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Department of Pathology, Microbiology, and Immunology

  

   Adam Seegmiller, M.D., Ph.D.

 

 

Assistant Professor

Dept of Pathology, Microbiology and Immunology
Executive Medical Director of Clinical Pathology
Director, Division of Laboratory Medicine

Director, Division of Hematopathology

 

 

  Contact Information

 

 

Office Location:

4605-A TVC

Phone: 615-322-0858

E-mail: adam.seegmiller@vanderbilt.edu

 

Campus Mail address:

Pathology Labs/Blood Bank

4601 TVC (5310)

 

US Mailing address:

Vanderbilt University School of Medicine

Pathology Labs/Blood Bank

4601 TVC

Nashville, TN 37232-5310

 

 

 

Education

 

 

PhD, University of Texas Southwestern Medical School
MD, University of Texas Southwestern Medical School
BS, University of Utah

 

 

Research Keywords

 

 

Lipids Metabolism Cystic fibrosis Hematopathology

 

 

Research Description

 

 

Cystic fibrosis (CF) is an inherited disease caused by mutations in the gene encoding CFTR, a chloride ion channel. Among the numerous consequences of these mutations are alterations in the composition of polyunsaturated fatty acids (PUFAs) in patient tissues. We have demonstrated that these changes are due to increased expression and activity of fatty acid desaturase enzymes. Furthermore, we and others have shown that these changes likely play a role in CF pathogenesis, perhaps through excessive production of eicosanoid hormones. We continue to investigate the regulation of PUFA metabolic pathways and the role that their function or dysfunction plays in the abnormal lipid metabolism of CF. In addition, we are studying the potential role of PUFAs both as biomarkers and therapies for patients with CF.

 

 

Clinical Research Description

 

 

I am a practicing hematopathologist and an engaged in projects relating to the diagnosis and monitoring of hematolymphoid malignancies with a focus on flow cytometry. I am also a leader of the hematopathology diagnostic management team, a multidisciplinary effort to optimize ordering, reporting, and application of molecular and genetic testing for hematolymphoid malignancies.

 

 

Publications

 

 

Seegmiller, AC, Wasserman, A, Kim, AS, Kressin, MK, Marx, ER, Zutter, MM, Mosse, CA. Limited utility of fluorescence in situ hybridization for common abnormalities of myelodysplastic syndrome at first presentation and follow-up of myeloid neoplasms. Leuk Lymphoma, 55(3), 601-5, 2014

Umunakwe, OC, Seegmiller, AC. Abnormal n-6 fatty acid metabolism in cystic fibrosis is caused by activation of AMP-activated protein kinase. J Lipid Res, 55(7), 1489-1497, 2014

Seegmiller, AC, Kim, AS, Mosse, CA, Levy, MA, Thompson, MA, Kressin, MK, Jagasia, MH, Strickland, SA, Reddy, NM, Marx, ER, Sinkfield, KJ, Pollard, HN, Plummer, WD, Dupont, WD, Shultz, EK, Dittus, RS, Stead, WW, Santoro, SA, Zutter, MM. Optimizing personalized bone marrow testing using an evidence-based, interdisciplinary team approach. Am J Clin Pathol, 140(5), 643-50, 2013

Katrangi, W, Lawrenz, J, Seegmiller, AC, Laposata, M. Interactions of linoleic and alpha-linolenic acids in the development of fatty acid alterations in cystic fibrosis. Lipids, 48(4), 333-42, 2013

Slone, JS, Smith, MC, Seegmiller, AC, Sidonio, RF, Yang, E. Idiopathic myelofibrosis in children: primary myelofibrosis, essential thrombocythemia, or transient process. J Pediatr Hematol Oncol, 35(7), 559-65, 2013

Njoroge, SW, Laposata, M, Katrangi, W, Seegmiller, AC. DHA and EPA reverse cystic fibrosis-related FA abnormalities by suppressing FA desaturase expression and activity. J Lipid Res, 53(2), 257-65, 2012

Castillo, JJ, Furman, M, Beltr??n, BE, Bibas, M, Bower, M, Chen, W, D??ez-Mart??n, JL, Liu, JJ, Miranda, RN, Montoto, S, Nanaji, NM, Navarro, JT, Seegmiller, AC, Vose, JM. Human immunodeficiency virus-associated plasmablastic lymphoma: poor prognosis in the era of highly active antiretroviral therapy. Cancer, 118(21), 5270-7, 2012

Gehrie, E, Neff, AT, Ciombor, KK, Harris, N, Seegmiller, AC, Young, PP. Transfusion medicine illustrated. Profound piperacillin-mediated drug-induced immune hemolysis in a patient with cystic fibrosis. Transfusion, 52(1), 4-5, 2012

Thomsen, KF, Laposata, M, Njoroge, SW, Umunakwe, OC, Katrangi, W, Seegmiller, AC. Increased elongase 6 and ??9-desaturase activity are associated with n-7 and n-9 fatty acid changes in cystic fibrosis. Lipids, 46(8), 669-77, 2011

