Department of Pathology, Microbiology, and Immunology


   Kelli L. Boyd, DVM, PhD, DACVP


Associate Professor
Dept. of Pathology, Microbiology and Immunology


  Contact Information



Office Location:
MCN AA-6220
Phone: 615-322-3596

Fax: 615-343-7682

E-mail: kelli.l.boyd@vanderbilt.edu


Campus Mail address:

Translational Pathology Shared Resource

S-1310 MCN

US Mailing address:

  Vanderbilt University School of Medicine

Division of Animal Care

AA-6206 MCN

Nashville, TN 37232-2130



  Disease Interests



Infectious disease models, Cell cycle regulation and cell death mechanisms in cancer and immunity, embryonic and placental development in mice



  Research Interests



Pathology of Genetically Engineered Mice












PhD, Universtiy of Georgia
DVM, Mississippi State
BS, Mississippi State



Research Keywords



Comparative Pathology, Mouse Pathology



Research Description








Liu, G, Burns, S, Huang, G, Boyd, K, Proia, RL, Flavell, RA, Chi, H. The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR. Nat Immunol, 10(7), 769-77, 2009

Karlstr??m, A, Boyd, KL, English, BK, McCullers, JA. Treatment with protein synthesis inhibitors improves outcomes of secondary bacterial pneumonia after influenza. J Infect Dis, 199(3), 311-9, 2009

Watanabe, M, Mishin, VP, Brown, SA, Russell, CJ, Boyd, K, Babu, YS, Taylor, G, Xiong, X, Yan, X, Portner, A, Alymova, IV. Effect of Hemagglutinin-Neuraminidase Inhibitors BCX 2798 and BCX 2855 on Growth and Pathogenicity of Sendai/Human Parainfluenza Type 3 Chimera Virus in Mice. Antimicrob Agents Chemother, 2009

Thomas, PG, Dash, P, Aldridge, JR, Ellebedy, AH, Reynolds, C, Funk, AJ, Martin, WJ, Lamkanfi, M, Webby, RJ, Boyd, KL, Doherty, PC, Kanneganti, TD. The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity, 30(4), 566-75, 2009

Lamkanfi, M, Moreira, LO, Makena, P, Spierings, DC, Boyd, K, Murray, PJ, Green, DR, Kanneganti, TD. Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival. Blood, 113(12), 2742-5, 2009

Steimer, DA, Boyd, K, Takeuchi, O, Fisher, JK, Zambetti, GP, Opferman, JT. Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function. Blood, 113(12), 2805-15, 2009

Yang, L, Boyd, K, Kaste, SC, Kamdem Kamdem, L, Rahija, RJ, Relling, MV. A mouse model for glucocorticoid-induced osteonecrosis: effect of a steroid holiday. J Orthop Res, 27(2), 169-75, 2009

Pestina, TI, Hargrove, PW, Jay, D, Gray, JT, Boyd, KM, Persons, DA. Correction of murine sickle cell disease using gamma-globin lentiviral vectors to mediate high-level expression of fetal hemoglobin. Mol Ther, 17(2), 245-52, 2009

Chao, JR, Parganas, E, Boyd, K, Hong, CY, Opferman, JT, Ihle, JN. Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons. Nature, 452(7183), 98-102, 2008

Marino, R, Martinez, C, Boyd, K, Dominici, M, Hofmann, TJ, Horwitz, EM. Transplantable marrow osteoprogenitors engraft in discrete saturable sites in the marrow microenvironment. Exp Hematol, 36(3), 360-8, 2008

Tian, Y, Pate, C, Andreolotti, A, Wang, L, Tuomanen, E, Boyd, K, Claro, E, Jackowski, S. Cytokine secretion requires phosphatidylcholine synthesis. J Cell Biol, 181(6), 945-57, 2008

Holst, J, Wang, H, Eder, KD, Workman, CJ, Boyd, KL, Baquet, Z, Singh, H, Forbes, K, Chruscinski, A, Smeyne, R, van Oers, NS, Utz, PJ, Vignali, DA. Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity. Nat Immunol, 9(6), 658-66, 2008

