Department of Pathology, Microbiology, and Immunology



Terence S. Dermody, M.D.



Dorothy Overall Wells Professor of Pediatrics

Director, Medical Scientist Training Program
Director, Pediatric Infectious Diseases Division
Professor of Pathology, Microbiology and Immunology



Contact Information



Office Location:
MCN D-6227A
Phone: 615-343-9943

E-mail:  terry.dermody@vanderbilt.edu


Campus Mail address:
Elizabeth B. Lamb Center for Pediatric Research

Division of Pediatric Infectious Diseases

MCN D-7235 (2581)


Mailing Address:
Elizabeth B. Lamb Center for Pediatric Research
Vanderbilt University School of Medicine

1161 21st Ave South

MCN D-7235
Nashville, TN 37232-2581







Fellowship, Harvard Medical School, Boston, MA
Fellowship, Brigham and Women's Hospital, Boston MA
Residency, Presbyterian Hospital, New York, NY
M.D., Columbia University, New York, NY
B.S., Cornell University, Ithaca, NY



Research Keywords



Apoptosis, Biochemistry, Genetics, Immunology, Infectious Disease, Microbiology, Mouse, Receptors, Reovirus, Viral Pathogenesis, Virology



Research Description



Our lab studies the molecular pathogenesis of mammalian reovirus and chikungunya virus infections. Reovirus is an enteric, neurotropic virus that infects many mammalian species, including humans, but disease is restricted to the very young. Chikungunya virus is an emerging arthropod-borne alphavirus that causes epidemics of febrile arthritis in humans. Research in my laboratory encompasses several interrelated themes to better understand viral and cellular mediators of disease. These include the structural basis of viral attachment and entry into cells, mechanisms of genome replication and packaging, patterns of cell signaling and gene expression occurring in response to viral infection, mechanisms of virus-induced apoptosis and its significance in the viral life cycle, and roles of viral receptor distribution and utilization in disease pathology. We also are developing viral vectors for oncolytic and vaccine applications.

(1) Reovirus receptors and pathogenesis. Following peroral inoculation of newborn mice, reovirus disseminates systemically to target the heart, liver, and central nervous system. We are conducting experiments to investigate the role of reovirus receptors, sialic acid, junctional adhesion molecule A (JAM-A), and Nogo receptor-1 (NgR1) in reovirus dissemination and tropism. These studies employ primary cells and mice lacking reovirus receptors. This work will be interpreted in the context of ongoing studies to determine the structure of reovirus in complex with its receptors. Since not all of the reovirus receptors are known, we are working to identify additional reovirus receptors.

(2) Reovirus cell entry and replication. Reovirus enters cells by clathrin-dependent endocytosis in an integrin-dependent process and undergoes proteolytic disassembly in endosomes. Studies are in progress to define mechanisms of reovirus uptake and transport within the endocytic pathway. We also are working to define how the viral gene products reorganize cellular architecture to form the viral replication organelles that serve as sites for genome replication and particle assembly. This research will reveal mechanisms by which viral and cellular factors cooperate to facilitate viral replication and illuminate new targets for therapeutic intervention.

(3) Reovirus-induced apoptosis. Reovirus induces apoptosis in cultured cells and in the murine central nervous system and heart. Our studies indicate that apoptosis is triggered by innate immune response signal transducers initiated by viral components following reovirus disassembly. Experiments are in progress to identify components of the cell-signaling apparatus required for apoptosis induction by reovirus and to determine the relationship between apoptosis and virulence. These studies will establish new ideas about how RNA-containing viruses interact with innate immune response signaling circuits and lead to a better understanding of how viruses injure their host cells.

(4) Chikungunya virus (CHIKV) attachment and cell entry. CHIKV has produced explosive outbreaks in East Africa, several islands in the Indian Ocean, India, Southeast Asia, and most recently the Caribbean. We have found that attenuated CHIKV vaccine strain 181/25 engages heparan sulfate proteoglycans to initiate infection. Ongoing work is focused on identification of host cell proteins that contribute to CHIKV replication and definition of CHIKV virulence determinants. This research will fill major gaps in an understanding of CHIKV pathogenesis and illuminate new targets for antiviral therapies and vaccines.






