Department of Pathology, Microbiology, and Immunology



Eric Sebzda, Ph.D



Assistant Professor of Pathology, Microbiology and Immunology



Contact Information



Office Location:
MCN A-5211A

Phone: 615-343-6050

E-mail:  eric.sebzda@vanderbilt.edu


Lab URL:   https://my.vanderbilt.edu/ericsebzda/


Campus Mail address:

Pathology, Microbiology and Immunology, 5th Fl

A-5301 (2363)


US Mailing address:
Vanderbilt University School of Medicine
Dept of Pathology, Microbiology and Immunology-5th Fl
MCN A-5301
Nashville, TN 37232







Research Associate, University of Pennsylvania
Research Fellow, Cancer Research UK
PhD, University of Toronto
BSc, University of Toronto



Research Keywords



lymphocytes, T cells, autoimmunity, cell migration, chemokine receptors, chemokines,



Research Description



A unique aspect of the immune system is its ability to transport cells great distances in a short period of time. These trafficking mechanisms dictate the efficiency of an immune response, both in terms of pathogen clearance and susceptibility to autoimmune diseases. The Sebzda laboratory studies B and T cell trafficking during immune responses. Specially, we are interested in determining how cell activation releases these lymphocytes from a homeostatic migration pattern and targets these cells to sites of inflammation. We are currently using a series of genetically modified animal models to analyze early regulatory events in cellular trafficking. The ultimate goal of this research is to identify potential therapeutic targets that enhance/inhibit lymphocyte trafficking to specific tissues and thus aid in pathogen clearance or limit autoimmune reactions, respectively.






Pabbisetty, SK, Rabacal, W, Maseda, D, Cendron, D, Collins, PL, Hoek, KL, Parekh, VV, Aune, TM, Sebzda, E. KLF2 is a rate-limiting transcription factor that can be targeted to enhance regulatory T-cell production. Proc Natl Acad Sci U S A, 111(26), 9579-84, 2014

Hoek, KL, Gordy, LE, Collins, PL, Parekh, VV, Aune, TM, Joyce, S, Thomas, JW, Van Kaer, L, Sebzda, E. Follicular B Cell Trafficking within the Spleen Actively Restricts Humoral Immune Responses. Immunity, 33(2), 254-265, 2010

Bertozzi, CC, Schmaier, AA, Mericko, P, Hess, PR, Zou, Z, Chen, M, Chen, CY, Xu, B, Lu, MM, Zhou, D, Sebzda, E, Santore, MT, Merianos, DJ, Stadtfeld, M, Flake, AW, Graf, T, Skoda, R, Maltzman, JS, Koretzky, GA, Kahn, ML. Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood, 116(4), 661-70, 2010

Sebzda, E, Zou, Z, Lee, JS, Wang, T, Kahn, ML. Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns. Nat Immunol, 9(3), 292-300, 2008

Chen, H, Zou, Z, Sarratt, KL, Zhou, D, Zhang, M, Sebzda, E, Hammer, DA, Kahn, ML. In vivo beta1 integrin function requires phosphorylation-independent regulation by cytoplasmic tyrosines. Genes Dev, 20(8), 927-32, 2006

Sebzda, E, Hibbard, C, Sweeney, S, Abtahian, F, Bezman, N, Clemens, G, Maltzman, JS, Cheng, L, Liu, F, Turner, M, Tybulewicz, V, Koretzky, GA, Kahn, ML. Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development. Dev Cell, 11(3), 349-61, 2006

Abtahian, F, Bezman, N, Clemens, R, Sebzda, E, Cheng, L, Shattil, SJ, Kahn, ML, Koretzky, GA. Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells. Mol Cell Biol, 26(18), 6936-49, 2006

Lee, JS, Yu, Q, Shin, JT, Sebzda, E, Bertozzi, C, Chen, M, Mericko, P, Stadtfeld, M, Zhou, D, Cheng, L, Graf, T, MacRae, CA, Lepore, JJ, Lo, CW, Kahn, ML. Klf2 is an essential regulator of vascular hemodynamic forces in vivo. Dev Cell, 11(6), 845-57, 2006

Abtahian, F, Guerriero, A, Sebzda, E, Lu, MM, Zhou, R, Mocsai, A, Myers, EE, Huang, B, Jackson, DG, Ferrari, VA, Tybulewicz, V, Lowell, CA, Lepore, JJ, Koretzky, GA, Kahn, ML. Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science, 299(5604), 247-51, 2003

Sebzda, E, Bracke, M, Tugal, T, Hogg, N, Cantrell, DA. Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling. Nat Immunol, 3(3), 251-8, 2002

Ohteki, T, Hessel, A, Bachmann, MF, Zakarian, A, Sebzda, E, Tsao, MS, McKall-Faienza, K, Odermatt, B, Ohashi, PS. Identification of a cross-reactive self ligand in virus-mediated autoimmunity. Eur J Immunol, 29(9), 2886-96, 1999

Sebzda, E, Mariathasan, S, Ohteki, T, Jones, R, Bachmann, MF, Ohashi, PS. Selection of the T cell repertoire. Annu Rev Immunol, 17, 829-74, 1999

Sebzda, E, Choi, M, Fung-Leung, WP, Mak, TW, Ohashi, PS. Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner. Immunity, 6(5), 643-53, 1997

Speiser, DE, Sebzda, E, Ohteki, T, Bachmann, MF, Pfeffer, K, Mak, TW, Ohashi, PS. Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo. Eur J Immunol, 26(12), 3055-60, 1996

Bachmann, MF, Sebzda, E, Kundig, TM, Shahinian, A, Speiser, DE, Mak, TW, Ohashi, PS. T cell responses are governed by avidity and co-stimulatory thresholds. Eur J Immunol, 26(9), 2017-22, 1996

Kundig, TM, Shahinian, A, Kawai, K, Mittr??cker, HW, Sebzda, E, Bachmann, MF, Mak, TW, Ohashi, PS. Duration of TCR stimulation determines costimulatory requirement of T cells. Immunity, 5(1), 41-52, 1996

Sebzda, E, Kundig, TM, Thomson, CT, Aoki, K, Mak, SY, Mayer, JP, Zamborelli, T, Nathenson, SG, Ohashi, PS. Mature T cell reactivity altered by peptide agonist that induces positive selection. J Exp Med, 183(3), 1093-104, 1996

Sebzda, E, Wallace, VA, Mayer, J, Yeung, RS, Mak, TW, Ohashi, PS. Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science, 263(5153), 1615-8, 1994