.

Department of Pathology, Microbiology, and Immunology

 

 

Sebastian Joyce, Ph.D.

 

 

Professor

Dept of Pathology, Microbiology and Immunology

 

 

Contact Information

 

 

Office Location:
MCN A-4223A; Campus zip-2363
Phone: 615-322-1472
E-mail:  sebastian.joyce@vanderbilt.edu

 

Campus Mail address:

Pathology, Microbiology and Immunology-5th Fl

MCN A-5301 (2363)

 

US Mailing address:
Vanderbilt University School of Medicine
Dept of Pathology, Microbiology and Immunology-5th
MCN A-5301
Nashville, TN 37232-2363

 

 

 

Education

 

 

Postdoc, Albert Einstein College of Medicine, New York, NY
Ph.D., Medical College of Virginia, Virginia Commonwealth University, Richmond, VA
M.Sc., Saurashtra Univ., Rajkot, Gujarat, India
B.Sc., St. Joseph's Coll., Bangalore Univ, Bangalore, India

 

 

Research Keywords

 

 

infection and immunity, mucosal immunity, antigen processing and presentation, T cell development and function, cyrokine secretion

 

 

Research Description

 

 

"ANTIGENS, ANTIGEN RECOGNITION BY T CELLS AND MUCOSAL IMMUNITY"

For detailed description, visit us at https://medschool.vanderbilt.edu/joyce-lab/

Sensation and actuation are fundamental to physiologic systems, which evolved to sense perturbations in homeostasis and actuate an appropriate response so as to restore a set homeostatic state unique to an organism. The immune system functions much like a sensor-actuator system akin to the nervous system. The immune system most times works rather quietly, unless o' course winter turns to spring???for those allergic begin coughing and sneezing and huffing and wheezing! So also, we have all felt the power of the immune system when recovering from an infectious disease or expulsing an intestinal worm or, alternatively, its wrath in those suffering autoimmune diseases. In all of these instances, the initiation of an immune response begins with sensing of an antigenic substance--this sensing is called immunologic recognition.

The focus of our research programme is on immunologic recognition that regulates T lymphocyte function in health and disease. This entails an in-depth understanding of (a) what T cells recognize during development and during an immune response; (b) how T cell antigens are processed and transported to cellular sites of assembly for presentation by MHC and MHC-like molecules; and (c) how antigen presentation leads to the induction of the proper immune response?

Our laboratory addresses these questions through three major projects: (a) large-scale pathogen-derived CD8 T cell epitope discovery and mechanisms of action of new generation, microbe-free mucosal vaccines; (b) mechanisms of peptide and lipid antigen processing and presentation; and (c) the molecular basis of NKT cell ontogeny and function. We take a systematic, multidisciplinary approach--immunologic, cell and molecular biologic, biochemical, proteomics and genomics--to address questions in these areas.

 

 

Publications

 

 

Hill TM, Gilchuk P, Cicek BB, Osina MA, Boyd KL, Durrant DM, Metzger DW, Khanna KM, Joyce S. Border patrol gone awry: lung NKT cell activation by Francisella tularensis exacerbates tularemia-like disease. PLoS Path, 11, e1004975, 2015

Hastings, AK, Erickson, JJ, Schuster, JE, Boyd, KL, Tollefson, SJ, Johnson, M, Gilchuk, P, Joyce, S, and Williams, JV . Role of type I interferon signaling in human metapneumovirus pathogenesis and control of viral replication. J Virol, 89, 4405-4420, 2015

Wen SC, Schuster JE, Gilchuk P, Boyd KL, Joyce S. and Williams JV. Lung CD8+ T cell impairment occurs during human metapneumovirus infection despite virus-like particle (VLP) induction of functional CD8+ T cells. J Virol, 89, doi:10.1128/JVI.00670-15, 2015

Gilchuk, P, Hill, TM, Wilson, JT, Joyce, S. Discovering protective CD8 T cell epitopes: no single immunologic property predicts it!. Curr. Opinion Immunol. , 34, 43-51, 2015

