.

Department of Pathology, Microbiology, and Immunology

 

 

   Mildred T. Stahlman, M.D.

 

 

Professor

Dept of Pediatrics

Dept of Pathology, Microbiology and Immunology

 

 

  Contact Information

 

 

Vanderbilt University School of Medicine

1125 MRB IV/Light Hall

Nashville, TN 37232-0656

Phone: 615-343-0443

Fax: 615-343-6182

E-mail: mildred.stahlman@vanderbilt.edu

 

 

  Research Specialty

 

 
 Neonatal pulmonary development outcome and pathology

 

 

  Disease Interests

 

 

Hyaline Membrane Disease

Prematurity, perinatal outcome

 

 

  Research Specialty

 

 

Lung development

 

 

  Research Description

 

 

Immunohistology and electron microscopy of  immature  lungs of mice and humans

 

 

  Clinical Interests

 

 

Perinatal outcome

 

 

  Other interests

 

 

Effects of poverty and social ills on perinatal disease and deaths

 

 

  Selected Publications

 

 

Stahlman MT, Gray ME: Immunogold EM localization of neurochemicals in human pulmonary neuroendocrine cells.  Microsc Res and Tech  37:77-91, 1997.

 

Stahlman MT, Gray ME, Whitsett JA:  Temporal-spatial distribution of hepatocyte nuclear factor-3b in developing human lung and other foregut derivatives.  J Histochem Cytochem 46:955, 1998.

 

Korfhagen TR, Sheftelyevich V, Burhans MS, Bruno MD, Ross GF, Wert SE, Stahlman MT, Jobe AH, Ikegami M, Whitsett JA, Fisher JH:  Surfactant protein-D regulates surfactant phospholipid homeostasis in vivo.   J Biol Chem  273:28438-28443, 1998.

 

Khoor A, Whitsett JA, Stahlman MT, Olson SJ, Cagle PT:  Utility of surfactant protein B precursor and thyroid transcription factor 1 in differentiating adenocarcinoma of the lung from malignant mesothelioma.   Human Pathology 30:695-700, 1999.

 

Stahlman MT, Gray MP, Falconieri MW, Whitsett JA, Weaver TE:  Lamellar body formation in normal and surfactant protein B-deficient fetal mice.  Laboratory Investigation 80:395, 2000.

 

Zeng X, Gray M, Stahlman M, Whitsett JA:  TGF-$1 perturbs vascular development and inhibits epithelial differentiation in fetal lung in vivo.  Dev Dyn 221:289-301, 2001.

 

Clark JC, Tichelear JW, Wert SE, Itoh N, Perl AKT, Stahlman MT, Whitsett JA:  FGF-10 disrupts lung morphogenesis and causes pulmonary adenomas in vivo.   Am J Physiol Lung Cell Mol Physiol  280:L705-L715, 2001.

 

Stahlman MT, Gray ME, Hull WM, Whitsett JA:  Immunolocalization of surfactant

Protein-D (SP-D) in human fetal, newborn, and adult tissues. J Histochem Cytochem 50:651-660, 2002.

 

Whitsett JA, Clark JC, Picard L, Tichelaar JW, Wert SE, Itoh N, Perl AKT, Stahlman MT:  Fibroblast growth factor 18 influences proximal programming during lung morphogenesis.  J Biol Chem 277:22743-22749, 2002.

 

Thomas AQ, Lane K, Phillips III J, Prince M, Markin C, Speer M, Schwartz DA, Gaddipati R, Marney A, Johnson J, Roberts R, Haines J, Stahlman M, Loyd JE:  Heterozygosity foe a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred. Am J Respir Crit Care Med 165:1322-1328, 2002.

 

Weaver TE, Na C-L, Stahlman M: Biogenesis of lamellar bodies and lysosomal organelles involved in storage and secretion of pulmonary surfactant. Cell Devel Biol 319:1-8, 2002.

