Department of Pathology, Microbiology, and Immunology



   Herbert S. Schwartz, M.D.




Dept of Orthopaedic Surgery and Rehabilitation

Dept of Pathology, Microbiology and Immunology



  Contact Information



Vanderbilt University School of Medicine

Medical Center East, South Tower, Suite 4200

1215 21st Ave. So

Nashville, TN 37232-8774

  Phone: 615-343-8612

Fax: 615-343-1028

E-mail: herbert.s.schwartz@vanderbilt.edu







Post Doc, Vanderbilt University, Nashville, TN
Fellowship, Mayo Clinic, Rochester, MN
Residency, University of Chicago, Chicago, IL
M.D., University of Chicago, Chicago, IL
B.S., University of Illinois, Chicago, IL



Research Keywords



Sarcomas, Tissue Engineering



Research Description





Clinical Research Description



A comprehensive orthopaedic oncology unit is involved in both clinical and basic science research concerned with sarcomas and other neoplasms. Participation in multi-institutional cancer protocols are underway for osteosarcoma and Ewing's sarcoma, and soft tissue sarcomas.






Jiro Ichikawa MD, PhD, Heather A Cole BS, Robert A Magnussen MD, Nicholas A Mignemi BS, Matthew Butler MD, Ginger E Holt MD, Hirotaka Haro MD, PhD, Doha Ihati MD, Justin MM Cates MD, PhD, Heidi E Hamm PhD, Herbert S Schwartz MD, Jonathan G Schoenecker MD, PhD.. The ProCoagulant Nature of Osteosarcoma. CANCER, 118(9), 2494-2506, 2012

Alamanda VK, Crosby SN, Archer KR, Song Y, Schwartz HS, Holt GE. Amputation for extremity soft tissue sarcoma does not increase overall survival: a retrospective cohort study. Eur J Surg Oncol, 38(12), 1178-83, 2012

Alamanda VK, Crosby SN, Archer KR, Song Y, Schwartz HS, Holt GE. Primary Excision Compared with Re-Excision of Extremity Soft Tissue Sarcomas??? Is Anything New? . J Surg Oncol, 105(7), 662-7, 2012

Jiro Ichikawa MD, PhD, Heather A Cole BS, Robert A Magnussen MD, Nicholas A Mignemi BS, Matthew Butler MD, Ginger E Holt MD, Hirotaka Haro MD, PhD, Doha Ihati MD, Justin MM Cates MD, PhD, Heidi E Hamm PhD, Herbert S Schwartz MD, Jonathan G Schoenecker MD, PhD. Thrombin Induces Osteosarcoma Growth, a Function Inhibited by Low Molecular Weight Heparin In Vitro and In Vivo. ProCoagulant Nature of Osteosarcoma. CANCER, 118, 2494-2506, 2012

Brandon A. Ramo, Anthony M. Griffin, Corey S. Gill, Douglas J. McDonald, Jay S. Wunder, Peter Ferguson, Robert S. Bell, Sharon E. Phillips, Herbert S. Schwartz, Ginger E. Holt.. Incidence of Symptomatic Venous Thromboembolism in Lower Extremity Oncologic Endoprostheses. . JBJS , 93A(9), 847-854, 2011

Sommer J, Itani DM, Homlar KC, Keedy VL, Halpern JL, Holt GE, Schwartz HS, Coffin CM, Kelley MJ, Cates JM.. Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma. . J Pathology, 220, 608-17., 2010

JG Schoenecker, N Mignemi, C Stutz, Q Liu, J Edwards, C Lynch, G Holt, HS Schwartz, GA Mencio, H Hamm.. Therapeutic Aprotinin Stimulates Osteoblast Proliferation but Inhibits Differentiation and Bone Matrix Mineralization. . Spine, 35, 1008-16., 2010