Stengel, K, Zhao, Y, Klus, NJ, Kaiser, JF, Gordy, LE, Joyce, S, Hiebert, SW, and Summers, AR.. Histone deacetylase 3 is required for efficient T-cell development. Mol. Cell. Biol., 35, in press, 2015

Hoek, KL, Samir, P, Niu, X, Howard, LM, Prasad, N, Galassie, A, Liu, Q, Allos, TM, Guo, Y, Shyr, Y, Levy, S., Joyce, S, Edwards, KE, Link, AJ . A cell-based systems biology assessment of human blood to monitor immune responses following influenza vaccination. PLoS ONE, 10, e0118528 doi: 10.1371/journal.pone.0118528, 2015

Wen, SC, Tollefson, SJ, Johnson, M, Gilchuk, P, Boyd, KL, Shepherd, B, Joyce, S, Williams, JV. Acute clearance of human metapneumovirus occurs independently of natural killer cells. J Virol, 88(18), 10963-9, 2014

Yang, J, Hawkins, OE, Barham, W, Gilchuk, P, Boothby, M, Ayers, GD, Joyce, S, Karin, M, Yull, FE, Richmond, A. Myeloid IKK?? Promotes Antitumor Immunity by Modulating CCL11 and the Innate Immune Response. Cancer Res, 74(24), 7274-84, 2014

Gilchuk, P, Spencer, CT, Conant, SB, Hill, T, Gray, JJ, Niu, X, Zheng, M, Erickson, JJ, Boyd, KL, McAfee, KJ, Oseroff, C, Hadrup, SR, Bennink, JR, Hildebrand, W, Edwards, KM, Crowe, JE, Williams, JV, Buus, S, Sette, A, Schumacher, TN, Link, AJ, Joyce, S. Discovering naturally processed antigenic determinants that confer protective T cell immunity. J Clin Invest, 123(5), 1976-87, 2013

Spencer CT, Dragovic SM, Conant SB, Gray JJ, Zheng M, Samir P, Niu X, Moutaftsi M, Van Kaer L, Sette A, Link AJ and Joyce S. Sculpting MHC class II-restricted self and non-self peptidome by the class I antigen-processing machinery and its impact on CD4+ TCR repertoire and TH cell responses. Eur J Immunol, 43, 1162-1172; DOI: 10.1002/eji.201243087, 2013

Spencer CT and Joyce S. Know thyself: variations in self peptidome and their immunologic consequences. ASHI Quarterly, 36(3), 28-36, 2012

Erickson JJ, Gilchuk P, Hastings AK, Tollefson, SJ, Downing MB, Boyd KL, Johnson JE, Kim AS, Joyce S and Willialms JV. Viral acute lower respiratory infections impair CD8+ T cells through PD-1.. J Clin Invest, 122, 2967-2982, 2012

Joyce S, Girardi E and Zajonc DM. NKT cell ligand recognition logic: molecular basis for a synaptic duet and transmission of inflammatory effectors. J Immunol, 187, 1081-1089, 2011

Gordy LE, Bezbradica JS, Flyak AI, Spencer CT, Dunkle A, Stanic A.K., Sun J, Boothby MR, He Y-W, Zhao Z, Van Kaer L, and Joyce S. IL-15 regulates homeostasis and terminal maturation of NKT cells. J Immunol, 187, 6335-6345, 2011

Dragovic SM, Hill T, Christianson GJ, Kim S, Elliott T, Scott D, Roopenian D, Van Kaer L and Joyce S. Proteasomes, TAP and endoplasmic reticulum-associated aminopeptidase associated with antigen processing control CD4+ TH cell responses by regulating indirect presentation of MHC class II-restricted cytoplasmic antigens. J Immunol, 186, 6683-6692, 2011

Aiken C and Joyce S. TRIM5 does double duty. Nature, 472, 305-306, 2011

Boelte, KC, Gordy, LE, Joyce, S, Thompson, MA, Yang, L, Lin, PC. Rgs2 mediates pro-angiogenic function of myeloid derived suppressor cells in the tumor microenvironment via upregulation of MCP-1. PLoS One, 6(4), e18534, 2011