Stettner, E, Dietrich, MH, Reiss, K, Dermody, TS, Stehle, T. Structure of Serotype 1 Reovirus Attachment Protein Sigma 1 in Complex with Junctional Adhesion Molecule A Reveals a Conserved Serotype-Independent Binding Epitope. J Virol, 89(11), 6136-40, 2015

Smith, SA, Silva, LA, Fox, JM, Flyak, AI, Kose, N, Sapparapu, G, Khomadiak, S, Ashbrook, AW, Kahle, KM, Fong, RH, Swayne, S, Doranz, BJ, McGee, CE, Heise, MT, Pal, P, Brien, JD, Austin, SK, Diamond, MS, Dermody, TS, Crowe, JE. Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus. Cell Host Microbe, 18(1), 86-95, 2015

Mainou, BA, Ashbrook, AW, Smith, EC, Dorset, DC, Denison, MR, Dermody, TS. Serotonin Receptor Agonist 5-Nonyloxytryptamine Alters the Kinetics of Reovirus Cell Entry. J Virol, 89(17), 8701-12, 2015

Doyle, JD, Stencel-Baerenwald, JE, Copeland, CA, Rhoads, JP, Brown, JJ, Boyd, KL, Atkinson, JB, Dermody, TS. Diminished reovirus capsid stability alters disease pathogenesis and littermate transmission. PLoS Pathog, 11(3), e1004693, 2015

Stencel-Baerenwald, J, Reiss, K, Blaum, BS, Colvin, D, Li, XN, Abel, T, Boyd, K, Stehle, T, Dermody, TS. Glycan engagement dictates hydrocephalus induction by serotype 1 reovirus. MBio, 6(2), e02356, 2015

Lai, CM, Boehme, KW, Pruijssers, AJ, Parekh, VV, Van Kaer, L, Parkos, CA, Dermody, TS. Endothelial JAM-A promotes reovirus viremia and bloodstream dissemination. J Infect Dis, 211(3), 383-93, 2015

Fernandez de Castro, I., Zamora, P. F., Ooms, L. S., Fernandez, J. J., Lai, C. M., Mainou, B. A., Dermody, T. S., and C. Risco. Reovirus forms neoorganelles for progeny particle assembly within reorganized cell membranes. mBio, 5, e00931-13, 2014

Silva, LA, Khomandiak, S, Ashbrook, AW, Weller, R, Heise, MT, Morrison, TE, Dermody, TS. A single-amino-acid polymorphism in Chikungunya virus E2 glycoprotein influences glycosaminoglycan utilization. J Virol, 88(5), 2385-97, 2014

Goubau, D, Schlee, M, Deddouche, S, Pruijssers, AJ, Zillinger, T, Goldeck, M, Schuberth, C, Van der Veen, AG, Fujimura, T, Rehwinkel, J, Iskarpatyoti, JA, Barchet, W, Ludwig, J, Dermody, TS, Hartmann, G, Sousa, CR. Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates. Nature, 514, 372-375, 2014

Zhang, B, Chassaing, B, Shi, Z, Uchiyama, R, Zhang, Z, Denning, TL, Crawford, SE, Pruijssers, AJ, Iskarpatyoti, JA, Estes, MK, Dermody, TS, Ouyang, W, Williams, IR, Vijay-Kumar, M, Gewirtz, AT. Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18. Science, 346(6211), 861-5, 2014

Stencel-Baerenwald, JE, Reiss, K, Reiter, DM, Stehle, T, Dermody, TS. The sweet spot: defining virus-sialic acid interactions. Nat Rev Microbiol, 12(11), 739-49, 2014