Mansour, AA, Kelley, MC, Hatmaker, AR, Holt, GE, Schwartz, HS. Verification of musculoskeletal FDG-PET-CT findings performed for melanoma staging. Ann Surg Oncol, 17(4), 1144-51, 2010

Crosby, SN, Polkowski, GG, Schwartz, HS, Shinar, AA, Holt, GE. Metal-Backed Versus All-Polyethylene Tibias in Megaprostheses of the Distal Femur. J Arthroplasty, 2010

Cates, JM, Friedman, DB, Seeley, EH, Dupont, WD, Schwartz, HS, Holt, GE, Caprioli, RM, Young, PP. Proteomic analysis of osteogenic sarcoma: association of tumour necrosis factor with poor prognosis. Int J Exp Pathol, 91(4), 335-49, 2010

Adelani, MA, Stover, DG, Halpern, JL, Schwartz, HS, Holt, GE. Caveat Arthroplasty. J Arthroplasty, 24, 728-34., 2009

Biermann, JS, Holt, GE, Lewis, VO, Schwartz, HS, Yaszemski, MJ. Metastatic bone disease: diagnosis, evaluation, and treatment. J Bone Joint Surg Am, 91(6), 1518-30, 2009

Holt, GE, Christie, MJ, Schwartz, HS. Trabecular Metal Endoprosthetic Limb Salvage Reconstruction of the Lower Limb. J Arthroplasty, 24, 1079-85., 2009

Thiolloy, S, Halpern, J, Holt, GE, Schwartz, HS, Mundy, GR, Matrisian, LM, Lynch, CC. Osteoclast-derived matrix metalloproteinase-7, but not matrix metalloproteinase-9, contributes to tumor-induced osteolysis. Cancer Res, 69(16), 6747-55, 2009

Herceg, ME, Tsiatis, AC, Halpern, JL, Holt, GE, Schwartz, HS, Keedy, VL, Cates, JM. Cyclooxygenase 2 expression in soft tissue leiomyosarcoma. Anticancer Res, 29(8), 2913-7, 2009

Holt, GE, Halpern, JL, Lynch, CC, Devin, CJ, Schwartz, HS. Imaging analysis of the in vivo bioreactor: a preliminary study. Clin Orthop Relat Res, 466(8), 1890-6, 2008

Adelani, MA, Holt, GE, Dittus, RS, Passman, MA, Schwartz, HS. Revascularization after segmental resection of lower extremity soft tissue sarcomas. J Surg Oncol, 95(6), 455-60, 2007

Klingler, L, Trammell, R, Allan, DG, Butler, MG, Schwartz, HS. Clonality studies in sacral chordoma. Cancer Genet Cytogenet, 171(1), 68-71, 2006

Devin, C, Chong, PY, Holt, GE, Feurer, I, Gonzalez, A, Merchant, N, Schwartz, HS. Level-adjusted perioperative risk of sacral amputations. J Surg Oncol, 94(3), 203-11, 2006

Holt, GE, Thomson, AB, Griffin, AM, Bell, R, Wunder, J, Rougraff, B, Schwartz, HS. Multifocality and multifocal postradiation sarcomas. Clin Orthop Relat Res, 450, 67-75, 2006

Holt, GE, Schwartz, HS, Caldwell, RL. Proteomic profiling in musculoskeletal oncology by MALDI mass spectrometry. Clin Orthop Relat Res, 450, 105-10, 2006

Pitchford, CW, Schwartz, HS, Atkinson, JB, Cates, JM. Soft tissue perineurioma in a patient with neurofibromatosis type 2: a tumor not previously associated with the NF2 syndrome. Am J Surg Pathol, 30(12), 1624-9, 2006

Halpern, J, Lynch, CC, Fleming, J, Hamming, D, Martin, MD, Schwartz, HS, Matrisian, LM, Holt, GE. The application of a murine bone bioreactor as a model of tumor: bone interaction. Clin Exp Metastasis, 23(7-8), 345-56, 2006

