Department of Pathology, Microbiology, and Immunology



 Wonder Puryear Drake, M.D.



Associate Professor

Dept of Medicine

Dept of Pathology, Microbiology and Immunology



Contact Information



Office Location:
MCN A-2206

Phone: 615-322-8958

E-mail:  wonder.drake@vanderbilt.edu/


Campus Mail address:

Dept of Medicine/Infectious Disease

MCN A-2200 (2582)


Mailing Address:
Vanderbilt University School of Medicine

Department of Medicine/Infectious Diseases

MCN A-2200
Nashville, TN 37232-2582







M.D., Vanderbilt
B.S., Univ of Alabama



Research Keywords






Research Description



I am interested in exploring the etiology as well as pathogenesis of chronic inflammatory states, particularly sarcoidosis. I am currently using polymerase chain reactions to investigate possible infectious etiologies of sarcoidosis. We are also using techniques such as in situ hybridization to directly localize microbial nucleic acid in the tissue specimens and molecular microarrays in collaboration with our colleagues at Cleveland Clinic, and Medical University of South Carolina.






Drake, WP, Oswald-Richter, K, Richmond, BW, Isom, J, Burke, VE, Algood, H, Braun, N, Taylor, T, Pandit, KV, Aboud, C, Yu, C, Kaminski, N, Boyd, AS, King, LE. Oral Antimycobacterial Therapy in Chronic Cutaneous Sarcoidosis: A Randomized, Single-Masked, Placebo-Controlled Study. JAMA Dermatol, 2013

Richmond, BW, Ploetze, K, Isom, J, Chambers-Harris, I, Braun, NA, Taylor, T, Abraham, S, Mageto, Y, Culver, DA, Oswald-Richter, KA, Drake, WP. Sarcoidosis Th17 cells are ESAT-6 antigen specific but demonstrate reduced IFN-?? expression. J Clin Immunol, 33(2), 446-55, 2013

Oswald-Richter, KA, Richmond, BW, Braun, NA, Isom, J, Abraham, S, Taylor, TR, Drake, JM, Culver, DA, Wilkes, DS, Drake, WP. Reversal of global CD4+ subset dysfunction is associated with spontaneous clinical resolution of pulmonary sarcoidosis. J Immunol, 190(11), 5446-53, 2013

Oswald-Richter, KA, Beachboard, DC, Seeley, EH, Abraham, S, Shepherd, BE, Jenkins, CA, Culver, DA, Caprioli, RM, Drake, WP. Dual Analysis for Mycobacteria and Propionibacteria in Sarcoidosis BAL. J Clin Immunol, 2012

Swaisgood, CM, Oswald-Richter, K, Moeller, SD, Klemenc, JM, Ruple, LM, Farver, CF, Drake, JM, Culver, DA, Drake, WP. Development of a sarcoidosis murine lung granuloma model using Mycobacterium superoxide dismutase A peptide. Am J Respir Cell Mol Biol, 44(2), 166-74, 2011

Noth, I, Gibson, KF, Drake, WP. Where next for gene expression profiling? So much promise. Am J Respir Crit Care Med, 184(10), 1102-3, 2011

Oswald-Richter, K, Sato, H, Hajizadeh, R, Shepherd, BE, Sidney, J, Sette, A, Newman, LS, Drake, WP. Mycobacterial ESAT-6 and katG are recognized by sarcoidosis CD4+ T cells when presented by the American sarcoidosis susceptibility allele, DRB1*1101. J Clin Immunol, 30(1), 157-66, 2010

Oswald-Richter, KA, Beachboard, DC, Zhan, X, Gaskill, CF, Abraham, S, Jenkins, C, Culver, DA, Drake, W. Multiple mycobacterial antigens are targets of the adaptive immune response in pulmonary sarcoidosis. Respir Res, 11, 161, 2010

Chambers, IR, Cone, TR, Oswald-Richter, K, Drake, WP. Enzyme-linked immunospot assay (ELISPOT): Quantification of Th-1 cellular immune responses against microbial antigens. J Vis Exp(45), 2010

Oswald-Richter, KA, Drake, WP. The etiologic role of infectious antigens in sarcoidosis pathogenesis. Semin Respir Crit Care Med, 31(4), 375-9, 2010

Richmond, BW, Drake, WP. Vitamin D, innate immunity, and sarcoidosis granulomatous inflammation: insights from mycobacterial research. Curr Opin Pulm Med, 2010

Moss, J, Zic, J, Drake, W. Mycobacterial infection masquerading as cutaneous sarcoidosis. Clin Exp Dermatol, 34(5), e199-201, 2009

