Department of Pathology, Microbiology, and Immunology


   Bret Mobley, M.D.



Assistant Professor

Dept of Pathology, Microbiology and Immunology


  Contact Information



Office Location:

C-2318 MCN

Phone: 615-322-3998  

Fax: 615-343-7089

E-mail: bret.mobley@vanderbilt.edu


Campus Mail address:

Pathology, Microbiology and Immunology-3rd Fl

C-3321 MCN (2561)


US Mailing address:

Vanderbilt University School of Medicine

Dept of Pathology, Microbiology and Immunology-3rd Fl

C-3321 MCN

Nashville, TN 37232-2561



Research Keywords



Glioblastoma, Glioma, IDH mutation



Research Description



Currently working in the Rebecca Ihrie laboratory (Department of Cancer Biology) on projects exploring heterogeneity and tumor propagating cells in glioblastoma and IDH-mutated gliomas.



Clinical Research Description



Histologic, Immunohistochemical, and Molecular predictors of Brain Metastasis Recurrence and Patient Survival






Hata, JL, Correa, H, Krishnan, C, Esbenshade, AJ, Black, JO, Chung, DH, Mobley, BC. Diagnostic utility of PHOX2B in primary and treated neuroblastoma and in neuroblastoma metastatic to the bone marrow. Arch Pathol Lab Med, 139(4), 543-6, 2015

Georgescu, MM, Yell, P, Mobley, BC, Shang, P, Georgescu, T, Wang, SH, Canoll, P, Hatanpaa, KJ, White, CL, Raisanen, JM. NHERF1/EBP50 is an organizer of polarity structures and a diagnostic marker in ependymoma. Acta Neuropathol Commun, 3, 11, 2015

Mobley, BC, Kumar, M, Sanger, WG, Nelson, M, Nickols, HH, Chambless, LB, Gokden, M. Papillary tumor of the pineal region with synchronous suprasellar focus and novel cytogenetic features. Hum Pathol, 2015

Gong, Y, Ma, Y, Sinyuk, M, Loganathan, S, Thompson, RC, Sarkaria, JN, Chen, W, Lathia, JD, Mobley, BC, Clark, SW, Wang, J. Insulin-mediated signaling promotes proliferation and survival of glioblastoma through Akt activation. Neuro Oncol, 2015

Yeom, KW, Mobley, BC, Lober, RM, Andre, JB, Partap, S, Vogel, H, Barnes, PD. Distinctive MRI features of pediatric medulloblastoma subtypes. AJR Am J Roentgenol, 200(4), 895-903, 2013

Paul, P, Qiao, J, Kim, KW, Romain, C, Lee, S, Volny, N, Mobley, B, Correa, H, Chung, DH. Targeting gastrin-releasing peptide suppresses neuroblastoma progression via upregulation of PTEN signaling. PLoS One, 8(9), e72570, 2013

Daniels, BH, McComb, RD, Mobley, BC, Gultekin, SH, Lee, HS, Margeta, M. LC3 and p62 as diagnostic markers of drug-induced autophagic vacuolar cardiomyopathy: a study of 3 cases. Am J Surg Pathol, 37(7), 1014-21, 2013

Ghazi, SO, Stark, M, Zhao, Z, Mobley, BC, Munden, A, Hover, L, Abel, TW. Cell of origin determines tumor phenotype in an oncogenic Ras/p53 knockout transgenic model of high-grade glioma. J Neuropathol Exp Neurol, 71(8), 729-40, 2012

Azimian, M, Gultekin, SH, Hata, JL, Atkinson, JB, Ely, KA, Fuchs, HA, Mobley, BC. Fatal antimalarial-induced cardiomyopathy: report of 2 cases. J Clin Rheumatol, 18(7), 363-6, 2012

Kleinfeld, K, Mobley, B, Hedera, P, Wegner, A, Sriram, S, Pawate, S. Adult-onset leukoencephalopathy with neuroaxonal spheroids and pigmented glia: report of five cases and a new mutation. J Neurol, 2012