Caldwell, R.L., Gonzalez, A., Oppenheimer, S.R., Schwartz, H.S., Caprioli, R.L.. Molecular Assessment of the Tumor Protein Microenvironment Using Imaging Mass Spectrometry. . Cancer Genomics and Proteomics, 3(5), 279-288, 2006

Halpern JL, Lynch CC, Fleming J, Hamming D, Martin MD, Schwartz HS, Matrisian LM, Holt GE.. The application of a murine bone bioreactor as a model of tumor: bone interaction. . Clin Exp Metastases. , 23(7-8), 345-56, 2006

Holt, GE, Halpern, JL, Dovan, TT, Hamming, D, Schwartz, HS. Evolution of an in vivo bioreactor. J Orthop Res, 23(4), 916-23, 2005

Moore, DR, Halpern, JL, Schwartz, HS. Allograft ankle arthrodesis: a limb salvage technique for distal tibial tumors. Clin Orthop Relat Res, 440, 213-21, 2005

Jasko, JJ, Wood, JH, Schwartz, HS. Publication rates of abstracts presented at annual musculoskeletal tumor society meetings. Clin Orthop Relat Res(415), 98-103, 2003

Rubin, G, Dean, A, Schwartz, HS. Orthopaedic malpractice claims in the VA medical system. J South Orthop Assoc, 12(2), 56-9, 2003

Rubin, G, Dean, A Schwartz, HS. Orthopaedic Malpractice Claims in the VA Medical System. Journal of the Southern Orthopaedic Association, 12(2), 56-59, 2003

Schwartz, HS, Eskew, JD, Butler, MG. Clonality studies in giant cell tumor of bone. J Orthop Res, 20(2), 387-90, 2002

Juliao, SF, Rand, N, Schwartz, HS. Galectin-3: a biologic marker and diagnostic aid for chordoma. Clin Orthop Relat Res(397), 70-5, 2002

Zhang K, Dion N, Fuchs B, Damron T, Gitelis S, Schwartz, HS, et al. The human homolog of yeast SEP1 is a novel candidate tumor suppressor gene in osteogenic sarcoma. Gene(298), 121-127, 2002

Juliao SF, Dawson JM, Lennington WJ, Schwartz HS. Purification and Characterization of Canine Collagens I and II. Journal of Histotechnology, 24(1), 51-56, 2001 Mar

Eisenburg, BL, Alektiar, K, Ballo, M, DeLaney, TF, Ettinger, D, Harmon, D, Harris, J, Joyce, M, Kraybill, WG, Leider, S, Lucas, D, Peterson, I, Pollock, RE, Pritchard, D, Schwartz, HS, Yasko, AW, Pisters, PT, Patel, SR, watson, J, , . Radiation Therapy Oncology Group. Research Plan 2002-2006. Sarcoma Committee. Int J Radiat Oncol Biol Phys, 51(3 Suppl 2), 53-5, 2001

Klingler, L, Shooks, J, Fiedler, PN, Marney, A, Butler, MG, Schwartz, HS. Microsatellite instability in sacral chordoma. J Surg Oncol, 73(2), 100-3, 2000

Sciadini, MF, Dawson, JM, Banit, D, Juliao, SF, Johnson, KD, Lennington, WJ, Schwartz, HS. Growth factor modulation of distraction osteogenesis in a segmental defect model. Clin Orthop Relat Res(381), 266-77, 2000

Murrey, DB, Wright, RW, Seiler, JG, Day, TE, Schwartz, HS. Publication rates of abstracts presented at the 1993 annual Academy meeting. Clin Orthop Relat Res(359), 247-53, 1999

Esther, RJ, Lamps, L, Schwartz, HS. Marjolin ulcers: secondary carcinomas in chronic wounds. J South Orthop Assoc, 8(3), 181-7, 1999

