Department of Pathology, Microbiology, and Immunology



   Chanjuan Shi, M.D., Ph.D.



Associate Professor

Dept of Pathology, Microbiology and Immunology


  Contact Information


Office Location:

C-2310D MCN

Phone:  615-936-8342

E-mail: chanjuan.shi@vanderbilt.edu

Campus Mail address:

Pathology, Microbiology and Immunology -3rd Fl 

C-3321 MCN (2561)

US Mailing address:

Vanderbilt University School of Medicine

Dept Pathology, Microbiology and Immunology - 3rd Fl

C-3321 MCN

Nashville, TN 37232-2561



Research Keywords





Research Description





Clinical Research Description



Early detection and biomarkers in pancreatic cancer. Histopathology and molecular biology of gastroenteropancreatic neuroendocrine neoplasms.






O''Neal, RL, Nam, KT, LaFleur, BJ, Barlow, B, Nozaki, K, Lee, HJ, Kim, WH, Yang, HK, Shi, C, Maitra, A, Montgomery, E, Washington, MK, El Rifai, W, Drapkin, RI, Goldenring, JR. Human epididymis protein 4 is up-regulated in gastric and pancreatic adenocarcinomas. Hum Pathol, 44(5), 734-42, 2013

Ellison, TA, Wolfgang, CL, Shi, C, Cameron, JL, Murakami, P, Mun, LJ, Singhi, AD, Cornish, TC, Olino, K, Meriden, Z, Choti, M, Diaz, LA, Pawlik, TM, Schulick, RD, Hruban, RH, Edil, BH. A Single Institution''s 26-Year Experience With Nonfunctional Pancreatic Neuroendocrine Tumors: A Validation of Current Staging Systems and a New Prognostic Nomogram. Ann Surg, 2013

Kawamoto, S, Johnson, PT, Shi, C, Singhi, AD, Hruban, RH, Wolfgang, CL, Edil, BH, Fishman, EK. Pancreatic neuroendocrine tumor with cystlike changes: evaluation with MDCT. AJR Am J Roentgenol, 200(3), W283-90, 2013

Ayers, K, Shi, C, Washington, K, Yachimski, P. Expert pathology review and endoscopic mucosal resection alters the diagnosis of patients referred to undergo therapy for Barrett''s esophagus. Surg Endosc, 27(8), 2836-40, 2013

Singhi, AD, Chu, LC, Tatsas, AD, Shi, C, Ellison, TA, Fishman, EK, Kawamoto, S, Schulick, RD, Wolfgang, CL, Hruban, RH, Edil, BH. Cystic pancreatic neuroendocrine tumors: a clinicopathologic study. Am J Surg Pathol, 36(11), 1666-73, 2012

McCall, CM, Shi, C, Klein, AP, Konukiewitz, B, Edil, BH, Ellison, TA, Wolfgang, CL, Schulick, RD, Kl??ppel, G, Hruban, RH. Serotonin expression in pancreatic neuroendocrine tumors correlates with a trabecular histologic pattern and large duct involvement. Hum Pathol, 43(8), 1169-76, 2012

Shi, C, Hruban, RH. Intraductal papillary mucinous neoplasm. Hum Pathol, 43(1), 1-16, 2012

Deery, S, Yates, R, Hata, J, Shi, C, Parikh, AA. Gastric adenocarcinoma associated with gastritis cystica profunda in an unoperated stomach. Am Surg, 78(8), E379-80, 2012

Shi, C, Washington, K. Molecular testing in colorectal cancer: diagnosis of Lynch syndrome and personalized cancer medicine. Am J Clin Pathol, 137(6), 847-59, 2012

Yachida, S, Vakiani, E, White, CM, Zhong, Y, Saunders, T, Morgan, R, de Wilde, RF, Maitra, A, Hicks, J, Demarzo, AM, Shi, C, Sharma, R, Laheru, D, Edil, BH, Wolfgang, CL, Schulick, RD, Hruban, RH, Tang, LH, Klimstra, DS, Iacobuzio-Donahue, CA. Small Cell and Large Cell Neuroendocrine Carcinomas of the Pancreas are Genetically Similar and Distinct From Well-differentiated Pancreatic Neuroendocrine Tumors. Am J Surg Pathol, 36(2), 173-84, 2012