Konopka-Anstadt, JL, Mainou, BA, Sutherland, DM, Sekine, Y, Strittmatter, SM, Dermody, TS. The Nogo receptor NgR1 mediates infection by mammalian reovirus. Cell Host Microbe, 15(6), 681-91, 2014

Ashbrook, AW, Burrack, KS, Silva, LA, Montgomery, SA, Heise, MT, Morrison, TE, Dermody, TS. Residue 82 of the Chikungunya virus E2 attachment protein modulates viral dissemination and arthritis in mice. J Virol, 88(21), 12180-92, 2014

Lai, CM, Mainou, BA, Kim, KS, Dermody, TS. Directional release of reovirus from the apical surface of polarized endothelial cells. MBio, 4(2), e00049-13, 2013

Mainou, BA, Zamora, PF, Ashbrook, AW, Dorset, DC, Kim, KS, Dermody, TS. Reovirus cell entry requires functional microtubules. MBio, 4(4), 2013

Fites, JS, Ramsey, JP, Holden, WM, Collier, SP, Sutherland, DM, Reinert, LK, Gayek, AS, Dermody, TS, Aune, TM, Oswald-Richter, K, Rollins-Smith, LA. The invasive chytrid fungus of amphibians paralyzes lymphocyte responses. Science, 342(6156), 366-9, 2013

Mainou, BA, Dermody, TS. Transport to late endosomes is required for efficient reovirus infection. J Virol, 86(16), 8346-58, 2012

Ooms, LS, Jerome, WG, Dermody, TS, Chappell, JD. Reovirus replication protein mu2 influences cell tropism by promoting particle assembly within viral inclusions. J Virol, 86(20), 10979-87, 2012

Iskarpatyoti, JA, Morse, EA, McClung, RP, Ikizler, M, Wetzel, JD, Contractor, N, Dermody, TS. Serotype-specific differences in inhibition of reovirus infectivity by human-milk glycans are determined by viral attachment protein sigma1. Virology, 433(2), 489-97, 2012

Doyle, JD, Danthi, P, Kendall, EA, Ooms, LS, Wetzel, JD, Dermody, TS. Molecular determinants of proteolytic disassembly of the reovirus outer capsid. J Biol Chem, 287(11), 8029-38, 2012

Bokiej, M, Ogden, KM, Ikizler, M, Reiter, DM, Stehle, T, Dermody, TS. Optimum length and flexibility of reovirus attachment protein sigma 1 are required for efficient viral infection. J Virol, 86(19), 10270-80, 2012

Frierson, JM, Pruijssers, AJ, Konopka, JL, Reiter, DM, Abel, TW, Stehle, T, Dermody, TS. Utilization of sialylated glycans as coreceptors enhances the neurovirulence of serotype 3 reovirus. J Virol, 86(24), 13164-73, 2012

Boehme, KW, Frierson, JM, Konopka, JL, Kobayashi, T, Dermody, TS. The reovirus sigma1s protein is a determinant of hematogenous but not neural virus dissemination in mice. J Virol, 85(22), 11781-90, 2011

Boehme, KW, Ikizler, M, Kobayashi, T, Dermody, TS. Reverse genetics for mammalian reovirus. Methods, 55(2), 109-13, 2011

Mainou, BA, Dermody, TS. Src kinase mediates productive endocytic sorting of reovirus during cell entry. J Virol, 85(7), 3203-13, 2011

Kobayashi, T, Ooms, LS, Ikizler, M, Chappell, JD, Dermody, TS. An improved reverse genetics system for mammalian orthoreoviruses. Virology, 398(2), 194-200, 2010

Holm, GH, Pruijssers, AJ, Li, L, Danthi, P, Sherry, B, Dermody, TS. Interferon regulatory factor 3 attenuates reovirus myocarditis and contributes to viral clearance. J Virol, 84(14), 6900-8, 2010

Ooms, LS, Kobayashi, T, Dermody, TS, Chappell, JD. A post-entry step in the mammalian orthoreovirus replication cycle is a determinant of cell tropism. J Biol Chem, 285(53), 41604-13, 2010