Holt G, Feurer ID, Schwartz HS, Bridge JA, Neff JR, Butler MG. An analysis of concordance among hospital databases and physician records. Annals of Surgical Oncology, 5(6), 553-556, 1998 Sep

Butler MG, Tilburt J, DeVries A, Buraldhar B, Aue G, Hedges L, Atkinson J, Schwartz HS. Comparison of Chromosome Telomere Integrity in Multiple Tissue from Subjects of Different Ages. Cancer Genetics & Cytogenetics, 105, 138-144, 1998

Aue, G, Muralidhar, B, Schwartz, HS, Butler, MG. Telomerase activity in skeletal sarcomas. Ann Surg Oncol, 5(7), 627-34, 1998

Schwartz, HS. Update on giant cell tumor of bone. Compr Ther, 24(10), 488-93, 1998

Aue, G, Hedges, LK, Schwartz, HS, Bridge, JA, Neff, JR, Butler, MG. Clear cell sarcoma or malignant melanoma of soft parts: molecular analysis of microsatellite instability with clinical correlation. Cancer Genet Cytogenet, 105(1), 24-8, 1998

Talwalkar, VR, Scheiner, M, Hedges, LK, Butler, MG, Schwartz, HS. Microsatellite instability in malignant melanoma. Cancer Genet Cytogenet, 104(2), 111-4, 1998

Martin, SS, Hurt, WG, Hedges, LK, Butler, MG, Schwartz, HS. Microsatellite instability in sarcomas. Ann Surg Oncol, 5(4), 356-60, 1998

Holt, G, Feurer, ID, Schwartz, HS. An analysis of concordance among hospital databases and physician records. Ann Surg Oncol, 5(6), 553-6, 1998

Schwartz HS, and Butler, MG. Robertsonian Translocations in Paget's Disease of Bone- Letter to the Editor. Journal of Orthopaedic Research, 15, 788-789, 1997

Schwartz, HS, Walker, R. Recognizable magnetic resonance imaging characteristics of intramuscular myxoma. Orthopedics, 20(5), 431-5, 1997

Schwartz, HS, Butler, MG. Robertsonian translocations in Paget''s disease of bone. J Orthop Res, 15(5), 788-9, 1997

Schwartz, HS, Spengler, DM. Needle tract recurrences after closed biopsy for sarcoma: three cases and review of the literature. Ann Surg Oncol, 4(3), 228-36, 1997

DeBoer, DK, Schwartz, HS, Thelman, S, Reynolds, VH. Heterogeneous survival rates for isolated skeletal metastases from melanoma. Clin Orthop Relat Res(323), 277-83, 1996

Wyrsch, B, McFerran, MA, McAndrew, M, Limbird, TJ, Harper, MC, Johnson, KD, Schwartz, HS. Operative treatment of fractures of the tibial plafond. A randomized, prospective study. J Bone Joint Surg Am, 78(11), 1646-57, 1996

Dawson, JM, DeBoer, DK, Spengler, DM, Schwartz, HS. The spinal nail: a new implant for short-segment anterior instrumentation of the thoracolumbar spine. J Spinal Disord, 9(4), 299-305, 1996

Scheiner, M, Hedges, L, Schwartz, HS, Butler, MG. Lack of microsatellite instability in giant cell tumor of bone. Cancer Genet Cytogenet, 88(1), 35-8, 1996

Chmell, MJ, Schwartz, HS. Analysis of variables affecting wound healing after musculoskeletal sarcoma resections. J Surg Oncol, 61(3), 185-9, 1996

Butler, MG, Sciadini, M, Hedges, LK, Schwartz, HS. Chromosome telomere integrity of human solid neoplasms. Cancer Genet Cytogenet, 86(1), 50-3, 1996

Schwartz, HS, Limbird, TJ. Caveat arthroscopy: definition and guidelines for prevention. J South Orthop Assoc, 5(2), 96-100, 1996