Pettit, AC, Kropski, JA, Castilho, JL, Schmitz, JE, Rauch, CA, Mobley, BC, Wang, XJ, Spires, SS, Pugh, ME. The index case for the fungal meningitis outbreak in the United States. N Engl J Med, 367(22), 2119-25, 2012

Yeom, KW, Lober, RM, Mobley, BC, Harsh, G, Vogel, H, Allagio, R, Pearson, M, Edwards, MS, Fischbein, NJ. Diffusion-Weighted MRI: Distinction of Skull Base Chordoma From Chondrosarcoma. AJNR Am J Neuroradiol, 2012

Bredel, M, Scholtens, DM, Yadav, AK, Alvarez, AA, Renfrow, JJ, Chandler, JP, Yu, IL, Carro, MS, Dai, F, Tagge, MJ, Ferrarese, R, Bredel, C, Phillips, HS, Lukac, PJ, Robe, PA, Weyerbrock, A, Vogel, H, Dubner, S, Mobley, B, He, X, Scheck, AC, Sikic, BI, Aldape, KD, Chakravarti, A, Harsh, GR. NFKBIA deletion in glioblastomas. N Engl J Med, 364(7), 627-37, 2011

Forbes, JA, Mobley, BC, O''Lynnger, TM, Cooper, CM, Ghiassi, M, Hanif, R, Pearson, MM. Pediatric cerebellar pilomyxoid-spectrum astrocytomas. J Neurosurg Pediatr, 8(1), 90-6, 2011

Mobley, BC, McKenney, JK, Bangs, CD, Callahan, K, Yeom, KW, Schneppenheim, R, Hayden, MG, Cherry, AM, Gokden, M, Edwards, MS, Fisher, PG, Vogel, H. Loss of SMARCB1/INI1 expression in poorly differentiated chordomas. Acta Neuropathol, 120(6), 745-53, 2010

Mobley, BC, Enns, GM, Wong, LJ, Vogel, H. A novel homozygous SCO2 mutation, p.G193S, causing fatal infantile cardioencephalomyopathy. Clin Neuropathol, 28(2), 143-9, 2009

Hayden, MG, Guzman, R, Dulai, MS, Mobley, BC, Edwards, MS. Recurring osteoma within a calcium phosphate bone cement cranioplasty: case report. Neurosurgery, 64(4), E775-6; discussion E776, 2009

Boyd, SD, Mobley, BC, Regula, DP, Arber, DA. Features of hemolysis due to Clostridium perfringens infection. Int J Lab Hematol, 31(3), 364-7, 2009

Murovic, JA, Gibbs, IC, Chang, SD, Mobley, BC, Park, J, Adler, JR. Foraminal nerve sheath tumors: intermediate follow-up after cyberknife radiosurgery. Neurosurgery, 64(2 Suppl), A33-43, 2009

Mobley, B, Kalani, MY, Harsh, GR, Edwards, MS, Vogel, H. Papillary tumor of the spinal cord: report of 2 cases. Am J Surg Pathol, 33(8), 1191-7, 2009

Tsao, GJ, Tsang, MW, Mobley, BC, Cheng, WW. Foramen magnum meningioma: Dysphagia of atypical etiology. J Gen Intern Med, 23(2), 206-9, 2008

Mobley, BC, Roulston, D, Shah, GV, Bijwaard, KE, McKeever, PE. Peripheral primitive neuroectodermal tumor/Ewing''s sarcoma of the craniospinal vault: case reports and review. Hum Pathol, 37(7), 845-53, 2006

Vincent, AM, Mobley, BC, Hiller, A, Feldman, EL. IGF-I prevents glutamate-induced motor neuron programmed cell death. Neurobiol Dis, 16(2), 407-16, 2004

Rubin, A, Mobley, B, Hogikyan, N, Bell, K, Sullivan, K, Boulis, N, Feldman, E. Delivery of an adenoviral vector to the crushed recurrent laryngeal nerve. Laryngoscope, 113(6), 985-9, 2003

Minor, DL, Lin, YF, Mobley, BC, Avelar, A, Jan, YN, Jan, LY, Berger, JM. The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel. Cell, 102(5), 657-70, 2000