Danthi, P, Pruijssers, AJ, Berger, AK, Holm, GH, Zinkel, SS, Dermody, TS. Bid regulates the pathogenesis of neurotropic reovirus. PLoS Pathog, 6, e1000980, 2010

Danthi, P, Guglielmi, KM, Kirchner, E, Mainou, B, Stehle, T, Dermody, TS. From touchdown to transcription: the reovirus cell entry pathway. Curr Top Microbiol Immunol, 343, 91-119, 2010

Antar, AA, Konopka, JL, Campbell, JA, Henry, RA, Perdigoto, AL, Carter, BD, Pozzi, A, Abel, TW, Dermody, TS. Junctional adhesion molecule-A is required for hematogenous dissemination of reovirus. Cell Host Microbe, 5(1), 59-71, 2009

Cseke, G, Maginnis, MS, Cox, RG, Tollefson, SJ, Podsiad, AB, Wright, DW, Dermody, TS, Williams, JV. Integrin alphavbeta1 promotes infection by human metapneumovirus. Proc Natl Acad Sci U S A, 106(5), 1566-71, 2009

Kobayashi, T, Ooms, LS, Chappell, JD, Dermody, TS. Identification of functional domains in reovirus replication proteins muNS and mu2. J Virol, 83(7), 2892-906, 2009

Dermody, TS, Kirchner, E, Guglielmi, KM, Stehle, T. Immunoglobulin superfamily virus receptors and the evolution of adaptive immunity. PLoS Pathog, 5(11), e1000481, 2009

Boehme, KW, Guglielmi, KM, Dermody, TS. Reovirus nonstructural protein sigma1s is required for establishment of viremia and systemic dissemination. Proc Natl Acad Sci U S A, 106(47), 19986-91, 2009

Johnson, EM, Doyle, JD, Wetzel, JD, McClung, RP, Katunuma, N, Chappell, JD, Washington, MK, Dermody, TS. Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis. J Virol, 83(19), 9630-40, 2009

Danthi, P, Coffey, CM, Parker, JS, Abel, TW, Dermody, TS. Independent regulation of reovirus membrane penetration and apoptosis by the mu1 phi domain. PLoS Pathog, 4(12), e1000248, 2008

Danthi, P, Kobayashi, T, Holm, GH, Hansberger, MW, Abel, TW, Dermody, TS. Reovirus apoptosis and virulence are regulated by host cell membrane penetration efficiency. J Virol, 82(1), 161-72, 2008

Kirchner, E, Guglielmi, KM, Strauss, HM, Dermody, TS, Stehle, T. Structure of reovirus sigma1 in complex with its receptor junctional adhesion molecule-A. PLoS Pathog, 4(12), e1000235, 2008

Excoffon, KJ, Guglielmi, KM, Wetzel, JD, Gansemer, ND, Campbell, JA, Dermody, TS, Zabner, J. Reovirus preferentially infects the basolateral surface and is released from the apical surface of polarized human respiratory epithelial cells. J Infect Dis, 197(8), 1189-97, 2008

Maginnis, MS, Mainou, BA, Derdowski, A, Johnson, EM, Zent, R, Dermody, TS. NPXY motifs in the beta1 integrin cytoplasmic tail are required for functional reovirus entry. J Virol, 82(7), 3181-91, 2008

Guglielmi, KM, Kirchner, E, Holm, GH, Stehle, T, Dermody, TS. Reovirus binding determinants in junctional adhesion molecule-A. J Biol Chem, 282(24), 17930-40, 2007

Johansson, C, Wetzel, JD, He, J, Mikacenic, C, Dermody, TS, Kelsall, BL. Type I interferons produced by hematopoietic cells protect mice against lethal infection by mammalian reovirus. J Exp Med, 204(6), 1349-58, 2007