Krishnamurthy, P, Schwab, M, Takenaka, K, Nachagari, D, Morgan, J, Leslie, M, Du, W, Boyd, K, Cheok, M, Nakauchi, H, Marzolini, C, Kim, RB, Poonkuzhali, B, Schuetz, E, Evans, W, Relling, M, Schuetz, JD. Transporter-mediated protection against thiopurine-induced hematopoietic toxicity. Cancer Res, 68(13), 4983-9, 2008

Alymova, IV, Taylor, G, Mishin, VP, Watanabe, M, Murti, KG, Boyd, K, Chand, P, Babu, YS, Portner, A. Loss of the N-linked glycan at residue 173 of human parainfluenza virus type 1 hemagglutinin-neuraminidase exposes a second receptor-binding site. J Virol, 82(17), 8400-10, 2008

Vigerust, DJ, Ulett, KB, Boyd, KL, Madsen, J, Hawgood, S, McCullers, JA. N-linked glycosylation attenuates H3N2 influenza viruses. J Virol, 81(16), 8593-600, 2007

McAuley, JL, Hornung, F, Boyd, KL, Smith, AM, McKeon, R, Bennink, J, Yewdell, JW, McCullers, JA. Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia. Cell Host Microbe, 2(4), 240-9, 2007

Humberd, J, Boyd, K, Webster, RG. Emergence of influenza A virus variants after prolonged shedding from pheasants. J Virol, 81(8), 4044-51, 2007

Li, N, Boyd, K, Dempsey, PJ, Vignali, DA. Non-cell autonomous expression of TNF-alpha-converting enzyme ADAM17 is required for normal lymphocyte development. J Immunol, 178(7), 4214-21, 2007

Keller, UB, Old, JB, Dorsey, FC, Nilsson, JA, Nilsson, L, MacLean, KH, Chung, L, Yang, C, Spruck, C, Boyd, K, Reed, SI, Cleveland, JL. Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis. EMBO J, 26(10), 2562-74, 2007

Hulse-Post, DJ, Franks, J, Boyd, K, Salomon, R, Hoffmann, E, Yen, HL, Webby, RJ, Walker, D, Nguyen, TD, Webster, RG. Molecular changes in the polymerase genes (PA and PB1) associated with high pathogenicity of H5N1 influenza virus in mallard ducks. J Virol, 81(16), 8515-24, 2007

Ozbek, U, Kandilci, A, van Baal, S, Bonten, J, Boyd, K, Franken, P, Fodde, R, Grosveld, GC. SET-CAN, the product of the t(9;9) in acute undifferentiated leukemia, causes expansion of early hematopoietic progenitors and hyperproliferation of stomach mucosa in transgenic mice. Am J Pathol, 171(2), 654-66, 2007

Inoue, A, Li, T, Roby, SK, Valentine, MB, Inoue, M, Boyd, K, Kidd, VJ, Lahti, JM. Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation. Cell Cycle, 6(13), 1646-54, 2007

Gingras, S, Pelletier, S, Boyd, K, Ihle, JN. Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). PLoS One, 2(8), e808, 2007

Torchia, EC, Boyd, K, Rehg, JE, Qu, C, Baker, SJ. EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice. Mol Cell Biol, 27(22), 7918-34, 2007

Ajioka, I, Martins, RA, Bayazitov, IT, Donovan, S, Johnson, DA, Frase, S, Cicero, SA, Boyd, K, Zakharenko, SS, Dyer, MA. Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice. Cell, 131(2), 378-90, 2007

Collison, LW, Workman, CJ, Kuo, TT, Boyd, K, Wang, Y, Vignali, KM, Cross, R, Sehy, D, Blumberg, RS, Vignali, DA. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature, 450(7169), 566-9, 2007