Schwartz, HS, Juliao, SF, Sciadini, MF, Miller, LK, Butler, MG. Telomerase activity and oncogenesis in giant cell tumor of bone. Cancer, 75(5), 1094-9, 1995

Kells, AF, Coats, SR, Schwartz, HS, Hoover, RL. TGF-beta and PDGF act synergistically in affecting the growth of human osteoblast-enriched cultures. Connect Tissue Res, 31(2), 117-24, 1995

Butler, MG, Dahir, GA, Hedges, LK, Juliao, SF, Sciadini, MF, Schwartz, HS. Cytogenetic, telomere, and telomerase studies in five surgically managed lumbosacral chordomas. Cancer Genet Cytogenet, 85(1), 51-7, 1995

Wang, H, Rodgers, WH, Chmell, MJ, Svitek, C, Schwartz, HS. Osteosarcoma oncogene expression detected by in situ hybridization. J Orthop Res, 13(5), 671-8, 1995

Chmell, MJ, McAndrew, MP, Thomas, R, Schwartz, HS. Structural allografts for reconstruction of lower extremity open fractures with 10 centimeters or more of acute segmental defects. J Orthop Trauma, 9(3), 222-6, 1995

Buchwald, A, Schwartz, HS. Extensive palm thorn hematoma with associated hematuria. Am J Emerg Med, 12(2), 259-60, 1994

Wright, RW, Schwartz, HS. Pathologic acetabular fractures: new concepts in surgical management. Semin Arthroplasty, 5(2), 95-105, 1994

Dahir, GA, Vnencak-Jones, CL, Schwartz, HS, Butler, MG. Dosage and allelic restriction fragment studies and PCR analysis of the H-ras locus in giant cell tumor of bone. Cancer Genet Cytogenet, 74(2), 95-8, 1994

Stephens, GC, Lennington, WJ, Schwartz, HS. Primary lymphoma and Paget's disease of the femur. Am J Clin Pathol, 101(6), 783-6, 1994

Schwartz, HS. Giant cell tumor of bone. Compr Ther, 19(2), 64-8, 1993

Harrington, MA, Keller, TS, Seiler, JG, Weikert, DR, Moeljanto, E, Schwartz, HS. Geometric properties and the predicted mechanical behavior of adult human clavicles. J Biomech, 26(4-5), 417-26, 1993

Butler, MG, Dahir, GA, Schwartz, HS. Molecular analysis of transforming growth factor beta in giant cell tumor of bone. Cancer Genet Cytogenet, 66(2), 108-12, 1993

Hourigan, AJ, Kells, AF, Schwartz, HS. In vitro photodynamic therapy of musculoskeletal neoplasms. J Orthop Res, 11(5), 633-7, 1993

Stephens, GC, Schwartz, HS. Lumbosacral chordoma resection: image integration and surgical planning. J Surg Oncol, 54(4), 226-32, 1993

Schwartz, HS, Dahir, GA, Butler, MG. Telomere reduction in giant cell tumor of bone and with aging. Cancer Genet Cytogenet, 71(2), 132-8, 1993

Kells, AF, Schwartz, HS, Bascom, CC, Hoover, RL. Identification and analysis of transforming growth factor beta receptors on primary osteoblast-enriched cultures derived from adult human bone. Connect Tissue Res, 27(4), 197-209, 1992

McFerran, MA, Smith, SW, Boulas, HJ, Schwartz, HS. Complications encountered in the treatment of pilon fractures. J Orthop Trauma, 6(2), 195-200, 1992

Schwartz, HS, Allen, GA, Chudoba, I, Butler, MG. Cytogenetic abnormalities in a rare case of giant cell osteogenic sarcoma. Cancer Genet Cytogenet, 58(1), 60-5, 1992

Schwartz, HS, Jones, CK. The efficacy of gallium scintigraphy in detecting malignant soft tissue neoplasms. Ann Surg, 215(1), 78-82, 1992