Kobayashi, T, Antar, AA, Boehme, KW, Danthi, P, Eby, EA, Guglielmi, KM, Holm, GH, Johnson, EM, Maginnis, MS, Naik, S, Skelton, WB, Wetzel, JD, Wilson, GJ, Chappell, JD, Dermody, TS. A plasmid-based reverse genetics system for animal double-stranded RNA viruses. Cell Host Microbe, 1(2), 147-57, 2007

Hansberger, MW, Campbell, JA, Danthi, P, Arrate, P, Pennington, KN, Marcu, KB, Ballard, DW, Dermody, TS. I{kappa}B kinase subunits {alpha} and {gamma} are required for activation of NF-{kappa}B and induction of apoptosis by mammalian reovirus. J Virol, 81(3), 1360-71, 2007

Schelling, P, Guglielmi, KM, Kirchner, E, Paetzold, B, Dermody, TS, Stehle, T. The reovirus sigma 1 aspartic acid sandwich: A trimerization motif poised for conformational change. J Biol Chem, 282(15), 17930-40, 2007

Holm, GH, Zurney, J, Tumilasci, V, Leveille, S, Danthi, P, Hiscott, J, Sherry, B, Dermody, TS. RIG-I and IPS-1 augment proapoptotic responses following mammalian reovirus infection via IRF-3. J Biol Chem, 282(30), 21953-61, 2007

Laukoetter, MG, Nava, P, Lee, WY, Severson, EA, Capaldo, CT, Babbin, BA, Williams, IR, Koval, M, Peatman, E, Campbell, JA, Dermody, TS, Nusrat, A, Parkos, CA. JAM-A regulates permeability and inflammation in the intestine in vivo. J Exp Med, 204(13), 3067-76, 2007

Clark, KM, Wetzel, JD, Gu, Y, Ebert, DH, McAbee, SA, Stoneman, EK, Baer, GS, Zhu, Y, Wilson, GJ, Prasad, BV, Dermody, TS. Reovirus variants selected for resistance to ammonium chloride have mutations in viral outer-capsid protein sigma3. J Virol, 80(2), 671-81, 2006

ODonnell, SM, Holm, GH, Pierce, JM, Tian, B, Watson, MJ, Chari, RS, Ballard, DW, Brasier, AR, Dermody, TS. Identification of an NF-kappaB-dependent gene network in cells infected by mammalian reovirus. J Virol, 80(3), 1077-86, 2006

Wetzel, JD, Barton, ES, Chappell, JD, Baer, GS, Mochow-Grundy, M, Rodgers, SE, Shyr, Y, Powers, AC, Thomas, JW, Dermody, TS. Reovirus delays diabetes onset but does not prevent insulitis in nonobese diabetic mice. J Virol, 80(6), 3078-82, 2006

Maginnis, MS, Forrest, JC, Kopecky-Bromberg, SA, Dickeson, SK, Santoro, SA, Zutter, MM, Nemerow, GR, Bergelson, JM, Dermody, TS. Beta 1 Integrin Mediates Internalization of Mammalian Reovirus. J Virol, 80(6), 2760-70, 2006

Kobayashi, T, Chappell, JD, Danthi, P, Dermody, TS. Gene-specific inhibition of reovirus replication by RNA interference. J Virol, 80(18), 9053-63, 2006

Danthi, P, Hansberger, MW, Campbell, JA, Forrest, JC, Dermody, TS. JAM-A-independent, antibody-mediated uptake of reovirus into cells leads to apoptosis. J Virol, 80(3), 1261-70, 2006

O'Donnell, SM, Connolly, JL, Hansberger, MW, Chappell, JD, Watson, MJ, Han, W, Barton, ES, Forrest, Valyi-Nagy, T, JC, Pierce, JM, Yull, FE, Blackwell, TS, Rottman, JN, Sherry, B, Dermody, TS. Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease. J Clin Invest, 115(9), 2341-50, 2005