Wentz, SC, Zhao, ZG, Shyr, Y, Shi, CJ, Merchant, NB, Washington, K, Xia, F, Chakravarthy, AB. Lymph node ratio and preoperative CA 19-9 levels predict overall survival and recurrence-free survival in patients with resected pancreatic adenocarcinoma. World J Gastrointest Oncol, 4(10), 207-15, 2012

Kawamoto S, Shi C, Hruban RH, Choti MA, Schulick RD, Fishman EK, Siegelman SS. Small serotonin-producing neuroendocrine tumor of the pancreas associated with pancreatic duct obstruction. AJR Am J Roentgenol, 197(3), W482-8, 2011 PMID:21862776

Meriden Z, Shi C, Edil BH, Ellison T, Wolfgang CL, Cornish TC, Schulick RD, Hruban RH. . Hyaline globules in neuroendocrine and solid-pseudopapillary neoplasms of the pancreas: a clue to the diagnosis. Am J Surg Pathol, 35(7), 981-8, 2011 PMID: 21677537

Heaphy CM, de Wilde RF, Jiao Y, Klein AP, Edil BH, Shi C, Bettegowda C, Rodriguez FJ, Eberhart CG, Hebbar S, Offerhaus GJ, McLendon R, Rasheed BA, He Y, Yan H, Bigner DD, Oba-Shinjo SM, Marie SK, Riggins GJ, Kinzler KW, Vogelstein B, Hruban RH, Maitra A, Papadopoulos N, Meeker AK. Altered telomeres in tumors with ATRX and DAXX mutations. Science, 333(6041 Epub), 425, 2011 PMC3174141

Kern, SE, Shi, C, Hruban, RH. The complexity of pancreatic ductal cancers and multidimensional strategies for therapeutic targeting. J Pathol, 223(2), 295-306, 2011

Jiao, Y, Shi, C, Edil, BH, de Wilde, RF, Klimstra, DS, Maitra, A, Schulick, RD, Tang, LH, Wolfgang, CL, Choti, MA, Velculescu, VE, Diaz, LA, Vogelstein, B, Kinzler, KW, Hruban, RH, Papadopoulos, N. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science, 331(6021), 1199-203, 2011

Hong, SM, Heaphy, CM, Shi, C, Eo, SH, Cho, H, Meeker, AK, Eshleman, JR, Hruban, RH, Goggins, M. Telomeres are shortened in acinar-to-ductal metaplasia lesions associated with pancreatic intraepithelial neoplasia but not in isolated acinar-to-ductal metaplasias. Mod Pathol, 24(2), 256-66, 2011

Xiong, W, Shi, C. Images in clinical medicine. Malignant pericardial effusion. N Engl J Med, 364(9), e18, 2011

Kamiyama, H, Kamiyama, M, Hong, SM, Karikari, CA, Lin, MT, Borges, MW, Griffith, M, Young, A, Norris-Kirby, A, Lubek, C, Mizuma, M, Feldmann, G, Shi, C, Liang, H, Goggins, MG, Maitra, A, Hruban, RH, Eshleman, JR. In vivo and in vitro propagation of intraductal papillary mucinous neoplasms. Lab Invest, 90(5), 665-73, 2010

Xiong, W, Shi, C. Images in cardiovascular medicine: Concomitant persistent left superior vena cava and agenesis of right superior vena cava: a rare congenital anomaly. Circulation, 121(21), 2329-30, 2010

Scudiere, JR, Shi, C, Hruban, RH, Herman, JM, Fishman, EK, Schulick, RD, Wolfgang, CL, Makary, MA, Thornton, K, Montgomery, E, Horton, KM. Sclerosing mesenteritis involving the pancreas: a mimicker of pancreatic cancer. Am J Surg Pathol, 34(4), 447-53, 2010

Shi, C, Scudiere, JR, Cornish, TC, Lam-Himlin, D, Park, JY, Fox, MR, Montgomery, EA. Clear cell change in colonic tubular adenoma and corresponding colonic clear cell adenocarcinoma is associated with an altered mucin core protein profile. Am J Surg Pathol, 34(9), 1344-50, 2010

Shi, C, Siegelman, SS, Kawamoto, S, Wolfgang, CL, Schulick, RD, Maitra, A, Hruban, RH. Pancreatic duct stenosis secondary to small endocrine neoplasms: a manifestation of serotonin production. Radiology, 257(1), 107-14, 2010