Van Kaer L and S Joyce. The hunt for iNKT cell antigens: I?-galactosidase-deficient mice to the rescue?. Immunity, 33, 143-145, 2010

Joyce S and Gordy LE. Natural killer T cell-a cat o' nine lives!. EMBO J, 29, 1475-1476, 2010

Escande-Beillard N, Washburn L, Zekzer D, Wu ZP, Eitan S, Ivkovic S, Lu Y, Dang H, Middleton B, Bilousova TV, Yoshimura Y, Evans CJ, Joyce S, Tian J and Kaufman DL. Neurons preferentially respond to self-MHC class I allele products regardless of peptide presented. J Immunol, 184, 816-823, 2010

Spencer CT, G Pavlo, SM Dragovic and S Joyce. Minor histocompatibility antigens: presentation principles, recognition logic and the potential for a healing hand. Current Opinion in Organ Transplantation , 15(4), 512-525, 2010

Hoek KL, LE Gordy, PL Collins, VV Parekh, TM Aune, S Joyce, JW Thomas, L Van Kaer and Eric Sebzda. Follicular B cell trafficking within the spleen actively restricts humoral immune responses. Immunity, 33, 254-265, 2010

Lee K, Gudapati P, Dragovic S, Spencer C, Joyce S, Killeen N, Magnuson MA and Boothby M. Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity, 32, 743-753, 2010

WC Florence, C Xia, LE Gordy, W Chen, Y Zhang, J Scott-Browne, Y Kinjo, KOA Yu, S Keshipeddy, DG Pellicci, O Patel, L Kjer-Nielsen, J McCluskey, DI Godfrey, J Rossjohn, SK Richardson, SA Porcelli, AR Howell, K Hayakawa, L Gapin, DM Zajonc, PG Wang and S Joyce. Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands. EMBO J, 28, 3579-3590, 2009

Florence, WC, Xia, C, Gordy, LE, Chen, W, Zhang, Y, Scott-Browne, J, Kinjo, Y, Yu, KO, Keshipeddy, S, Pellicci, DG, Patel, O, Kjer-Nielsen, L, McCluskey, J, Godfrey, DI, Rossjohn, J, Richardson, SK, Porcelli, SA, Howell, AR, Hayakawa, K, Gapin, L, Zajonc, DM, Wang, PG, Joyce, S. Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands. EMBO J, 28(23), 3781, 2009

WC Florence, RK Bhat and Joyce, S. CD1d-restricted glycolipid antigens: presentation principles, recognition logic and functional consequences. Expert Rev Mol Med, 10, e20, 2008

Ni, CY, Wu, ZH, Florence, WC, Parekh, VV, Arrate, MP, Pierce, S, Schweitzer, B, Van Kaer, L, Joyce, S, Miyamoto, S, Ballard, DW, Oltz, EM. Cutting edge: K63-linked polyubiquitination of NEMO modulates TLR signaling and inflammation in vivo. J Immunol, 180(11), 7107-7111, 2008

Villarino AV, Artis D, Bezbradica JS, Miller O, Saris CJ, Joyce S and Hunter CA. IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD. Int Immunol, 20, 739-752, 2008

Joyce, S. and Van Kaer, L. Invariant natural killer T cells trigger adaptive lymphocytes to churn up bile. Cell Host Microbe, 3(5), 275-7, 2008

Joyce, S. and Van Kaer, L. Lung NKT cell commotion takes your breath away. Nature Med, 14, 609-610, 2008

Torres, V.J., Stauff, D.L., Pishchany, G., Bezbradica, J.S., Gordy, L.E., Iturregui, J., Anderson, K.L., Dunman, P.M., Joyce, S. and Skaar. A Staphylococcus aureus regulatory system that responds to host heme and modulates virulence. Cell Host Microbe, 1, 109-119, 2007