 

Glasser SW, Detmer EA, Ikegami M, Na C-L, Stahlman MT, Whitsett JA: Interstitial pneumonitis in SP-C gene targeted mice. J Biolog Chemis 278:14291-14298, 2003.

 

Glasser SW, Detmer EA, Ikegami M, Na C-L, Stahlman MT, Whitsett JA:  Pneumonitis and emphysema in sp-C gene targeted mice.  J Biol Chem: 278:14291-14298; 2003.

 

Noah TL, Murphy PC, Alink JJ, Leigh MW, Hull WM, Stahlman MT, Whitsett JA: Bronchoalvelar lavage fluid surfactant protein-A and surfactant protein-D are inversely related to inflammation in early cystic fibrosis.  Am J Respir Crit Care Med 168:685-691; 2003

 

Liu C, Ikegami M, Stahlman MT, Dey CR, Whitsett JA: Inhibition of alveolarization and altered pulmonary mechanics in mice expressing Gata-6.  Am J Physiol Lung Cell Mol Physiol 285:L1246-1254; 2003

 

Wan H, Kaestner KH, Ang SL, Ikegami M, Finkelman FD, Stahlman MT, Fulkerson P, Rothenberg, Whitsett JA: Foxa2 regulates alveolarization and goblet cell hyperplasia. Development 131:953-964, 2004.

 

Khoor A, Stahlman MT, Johnson JM, Olson SJ, Whitsett JA.  Forkhead hox A2 transcription factor is expressed in all types of neuroendocrine lung tumors.  Hum Pathol 35:560-564; 2004.

 

Wan H, Xu Y, Ikegami M, Stahlman MT, Kaestner KH, Ang SL, Whitsett JA.  Foxa2 is required for transition to air breathing at birth.  Proc Natl Acad Sci USA  101(40):14449-54, 2004.

 

Wan, Huajing, Dingle S, Xu Y, Besnard V, Kaestner KH, Ang SL, Wert S, Stahlman MT, Whitsett JA.  Compensatory roles of Fox a1 and Fox a2 during lung morphogenesis.  J Biol Chemis 280:13809-13816, 2005.

 

Ikegami M, LeCras TD, Hardie WD, Stahlman MT, Whitsett JA, Korfhagen TR.  TGF-a perturbs surfactant homeostasis in vivo. Am J Lung Cell Mol Physiol 289(1)L34-43,2005. Epub 2005 Mar 11.

 

Mucenski ML, Nation JM, Thitoff AR, Besnard V, Xu Y, Wert SE, Harada N, Taketo MM, Stahlman MT, Whitsett JA. Beta-catenin relates differentiation of respiratory epithelial cells in vivo. Am J Physiol Lung Cell Mol Physiol 289(6): L971-9, 2005. Epub 2005 Jul 22.

 

Altiok O, Yasumatsu R, Bingol-Karakoc G, Riese RJ, Stahlman MT, Dwyer W, Pierce RA, Bromme D, Weber E, Cataltepe S.  Imbalance between cysteine proteases and inhibitors in a baboon model of bronchopulmonary dysplasia.  Am J Respir Crit Care Med 173(3):318-26, 2006. Epub 2005  Sep 15.

 

Rehan VK, Sugano S, Wang Y, Santos J, Romero S, Dasgupta C, Keane MP, Stahlman MT, Torday JS. Evidence for the presence of lipofibroblasts in human lung. Exp Lung Res  32:379-393, 2006.

 

Stahlman MT, Besnard V, Wert SE, Weaver TE, Dingle S, XU Y, von Zychlin K, Olson SJ, Whitsett JA. Expression of ABCA3 in developing lung and other tissues. J Histochem Cytochem  55(1):71-83, 2007.

 

Metzger DE, Stahlman MT, Shannon JM. Misexpression of ELF5 disrupts lung branching  and inhibits epithelial differentiation. Dev Biol 320 (2008) 149-160.