Oswald-Richter, KA, Culver, DA, Hawkins, C, Hajizadeh, R, Abraham, S, Shepherd, BE, Jenkins, CA, Judson, MA, Drake, WP. Cellular responses to mycobacterial antigens are present in bronchoalveolar lavage fluid used in the diagnosis of sarcoidosis. Infect Immun, 77(9), 3740-8, 2009

Idell, S, Jun Na, M, Liao, H, Gazar, AE, Drake, W, Lane, KB, Koenig, K, Komissarov, A, Tucker, T, Light, RW. Single-chain urokinase in empyema induced by Pasturella multocida. Exp Lung Res, 35(8), 665-81, 2009

Drake, W. Infectious antigens may play a role in the pathogenesis of sarcoidosis. Medscape J Med, 10(12), 288, 2008

Allen, SS, Evans, W, Carlisle, J, Hajizadeh, R, Nadaf, M, Shepherd, BE, Pride, DT, Johnson, JE, Drake, WP. Superoxide dismutase A antigens derived from molecular analysis of sarcoidosis granulomas elicit systemic Th-1 immune responses. Respir Res, 9, 36, 2008

Drake, WP. When a commensal becomes a pathogen. Sarcoidosis Vasc Diffuse Lung Dis, 25(1), 10-1, 2008

Carlisle, J, Evans, W, Hajizadeh, R, Nadaf, M, Shepherd, B, Ott, RD, Richter, K, Drake, W. Multiple Mycobacterium antigens induce interferon-gamma production from sarcoidosis peripheral blood mononuclear cells. Clin Exp Immunol, 150(3), 460-8, 2007

Hajizadeh, R, Sato, H, Carlisle, J, Nadaf, MT, Evans, W, Shepherd, BE, Miller, RF, Kalams, SA, Drake, WP. Mycobacterium tuberculosis Antigen 85A induces Th-1 immune responses in systemic sarcoidosis. J Clin Immunol, 27(4), 445-54, 2007

Drake, WP, Dhason, MS, Nadaf, M, Shepherd, BE, Vadivelu, S, Hajizadeh, R, Newman, LS, Kalams, SA. Cellular recognition of Mycobacterium tuberculosis ESAT-6 and KatG peptides in systemic sarcoidosis. Infect Immun, 75(1), 527-30, 2007

Drake, WP, Newman, LS. Mycobacterial antigens may be important in sarcoidosis pathogenesis. Curr Opin Pulm Med, 12(5), 359-63, 2006

Zhiwen Zhu, Hawthorne ML, Guo Y, Drake WP, Bilaceroglu S, Misra HL, Light RW. ?Tissue Plasminogen Activator combined with human recombinant DNase is effective therapy for empyema in a rabbit model.?. Chest, 129, 1577-83, 2006

Blaha, MJ, Kusz, KL, Drake, W, Elasy, TA. Hypertension prevalence awareness, treatment and control in North Nashville. Tenn Med, 99(4), 35-7, 2006

Drake, WP, Byrd, VM, Olsen, NJ. Reactivation of systemic lupus erythematosus after initiation of highly active antiretroviral therapy for acquired immunodeficiency syndrome. J Clin Rheumatol, 9(3), 176-80, 2003

Drake, Wonder Puryear, Pei, Zhiheng, Pride, David T, Collins, Robert D, Cover, Timothy L, Blaser, Martin J. Molecular analysis of sarcoidosis tissues for mycobacterium species DNA. Emerg Infect Dis, 8, 1334-41, 2002

Lucas, G M, Lechtzin, N, Puryear, D W, Yau, L L, Flexner, C W, Moore, R D. Vancomycin-resistant and vancomycin-susceptible enterococcal bacteremia: comparison of clinical features and outcomes.. Clin Infect Dis, 26(5), 1127-33, 1998

Wilson, G J, Wetzel, J D, Puryear, W, Bassel-Duby, R, Dermody, T S. Persistent reovirus infections of L cells select mutations in viral attachment protein sigma1 that alter oligomer stability.. J Virol, 70(10), 6598-606, 1996

Schlundt, D G, Pichert, J W, Rea, M R, Puryear, W, Penha, M L, Kline, S S. Situational obstacles to adherence for adolescents with diabetes.. Diabetes Educ, 20(3), 207-11, 1994

Drake, ME. Deafness, dysesthesia, depression, diarrhea, dropsy, and death: the case for sarcoidosis in Ludwig van Beethoven. Neurology, 44(3 Pt 1), 562-5, 1994

Cover, T L, Puryear, W, Perez-Perez, G I, Blaser, M J. Effect of urease on HeLa cell vacuolation induced by Helicobacter pylori cytotoxin.. Infect Immun, 59(4), 1264-70, 1991