Zhan, X, Hurwitz, JL, Krishnamurthy, S, Takimoto, T, Boyd, K, Scroggs, RA, Surman, S, Portner, A, Slobod, KS. Respiratory syncytial virus (RSV) fusion protein expressed by recombinant Sendai virus elicits B-cell and T-cell responses in cotton rats and confers protection against RSV subtypes A and B. Vaccine, 25(52), 8782-93, 2007

Hill, WA, Randolph, MM, Lokey, SJ, Hayes, E, Boyd, KL, Mandrell, TD. Efficacy and safety of topical selamectin to eradicate pinworm (Syphacia spp.) infections in rats (Rattus norvegicus) and mice (Mus musculus). J Am Assoc Lab Anim Sci, 45(3), 23-6, 2006

Xu, W, Fukuyama, T, Ney, PA, Wang, D, Rehg, J, Boyd, K, van Deursen, JM, Brindle, PK. Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells. Blood, 107(11), 4407-16, 2006

Peltola, VT, Boyd, KL, McAuley, JL, Rehg, JE, McCullers, JA. Bacterial sinusitis and otitis media following influenza virus infection in ferrets. Infect Immun, 74(5), 2562-7, 2006

Sun, Y, Boyd, K, Xu, W, Ma, J, Jackson, CW, Fu, A, Shillingford, JM, Robinson, GW, Hennighausen, L, Hitzler, JK, Ma, Z, Morris, SW. Acute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland function. Mol Cell Biol, 26(15), 5809-26, 2006

Park, TJ, Boyd, K, Curran, T. Cardiovascular and craniofacial defects in Crk-null mice. Mol Cell Biol, 26(16), 6272-82, 2006

Funk, AJ, Rogers, TD, Dobbins, RM, Boyd, K. Exophthalmos and corneal edema in a young ferret. Diagnosis: glaucoma. Lab Anim (NY), 35(9), 19, 20-1, 2006

Lee, Y, Miller, HL, Russell, HR, Boyd, K, Curran, T, McKinnon, PJ. Patched2 modulates tumorigenesis in patched1 heterozygous mice. Cancer Res, 66(14), 6964-71, 2006

Dominici, M, Tadjali, M, Kepes, S, Allay, ER, Boyd, K, Ney, PA, Horwitz, E, Persons, DA. Transgenic mice with pancellular enhanced green fluorescent protein expression in primitive hematopoietic cells and all blood cell progeny. Genesis, 42(1), 17-22, 2005

Harvey, NL, Srinivasan, RS, Dillard, ME, Johnson, NC, Witte, MH, Boyd, K, Sleeman, MW, Oliver, G. Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. Nat Genet, 37(10), 1072-81, 2005

Kasper, LH, Boussouar, F, Boyd, K, Xu, W, Biesen, M, Rehg, J, Baudino, TA, Cleveland, JL, Brindle, PK. Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. EMBO J, 24(22), 3846-58, 2005

Alymova, IV, Portner, A, Takimoto, T, Boyd, KL, Babu, YS, McCullers, JA. The novel parainfluenza virus hemagglutinin-neuraminidase inhibitor BCX 2798 prevents lethal synergism between a paramyxovirus and Streptococcus pneumoniae. Antimicrob Agents Chemother, 49(1), 398-405, 2005

Cardone, M, Kandilci, A, Carella, C, Nilsson, JA, Brennan, JA, Sirma, S, Ozbek, U, Boyd, K, Cleveland, JL, Grosveld, GC. The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis. Mol Cell Biol, 25(6), 2395-405, 2005

Desmots, F, Russell, HR, Lee, Y, Boyd, K, McKinnon, PJ. The reaper-binding protein scythe modulates apoptosis and proliferation during mammalian development. Mol Cell Biol, 25(23), 10329-37, 2005

Nilsson, JA, Nilsson, LM, Keller, U, Yokota, Y, Boyd, K, Cleveland, JL. Id2 is dispensable for myc-induced lymphomagenesis. Cancer Res, 64(20), 7296-301, 2004