 

Besnard V, Wert SE, Stahlman MT, Postle AD, Xu Y, Ikegami M, Whitsett, JA. Deletion of SCAP in Alveolar Type II Cells Influences Lung Lipid Homeostasis and Identifies a Compensatory Rold for Pulmonary Lipofibroblasts. Submitted for publication to the Journal of Biological Chemistry.

 

Sutherland MR, Gubhaju L, Stahlman MT, Black MJ. The Effects of Postnatal Retinoic Acid Administration on Nepron Endowment in the Preterm Baboon Kidney. Submitted for publication to Pediatric Research.

 

 

 

 

Education

 

 

M.D., Vanderbilt
B.A., Vanderbilt

 

 

Research Keywords

 

 


 

 

Research Description

 

 


 

 

Publications

 

 

Stahlman, Mildred T, Gray, Mary E, Hull, William M, Whitsett, Jeffrey A. Immunolocalization of surfactant protein-D (SP-D) in human fetal, newborn, and adult tissues. J Histochem Cytochem, 50(5), 651-60, 2002

Stahlman, M T, Gray, M P, Falconieri, M W, Whitsett, J A, Weaver, T E. Lamellar body formation in normal and surfactant protein B-deficient fetal mice. Lab Invest, 80(3), 395-403, 2000

Stahlman, M T, Gray, M E. Immunogold EM localization of neurochemicals in human pulmonary neuroendocrine cells. Microsc Res Tech, 37(1), 77-91, 1997

Khoor, A, Whitsett, J A, Stahlman, M T, Halter, S A. Expression of surfactant protein B precursor and surfactant protein B mRNA in adenocarcinoma of the lung. Mod Pathol, 10(1), 62-7, 1997

Khoor, A, Gray, M E, Singh, G, Stahlman, M T. Ontogeny of Clara cell-specific protein and its mRNA: their association with neuroepithelial bodies in human fetal lung and in bronchopulmonary dysplasia. J Histochem Cytochem, 44(12), 1429-38, 1996

Stahlman, M T. Acceptance of the 1996 American Pediatric Society John Howland Award: who will save our children. Pediatr Res, 40(5), 772-3, 1996

Stahlman, M T, Gray, M E, Whitsett, J A. Expression of thyroid transcription factor-1(TTF-1) in fetal and neonatal human lung. J Histochem Cytochem, 44(7), 673-8, 1996

Shenai, J P, Chytil, F, Parker, R A, Stahlman, M T. Vitamin A status and airway infection in mechanically ventilated very-low-birth-weight neonates. Pediatr Pulmonol, 19(5), 256-61, 1995

Neuzil, K M, Gruber, W C, Chytil, F, Stahlman, M T, Graham, B S. Safety and pharmacokinetics of vitamin A therapy for infants with respiratory syncytial virus infections. Antimicrob Agents Chemother, 39(5), 1191-3, 1995

Neuzil, K M, Gruber, W C, Chytil, F, Stahlman, M T, Engelhardt, B, Graham, B S. Serum vitamin A levels in respiratory syncytial virus infection. J Pediatr, 124(3), 433-6, 1994

Khoor, A, Stahlman, M T, Gray, M E, Whitsett, J A. Temporal-spatial distribution of SP-B and SP-C proteins and mRNAs in developing respiratory epithelium of human lung. J Histochem Cytochem, 42(9), 1187-99, 1994

Khoor, A, Gray, M E, Hull, W M, Whitsett, J A, Stahlman, M T. Developmental expression of SP-A and SP-A mRNA in the proximal and distal respiratory epithelium in the human fetus and newborn. J Histochem Cytochem, 41(9), 1311-9, 1993

Stahlman, M T. Improving health care provision to neonates in the United States. Am J Dis Child, 147(5), 516, 1993

Stahlman, M T, Gray, M E. Colocalization of peptide hormones in neuroendocrine cells of human fetal and newborn lungs: an electron microscopic study. Anat Rec, 236(1), 206-12, 1993