Campbell, JA, Schelling, P, Wetzel, JD, Johnson, EM, Wilson, GAR, Forrest, JC, Aurrand-Lions, M, Imhof, BA, Stehle, T, Dermody, TS. Junctional adhesion molecule A serves as a receptor for prototype and field-isolate strains of mammalian reovirus. J Virol, 79(13), 7967-78, 2005

Tai, JH, Williams, JV, Edwards, KM, Wright, PF, Crowe, JE, Dermody, TS. Prevalence of reovirus-specific antibodies in young children in Nashville, Tennessee. J Infect Dis, 191(8), 1221-4, 2005

Dong, X, Li, H, Derdowski, A, Ding, L, Burnett, A, Chen, X, Peters, TR, Dermody, TS, Woodruff, E, Wang, JJ, Spearman, P. AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly. Cell, 120(5), 663-74, 2005

Tyler, K L, Barton, E S, Ibach, M L, Robinson, C, Campbell, J A, O'Donnell, S M, Valyi-Nagy, T, Clarke, P, Wetzel, J D, Dermody, T S. Isolation and molecular characterization of a novel type 3 reovirus from a child with meningitis. J Infect Dis, 189(9), 1664-75, 2004

Fleeton, M N, Contractor, N, Leon, F, Wetzel, J D, Dermody, T S, Kelsall, B L. Peyer's patch dendritic cells process viral antigen from apoptotic epithelial cells in the intestine of reovirus-infected mice. J Exp Med, 200(2), 235-45, 2004

Ebert, D H, Kopecky-Bromberg, S A, Dermody, T S. Cathepsin B is inhibited in mutant cells selected during persistent reovirus infection. J Biol Chem, 279(5), 3837-51, 2004

Prota, A E, Campbell, J A, Schelling, P, Forrest, J C, Watson, M J, Peters, T R, Aurrand-Lions, M, Imhof, B A, Dermody, T S, Stehle, T. Crystal structure of human junctional adhesion molecule 1: Implications for reovirus binding. Proc Natl Acad Sci U S A, 100(9), 5366-71, 2003

Forrest, J C, Campbell, J A, Schelling, P, Stehle, T, Dermody, T S. Structure-function analysis of reovirus binding to junctional adhesion molecule 1: Implications for the mechanism of reovirus attachment. J Biol Chem, 278(48), 48434-44, 2003

Becker, M M, Peters, T R, Dermody, T S. Reovirus sigma NS and mu NS proteins form cytoplasmic inclusion structures in the absence of viral infection. J Virol, 77(10), 5948-63, 2003

Barton, E S, Youree, B E, Ebert, D H, Forrest, J C, Connolly, J L, Valyi-Nagy, T, Washington, K, Wetzel, J D, Dermody, T S. Utilization of sialic acid as a coreceptor is required for reovirus-induced biliary disease. J Clin Invest, 111(12), 1823-33, 2003

Wilson, G J, Nason, E L, Hardy, C S, Ebert, D H, Wetzel, J D, Prasad, B V, Dermody, T S. A single mutation in the carboxy terminus of reovirus outer-capsid protein sigma 3 confers enhanced kinetics of sigma 3 proteolysis, resistance to inhibitors of viral disassembly, and alterations in sigma 3 structure. J Virol, 76(19), 9832-43, 2002

Ebert, D H, Deussing, J, Peters, C, Dermody, T S. Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells. J Biol Chem, 277(27), 24609-17, 2002

Chappell, J D, Prota, A E, Dermody, T S, Stehle, T. Crystal structure of reovirus attachment protein sigma1 reveals evolutionary relationship to adenovirus fiber. EMBO J, 21(1-2), 1-11, 2002

Connolly, J L, Dermody, T S. Virion disassembly is required for apoptosis induced by reovirus. J Virol, 76(4), 1632-41, 2002

Becker, M M, Goral, M I, Hazelton, P R, Baer, G S, Rodgers, S E, Brown, E G, Coombs, K M, Dermody, T S. Reovirus sigmaNS protein is required for nucleation of viral assembly complexes and formation of viral inclusions. J Virol, 75, 1459-75, 2001