Cramer, KE, Schwartz, HS. Open biopsy without wound closure for skeletal neoplasms. J Surg Oncol, 47(2), 75-8, 1991

Weikert, DR, Schwartz, HS. Intramedullary nailing for impending pathological subtrochanteric fractures. J Bone Joint Surg Br, 73(4), 668-70, 1991

Schwartz, HS, Shockley, TE, Lennington, WJ, Mackey, ES. The significance of skeletal magnetic resonance imaging after open bone biopsy. J Orthop Res, 9(1), 120-30, 1991

Stiles, RG, Spottswood, SE, Jolgren, DL, Stewart, JR, DeVito, DP, Schwartz, HS. An unusual appearance of an aneurysmal bone cyst of the thoracic spine. J Spinal Disord, 4(1), 104-9, 1991

Schwartz, HS, Butler, MG, Jenkins, RB, Miller, DA, Moses, HL. Telomeric associations and consistent growth factor overexpression detected in giant cell tumor of bone. Cancer Genet Cytogenet, 56(2), 263-76, 1991

Stiehl, JB, Schwartz, HS. Long-term results of pronation-external rotation ankle fracture-dislocations treated with anatomical open reduction, internal fixation. J Orthop Trauma, 4(3), 339-45, 1990

Schwartz, HS. Traumatic Charcot spine. J Spinal Disord, 3(3), 269-75, 1990

Schwartz, HS, Pinto, M. Osteoblastomas of the cervical spine. J Spinal Disord, 3(2), 179-82, 1990

Furia, JP, Schwartz, HS. Hereditary multiple diaphyseal sclerosis: a tumor simulator. Orthopedics, 13(11), 1267-74, 1990

Schwartz HS, Frassica FJ, and Sim FH. Rotationplasty: An option for Limb Salvage in Childhood Osteosarcoma. Orthopaedics, 12, 257-263, 1989

Schwartz, HS, Jenkins, RB, Dahl, RJ, Dewald, GW. Cytogenetic analyses on giant-cell tumors of bone. Clin Orthop Relat Res(240), 250-60, 1989

Schwartz, HS, Unni, KK, Pritchard, DJ. Pigmented villonodular synovitis. A retrospective review of affected large joints. Clin Orthop Relat Res(247), 243-55, 1989

Schwartz, HS, Frassica, FJ, Sim, FH. Rotationplasty: an option for limb salvage in childhood osteosarcoma. Orthopedics, 12(2), 257-63, 1989

Frassica FJ, Schwartz HS, Pairolero PC, and Sim FH. Rotation-plasty: Surgical Technique of Resection and Reconstruction in the Treatment of Osteosarcoma About the Knee in Children. Clinical Anatomy, 1, 105-116, 1988

Schwartz, HS, Weiss, SW, Sim, FH, Beabout, JW. Liposarcoma of the soft tissues. Orthopedics, 10(7), 1065-8, 1987

Schwartz HS, Zimmerman NB, Simon MA, Wroble RR, Miller EA, and Bonfiglio M. The Malignant Potential of Multiple Enchondromatosis. J. Bone and Joint Surgery, 69A, 269-274, 1987

Schwartz HS, Pritchard DJ, Sim FH, Weiss SW, and Beabout JW. Epithelioid Sarcoma. Orthopaedics, 9, 1299-1302, 1987

Schwartz HS, Weiss SW, Sim FH, Beobout JW. Liposarcoma of the Soft Tissues. Orthopaedics, 10, 1065-1068, 1987

Schwartz, HS, Pritchard, DJ, Sim, FH, Weiss, SW, Beabout, JW. Epithelioid sarcoma. Orthopedics, 10(9), 1299-302, 1987

Phillips, WA, Schwartz, HS, Keller, CS, Woodward, HR, Rudd, WS, Spiegel, PG, Laros, GS. A prospective, randomized study of the management of severe ankle fractures. J Bone Joint Surg Am, 67(1), 67-78, 1985