Bezbradica JS, Van Kaer L and Joyce S. A20180: Natural killer T cells. Encyclopaedia of Life Sciences , A20180, DOI: 10.1002/9780470015902.a0020180, 2007

Bezbradica, JS, Stanic, AK, Joyce, S. Characterization and functional analysis of mouse invariant natural T (iNKT) cells. Curr Protoc Immunol, Chapter 14, Unit 14.13, 2006

Yan, J, Parekh, VV, Mendez-Fernandez, Y, Olivares-Villag??mez, D, Dragovic, S, Hill, T, Roopenian, DC, Joyce, S, Van Kaer, L. In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules. J Exp Med, 203(3), 647-59, 2006

Bezbradica, J.S., Gordy, L.E., Stanic, A.K., Dragovic, S., Hill, T., Hawiger, J., Unutmaz, D., Van Kaer, L. and Joyce, S. Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny. Immunity, 25, 487-497, 2006

Major, AS, Joyce, S, Van Kaer, L. Lipid metabolism, atherogenesis and CD1-restricted antigen presentation. Trends Mol Med, 12(6), 270-8, 2006

Major, AS, Singh, RR, Joyce, S, Van Kaer, L. The role of invariant natural killer T cells in lupus and atherogenesis. Immunol Res, 34(1), 49-66, 2006

Van Kaer, L. and Joyce, S. Viral evasion of antigen presentation: not just for peptides anymore. Nature Immunol., 7, 795-797, 2006

Singh, A.K., Yang, J.-Q., Parekh, V.V., Wei, J., Wang, C.-R., Joyce, S., Singh, R.R. and Van Kaer, R.. The natural killer T cell ligand alpha-galactosylceramide prevents or promotes pristane-induced lupus in mice. Eur. J. Immunol., 35, 1143-1154, 2005

Bezbradica, J.S. and Joyce, S. Natural T lymphocytes and dendritic cells: an innate duet that arouses and tempers immune responses. In R. Gorczynski Ed. Altered Immunoregulation and Human Disease, 137-163, 2005

Parekh, V.V., Wilson, M.T., Olivares-Villagomez, D., Singh, A.K., Wu, L., Wang, C.-R., Joyce, S. and Van Kaer, L. . Glycolipid antigen induces long-term natural killer T cell anergy in mice. J. Clin. Invest., 115, 2572-2583, 2005

Van Kaer, L. and Joyce, S.. Innate Immunity: NKT cells in the spotlight. Current Biology, 15, R429-R431, 2005

Bezbradica, J.S., Hill, T., Stanic, A.K., Van Kaer, L. and Joyce, S. Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny. Proc. Natl. Acad. Sci. USA, 102, 5114-5119, 2005

Bezbradica, J.S., Stanic, A.K., Matsuki, N., Bour-jordan, H., Bluestone, J.A., Thomas, J.W., Unutmaz, D., Van Kaer, L. and Joyce, S.. Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo. J. Immunol., 174, 4696-4705, 2005

Yoshimura, Y., Yadav, R., Christainson, G.J., Ajayi, W.U., Roopenian, D.C. and Joyce, S. Duration of alloantigen presentation and the avidity of T cell antigen recognition correlate with immunodominance of CTL response to minor histocomptibility antigens. J. Immunol., 172, 6666-6674, 2004

Stanic, A.K., Bezbradica, J.S., Park, J.-J., Van Kaer, L., Boothby, M. and Joyce, S. The ontogeny and function of Va14Ja18 natural T lymphocytes require signal processing by protein kinase C-theta and NF-kB. J. Immunol. Cutting Edge, 172, 4667-4671, 2004

Stanic, A.K., Bezbradica, J.S., Park, J.-J., Matsuki, N., Mora, A.L., Van Kaer, L., Boothby, M. and Joyce, S. NF-kB controls cell fate specification, survival, and molecular differentiation of immunoregulatory natural T lymphocytes. J. Immunol., 172, 2265-2273, 2004