Mochow-Grundy, M, Dermody, T S. The reovirus S4 gene 3' nontranslated region contains a translational operator sequence. J Virol, 75(14), 6517-26, 2001

Ebert, D H, Wetzel, J D, Brumbaugh, D E, Chance, S R, Stobie, L E, Baer, G S, Dermody, T S. Adaptation of reovirus to growth in the presence of protease inhibitor E64 segregates with a mutation in the carboxy terminus of viral outer-capsid protein sigma3. J Virol, 75, 3197-206, 2001

Connolly, J L, Barton, E S, Dermody, T S. Reovirus binding to cell surface sialic acid potentiates virus-induced apoptosis. J Virol, 75, 4029-39, 2001

Barton, E S, Connolly, J L, Forrest, J C, Chappell, J D, Dermody, T S. Utilization of sialic acid as a coreceptor enhances reovirus attachment by multistep adhesion strengthening. J Biol Chem, 276, 2200-11, 2001

Barton, E S, Forrest, J C, Connolly, J L, Chappell, J D, Liu, Y, Schnell, F J, Nusrat, A, Parkos, C A, Dermody, T S. Junction adhesion molecule is a receptor for reovirus. Cell, 104, 441-51, 2001

Chandran, K, Zhang, X, Olson, N H, Walker, S B, Chappell, J D, Dermody, T S, Baker, T S, Nibert, M L. Complete in vitro assembly of the reovirus outer capsid produces highly infectious particles suitable for genetic studies of the receptor-binding protein. J Virol, 75, 5335-42, 2001

Nason, E L, Wetzel, J D, Mukherjee, S K, Barton, E S, Prasad, B V, Dermody, T S. A monoclonal antibody specific for reovirus outer-capsid protein sigma3 inhibits sigma1-mediated hemagglutination by steric hindrance. J Virol, 75, 6625-34, 2001

Connolly, J L, Rodgers, S E, Clarke, P, Ballard, D W, Kerr, L D, Tyler, K L, Dermody, T S. Reovirus-induced apoptosis requires activation of transcription factor NF-kappaB. J Virol, 74, 2981-9, 2000

Chappell, J D, Duong, J L, Wright, B W, Dermody, T S. Identification of carbohydrate-binding domains in the attachment proteins of type 1 and type 3 reoviruses. J Virol, 74, 8472-9, 2000

Baer, G S, Ebert, D H, Chung, C J, Erickson, A H, Dermody, T S. Mutant cells selected during persistent reovirus infection do not express mature cathepsin L and do not support reovirus disassembly. J Virol, 73, 9532-43, 1999

Chappell, J D, Barton, E S, Smith, T H, Baer, G S, Duong, D T, Nibert, M L, Dermody, T S. Cleavage susceptibility of reovirus attachment protein sigma1 during proteolytic disassembly of virions is determined by a sequence polymorphism in the sigma1 neck. J Virol, 72, 8205-13, 1998

Rodgers, S E, Connolly, J L, Chappell, J D, Dermody, T S. Reovirus growth in cell culture does not require the full complement of viral proteins: identification of a sigma1s-null mutant. J Virol, 72, 8597-604, 1998

Baer, G S, Dermody, T S. Mutations in reovirus outer-capsid protein sigma3 selected during persistent infections of L cells confer resistance to protease inhibitor E64. J Virol, 71, 4921-8, 1997

Chappell, J D, Gunn, V L, Wetzel, J D, Baer, G S, Dermody, T S. Mutations in type 3 reovirus that determine binding to sialic acid are contained in the fibrous tail domain of viral attachment protein sigma1. J Virol, 71, 1834-41, 1997

Rodgers, S E, Barton, E S, Oberhaus, S M, Pike, B, Gibson, C A, Tyler, K L, Dermody, T S. Reovirus-induced apoptosis of MDCK cells is not linked to viral yield and is blocked by Bcl-2. J Virol, 71, 2540-6, 1997

