LE, Wilson, KT, El-Rifai, W, Peek, RM, Correa, P. Virulence of infecting Helicobacter pylori strains and intensity of mononuclear cell infiltration are associated with levels of DNA hypermethylation in gastric mucosae. Epigenetics, 8(11), 1153-61, 2013

Noto, JM, Piazuelo, MB, Chaturvedi, R, Bartel, CA, Thatcher, EJ, Delgado, A, Romero-Gallo, J, Wilson, KT, Correa, P, Patton, JG, Peek, RM. Strain-specific suppression of microRNA-320 by carcinogenic Helicobacter pylori promotes expression of the antiapoptotic protein Mcl-1. Am J Physiol Gastrointest Liver Physiol, 305(11), G786-96, 2013

Piazuelo, MB, Correa, P. Gastric c??ncer: Overview. Colomb Med (Cali), 44(3), 192-201, 2013

Correa, P, Piazuelo, MB. Evolutionary History of the Helicobacter pylori Genome: Implications for Gastric Carcinogenesis. Gut Liver, 6(1), 21-8, 2012

Epplein, M, Zheng, W, Xiang, YB, Peek, RM, Li, H, Correa, P, Gao, J, Michel, A, Pawlita, M, Cai, Q, Shu, XO. Prospective study of Helicobacter pylori biomarkers for gastric cancer risk among Chinese men. Cancer Epidemiol Biomarkers Prev, 21(12), 2185-92, 2012

Mera, RM, Bravo, LE, Goodman, KJ, Yepez, MC, Correa, P. Long-term effects of clearing Helicobacter pylori on growth in school-age children. Pediatr Infect Dis J, 31(3), 263-6, 2012

Correa, P, Piazuelo, MB. The gastric precancerous cascade. J Dig Dis, 13(1), 2-9, 2012

Wei, J, Noto, J, Zaika, E, Romero-Gallo, J, Correa, P, El-Rifai, W, Peek, RM, Zaika, A. Pathogenic bacterium Helicobacter pylori alters the expression profile of p53 protein isoforms and p53 response to cellular stresses. Proc Natl Acad Sci U S A, 109(38), E2543-50, 2012

Loh, JT, Friedman, DB, Piazuelo, MB, Bravo, LE, Wilson, KT, Peek, RM, Correa, P, Cover, TL. Analysis of Helicobacter pylori cagA promoter elements required for salt-induced upregulation of CagA expression. Infect Immun, 80(9), 3094-106, 2012

Sicinschi, LA, Correa, P, Bravo, LE, Peek, RM, Wilson, KT, Loh, JT, Yepez, MC, Gold, BD, Thompson, DT, Cover, TL, Schneider, BG. Non-invasive genotyping of Helicobacter pylori cagA, vacA, and hopQ from asymptomatic children. Helicobacter, 17(2), 96-106, 2012

de Sablet, T, Piazuelo, MB, Shaffer, CL, Schneider, BG, Asim, M, Chaturvedi, R, Bravo, LE, Sicinschi, LA, Delgado, AG, Mera, RM, Israel, DA, Romero-Gallo, J, Peek, RM, Cover, TL, Correa, P, Wilson, KT. Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk. Gut, 60(9), 1189-95, 2011

Epplein, M, Signorello, LB, Zheng, W, Peek, RM, Michel, A, Williams, SM, Pawlita, M, Correa, P, Cai, Q, Blot, WJ. Race, African ancestry, and Helicobacter pylori infection in a low-income United States population. Cancer Epidemiol Biomarkers Prev, 20(5), 826-34, 2011

Soutto, M, Belkhiri, A, Piazuelo, MB, Schneider, BG, Peng, D, Jiang, A, Washington, MK, Kokoye, Y, Crowe, SE, Zaika, A, Correa, P, Peek, RM, El-Rifai, W. Loss of TFF1 is associated with activation of NF-??B-mediated inflammation and gastric neoplasia in mice and humans. J Clin Invest, 121(5), 1753-67, 2011

Nagy, TA, Wroblewski, LE, Wang, D, Piazuelo, MB, Delgado, A, Romero-Gallo, J, Noto, J, Israel, DA, Ogden, SR, Correa, P, Cover, TL, Peek, RM. ??-Catenin and p120 mediate PPAR??-dependent proliferation induced by Helicobacter pylori in human and rodent epithelia. Gastroenterology, 141(2), 553-64, 2011

Gobert, AP, Asim, M, Piazuelo, MB, Verriere, T, Scull, BP, de Sablet, T, Glumac, A, Lewis, ND, Correa, P, Peek, RM, Chaturvedi, R, Wilson, KT. Disruption of nitric oxide signaling by Helicobacter pylori results in enhanced inflammation by inhibition of heme oxygenase-1. J Immunol, 187(10), 5370-9, 2011

Loh, JT, Shaffer, CL, Piazuelo, MB, Bravo, LE, McClain, MS, Correa, P, Cover, TL. Analysis of cagA in Helicobacter pylori strains from Colombian populations with contrasting gastric cancer risk reveals a biomarker for disease severity. Cancer Epidemiol Biomarkers Prev, 20(10), 2237-49, 2011

Epplein, M, Signorello, LB, Zheng, W, Cai, Q, Hargreaves, MK, Michel, A, Pawlita, M, Fowke, JH, Correa, P, Blot, WJ. Helicobacter pylori prevalence and circulating micronutrient levels in a low-income United States population. Cancer Prev Res (Phila), 4(6), 871-8, 2011

Chaturvedi, R, Asim, M, Romero-Gallo, J, Barry, DP, Hoge, S, de Sablet, T, Delgado, AG, Wroblewski, LE, Piazuelo, MB, Yan, F, Israel, DA, Casero, RA, Correa, P, Gobert, AP, Polk, DB, Peek, RM, Wilson, KT. Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. Gastroenterology, 141(5), 1696-708.e1-2, 2011

Correa, P, Piazuelo, MB. Helicobacter pylori Infection and Gastric Adenocarcinoma. US Gastroenterol Hepatol Rev, 7(1), 59-64, 2011