Major, AS, Wilson, MT, McCaleb, JL, Ru Su, Y, Stanic, AK, Joyce, S, Van Kaer, L, Fazio, S, Linton, MF. Quantitative and qualitative differences in proatherogenic NKT cells in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol, 24(12), 2351-7, 2004

Park, J.-J., Kang, S.-J., De Silva, A.D., Stanic, A.K., Casorati, G., Hachey, D.L., Cresswell, P. and Joyce, S. Lipid-protein interactions: Biosynthetic assembly of CD1 with lipids in the endoplasmic reticulum is evolutionarily conserved. Proc. Natl. Acad. Sci. USA, 101, 1022-1026, 2004

Parekh, V.V., Singh, A.K., Wilson, M.T., Olivares-Villagomez, D., Bezbradica, J,S., Inazawa, H., Ehara, H., Sakai, T., Serizawa, I., Wu, L., Wang, C.-R., Joyce, S. and Van Kaer, L.. Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids. J. Immunol., 173, 3693-3706, 2004

Yang, L., Yamagata, N., Yadav, R., Brandon, S. Courtney, R.L., Marrow, J.D. Shyr, Y., Boothby, M., Joyce, S., Carbone, D.P. and Breyer, R.M. Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor. J. Clin. Invest., 111, 727-735, 2003

Chun, T., Page, M.J., Gapin, L., Matsuda, J.L., Xu, H., Nguyen, H., Kang, H.S., Stanic, A.K., Joyce, S., Chorney, M.J., Kronenberg, M. and Wang, C.-R. CD1d-espressing dendritic cells but not thymic epithelial cells can mediate negative selection of NKT cells. J. Exp. Med., 197, 907-918, 2003

Yadav, R., Yoshimura, Y., Boesteanu, A., Christianson, G.J., Ajayi, W.U., Shashidharamurthy, R., Stanic, A.K., Roopenian, D.C. and Joyce, S. The H4b minor histocompatibility antigen is caused by a combination of genetically determined and posttranslational modifications. J. Immunol., 170, 5133-5142, 2003

Stanic, A.K., De Silva, A.D., Park, J.-J. Sriram, V., Ichikawa, M., Hirabayashi, Y., Van Kaer, L., Brutkiewicz, R.R., and Joyce, S. Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by b-D-glucosylceramide synthase deficiency. Proc. Natl. Acad. Sci. USA, 100, 1849-1854, 2003

Matsuki, N., Stanic, A.K., Embers, M.E., Van Kaer, L., Morel, L. and Joyce, S. Genetic dissection of Va14Ja18 natural T cell number and function in autoimmune-prone mice. J. Immunol., 170, 5429-5437, 2003

Stanic, A.K., Park, J.-J. and Joyce, S. Innate self recognition by an invariant, rearranged T-cell receptor and its immune consequences. Immunology, 171-184, 2003

Mora, A.L., Corn, R.A., Stanic, A.K., Goenka, S., Aronica, M., Stanley, S., Ballard, D.W., Joyce, S. and Boothby, M. Antiapoptotic function of NF-kB in T lymphocytes is influenced by their differentiation status: roles of Fas, c-FLIP, and Bcl-xL. Cell Death Differentiation, 10, 1032-1044, 2003

Yang, J.-Q., Singh, A.K., Wilson, M.T., Satoh, M., Stanic, A.K., Park, J.-J., Hong, S., Gadola, S.D., Mizutani, A., Kakumanu, S.R., Reeves, W.H., Cerundolo, V., Joyce, S., Van Kaer, L., and Singh, R.R. Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis. J. Immunol., 171, 2142-2153, 2003

Motsinger, A., Azimzadeh, A., Stanic, A.K., Johnson, R.P., Van Kaer, L., Joyce, S. and Unutmaz, D. Identification and simian immunodeficiency virus infection of CD1d-restricted macaque natural killer T cells. J. Virol., 77, 8153-8158, 2003

