Department of Pathology, Microbiology, and Immunology


   Kelli L. Boyd, DVM, PhD, DACVP


Associate Professor
Dept. of Pathology, Microbiology and Immunology


  Contact Information



Office Location:
MCN AA-6220

Phone: 615-322-3596

Fax: 615-343-7682

E-mail: kelli.l.boyd@vanderbilt.edu


Campus Mail address:

Animal Care

AA-6206 MCN (2130)


US Mailing address:

Vanderbilt University School of Medicine

Division of Animal Care

AA-6206 MCN

Nashville, TN 37232-2130



  Disease Interests



Infectious disease models, Cell cycle regulation and cell death mechanisms in cancer and immunity, embryonic and placental development in mice



  Research Interests



Pathology of Genetically Engineered Mice






Liu G, Burns S, Huang G, Boyd K, Proia RL, Flavell RA, Chi H. The receptor S1P(1)   overrides regulatory T cell-mediated immune suppression through Akt-mTOR. Nat Immunol. 2009 May 31. [Epub ahead of print]


Thomas PG, Dash P, Aldridge JR Jr, Ellebedy AH, Reynolds C, Funk AJ, Martin WJ, Lamkanfi M, Webby RJ, Boyd KL, Doherty PC, Kanneganti TD. The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity. 2009 Apr;30(4):566-75. Epub 2009 Apr 9.


Morton D, Berent L, Bolon B, Boyd K, Coleman G, Hall R, Kinsel M, Tornquist S, Wilson D. The 2008 ACVP Role Delineation Survey and Initial Data Analysis. Vet Pathol. 2009 Mar 9. [Epub ahead of print]


Lamkanfi M, Moreira LO, Makena P, Spierings DC, Boyd K, Murray PJ, Green DR,Kanneganti TD. Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival. Blood. 2009 Mar 19;113(12):2742-5. Epub 2009 Jan 23.


Karlström A, Boyd KL, English BK, McCullers JA. Treatment with protein synthesis inhibitors improves outcomes of secondary bacterial pneumonia after influenza. J Infect Dis. 2009 Feb 1;199(3):311-9.


Steimer DA, Boyd K, Takeuchi O, Fisher JK, Zambetti GP, Opferman JT. Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function. Blood. 2009 Mar 19;113(12):2805-15. Epub 2008 Dec 8.


Pestina TI, Hargrove PW, Jay D, Gray JT, Boyd KM, Persons DA. Correction of murine sickle cell disease using gamma-globin lentiviral vectors to mediate high-level expression of fetal hemoglobin. Mol Ther. 2009 Feb;17(2):245-52.


Yang L, Boyd K, Kaste SC, Kamdem Kamdem L, Rahija RJ, Relling MV. A mouse model for glucocorticoid-induced osteonecrosis: effect of a steroid holiday. J Orthop Res. 2009 Feb;27(2):169-75.


Krishnamurthy P, Schwab M, Takenaka K, Nachagari D, Morgan J, Leslie M, Du W, Boyd K, Cheok M, Nakauchi H, Marzolini C, Kim RB, Poonkuzhali B, Schuetz E, Evans W, Relling M, Schuetz JD. Transporter-mediated protection against thiopurine-induced hematopoietic toxicity. Cancer Res. 2008 Jul;68(13):4983-9.


Alymova IV, Taylor G, Mishin VP, Watanabe M, Murti KG, Boyd K, Chand P, Babu YS, Portner A. Loss of the N-linked glycan at residue 173 of human parainfluenza virus type 1 hemagglutinin-neuraminidase exposes a second receptor-binding site. J Virol. 2008 Sep;82(17):8400-10. Epub 2008 Jun 25.


Tian Y, Pate C, Andreolotti A, Wang L, Tuomanen E, Boyd K, Claro E, Jackowski S. Cytokine secretion requires phosphatidylcholine synthesis. J Cell Biol. 2008 Jun 16;181(6):945-57.


Holst J, Wang H, Eder KD, Workman CJ, Boyd KL, Baquet Z, Singh H, Forbes K,Chruscinski A, Smeyne R, van Oers NS, Utz PJ, Vignali DA. Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity. Nat Immunol. 2008 Jun;9(6):658-66. Epub 2008 May 11.


Chao JR, Parganas E, Boyd K, Hong CY, Opferman JT, Ihle JN. Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons. Nature.2008 Mar 6;452(7183):98-102. Epub 2008 Feb 20. Erratum in: Nature. 2008 Apr 17;452(7189):900.


Marino R, Martinez C, Boyd K, Dominici M, Hofmann TJ, Horwitz EM. Transplantable marrow osteoprogenitors engraft in discrete saturable sites in the marrow microenvironment. Exp Hematol. 2008 Mar;36(3):360-8. Epub 2008 Jan 7.


Zhan X, Hurwitz JL, Krishnamurthy S, Takimoto T, Boyd K, Scroggs RA, Surman S, Portner A, Slobod KS. Respiratory syncytial virus (RSV) fusion protein expressed by recombinant Sendai virus elicits B-cell and T-cell responses in cotton rats and confers protection against RSV subtypes A and B. Vaccine. 2007 Dec 17;25(52):8782-93. Epub 2007 Nov 5.


Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D,Blumberg RS, Vignali DA. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature. 2007 Nov 22;450(7169):566-9.


McAuley JL, Hornung F, Boyd KL, Smith AM, McKeon R, Bennink J, Yewdell JW, McCullers JA. Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia. Cell Host Microbe. 2007 Oct 11;2(4):240-9.


Ajioka I, Martins RA, Bayazitov IT, Donovan S, Johnson DA, Frase S, Cicero SA, Boyd K, Zakharenko SS, Dyer MA. Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice. Cell. 2007 Oct 19;131(2):378-90.


Torchia EC, Boyd K, Rehg JE, Qu C, Baker SJ. EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice. Mol Cell Biol. 2007 Nov;27(22):7918-34. Epub 2007 Sep 17.


20: Gingras S, Pelletier S, Boyd K, Ihle JN. Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). PLoS ONE. 2007 Aug 29;2(8):e808.


Inoue A, Li T, Roby SK, Valentine MB, Inoue M, Boyd K, Kidd VJ, Lahti JM. Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation. Cell Cycle. 2007 Jul 1;6(13):1646-54. Epub 2007 May 8.


Ozbek U, Kandilci A, van Baal S, Bonten J, Boyd K, Franken P, Fodde R, Grosveld GC. SET-CAN, the product of the t(9;9) in acute undifferentiated leukemia, causes expansion of early hematopoietic progenitors and hyperproliferation of stomach mucosa in transgenic mice. Am J Pathol. 2007 Aug;171(2):654-66. Epub 2007 Jun 14.


Vigerust DJ, Ulett KB, Boyd KL, Madsen J, Hawgood S, McCullers JA. N-linked glycosylation attenuates H3N2 influenza viruses. J Virol. 2007 Aug;81(16):8593-600. Epub 2007 Jun 6.


Hulse-Post DJ, Franks J, Boyd K, Salomon R, Hoffmann E, Yen HL, Webby RJ, Walker D, Nguyen TD, Webster RG. Molecular changes in the polymerase genes (PA and PB1) associated with high pathogenicity of H5N1 influenza virus in mallard ducks. J Virol. 2007 Aug;81(16):8515-24. Epub 2007 Jun 6.