Stahlman, M T, Gray, M E, Ross, G F, Hull, W M, Wikenheiser, K, Dingle, S, Zelenski-Low, K R, Whitsett, J A. Human surfactant protein-A contains blood group A antigenic determinants. Pediatr Res, 31(4 Pt 1), 364-71, 1992

Stahlman, M T, Gray, M E, Whitsett, J A. The ontogeny and distribution of surfactant protein B in human fetuses and newborns. J Histochem Cytochem, 40(10), 1471-80, 1992

Stahlman, M T. Improving health care provision to neonates in the United States. Am J Dis Child, 145(5), 510-2, 1991

Johnson, M D, Gray, M E, Pepinsky, R B, Stahlman, M T. Lipocortin-1 immunoreactivity in the human pituitary gland. J Histochem Cytochem, 38(12), 1841-5, 1990

Johnson, M D, Gray, M E, Carpenter, G, Pepinsky, R B, Stahlman, M T. Ontogeny of epidermal growth factor receptor and lipocortin-1 in fetal and neonatal human lungs. Hum Pathol, 21(2), 182-91, 1990

Stahlman, M T. Ethical issues in the nursery: priorities versus limits. J Pediatr, 116(2), 167-70, 1990

Gr??gaard, J B, Lindstrom, D P, Parker, R A, Culley, B, Stahlman, M T. Increased survival rate in very low birth weight infants (1500 grams or less): no association with increased incidence of handicaps. J Pediatr, 117(1 Pt 1), 139-46, 1990

Shenai, J P, Rush, M G, Stahlman, M T, Chytil, F. Plasma retinol-binding protein response to vitamin A administration in infants susceptible to bronchopulmonary dysplasia. J Pediatr, 116(4), 607-14, 1990

Stahlman, M T, Orth, D N, Gray, M E. Immunocytochemical localization of epidermal growth factor in the developing human respiratory system and in acute and chronic lung disease in the neonate. Lab Invest, 60(4), 539-47, 1989

Johnson, M D, Gray, M E, Carpenter, G, Pepinsky, R B, Sundell, H, Stahlman, M T. Ontogeny of epidermal growth factor receptor/kinase and of lipocortin-1 in the ovine lung. Pediatr Res, 25(5), 535-41, 1989

Johnson, M D, Gray, M E, Stahlman, M T. Calcitonin gene-related peptide in human fetal lung and in neonatal lung disease. J Histochem Cytochem, 36(2), 199-204, 1988

Stahlman, M T, Gray, M E, Chytil, F, Sundell, H. Effect of retinol on fetal lamb tracheal epithelium, with and without epidermal growth factor. A model for the effect of retinol on the healing lung of human premature infants. Lab Invest, 59(1), 25-35, 1988

Sheller, J R, Lucht, W D, Goel, A K, Snell, J D, Stahlman, M T. Pulmonary function in long-term survivors of hyaline membrane disease. Chest, 93(4), 734-8, 1988

Stahlman, M T. Newborn intensive care--success, failure and opportunities. Equine Vet J Suppl(5), 1-4; discussion 5, 1988

Kenworthy, O T, Bess, F H, Stahlman, M T, Lindstrom, D P. Hearing, speech, and language outcome in infants with extreme immaturity. Am J Otol, 8(5), 419-25, 1987

Stahlman, M T. Newborn intensive care: Success or failure. J Pediatr, 105(1), 162-7, 1984

Mayes, L, Perkett, E, Stahlman, M T. Severe bronchopulmonary dysplasia: a retrospective review. Acta Paediatr Scand, 72(2), 225-9, 1983

Lannering, B, Larsson, L E, Rojas, J, Stahlman, M T. Early onset group B streptococcal disease. Seven year experience and clinical scoring system. Acta Paediatr Scand, 72(4), 597-602, 1983

Skelton, M A, Perkett, E A, Major, C W, Vaughan, R L, Stahlman, M T. Transport of the neonate. South Med J, 72(2), 144-8, 1979