Wilson, M.T., Johansson, C., Olivares-Villagomez, D., Singh, A.K., Stanic, A.K., Wang, C.-R., Joyce, S., Wick, M.J. and Van Kaer, L. The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion. Proc. Natl. Acad. Sci. USA, 100, 10919-10924, 2003

Yang, J., Jaramillo, A., Liu, W., Olack, B., Yoshimura, Y., Joyce, S., Kaleem, Z., Mohanakumar, T. Chronic rejection of murine cardiac allografts discordant at the H13 minor histocompatibility antigen correlates with the generation of the H13-specific CD8+ cytotoxic T cells. Transplantation, 76, 84-91, 2003

Stanic, A.K., Shashidharamurthy, R., Bezbradica, J.S., Matsuki, N., Yoshimura, Y., Miyake, S., Choi, E.Y., Schell, T.D., Van Kaer, L., Tevethia, S.S., Roopenian, D.C., Yamamura, T. and Joyce, S. . Another view of T cell antigen recognition: Cooperative engagement of glycolipid antigens by Va14Ja18 natural T cell receptor . J. Immunol., 171, 4539 - 4551, 2003

Zhang, F., Liang, Z., Matsuki, N., Van Kaer, L., Joyce, S., Wakeland, E.K., Aune, T.M.. A murine locus on chromosome 18 controls NKT cell homeostasis and Th cell differentiation. J. Immunol., 171, 4613-4620, 2003

Joyce, S, Van Kaer, L. CD1-restricted antigen presentation: an oily matter. Curr Opin Immunol, 15(1), 95-104, 2003

, 2002

, 2002

Choi, E.Y., Christianson, G.J., Yoshimura, Y., Jung, N., Sporule, T.J., Malarkannan, S., Joyce, S. and Roopenian, D.C. Real time profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease. Blood, 100, 4259-4265, 2002

, 2002

, 2002

Choi , E.Y, Christianson, G.J., Yoshimura, Y., Sproule, T.J., Jung, N., Joyce, S., and Roopenian, D.C. Immunodominance of H60 is caused by an abnormally high precursor T cell pool directed against its unique minor distocompatibility antigen peptide. Immunity, 17, 593-603, 2002

, 2001

, 2001

, 2001

, 2001

, 2001

, 2001

, 2000

Kennedy, M.K., Glacuum, M., Brown, S.N., Butz, E.A., Embers, M.E., Matsuki, N., Charrier, K., Sedger, L., Brasel, K., Morrissey, P.J., Stocking, K., Schuh, J.C.L., Joyce, S. and Peschon, J.J. Reversible defects in natural killer and memory CD8 T cell lineages in IL-15 deficient mice. J. Exp. Med., 191, 771-780, 2000

, 2000

De Silva, A.D., Boesteanu, A., Song, R., Harhaj, E., Harding, C.V. and Joyce, S. Thermolabile H-2Kb molecules expressed by transporters associated with antigen processing-deficient RMA-S cells are occupied by low affinity peptides. J. Immunol., 163, 4413-4420, 1999

Goyarts, E.C., Vegh, Z., Kalergis, A.M., Horig, H., Papadopolous, N.J., Young, A.C.M., Thomson, C.T., Chang, H.-C., Joyce, S. and Nathenson, S.G. Point mutations in the b-chain CDR3 can alter the T cell receptor recognition pattern on an MHC class I/peptide complex over a broad interface area. Mol. Immunol. , 35, 593-607, 1998

Boesteanu, A., Brehm, M., Mylin, L.M., Christionson, G,J., Tevethia, S.S., Roopenian, D.C. and Joyce, S. A molecular basis for how a single T cell receptor interfaces multiple ligands. J. Immunol., 161, 4719-4727, 1998

Joyce, S., Woods, A.S., Yewdell, J.W., Bennink, J.R., De Silva, A.D., Boesteanu, A., Balk, S.P., Cotter, R.J. and Brutkiewicz, R.R. A natural ligand of mouse CD1d1: cellular glycosylphosphatidylinositol. Science, 279, 1541-1544, 1998