Gold, DV, Goggins, M, Modrak, DE, Newsome, G, Liu, M, Shi, C, Hruban, RH, Goldenberg, DM. Detection of early-stage pancreatic adenocarcinoma. Cancer Epidemiol Biomarkers Prev, 19(11), 2786-94, 2010

Lam-Himlin, D, Park, JY, Cornish, TC, Shi, C, Montgomery, E. Morphologic characterization of syndromic gastric polyps. Am J Surg Pathol, 34(11), 1656-62, 2010

Park, JY, Cornish, TC, Lam-Himlin, D, Shi, C, Montgomery, E. Gastric lesions in patients with autoimmune metaplastic atrophic gastritis (AMAG) in a tertiary care setting. Am J Surg Pathol, 34(11), 1591-8, 2010

Shi C and Argani P. Synchronous primary perianal Pageta??s disease and rectal adenocarcinoma: Report of a hitherto unreported phenomenon. Int J of Surg Pathol, 17(1), 42-5, 2009 PMID:18499687

Koorstra, JB, Hong, SM, Shi, C, Meeker, AK, Ryu, JK, Offerhaus, GJ, Goggins, MG, Hruban, RH, Maitra, A. Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia. Mod Pathol, 22(11), 1439-45, 2009

Shi, C, Chandrasekaran, A, Thuluvath, PJ, Karikari, C, Argani, P, Goggins, M, Maitra, A, Eshleman, JR. Ultrasensitive detection of KRAS2 mutations in bile and serum from patients with biliary tract carcinoma using LigAmp technology. J Mol Diagn, 11(6), 583-9, 2009

Taube, JM, Begum, S, Shi, C, Eshleman, JR, Westra, WH. Benign nodal nevi frequently harbor the activating V600E BRAF mutation. Am J Surg Pathol, 33(4), 568-71, 2009

Shi, C, Hruban, RH, Klein, AP. Familial pancreatic cancer. Arch Pathol Lab Med, 133(3), 365-74, 2009

Shi, C, Hong, SM, Lim, P, Kamiyama, H, Khan, M, Anders, RA, Goggins, M, Hruban, RH, Eshleman, JR. KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin. Mol Cancer Res, 7(2), 230-6, 2009

Shi, C, Klein, AP, Goggins, M, Maitra, A, Canto, M, Ali, S, Schulick, R, Palmisano, E, Hruban, RH. Increased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients. Clin Cancer Res, 15(24), 7737-7743, 2009

Shi, C, Daniels, JA, Hruban, RH. Molecular characterization of pancreatic neoplasms. Adv Anat Pathol, 15(4), 185-95, 2008

Shi, C, Parker, AR, Hua, L, Morrell, CN, Lee, SC, Bandaru, V, Dumler, JS, Wu, TC, Eshleman, JR. Anti-gene padlocks eliminate Escherichia coli based on their genotype. J Antimicrob Chemother, 61(2), 262-72, 2008

Shi, C, Fukushima, N, Abe, T, Bian, Y, Hua, L, Wendelburg, BJ, Yeo, CJ, Hruban, RH, Goggins, MG, Eshleman, JR. Sensitive and quantitative detection of KRAS2 gene mutations in pancreatic duct juice differentiates patients with pancreatic cancer from chronic pancreatitis, potential for early detection. Cancer Biol Ther, 7(3), 353-360, 2008

Church, JD, Jones, D, Flys, T, Hoover, D, Marlowe, N, Chen, S, Shi, C, Eshleman, JR, Guay, LA, Jackson, JB, Kumwenda, N, Taha, TE, Eshleman, SH. Sensitivity of the ViroSeq HIV-1 genotyping system for detection of the K103N resistance mutation in HIV-1 subtypes A, C, and D. J Mol Diagn, 8(4), 430-2; quiz 527, 2006

Bertolesi, GE, Walia Da Silva, R, Jollimore, CA, Shi, C, Barnes, S, Kelly, ME. Ca(v)3.1 splice variant expression during neuronal differentiation of Y-79 retinoblastoma cells. Neuroscience, 141(1), 259-68, 2006