Wetzel, J D, Wilson, G J, Baer, G S, Dunnigan, L R, Wright, J P, Tang, D S, Dermody, T S. Reovirus variants selected during persistent infections of L cells contain mutations in the viral S1 and S4 genes and are altered in viral disassembly. J Virol, 71, 1362-9, 1997

Wetzel, J D, Chappell, J D, Fogo, A B, Dermody, T S. Efficiency of viral entry determines the capacity of murine erythroleukemia cells to support persistent infections by mammalian reoviruses. J Virol, 71, 299-306, 1997

Wilson, G J, Wetzel, J D, Puryear, W, Bassel-Duby, R, Dermody, T S. Persistent reovirus infections of L cells select mutations in viral attachment protein sigma1 that alter oligomer stability. J Virol, 70, 6598-606, 1996

Goral, M I, Mochow-Grundy, M, Dermody, T S. Sequence diversity within the reovirus S3 gene: Reoviruses evolve independently of host species, geographic locale, and date of isolation. Virology, 216(1), 265-71, 1996

Tyler, K L, Squier, M K, Brown, A L, Pike, B, Willis, D, Oberhaus, S M, Dermody, T S, Cohen, J J. Linkage between reovirus-induced apoptosis and inhibition of cellular DNA synthesis: Role of the S1 and M2 genes. J Virol, 70(11), 7984-91, 1996

Tyler, K L, Squier, M K, Rodgers, S E, Schneider, B E, Oberhaus, S M, Grdina, T A, Cohen, J J, Dermody, T S. Differences in the capacity of reovirus strains to induce apoptosis are determined by the viral attachment protein sigma 1. J Virol, 69, 6972-9, 1995

Nibert, M L, Chappell, J D, Dermody, T S. Infectious subvirion particles of reovirus type 3 Dearing exhibit a loss in infectivity and contain a cleaved sigma 1 protein. J Virol, 69(8), 5057-67, 1995

Chapell, J D, Goral, M I, Rodgers, S E, dePamphilis, C W, Dermody, T S. Sequence diversity within the reovirus S2 gene: Reovirus genes reassort in nature, and their termini are predicted to form a panhandle motif. J Virol, 68(2), 750-6, 1994

Dermody, T S, Nibert, M L, Wetzel, J D, Tong, X, Fields, B N. Cells and viruses with mutations affecting viral entry are selected during persistent infections of L cells with mammalian reoviruses. J Virol, 67, 2055-63, 1993

Morrison, L A, Fields, B N, Dermody, T S. Prolonged replication in the mouse central nervous system of reoviruses isolated from persistently infected cell cultures. J Virol, 67(6), 3019-26, 1993

Rubin, D H, Wetzel, J D, Williams, W V, Cohen, J A, Dworkin, C, Dermody, T S. Binding of type 3 reovirus by a domain of the sigma 1 protein important for hemagglutination leads to infection of murine erythroleukemia cells. J Clin Invest, 90(6), 2536-42, 1992

Dermody, T S, Schiff, L A, Nibert, M L, Coombs, K M, Fields, B N. The S2 gene nucleotide sequences of prototype strains of the three reovirus serotypes: Characterization of reovirus core protein sigma 2. J Virol, 65(11), 5721-31, 1991

Nibert, M L, Dermody, T S, Fields, B N. Structure of the reovirus cell-attachment protein: A model for the domain organization of sigma 1. J Virol, 64(6), 2976-89, 1990

Dermody, T S, Nibert, M L, Bassel-Duby, R, Fields, B N. Sequence diversity in S1 genes and S1 translation products of 11 serotype 3 reovirus strains. J Virol, 64(10), 4842-50, 1990

Dermody, T S, Nibert, M L, Bassel-Duby, R, Fields, B N. A sigma 1 region important for hemagglutination by serotype 3 reovirus strains. J Virol, 64(10), 5173-6, 1990