Seegmiller, AC, Wang, HY, Hladik, C, Chen, W. Uniform expression of Notch1, suppressor of B-cell-specific gene expression, in plasmablastic lymphoma. Arch Pathol Lab Med, 135(6), 770-5, 2011

Njoroge, SW, Seegmiller, AC, Katrangi, W, Laposata, M. Increased ??5- and ??6-desaturase, cyclooxygenase-2, and lipoxygenase-5 expression and activity are associated with fatty acid and eicosanoid changes in cystic fibrosis. Biochim Biophys Acta, 1811(7-8), 431-40, 2010

Qian, Y, Wei, C, Eun-Hyung Lee, F, Campbell, J, Halliley, J, Lee, JA, Cai, J, Kong, YM, Sadat, E, Thomson, E, Dunn, P, Seegmiller, AC, Karandikar, NJ, Tipton, CM, Mosmann, T, Sanz, I, Scheuermann, RH. Elucidation of seventeen human peripheral blood B-cell subsets and quantification of the tetanus response using a density-based method for the automated identification of cell populations in multidimensional flow cytometry data. Cytometry B Clin Cytom, 78 Suppl 1, S69-82, 2010

Seegmiller, AC, Garcia, R, Huang, R, Maleki, A, Karandikar, NJ, Chen, W. Simple karyotype and bcl-6 expression predict a diagnosis of Burkitt lymphoma and better survival in IG-MYC rearranged high-grade B-cell lymphomas. Mod Pathol, 2010

Seegmiller, AC, Kroft, SH, Karandikar, NJ, McKenna, RW. Characterization of immunophenotypic aberrancies in 200 cases of B acute lymphoblastic leukemia. Am J Clin Pathol, 132(6), 940-9, 2009

Seegmiller, AC, Karandikar, NJ, Kroft, SH, McKenna, RW, Xu, Y. Overexpression of CD7 in classical Hodgkin lymphoma-infiltrating T lymphocytes. Cytometry B Clin Cytom, 76(3), 169-74, 2009

Bogusz, AM, Seegmiller, AC, Garcia, R, Shang, P, Ashfaq, R, Chen, W. Plasmablastic lymphomas with MYC/IgH rearrangement: report of three cases and review of the literature. Am J Clin Pathol, 132(4), 597-605, 2009

Maleki, A, Seegmiller, AC, Uddin, N, Karandikar, NJ, Chen, W. Bright CD38 expression is an indicator of MYC rearrangement. Leuk Lymphoma, 50(6), 1054-7, 2009

Seegmiller, AC, Xu, Y, McKenna, RW, Karandikar, NJ. Immunophenotypic differentiation between neoplastic plasma cells in mature B-cell lymphoma vs plasma cell myeloma. Am J Clin Pathol, 127(2), 176-81, 2007

Seegmiller, A, Sarode, R. Laboratory evaluation of platelet function. Hematol Oncol Clin North Am, 21(4), 731-42, vii, 2007

Bennett, MJ, Russell, LK, Tokunaga, C, Narayan, SB, Tan, L, Seegmiller, A, Boriack, RL, Strauss, AW. Reye-like syndrome resulting from novel missense mutations in mitochondrial medium- and short-chain l-3-hydroxy-acyl-CoA dehydrogenase. Mol Genet Metab, 89(1-2), 74-9, 2006

Seegmiller, AC, Dobrosotskaya, I, Goldstein, JL, Ho, YK, Brown, MS, Rawson, RB. The SREBP pathway in Drosophila: regulation by palmitate, not sterols. Dev Cell, 2(2), 229-38, 2002

Dobrosotskaya, IY, Seegmiller, AC, Brown, MS, Goldstein, JL, Rawson, RB. Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila. Science, 296(5569), 879-83, 2002

Seegmiller, A, Herrick, G. A short internal eliminated sequence with central conserved sequences interrupting the LA-MSC gene of the 81 locus in the hypotrichous ciliates Oxytricha fallax and O. trifallax. J Eukaryot Microbiol, 45(1), 55-8, 1998

Sakai, J, Rawson, RB, Espenshade, PJ, Cheng, D, Seegmiller, AC, Goldstein, JL, Brown, MS. Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells. Mol Cell, 2(4), 505-14, 1998

Witherspoon, DJ, Doak, TG, Williams, KR, Seegmiller, A, Seger, J, Herrick, G. Selection on the protein-coding genes of the TBE1 family of transposable elements in the ciliates Oxytricha fallax and O. trifallax. Mol Biol Evol, 14(7), 696-706, 1997

Seegmiller, A, Williams, KR, Herrick, G. Two two-gene macronuclear chromosomes of the hypotrichous ciliates Oxytricha fallax and O. trifallax generated by alternative processing of the 81 locus. Dev Genet, 20(4), 348-57, 1997

Seegmiller, A, Williams, KR, Hammersmith, RL, Doak, TG, Witherspoon, D, Messick, T, Storjohann, LL, Herrick, G. Internal eliminated sequences interrupting the Oxytricha 81 locus: allelic divergence, conservation, conversions, and possible transposon origins. Mol Biol Evol, 13(10), 1351-62, 1996