Rubio-Viqueira, B, Jimeno, A, Cusatis, G, Zhang, X, Iacobuzio-Donahue, C, Karikari, C, Shi, C, Danenberg, K, Danenberg, PV, Kuramochi, H, Tanaka, K, Singh, S, Salimi-Moosavi, H, Bouraoud, N, Amador, ML, Altiok, S, Kulesza, P, Yeo, C, Messersmith, W, Eshleman, J, Hruban, RH, Maitra, A, Hidalgo, M. An in vivo platform for translational drug development in pancreatic cancer. Clin Cancer Res, 12(15), 4652-61, 2006

Rogers, CD, Fukushima, N, Sato, N, Shi, C, Prasad, N, Hustinx, SR, Matsubayashi, H, Canto, M, Eshleman, JR, Hruban, RH, Goggins, M. Differentiating pancreatic lesions by microarray and QPCR analysis of pancreatic juice RNAs. Cancer Biol Ther, 5(10), 1383-9, 2006

Flys, T, Nissley, DV, Claasen, CW, Jones, D, Shi, C, Guay, LA, Musoke, P, Mmiro, F, Strathern, JN, Jackson, JB, Eshleman, JR, Eshleman, SH. Sensitive drug-resistance assays reveal long-term persistence of HIV-1 variants with the K103N nevirapine (NVP) resistance mutation in some women and infants after the administration of single-dose NVP: HIVNET 012. J Infect Dis, 192(1), 24-9, 2005

Parker, AR, Sieber, OM, Shi, C, Hua, L, Takao, M, Tomlinson, IP, Eshleman, JR. Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair. Carcinogenesis, 26(11), 2010-8, 2005

Shi, C, Eshleman, SH, Jones, D, Fukushima, N, Hua, L, Parker, AR, Yeo, CJ, Hruban, RH, Goggins, MG, Eshleman, JR. LigAmp for sensitive detection of single-nucleotide differences. Nat Methods, 1(2), 141-7, 2004

Vessey, JP, Shi, C, Jollimore, CA, Stevens, KT, Coca-Prados, M, Barnes, S, Kelly, ME. Hyposmotic activation of ICl,swell in rabbit nonpigmented ciliary epithelial cells involves increased ClC-3 trafficking to the plasma membrane. Biochem Cell Biol, 82(6), 708-18, 2004

Shi, C, Szczesniak, A, Mao, L, Jollimore, C, Coca-Prados, M, Hung, O, Kelly, ME. A3 adenosine and CB1 receptors activate a PKC-sensitive Cl- current in human nonpigmented ciliary epithelial cells via a G beta gamma-coupled MAPK signaling pathway. Br J Pharmacol, 139(3), 475-86, 2003

Bertolesi, GE, Jollimore, CA, Shi, C, Elbaum, L, Denovan-Wright, EM, Barnes, S, Kelly, ME. Regulation of alpha1G T-type calcium channel gene (CACNA1G) expression during neuronal differentiation. Eur J Neurosci, 17(9), 1802-10, 2003

Thoreson, WB, Ryan, JS, Shi, C, Kelly, ME, Bryson, EJ, Toews, ML, Ediger, TL, Chacko, DM. Lysophosphatidic acid receptor signaling in mammalian retinal pigment epithelial cells. Invest Ophthalmol Vis Sci, 43(7), 2450-61, 2002

Bertolesi, GE, Shi, C, Elbaum, L, Jollimore, C, Rozenberg, G, Barnes, S, Kelly, ME. The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms. Mol Pharmacol, 62(2), 210-9, 2002

Shi, C, Barnes, S, Coca-Prados, M, Kelly, ME. Protein tyrosine kinase and protein phosphatase signaling pathways regulate volume-sensitive chloride currents in a nonpigmented ciliary epithelial cell line. Invest Ophthalmol Vis Sci, 43(5), 1525-32, 2002

Ryan, JS, Shi, C, Kelly, ME. Patch-clamp recording methods for examining adrenergic regulation of potassium currents in ocular epithelial cells. Methods Mol Biol, 126, 391-407, 2000

Shi, C, Ryan, JS, French, AS, Coca-Prados, M, Kelly, ME. Hyposmotically activated chloride channels in cultured rabbit non-pigmented ciliary epithelial cells. J Physiol, 521 Pt 1, 57-67, 1999