Joyce S. Traffic control of completely assembled MHC class I molecules beyond the endoplasmic reticulum. J. Mol. Biol., 266, 993-1001, 1997

Boesteanu, A., De Silva, A.D., Nakajima, H., Leonard, W.J., Peschon, J.J. and Joyce, S. Distinct roles for signals relayed through the common cytokine receptor g-chain and interleukin-7 receptor a-chain in natural T cell development. J. Exp. Med., 186, 331-336, 1997

Mendiratta S, Martin, DW, Hong S, Boesteanu A, Joyce S and Van Kaer L. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity, 6, 469-477, 1997

Joyce, S, Negishi, I, Boesteanu, A, DeSilva, A D, Sharma, P, Chorney, M J, Loh, D Y, Van Kaer, L. Expansion of natural (NK1+) T cells that express alpha beta T cell receptors in transporters associated with antigen presentation-1 null and thymus leukemia antigen positive mice. J Exp Med, 184(4), 1579-84, 1996

Sharma, P, Joyce, S, Chorney, K A, Griffith, J W, Bonneau, R H, Wilson, F D, Johnson, C A, Flavell, R A, Chorney, M J. Thymus-leukemia antigen interacts with T cells and self-peptides. J Immunol, 156(3), 987-96, 1996

Joyce, S, Nathenson, S G. Alloreactivity, antigen recognition and T-cell selection: three diverse T-cell recognition problems with a common solution. Immunol Rev, 154, 59-103, 1996

Joyce, S, Kuzushima, K, Kepecs, G, Angeletti, R H, Nathenson, S G. Characterization of an incompletely assembled major histocompatibility class I molecule (H-2Kb) associated with unusually long peptides: implications for antigen processing and presentation. Proc Natl Acad Sci U S A, 91(10), 4145-9, 1994

Joyce, S, Nathenson, S G. Methods to study peptides associated with MHC class I molecules. Curr Opin Immunol, 6(1), 24-31, 1994

Joyce, S, Tabaczewski, P, Angeletti, R H, Nathenson, S G, Stroynowski, I. A nonpolymorphic major histocompatibility complex class Ib molecule binds a large array of diverse self-peptides. J Exp Med, 179(2), 579-88, 1994

Joyce, S, Sun, R, Nathenson, S G. Mapping the orientation of an antigenic peptide bound in the antigen binding groove of H-2Kb using a monoclonal antibody. Biochem Biophys Res Commun, 186(3), 1449-54, 1992

Joyce, S, Mathew, J M, Flye, M W, Mohanakumar, T. A polymorphic human kidney-specific non-MHC alloantigen. Its possible role in tissue-specific allograft immunity. Transplantation, 53(5), 1119-27, 1992

Shibata, K, Imarai, M, van Bleek, G M, Joyce, S, Nathenson, S G. Vesicular stomatitis virus antigenic octapeptide N52-59 is anchored into the groove of the H-2Kb molecule by the side chains of three amino acids and the main-chain atoms of the amino terminus. Proc Natl Acad Sci U S A, 89(7), 3135-9, 1992

Mathew, J M, Joyce, S, Lawrence, W, Mohanakumar, T. Evidence that antibodies eluted from rejected kidneys of HLA-identical transplants define a non-MHC alloantigen expressed on human kidneys. Transplantation, 52(3), 559-62, 1991

Joyce, S, Flye, M W, Mohanakumar, T. Human kidney specific non-MHC antigen: isolation and characterization using eluates from rejected renal allografts. Transplant Proc, 21(1 Pt 1), 628-9, 1989

Joyce, S, Flye, M W, Mohanakumar, T. Characterization of kidney cell-specific, non-major histocompatibility complex alloantigen using antibodies eluted from rejected human renal allografts. Transplantation, 46(3), 362-9, 1988

Sood, P P, Joyce, S, Unnikumar, K R. Histoenzymological compartmentation of the embryonic shrew tooth. J Oral Med, 39(4), 250-3, 1984